The DOI matches its Crossref record; 46 of the 47 references it cites were found in a registry or an index.
Increased expression of extracellular signal-regulated kinase and angiotensin-converting enzyme in human atria during atrial fibrillation
Open accessAbstract
Objectives The purpose of this study was to determine whether atrial expression of the extracellular signal-regulated kinases Erk1/Erk2 and of the angiotensin-converting enzyme (ACE) is altered in patients with atrial fibrillation (AF).Background Recent studies have demonstrated that atrial fibrosis can provide a pathophysiologic substrate for AF. However, the molecular mechanisms responsible for the development of atrial fibrosis are unclear.Methods Atrial tissue samples of 43 patients undergoing open heart surgery were examined. Seventeen patients had chronic persistent AF (> or =6 months; CAF), 8 patients had paroxysmal AF (PAF) and 18 patients had no history of AF. Erk expression was analyzed at the mRNA (quantitative reverse transcription polymerase chain reaction), the protein (immunoblot techniques) and atrial tissue (immunohistochemistry) levels. Erk-activating kinases (MEK1/2) and ACE were analyzed by immunoblot techniques.Results Increased amounts of Erk2-mRNA were found in patients with CAF (75 +/- 20 U vs. sinus rhythm: 31 +/- 25 U; p < 0.05). Activated Erk1/Erk2 and MEK1/2 were increased to more than 150% in patients with AF compared to patients with sinus rhythm. No differences between CAF and PAF were found. The expression of ACE was three-fold increased during CAF. Amounts of activated Erk1/Erk2 were reduced in patients treated with ACE inhibitors. Patients with AF showed an increased expression of Erk1/Erk2 in interstitial cells and marked atrial fibrosis.Conclusions An ACE-dependent increase in the amounts of activated Erk1/Erk2 in atrial interstitial cells may contribute as a molecular mechanism for the development of atrial fibrosis in patients with AF. These findings may have important impact on the treatment of AF.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Inhibition of the renin-angiotensin-aldosterone system can prevent structural remodelling and recurrent AF.”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [244]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,515
Atrial Fibrillation Begets Atrial Fibrillation
WIJFFELS, M. C. E. F., Kirchhof, C. J. H. J., Dorland, R., & Allessie, M. A. (1995) · Circulation · doi:10.1161/01.cir.92.7.1954 · Cited by 3,500
Epidemiologic Features of Chronic Atrial Fibrillation
Kannel, W. B., Abbott, R. D., Savage, D. D., & McNamara, P. M. (1982) · New England Journal of Medicine · doi:10.1056/nejm198204293061703 · Cited by 2,304
Weber, K. T., & Brilla, C. G. (1991) · Circulation · doi:10.1161/01.cir.83.6.1849 · Cited by 2,035
Histological Substrate of Atrial Biopsies in Patients With Lone Atrial Fibrillation
Frustaci, A., Chimenti, C., Bellocci, F., Morgante, E., Russo, M. A., & Maseri, A. (1997) · Circulation · doi:10.1161/01.cir.96.4.1180 · Cited by 1,400
Promotion of Atrial Fibrillation by Heart Failure in Dogs
Li, D., Fareh, S., Leung, T. K., & Nattel, S. (1999) · Circulation · doi:10.1161/01.cir.100.1.87 · Cited by 1,343
Morillo, C. A., Klein, G. J., Jones, D. L., & Guiraudon, C. M. (1995) · Circulation · doi:10.1161/01.cir.91.5.1588 · Cited by 1,046
Atrial enlargement as a consequence of atrial fibrillation. A prospective echocardiographic study.
Sanfilippo, A. J., Abascal, V. M., Sheehan, M., Oertel, L. B., Harrigan, P., Hughes, R. A., & Weyman, A. E. (1990) · Circulation · doi:10.1161/01.cir.82.3.792 · Cited by 739 · cited 2×
“In addition, it is well known that persistent AF, as found in our patient population, is accompanied by a significant dilation of the atria (3,22).”
BackgroundStructural Changes of Atrial Myocardium due to Sustained Atrial Fibrillation in the Goat
Ausma, J., WIJFFELS, M. C. E. F., Thoné, F., Wouters, L., Allessie, M. A., & Borgers, M. J. (1997) · Circulation · doi:10.1161/01.cir.96.9.3157 · Cited by 669
Pedersen, O. D., Bagger, H., Køber, L., & Torp-Pedersen, C. T. (1999) · Circulation · doi:10.1161/01.cir.100.4.376 · Cited by 656
Research works printed but not linked: 1
- Goette, 1999, Atrial expression of pro- inflammatory cytokines during chronic atrial fibrillation in humans, PACE, 22, A117
Cited by
Sorted by citations
Items 501–576 of 576
Steimle, J. D., Laforest, B., Nadadur, R. D., Broman, M., & Moskowitz, I. P. G. (2020) · Springer eBooks · doi:10.1007/978-981-15-1185-1_51 · Cited by 1
Fuster, V., Ryden, L. E., Cannom, D. S., Crijns, H. J. G. M., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Heuzey, J. Y. L., Kay, G. N., Lowe, J. E., et al. (2007) · Rational Pharmacotherapy in Cardiology · doi:10.20996/1819-6446-2007-3-2-72-97 · Cited by 1
Humanization of Murine Monoclonal anti-hTNF Antibody: The F10 Story
Efimov, G. A., Raats, J. M. H., Chirivi, R. G. S., van Rosmalen, J. W. G., & Nedospasov, S. A. (2017) · Molecular Biology · doi:10.1134/s0026893317060061 · Cited by 1
Al-Seykal, I., Bose, A., Chevli, P. A., Hashmath, Z., Sharma, N. K., Mishra, A. K., & Laidlaw, D. W. (2022) · World Journal of Cardiology · doi:10.4330/wjc.v14.i10.537 · Cited by 1
Pathophysiology of Atrial Fibrillation
Byrne, R. A., & Daly, K. M. (2008) · doi:10.1002/9780470696354.ch2 · Cited by 1
Mascitelli, L., & Pezzetta, F. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.11.032 · Cited by 1
Angiotensin-converting enzyme inhibitors as a new therapy for atrial fibrillation? Controversy
Ogimoto, A., Shigematsu, Y., Higaki, J., & Miki, T. (2005) · American Heart Journal · doi:10.1016/j.ahj.2004.09.020 · Cited by 1
Shibata, R., Nakao, K., Fukae, S., Matsuo, K., & Yano, K. (2006) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2006.00311.x · Cited by 1
Rationale for and Design of the CREATIVE-AF Trial
Goette, A., D’Alessandro, A., Bukowska, A., Kropf, S., Mewis, C., Stellbrink, C., Tebbenjohanns, J., Weiß, C. H., & Lendeckel, U. (2008) · Clinical Drug Investigation · doi:10.2165/00044011-200828090-00003 · Cited by 1
Dai, S., Zhang, S., Chu, J., Guo, Y., Chen, K., & Yao, S. (2007) · Medical Hypotheses · doi:10.1016/j.mehy.2007.02.016 · Cited by 1
Antiadrenergic Therapy in the Control of Atrial Fibrillation
Naccarelli, G. V. (2005) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/10742484050100i405 · Cited by 1
Atrail Fibrillation after Carfiac Surgery: Benign or Deserving of Prophylaxis.
Westaby, S. (2010) · Europe PMC (PubMed Central) · doi:10.4022/jafib.337 · Cited by 1
Renin-angiotensin system inhibitors and atrial fibrillation.
Arbel, Y., & Glikson, M. (2005) · PubMed · Cited by 1
Novel Personalised Determinants of Atrial Substrate in Atrial Fibrillation
Wong, G. R. (2019) · Minerva Access (University of Melbourne) · Cited by 1
Biological mechanisms of aging predict age-related disease multimorbidities in patientsPreprint
Fraser, H. C., Kuan, V., Johnen, R., Zwierzyna, M., Hingorani, A. D., Beyer, A., & Partridge, L. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.04.442567 · Cited by 1
Fibrillation atriale et diabète de type 2
Bergerot, C. (2015) · Médecine des Maladies Métaboliques · doi:10.1016/s1957-2557(15)30139-5
Neue Aspekte der medikamentösen antiarrhythmischen Therapie
Goette, A. (2006) · Steinkopff eBooks · doi:10.1007/3-7985-1632-4_3
Atrial Fibrillation and Heart Failure in the Aging Population
Kazemian, P., & Jugdutt, B. I. (2014) · Springer eBooks · doi:10.1007/978-1-4939-0268-2_5
Lehto, M. (2009) · Työväentutkimus Vuosikirja
Pastorelli, C. P. (2009) · doi:10.11606/d.9.2009.tde-29032010-110814
Bluthochdruck und Herzrhythmusstörungen - eine gefährliche Kombination
Strohmer, B. (2009) · Journal für Kardiologie (Krause & Pachernegg GmbH)
Altın, T., Gürlek, A., Özdöl, Ç., Kılıçkap, M., Dinçer, İ., Turhan, S., & Erol, Ç. (2007) · DOAJ (DOAJ: Directory of Open Access Journals)
Conduction Disturbances in Patients with Atrial Fibrillation
Hertervig, E. J. (2006) · Lund University Publications (Lund University)
Stockburger, M. (2010) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-9002
GÜRLEK, A. T. (2007) · Ankara Üniversitesi Tıp Fakültesi Mecmuası · doi:10.1501/tipfak_0000000570
Efremidis, M., & Bramos, D. (2008) · Hospital chronicles/Hospital Chronicles
Geidel, S., Lass, M., Schneider, C., Jensen, F., Hassan, K., Boczor, S., Kuck, K., & Ostermeyer, J. (2007) · The Thoracic and Cardiovascular Surgeon · doi:10.1055/s-2007-967499
The Effect of Renal Sympathetic Denervation (RSD) in Atrial Fibrillation (AF) Inducibility
Upadhyay, I. P., Hu, J., Na, W. N., Kun, W., Linuer, T. D., Li, Z., Alia, A., & Hou, Y. (2014) · World Journal of Cardiovascular Diseases · doi:10.4236/wjcd.2014.44020
Dabigatran for prophylaxis of thromboembolic events in patients with atrial fibrillation
Götte, A. (2012) · Research Reports in Clinical Cardiology · doi:10.2147/rrcc.s17430
Durin, O., Pedrinazzi, C., & Inama, G. (2008) · Giornale italiano di cardiologia · doi:10.1714/675.7856
Pop, D., Zdrenghea, D. T., Maria, P. L., & Adela, P. (2010)
Geidel, S., Ostermeyer, J., Laß, M., Boczor, S., & Kück, K. (2003)
Febres‐Aldana, C. A., Fernandez‐Ruiz, R., Febres-Aldana, A. J., & Martínez, A. D. (2015) · Redalyc (Universidad Autónoma del Estado de México)
and Anatomy of the Left Atrial Appendage Why Does Thrombus Form
Kanmanthareddy, A., Reddy, Y. M., Vallakati, A., Earnest, M., Nath, J., Ferrell, R., Dawn, B., & Lakkireddy, D. (2014)
Dąbrowski, R., & Szwed, H. (2007) · PubMed
Atrial Fibrillation in Rural Adults: An Inpatient Evaluation of Clinical Guidelines Adherence
Klug, M. J. (2015) · UA Campus Repository (The University of Arizona)
Goette, A., Lendeckel, U., & Klein, H. (2004) · Zeitschrift für Kardiologie
Novikova, N. (2010) · CyberLeninK (CyberLeninka)
Medizin, A. I., Direktor, Ä., & Gawaz, M. (2012)
Geidel, S., Lass, M., Schneider, C., Jensen, F., Hassan, K., Boczor, S., Kück, K., & Ostermeyer, J. (2007) · Zeitschrift für Herz- Thorax- und Gefäßchirurgie · doi:10.1007/s00398-007-0580-6
Adhesion Molecules in Atrial Fibrillation
Hammw√∂hner, M., Bukowska, A., Braun-Dullaeus, R., & Goette, A. (2010) · Science Publishers eBooks · doi:10.1201/b10167-28
Dimitri, H. R. (2012) · Adelaide Research & Scholarship (AR&S) (University of Adelaide)
The effect of tachycardic irregularity on ventricular repolarization dynamics
Prinsen, J. K. (2013) · Michigan State University Libraries · doi:10.25335/m5175p
Zou, L. (2014) · TSpace (University of Toronto)
Novikova, Т. N. (2010) · Arterial’naya Gipertenziya (Arterial Hypertension) · doi:10.18705/1607-419x-2010-16-4-423-428
Sanders, P., Morton, J. B., SPARKS, P. B., & Kalman, J. M. (2005) · doi:10.1002/9780470994818.ch5
Molaee, P. (2012) · Adelaide Research & Scholarship (AR&S) (University of Adelaide)
Atrial Fibrillation and Other Arrhythmias in Hypertensive Heart Disease
Athanasiou, D., Kallistratos, M. S., Poulimenos, L. E., & Manolis, A. J. (2019) · Updates in hypertension and cardiovascular protection · doi:10.1007/978-3-319-93320-7_14
Hypertension artérielle et troubles du rythme
Champ‐Rigot, L., Alexandre, J., & Milliez, P. (2017)
Cognitive Decline in Elderly Patients with Hypertensive Heart Disease
Liguori, I., Curcio, F., Abete, P., & Testa, G. (2019) · Springer eBooks · doi:10.1007/978-3-319-90305-7_8-1
Okamura, K., Okuda, T., Takamiya, Y., Shirai, K., & Urata, H. (2020) · Heart and Vessels · doi:10.1007/s00380-020-01582-4
Гетьман, Т. В., & Getman, N. V. (2017) · Medicine of Ukraine · doi:10.37987/1997-9894.2017.3(209).222026
Serra, J. L. P., & Bendersky, M. (2009)
Pacella, J., Molina, F., Gómez, A., & Florio, L. (2020) · Revista Uruguaya de Cardiología · doi:10.29277/cardio.35.2.11
A Molecular Genetic Perspective on Atrial Fibrillation
Roberts, J. D., & Gollob, M. H. (2010) · Springer eBooks · doi:10.1007/978-1-84996-471-5_13
樋口ルミ, 浩之, 戸., 絵梨, 新., 裕子, 丸., 岡庭裕貴, 康之, 小., 貴子, 山., 上田正徳, 清美, 小., & 和利, 井. (2006) · doi:10.11272/jssabst.31.0.233.1
Atrial remodelling in persistent atrial fibrillation: the potential role of aldosterone: Reply
Ueng, K.-C. (2004) · European Heart Journal · doi:10.1016/j.ehj.2003.12.034
Left Atrial Size Is a Poor Predictor of Pathology in the Older Patient: Preliminary Observations
Goldman, J. H., Ehlgen, A., Ursell, P. C., & Schiller, N. B. (2005) · Echocardiography · doi:10.1111/j.1540-8175.2005.00174.x
Cognitive Decline in Elderly Patients with Hypertensive Heart Disease
Liguori, I., Curcio, F., Abete, P., & Testa, G. (2020) · Springer eBooks · doi:10.1007/978-3-030-28008-6_8
Nicholls, B. (2022) · Open Access Victoria University of Wellington | Te Herenga Waka (Figshare) · doi:10.26686/wgtn.19835542
Atrial Fibrilasyon İle ACE Gen Polimorfizmi Arasındaki İlişkinin İncelenmesi
Özyurtlu, F., & Bayturan, Ö. (2022) · Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi · doi:10.34087/cbusbed.1098537
ATRIAL FIBRILLATION: THE STAGES OF TREATMENT AND DIAGNOSTIC MEASURES (literature review)
Salivonchyk, D. P. (2013) · Health and Ecology Issues · doi:10.51523/2708-6011.2013-10-3-2
Tüm Yönleri ile AF ve Tedavi Yaklaşımları
Çelik, A., Hakgör, A., Çolak, A., Kunak, A. Ü., Sezenöz, B., Şengör, B. G., Arın, C. B., Coşkun, E. Ç., Ersoy, E. I. Y., Aksakal, E., et al. (2022) · Akademisyen Kitabevi eBooks · doi:10.37609/akya.1962
Perepeka, Y. O. (2024) · Актуальні проблеми сучасної медицини Вісник Української медичної стоматологічної академії · doi:10.31718/2077-1096.24.3.251
Wang, S. S. Y., Patidar, D., Mallavarapu, K., Luo, X. R., Ibakkanavar, R., & Javaid, M. M. (2026) · British Journal of Hospital Medicine · doi:10.31083/bjhm51833
Balan, A. I., Butoi, E. D., Vadana, M., Naie, M. L., Mihaila, A. C., & Scridon, A. (2026) · Romanian Journal of Cardiology · doi:10.2478/rjc-2026-0010
New-Onset Atrial Fibrillation and Accelerated Kidney Function Decline in Working-Age Adults
Mori, Y., Hirano, K., Ikenoue, T., Kobayashi, A., Yanagita, M., & Fukuma, S. (2026) · JAMA Network Open · doi:10.1001/jamanetworkopen.2026.12823
Yang, H., Yu, K., & Liang, B. (2026) · Journal of Diabetes Research · doi:10.1155/jdr/4189404
Metadata
- Authors
- Goette, A., Staack, T., Röcken, C., Arndt, M., Geller, J. C., Huth, C., Ansorge, S., Klein, H. U., & Lendeckel, U.
- Affiliations
- University Hospital Magdeburg (DE)
- Corresponding author
- Goette, Andreas
- ORCID
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2000-05
- Volume
- 35
- Issue
- 6
- Pages
- 1669-1677
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2038843437
- Cited by
- 583
- References
- 47
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 14 · 2023: 10 · 2022: 17 · 2021: 17 · 2020: 15 · 2019: 17 · 2018: 10 · 2017: 17 · 2016: 20 · 2015: 17 · 2014: 23 · 2013: 24 · 2012: 27
- FWCI
- 10.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- atrial fibrillation, extracellular signal-regulated kinase, ERK1/ERK2, angiotensin-converting enzyme, atrial fibrosis, MEK1/2, interstitial cells, chronic atrial fibrillation, paroxysmal atrial fibrillation, ACE inhibitors, MAPK signaling
- MeSH terms
- Aged, Atrial Fibrillation, Endomyocardial Fibrosis, Female, Heart Atria, Humans, Peptidyl-Dipeptidase A, Male, Middle Aged, RNA, Messenger, Gene Expression Regulation, Enzymologic, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinases, Mitogen-Activated Protein Kinase 3
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
