The DOI matches its Crossref record; 46 of the 47 references it cites were found in a registry or an index.
Increased expression of extracellular signal-regulated kinase and angiotensin-converting enzyme in human atria during atrial fibrillation
Open accessAbstract
Objectives The purpose of this study was to determine whether atrial expression of the extracellular signal-regulated kinases Erk1/Erk2 and of the angiotensin-converting enzyme (ACE) is altered in patients with atrial fibrillation (AF).Background Recent studies have demonstrated that atrial fibrosis can provide a pathophysiologic substrate for AF. However, the molecular mechanisms responsible for the development of atrial fibrosis are unclear.Methods Atrial tissue samples of 43 patients undergoing open heart surgery were examined. Seventeen patients had chronic persistent AF (> or =6 months; CAF), 8 patients had paroxysmal AF (PAF) and 18 patients had no history of AF. Erk expression was analyzed at the mRNA (quantitative reverse transcription polymerase chain reaction), the protein (immunoblot techniques) and atrial tissue (immunohistochemistry) levels. Erk-activating kinases (MEK1/2) and ACE were analyzed by immunoblot techniques.Results Increased amounts of Erk2-mRNA were found in patients with CAF (75 +/- 20 U vs. sinus rhythm: 31 +/- 25 U; p < 0.05). Activated Erk1/Erk2 and MEK1/2 were increased to more than 150% in patients with AF compared to patients with sinus rhythm. No differences between CAF and PAF were found. The expression of ACE was three-fold increased during CAF. Amounts of activated Erk1/Erk2 were reduced in patients treated with ACE inhibitors. Patients with AF showed an increased expression of Erk1/Erk2 in interstitial cells and marked atrial fibrosis.Conclusions An ACE-dependent increase in the amounts of activated Erk1/Erk2 in atrial interstitial cells may contribute as a molecular mechanism for the development of atrial fibrosis in patients with AF. These findings may have important impact on the treatment of AF.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Inhibition of the renin-angiotensin-aldosterone system can prevent structural remodelling and recurrent AF.”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [244]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,515
Atrial Fibrillation Begets Atrial Fibrillation
WIJFFELS, M. C. E. F., Kirchhof, C. J. H. J., Dorland, R., & Allessie, M. A. (1995) · Circulation · doi:10.1161/01.cir.92.7.1954 · Cited by 3,500
Epidemiologic Features of Chronic Atrial Fibrillation
Kannel, W. B., Abbott, R. D., Savage, D. D., & McNamara, P. M. (1982) · New England Journal of Medicine · doi:10.1056/nejm198204293061703 · Cited by 2,304
Weber, K. T., & Brilla, C. G. (1991) · Circulation · doi:10.1161/01.cir.83.6.1849 · Cited by 2,035
Histological Substrate of Atrial Biopsies in Patients With Lone Atrial Fibrillation
Frustaci, A., Chimenti, C., Bellocci, F., Morgante, E., Russo, M. A., & Maseri, A. (1997) · Circulation · doi:10.1161/01.cir.96.4.1180 · Cited by 1,400
Promotion of Atrial Fibrillation by Heart Failure in Dogs
Li, D., Fareh, S., Leung, T. K., & Nattel, S. (1999) · Circulation · doi:10.1161/01.cir.100.1.87 · Cited by 1,343
Morillo, C. A., Klein, G. J., Jones, D. L., & Guiraudon, C. M. (1995) · Circulation · doi:10.1161/01.cir.91.5.1588 · Cited by 1,046
Atrial enlargement as a consequence of atrial fibrillation. A prospective echocardiographic study.
Sanfilippo, A. J., Abascal, V. M., Sheehan, M., Oertel, L. B., Harrigan, P., Hughes, R. A., & Weyman, A. E. (1990) · Circulation · doi:10.1161/01.cir.82.3.792 · Cited by 739 · cited 2×
“In addition, it is well known that persistent AF, as found in our patient population, is accompanied by a significant dilation of the atria (3,22).”
BackgroundStructural Changes of Atrial Myocardium due to Sustained Atrial Fibrillation in the Goat
Ausma, J., WIJFFELS, M. C. E. F., Thoné, F., Wouters, L., Allessie, M. A., & Borgers, M. J. (1997) · Circulation · doi:10.1161/01.cir.96.9.3157 · Cited by 669
Pedersen, O. D., Bagger, H., Køber, L., & Torp-Pedersen, C. T. (1999) · Circulation · doi:10.1161/01.cir.100.4.376 · Cited by 656
Research works printed but not linked: 1
- Goette, 1999, Atrial expression of pro- inflammatory cytokines during chronic atrial fibrillation in humans, PACE, 22, A117
Cited by
Sorted by citations
Hindricks, G., Potpara, T., Dagres, N., Arbelo, E., Bax, J. J., Blomström‐Lundqvist, C., Boriani, G., Castella, M., Dan, G.-A., Dilaveris, P., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa612 · Cited by 10,550
2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation
January, C. T., Wann, L. S., Alpert, J. S., Calkins, H. G., Cigarroa, J. E., Cleveland, J. C., CONTI, J. B., Ellinor, P. T., Ezekowitz, M. D., Field, M. E., et al. (2014) · Circulation · doi:10.1161/cir.0000000000000041 · Cited by 7,145
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P. F., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castellà, M., Diener, H., Heidbüchel, H., Hendriks, J., et al. (2016) · EP Europace · doi:10.1093/europace/euw295 · Cited by 6,438
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw210 · Cited by 6,418
Guidelines for the management of atrial fibrillation
Authors/Task Force Members, Camm, A. J., Kirchhof, P. F., Lip, G. Y. H., Schotten, U., Savelieva, I., Ernst, S., Gelder, I. C. V., Al‐Attar, N., Hindricks, G., et al. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq278 · Cited by 5,924
Fuster, V., Rydén, L. E., Cannom, D. S., Crijns, H. J., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Le Heuzey, J.-Y., Kay, G. N., Lowe, J. E., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.177292 · Cited by 2,805
Guidelines for the management of atrial fibrillation
Authors/Task Force Members, Camm, A. J., Kirchhof, P. F., Lip, G. Y. H., Schotten, U., Savelieva, I., Ernst, S., Gelder, I. C. V., Al‐Attar, N., Hindricks, G., et al. (2010) · EP Europace · doi:10.1093/europace/euq350 · Cited by 1,764
Physiology of Local Renin-Angiotensin Systems
Paul, M., Poyan Mehr, A., & Kreutz, R. (2006) · Physiological Reviews · doi:10.1152/physrev.00036.2005 · Cited by 1,739
New ideas about atrial fibrillation 50 years on
Nattel, S. (2002) · Nature · doi:10.1038/415219a · Cited by 1,481
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezw313 · Cited by 1,403
Pathophysiological mechanisms of atrial fibrillation: a translational appraisal
Schotten, U., Verheule, S., Kirchhof, P., & Goette, A. (2011) · Physiological Reviews · doi:10.1152/physrev.00031.2009 · Cited by 1,273
A multicenter risk index for atrial fibrillation after cardiac surgery
Mathew, J. P. (2004) · JAMA · doi:10.1001/jama.291.14.1720 · Cited by 1,234
Fuster, V., Rydén, L., Cannom, D. S., Crijns, H. J. G. M., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Heuzey, J. L., Kay, G. N., Lowe, J. E., et al. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.07.009 · Cited by 1,161
Mechanisms of thrombogenesis in atrial fibrillation: Virchow's triad revisited
Watson, T., Shantsila, E., & Lip, G. Y. H. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60040-4 · Cited by 1,124
Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology
Forrester, S. J., Booz, G. W., Sigmund, C. D., Coffman, T. M., Kawai, T., Rizzo, V., Scalia, R. G., & Eguchi, S. (2018) · Physiological Reviews · doi:10.1152/physrev.00038.2017 · Cited by 1,135
Fuster, V., Rydén, L., Cannom, D. S., Crijns, H. J. G. M., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Kay, G. N., Huezey, J.-Y. L., Lowe, J. E., et al. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.09.013 · Cited by 928
Fuster, V., Rydén, L. E., Cannom, D. S., Crijns, H. J., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Kay, G. N., Le Huezey, J.-Y., Lowe, J. E., et al. (2011) · Circulation · doi:10.1161/cir.0b013e318214876d · Cited by 859
Goette, A., Kalman, J. M., Aguinaga, L., Akar, J. G., Cabrera, J. Á., Chen, S. A., Chugh, S. S., Corradi, D., d’Ávila, A., Dobrev, D., et al. (2016) · Heart Rhythm · doi:10.1016/j.hrthm.2016.05.028 · Cited by 791
Goette, A., Kalman, J. M., Aguinaga, L., Akar, J. G., Cabrera, J. Á., Chen, S. A., Chugh, S. S., Corradi, D., d’Ávila, A., Dobrev, D., et al. (2016) · EP Europace · doi:10.1093/europace/euw161 · Cited by 805
Li, D., Shinagawa, K., Pang, L., Leung, T. K., Cardin, S., Wang, Z., & Nattel, S. (2001) · Circulation · doi:10.1161/hc4601.099402 · Cited by 702
ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation: full text
Fuster, V., Rydén, L., Cannom, D. S., Crijns, H. J. G. M., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Heuzey, J. L., Kay, G. N., Lowe, J. E., et al. (2006) · EP Europace · doi:10.1093/europace/eul097 · Cited by 670
Authors Task Force Members, Fuster, V., Rydén, L., Cannom, D. S., Crijns, H. J. G. M., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Heuzey, J. L., Kay, G. N., et al. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehl176 · Cited by 646
Vermès, E., Tardif, J., Bourassa, M. G., Racine, N., Lévesque, S., White, M., Guerra, P. G., & Ducharme, A. (2003) · Circulation · doi:10.1161/01.cir.0000072793.81076.d4 · Cited by 575
Is atrial fibrillation an inflammatory disorder?
Boos, C. J., Anderson, R. A., & Lip, G. Y. H. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi645 · Cited by 552
Structural and Functional Remodeling of the Left Atrium
Casaclang‐Verzosa, G., Gersh, B. J., & Tsang, T. S. M. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.09.026 · Cited by 533
Role of Inflammation in Initiation and Perpetuation of Atrial Fibrillation
Issac, T. T., Dokainish, H., & Lakkis, N. M. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.06.054 · Cited by 525
Structural correlate of atrial fibrillation in human patients
Sawa Kostin, D. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00273-0 · Cited by 512
Karam, B. S., Alejandro, C.-M., Koh, W.-J., Akar, J. G., & Akar, F. G. (2017) · Cardiovascular Diabetology · doi:10.1186/s12933-017-0604-9 · Cited by 517
Kumagai, K., Nakashima, H., Urata, H., Gondo, N., Arakawa, K., & Saku, K. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00464-9 · Cited by 472
ACC/AHA/ESC 2006 Guidelines for the Management of Patients With Atrial Fibrillation
Fuster, V., Rydén, L., Cannom, D. S., Crijns, H. J. G. M., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Heuzey, J. L., Kay, G. N., Lowe, J. E., et al. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.07.018 · Cited by 468
Prevention of Atrial Fibrillation by Renin-Angiotensin System Inhibition
Schneider, M. P., Hua, T. A., Böhm, M., Wachtell, K., Kjeldsen, S. E., & Schmieder, R. E. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.01.043 · Cited by 417
Atrial Fibrillation Increases Production of Superoxide by the Left Atrium and Left Atrial Appendage
Dudley, S. C., Hoch, N. E., McCann, L. A., Honeycutt, C., Diamandopoulos, L., Fukai, T., Harrison, D. G., Dikalov, S., & Langberg, J. J. (2005) · Circulation · doi:10.1161/circulationaha.105.538108 · Cited by 375
EHRA/EAPCI expert consensus statement on catheter-based left atrial appendage occlusion – an update
Glikson, M., Wolff, R., Hindricks, G., Mandrola, J. M., Camm, A. J., Lip, G. Y. H., Fauchier, L., Betts, T. R., Lewalter, T., Saw, J., et al. (2020) · EuroIntervention · doi:10.4244/eijy19m08_01 · Cited by 374
Watanabe, H., Watanabe, T., Sasaki, S., Nagai, K., Roden, D. M., & Aizawa, Y. (2009) · American Heart Journal · doi:10.1016/j.ahj.2009.06.031 · Cited by 352
Renin-Angiotensin System Gene Polymorphisms and Atrial Fibrillation
Tsai, C., Lai, L., Lin, J.-L., Chiang, F., Hwang, J., Ritchie, M. D., Moore, J. H., Hsu, K.-L., Tseng, C.-D., Liau, C., et al. (2004) · Circulation · doi:10.1161/01.cir.0000124487.36586.26 · Cited by 345
The role of oxidative stress in the pathogenesis and perpetuation of atrial fibrillation
Korantzopoulos, P. G., Kolettis, T. M., Galaris, D., & Goudevenos, J. A. (2006) · International Journal of Cardiology · doi:10.1016/j.ijcard.2006.04.026 · Cited by 342
Fuster, V., Rydén, L., Cannom, D. S., Crijns, H. J. G. M., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Heuzey, J. L., Kay, G. N., Lowe, J. E., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.177031 · Cited by 345
Atrial fibrosis and the mechanisms of atrial fibrillation
Everett, T. H., & Olgin, J. E. (2006) · Heart Rhythm · doi:10.1016/j.hrthm.2006.12.040 · Cited by 338
Röcken, C., Peters, B., Juenemann, G., Saeger, W., Klein, H., Huth, C., Roessner, A., & Goette, A. (2002) · Circulation · doi:10.1161/01.cir.0000034511.06350.df · Cited by 336
EHRA/EAPCI expert consensus statement on catheter-based left atrial appendage occlusion – an update
Glikson, M., Wolff, R., Hindricks, G., Mandrola, J. M., Camm, A. J., Lip, G. Y. H., Fauchier, L., Betts, T. R., Lewalter, T., Saw, J., et al. (2019) · EP Europace · doi:10.1093/europace/euz258 · Cited by 341
Savelieva, I., Kakouros, N., Kourliouros, A., & Camm, A. J. (2011) · EP Europace · doi:10.1093/europace/eur002 · Cited by 315
Ehrlich, J. R., Hohnloser, S. H., & Nattel, S. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi668 · Cited by 300
Ueng, K. (2003) · European Heart Journal · doi:10.1016/j.ehj.2003.08.014 · Cited by 293
Regulation of Angiotensin II Receptor Subtypes During Atrial Fibrillation in Humans
Goette, A., Arndt, M., Röcken, C., Spiess, A., Staack, T., Geller, J. C., Huth, C., Ansorge, S., Klein, H., & Lendeckel, U. (2000) · Circulation · doi:10.1161/01.cir.101.23.2678 · Cited by 280
HANNA, N. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.03.026 · Cited by 275
de Jong, A. M., Maass, A. H., Oberdorf‐Maass, S. U., van Veldhuisen, D. J., van Gilst, W. H., & Gelder, I. C. V. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq357 · Cited by 266
Abhayaratna, W. P., Fatema, K., Barnes, M. E., Seward, J. B., Gersh, B. J., Bailey, K. R., Casaclang‐Verzosa, G., & Tsang, T. S. M. (2008) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2008.01.051 · Cited by 259
Cardin, S. (2003) · Cardiovascular Research · doi:10.1016/j.cardiores.2003.08.014 · Cited by 255
Shi, Y. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00243-2 · Cited by 237
ANNE, W., WILLEMS, R., ROSKAMS, T., SERGEANT, P., HERIJGERS, P., HOLEMANS, P., ECTOR, H., & HEIDBUCHEL, H. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.04.016 · Cited by 210
Bukowska, A., Spiller, L., Wolke, C., Lendeckel, U., Weinert, S., Hoffmann, J., Bornfleth, P., Kutschka, I., Gardemann, A., Isermann, B., et al. (2017) · Experimental Biology and Medicine · doi:10.1177/1535370217718808 · Cited by 200
Gheorghiade, M., Fonarow, G. C., van Veldhuisen, D. J., Cleland, J. G. F., Butler, J., Epstein, A. E., Patel, K., Aban, I. B., Aronow, W. S., Anker, S. D., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht120 · Cited by 192
Remodeling of cardiomyocyte ion channels in human atrial fibrillation
Dobrev, D., & Ravens, U. (2003) · Basic Research in Cardiology · doi:10.1007/s00395-003-0409-8 · Cited by 192
Angiotensin II-antagonist in paroxysmal atrial fibrillation (ANTIPAF) trial
Goette, A., Schön, N., Kirchhof, P., Breithardt, G., Fetsch, T., Häusler, K. G., Klein, H. U., Steinbeck, G., Wegscheider, K., & Meinertz, T. (2012) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.111.965178 · Cited by 187
Determinants and consequences of atrial fibrosis in patients undergoing open heart surgery
Goette, A. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00251-1 · Cited by 179
Electrophysiological and molecular mechanisms of paroxysmal atrial fibrillation
Nattel, S., & Dobrev, D. (2016) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.118 · Cited by 172
L’Allier, P. L., Ducharme, A., Keller, P., Yu, H., Guertin, M., & Tardif, J. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.03.056 · Cited by 170
Left Atrial Volume Is a Predictor of Atrial Fibrillation Recurrence After Catheter Ablation
Shin, S., Park, M.-Y., Oh, W.-J., Hong, S. J., Pak, H., Song, W.-H., Lim, D., Kim, Y., & Shim, W. (2008) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2007.10.022 · Cited by 169
Cigarette smoking induces atrial fibrosis in humans via nicotine
Goette, A., Lendeckel, U., Kuchenbecker, A., Bukowska, A., Peters, B., Klein, H., Huth, C., & Röcken, C. (2007) · Heart · doi:10.1136/hrt.2005.087171 · Cited by 163
Meta-analysis: Inhibition of renin-angiotensin system prevents new-onset atrial fibrillation
Anand, K., Mooss, A. N., Hee, T. T., & Mohiuddin, S. M. (2006) · American Heart Journal · doi:10.1016/j.ahj.2006.01.007 · Cited by 159
Goudis, C. A., Korantzopoulos, P. G., Ntalas, I. V., Kallergis, E. M., & Ketikoglou, D. G. (2015) · Journal of Cardiology · doi:10.1016/j.jjcc.2015.04.002 · Cited by 154
Matrix metalloproteinase-9 contributes to human atrial remodeling during atrial fibrillation
Nakano, Y., Niida, S., Dote, K., Takenaka, S., Hirao, H., Miura, F., Ishida, M., Shingu, T., Sueda, T., Yoshizumi, M., et al. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.08.060 · Cited by 153
Shiroshita-Takeshita, A., Brundel, B. J. J. M., Burstein, B., Leung, T. K., Mitamura, H., Ogawa, S., & Nattel, S. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.01.002 · Cited by 149
Atrial Fibrillation: Mechanisms, Therapeutics, and Future Directions
Pellman, J., & Sheikh, F. (2015) · Comprehensive physiology · doi:10.1002/cphy.c140047 · Cited by 191
Tsai, C., Lai, L., Kuo, K., Hwang, J., Hsieh, C.-S., Hsu, K.-L., Tseng, C.-D., Tseng, Y.-Z., Chiang, F., & Lin, J.-L. (2008) · Circulation · doi:10.1161/circulationaha.107.695346 · Cited by 146
Goette, A., Kalman, J. M., Aguinaga, L., Akar, J. G., Cabrera, J. Á., Chen, S. A., Chugh, S. S., Corradi, D., d’Ávila, A., Dobrev, D., et al. (2016) · Journal of Arrhythmia · doi:10.1016/j.joa.2016.05.002 · Cited by 149
Pathophysiology of atrial fibrillation and chronic kidney disease
Ding, W. Y., Gupta, D., Wong, C. F., & Lip, G. Y. H. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa258 · Cited by 144
Sakabe, M., Shiroshita-Takeshita, A., Maguy, A., Dumesnil, C., Nigam, A., Leung, T. K., & Nattel, S. (2007) · Circulation · doi:10.1161/circulationaha.107.704759 · Cited by 138
Guidelines for Pharmacotherapy of Atrial Fibrillation (JCS 2008)
JCS Joint Working Group (2010) · Circulation Journal · doi:10.1253/circj.cj-88-0001 · Cited by 137
Goette, A., Bukowska, A., Dobrev, D., Pfeiffenberger, J., Morawietz, H., Strugala, D., Wiswedel, I., Röhl, F. W., Wolke, C., Bergmann, S., et al. (2009) · European Heart Journal · doi:10.1093/eurheartj/ehp046 · Cited by 135
What are Arrhythmogenic Substrates in Diabetic Rat Atria?
Kato, T., Yamashita, T., SEKIGUCHI, A., Sagara, K., Takamura, M., Takata, S., Kaneko, S., Aizawa, T., & Fu, L.-T. (2006) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2006.00528.x · Cited by 134
Kokubu, N., Yuda, S., Tsuchihashi, K., Hashimoto, A., Nakata, T., Miura, T., Ura, N., Nagao, K., TSUZUKI, M., Wakabayashi, C., et al. (2007) · Hypertension Research · doi:10.1291/hypres.30.13 · Cited by 133
Guidelines for Pharmacotherapy of Atrial Fibrillation (JCS 2008) : Digest Version
Ogawa, S., Aizawa, Y., Atarashi, H., Inoue, H., Kamakura, S., Koretsune, Y., Kumagai, K., Mitamura, H., Okumura, K., Sugi, K., et al. (2010) · Japanese Circulation Journal-english Edition · Cited by 130
Tsai, C., Chiang, F., Tseng, C.-D., Hwang, J., Kuo, K., Wu, C., Yu, C., Wang, Y., Lai, L., & Lin, J.-L. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.09.045 · Cited by 131
Boldt, A., Wetzel, U., Weigl, J., Garbade, J., Lauschke, J., Hindricks, G., Kottkamp, H., Gummert, J. F., & Dhein, S. (2003) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.07.014 · Cited by 127
Molecular mechanisms of remodeling in human atrial fibrillation
Brundel, B. J. J. M. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00222-5 · Cited by 126
The prothrombotic state in atrial fibrillation: pathophysiological and management implications
Khan, A. A., & Lip, G. Y. H. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy272 · Cited by 123
Atrial fibrillation and heart failure: natural history and pharmacological treatment
Savelieva, I., & JOHNCAMM, A. (2004) · EP Europace · doi:10.1016/j.eupc.2004.07.003 · Cited by 120
Galectin 3 and incident atrial fibrillation in the community
Ho, J. E., Yin, X., Levy, D. A., Vasan, R. S., Magnani, J. W., Ellinor, P. T., McManus, D. D., Lubitz, S. A., Larson, M. G., & Benjamin, E. J. (2014) · American Heart Journal · doi:10.1016/j.ahj.2014.02.009 · Cited by 119
Angiotensin II Receptor Blockade Reduces Tachycardia-Induced Atrial Adhesion Molecule Expression
Goette, A., Bukowska, A., Lendeckel, U., Erxleben, M., Hammwöhner, M., Strugala, D., Pfeiffenberger, J., Röhl, F., Huth, C., Ebert, M. P. A., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.730101 · Cited by 117
Yin, Y. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehl135 · Cited by 117
Molecular Genetics of Atrial Fibrillation
Tsai, C., Lai, L., Hwang, J., Lin, J.-L., & Chiang, F. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.02.072 · Cited by 119
Jibrini, M. B., Molnar, J., & Arora, R. R. (2008) · American Journal of Therapeutics · doi:10.1097/mjt.0b013e31804beb59 · Cited by 111
Lau, D. H., Mackenzie, L., Kelly, D. J., Psaltis, P. J., Worthington, M. G., Rajendram, A., Kelly, D. R., Nelson, A. J., Zhang, Y., Kuklik, P., et al. (2009) · Heart Rhythm · doi:10.1016/j.hrthm.2009.11.031 · Cited by 111
Goette, A., & Lendeckel, U. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.03.026 · Cited by 111
Ze-Zhou, S. O. N. G. (2008) · Hypertension Research · doi:10.1291/hypres.31.585 · Cited by 110
Deshmukh, A., Barnard, J., Sun, H., Newton, D., Castel, L., Pettersson, G., Johnston, D. R., Roselli, E. E., Gillinov, A. M., McCurry, K. R., et al. (2014) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.114.001632 · Cited by 109
Goette, A., Hoffmanns, P., Enayati, W., Meltendorf, U., Geller, J. C., & Klein, H. (2001) · The American Journal of Cardiology · doi:10.1016/s0002-9149(01)01905-1 · Cited by 107
Electrical and Structural Remodeling: Role in the Genesis and Maintenance of Atrial Fibrillation
SCHOONDERWOERD, B. A., Gelder, I. C. V., van Veldhuisen, D. J., van den Berg, M. P., & Crijns, H. J. G. M. (2005) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2005.06.014 · Cited by 106
Boldt, A., Scholl, A., Garbade, J., Resetar, M., Mohr, F., Gummert, J. F., & Dhein, S. (2005) · Basic Research in Cardiology · doi:10.1007/s00395-005-0571-2 · Cited by 101
Mitochondrial Dysfunction and Redox Signaling in Atrial Tachyarrhythmia
Bukowska, A., Schild, L., Keilhoff, G., Hirte, D., Neumann, M., Gardemann, A., Neumann, K. H., Röhl, F., Huth, C., Goette, A., et al. (2008) · Experimental Biology and Medicine · doi:10.3181/0706-rm-155 · Cited by 100
Altered Expression of ADAMs ( A D isintegrin A nd M etalloproteinase) in Fibrillating Human Atria
Arndt, M., Lendeckel, U., Röcken, C., Nepple, K., Wolke, C., Spiess, A., Huth, C., Ansorge, S., Klein, H., & Goette, A. (2002) · Circulation · doi:10.1161/hc0602.103639 · Cited by 98
Regulatory mechanisms of atrial fibrotic remodeling in atrial fibrillation
Lin, C., & Pan, C. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-7408-8 · Cited by 100
Boriani, G., Vitolo, M., Diemberger, I., Proietti, M., Valenti, A. C., Malavasi, V. L., & Lip, G. Y. H. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab147 · Cited by 105
Heat shock proteins in fibrosis and wound healing: Good or evil?
Bellaye, P., Burgy, O., Causse, S., Garrido, C., & Bonniaud, P. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.02.009 · Cited by 97
Nattel, S. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(01)00562-4 · Cited by 97
The Effects of Vitamin D Deficiency on Atrial Fibrillation
Demir, M., Uyan, U., & Melek, M. (2012) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/1076029612453762 · Cited by 91
Goktekin, O. (2014) · Medical Science Monitor · doi:10.12659/msm.890635 · Cited by 92
Anné, W., Willems, R., Holemans, P., Beckers, F., Roskams, T., Lenaerts, I., Ector, H., & Heidbüchel, H. (2007) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2007.05.010 · Cited by 91
Darbar, D., Motsinger‐Reif, A. A., Ritchie, M. D., Gainer, J. V., & Roden, D. M. (2007) · Heart Rhythm · doi:10.1016/j.hrthm.2007.02.006 · Cited by 91
Metadata
- Authors
- Goette, A., Staack, T., Röcken, C., Arndt, M., Geller, J. C., Huth, C., Ansorge, S., Klein, H. U., & Lendeckel, U.
- Affiliations
- University Hospital Magdeburg (DE)
- Corresponding author
- Goette, Andreas
- ORCID
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2000-05
- Volume
- 35
- Issue
- 6
- Pages
- 1669-1677
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2038843437
- Cited by
- 583
- References
- 47
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 14 · 2023: 10 · 2022: 17 · 2021: 17 · 2020: 15 · 2019: 17 · 2018: 10 · 2017: 17 · 2016: 20 · 2015: 17 · 2014: 23 · 2013: 24 · 2012: 27
- FWCI
- 10.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- atrial fibrillation, extracellular signal-regulated kinase, ERK1/ERK2, angiotensin-converting enzyme, atrial fibrosis, MEK1/2, interstitial cells, chronic atrial fibrillation, paroxysmal atrial fibrillation, ACE inhibitors, MAPK signaling
- MeSH terms
- Aged, Atrial Fibrillation, Endomyocardial Fibrosis, Female, Heart Atria, Humans, Peptidyl-Dipeptidase A, Male, Middle Aged, RNA, Messenger, Gene Expression Regulation, Enzymologic, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinases, Mitogen-Activated Protein Kinase 3
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
