The DOI matches its Crossref record; 46 of the 47 references it cites were found in a registry or an index.
Increased expression of extracellular signal-regulated kinase and angiotensin-converting enzyme in human atria during atrial fibrillation
Open accessAbstract
Objectives The purpose of this study was to determine whether atrial expression of the extracellular signal-regulated kinases Erk1/Erk2 and of the angiotensin-converting enzyme (ACE) is altered in patients with atrial fibrillation (AF).Background Recent studies have demonstrated that atrial fibrosis can provide a pathophysiologic substrate for AF. However, the molecular mechanisms responsible for the development of atrial fibrosis are unclear.Methods Atrial tissue samples of 43 patients undergoing open heart surgery were examined. Seventeen patients had chronic persistent AF (> or =6 months; CAF), 8 patients had paroxysmal AF (PAF) and 18 patients had no history of AF. Erk expression was analyzed at the mRNA (quantitative reverse transcription polymerase chain reaction), the protein (immunoblot techniques) and atrial tissue (immunohistochemistry) levels. Erk-activating kinases (MEK1/2) and ACE were analyzed by immunoblot techniques.Results Increased amounts of Erk2-mRNA were found in patients with CAF (75 +/- 20 U vs. sinus rhythm: 31 +/- 25 U; p < 0.05). Activated Erk1/Erk2 and MEK1/2 were increased to more than 150% in patients with AF compared to patients with sinus rhythm. No differences between CAF and PAF were found. The expression of ACE was three-fold increased during CAF. Amounts of activated Erk1/Erk2 were reduced in patients treated with ACE inhibitors. Patients with AF showed an increased expression of Erk1/Erk2 in interstitial cells and marked atrial fibrosis.Conclusions An ACE-dependent increase in the amounts of activated Erk1/Erk2 in atrial interstitial cells may contribute as a molecular mechanism for the development of atrial fibrosis in patients with AF. These findings may have important impact on the treatment of AF.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Inhibition of the renin-angiotensin-aldosterone system can prevent structural remodelling and recurrent AF.”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [244]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,515
Atrial Fibrillation Begets Atrial Fibrillation
WIJFFELS, M. C. E. F., Kirchhof, C. J. H. J., Dorland, R., & Allessie, M. A. (1995) · Circulation · doi:10.1161/01.cir.92.7.1954 · Cited by 3,500
Epidemiologic Features of Chronic Atrial Fibrillation
Kannel, W. B., Abbott, R. D., Savage, D. D., & McNamara, P. M. (1982) · New England Journal of Medicine · doi:10.1056/nejm198204293061703 · Cited by 2,304
Weber, K. T., & Brilla, C. G. (1991) · Circulation · doi:10.1161/01.cir.83.6.1849 · Cited by 2,035
Histological Substrate of Atrial Biopsies in Patients With Lone Atrial Fibrillation
Frustaci, A., Chimenti, C., Bellocci, F., Morgante, E., Russo, M. A., & Maseri, A. (1997) · Circulation · doi:10.1161/01.cir.96.4.1180 · Cited by 1,400
Promotion of Atrial Fibrillation by Heart Failure in Dogs
Li, D., Fareh, S., Leung, T. K., & Nattel, S. (1999) · Circulation · doi:10.1161/01.cir.100.1.87 · Cited by 1,343
Morillo, C. A., Klein, G. J., Jones, D. L., & Guiraudon, C. M. (1995) · Circulation · doi:10.1161/01.cir.91.5.1588 · Cited by 1,046
Atrial enlargement as a consequence of atrial fibrillation. A prospective echocardiographic study.
Sanfilippo, A. J., Abascal, V. M., Sheehan, M., Oertel, L. B., Harrigan, P., Hughes, R. A., & Weyman, A. E. (1990) · Circulation · doi:10.1161/01.cir.82.3.792 · Cited by 739 · cited 2×
“In addition, it is well known that persistent AF, as found in our patient population, is accompanied by a significant dilation of the atria (3,22).”
BackgroundStructural Changes of Atrial Myocardium due to Sustained Atrial Fibrillation in the Goat
Ausma, J., WIJFFELS, M. C. E. F., Thoné, F., Wouters, L., Allessie, M. A., & Borgers, M. J. (1997) · Circulation · doi:10.1161/01.cir.96.9.3157 · Cited by 669
Pedersen, O. D., Bagger, H., Køber, L., & Torp-Pedersen, C. T. (1999) · Circulation · doi:10.1161/01.cir.100.4.376 · Cited by 656
Research works printed but not linked: 1
- Goette, 1999, Atrial expression of pro- inflammatory cytokines during chronic atrial fibrillation in humans, PACE, 22, A117
Cited by
Sorted by citations
Items 301–400 of 576
New antiarrhythmic agents for atrial fibrillation and atrial flutter
Pecini, R., Elming, H., Pedersen, O. D., & Torp-Pedersen, C. T. (2005) · Expert Opinion on Emerging Drugs · doi:10.1517/14728214.10.2.311 · Cited by 15
Nakajima, T., Haruyama, A., Fukuda, T., Minami, K., Hirose, S., Yazawa, H., Nakajima, T., Hasegawa, T., Kitagawa, Y., Obi, S., et al. (2024) · PLoS ONE · doi:10.1371/journal.pone.0306323 · Cited by 14
Updates on the Renin–Angiotensin–Aldosterone System and the Cardiovascular Continuum
Pop, D., Dădârlat‐Pop, A., Tomoaia, R., Zdrenghea, D. T., & Caloian, B. (2024) · Biomedicines · doi:10.3390/biomedicines12071582 · Cited by 14
Biomarkers of Atrial Fibrillation: Which One Is a True Marker?
Ardhianto, P., & Yuniadi, Y. (2019) · Cardiology Research and Practice · doi:10.1155/2019/8302326 · Cited by 14
Koniari, I. C., Artopoulou, E., Mplani, V., Mulita, F., Alexopoulou, E., Chourdakis, E., Abo-Elseoud, M., Tsigkas, G., Panagiotopoulos, I. A., Kounis, N. G., et al. (2022) · Cardiology Journal · doi:10.5603/cj.a2022.0061 · Cited by 14
Renin-angiotensin system–related gene polymorphisms are associated with risk of atrial fibrillation
Xiao, P., Ling, Z., Woo, K.-S., Du, H., Su, L., Liu, Z., & Yin, Y. (2010) · American Heart Journal · doi:10.1016/j.ahj.2010.06.013 · Cited by 14
Park, J., Lee, S. H., Lee, J. S., Park, J. H., Joung, B., Lee, M., Chang, B., & Pak, H. (2016) · Journal of Cardiology · doi:10.1016/j.jjcc.2016.07.012 · Cited by 14
Geidel, S., Laß, M., Boczor, S., Kück, K., & Ostermeyer, J. (2004) · The Heart Surgery Forum · doi:10.1532/hsf98.20041054 · Cited by 14
Geidel, S., Ostermeyer, J., Laß, M., Boczor, S., & Kück, K. (2003) · PubMed · Cited by 14
Atrial Fibrillation and Chronic Kidney Disease: Aetiology and Management
Sidhu, B., Mavilakandy, A. K., Hull, K. L., Koev, I. M., Vali, Z., Burton, J. O., & Ng, G. A. (2024) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2504143 · Cited by 16
Mechanisms underlying atrial fibrillation in chronic kidney disease
Navarro‐García, J. A., Keefe, J. A., Song, J., Li, N., & Wehrens, X. H. T. (2025) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2025.06.002 · Cited by 14
Comparison of the effects of quinapril and irbesartan on P-wave dispersion in hypertensive patients
Güntekin, Ü., Güneş, Y., Tuncer, M., Şimşek, H., & Güneş, A. K. (2008) · Advances in Therapy · doi:10.1007/s12325-008-0083-1 · Cited by 12
Upstream Effect for Atrial Fibrillation: Still a Dilemma?
Calò, L., Martino, A., Sciarra, L., Ciccaglioni, A., Ruvo, E. D., Luca, L. D., Sette, A., Giunta, G., Lioy, E., & Fedele, F. (2010) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2010.02942.x · Cited by 13
Chung, I., Khan, Y. M. A., Warrens, H., Seshasai, R. K., Sohal, M., & Banerjee, D. (2022) · Cardiorenal Medicine · doi:10.1159/000525388 · Cited by 13
Blood Pressure Variability and Risk of Atrial Fibrillation in Adults With Type 2 Diabetes
Kazé, A. D., Yuyun, M., Fonarow, G., & Echouffo-Tcheugui, J. (2023) · JACC: Advances · doi:10.1016/j.jacadv.2023.100382 · Cited by 13
Okumura, K. (2007) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2007.00918.x · Cited by 13
Galectin-3: A biochemical marker to detect paroxysmal atrial fibrillation?
Selçoki, Y., Aydin, H. İ., Çelik, T., İşleyen, A., Erayman, A., Demirçelik, M. B., Demirin, H., Köşüş, A., & Eryonucu, B. (2016) · Clinical and investigative medicine · doi:10.25011/cim.v39i6.27528 · Cited by 13
Chung, Y., Yang, Y., Wu, C., Yu, C., Juang, J. J., Wang, Y., Tsai, C., Lin, L., Lai, L., Hwang, J., et al. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.05.167 · Cited by 13
Upstream Targets to Treat Atrial Fibrillation
Sanders, P., Elliott, A. D., & Linz, D. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.10.043 · Cited by 13
Chen, M., Chang, J.-P., Chang, T., Hsu, S., Huang, H., Ho, W., Wang, F., Hsiao, C., & Liu, W.-H. (2014) · Translational research · doi:10.1016/j.trsl.2014.11.005 · Cited by 12
Goette, A., Weber, M., Lendeckel, U., Welte, T., Lutze, G., & Klein, H. (2004) · Journal of Interventional Cardiac Electrophysiology · doi:10.1023/b:jice.0000019267.24208.c4 · Cited by 12
Biomarkers in electrophysiology: role in arrhythmias and resynchronization therapy
Bose, A., Truong, Q. A., & Singh, J. P. (2015) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-015-9982-7 · Cited by 11
Jiang, M.-H., Su, Y.-M., Tang, J.-Z., Shen, Y.-B., Deng, X., Yuan, D., Wu, J., Pan, M., & Huang, Z. (2013) · Clinics · doi:10.6061/clinics/2013(11)08 · Cited by 12
Ablation surgery in patients with persistent atrial fibrillation: An 8-year clinical experience
Geidel, S., Krause, K., Boczor, S., Kück, K., Laß, M., Ostermeyer, J., & Schmoeckel, M. (2010) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2010.03.024 · Cited by 12
Ebana, Y., Sun, Y., Yang, X., Watanabe, T., Makita, S., Ozaki, K., Tanaka, T., Arai, H., & Furukawa, T. (2019) · IJC Heart & Vasculature · doi:10.1016/j.ijcha.2019.100383 · Cited by 13
Plasma biomarkers as predictors of recurrence of atrial fibrillation
Lewicka, E., Dudzińska-Gehrmann, J., Dąbrowska-Kugacka, A., Zagożdżon, P., Stepnowska, E., Liżewska-Springer, A., Kozłowski, D., & Raczak, G. (2015) · Polskie Archiwum Medycyny Wewnętrznej · doi:10.20452/pamw.2882 · Cited by 12
Cong, X., Tian, B., Zhu, X., Zhang, X., Gu, W., Zhao, H., Hao, S., & Ning, Z. (2023) · Cerebrovascular Diseases · doi:10.1159/000527740 · Cited by 11
MASOOD, S. O., Wasmund, S. L., AKOUM, N. W., Egger, M. J., Hsiai, T. K., & Hamdan, M. H. (2010) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2010.01792.x · Cited by 10
Atrial Fibrillation: Can We Cure It If We Can't Explain It?
Sung, R. J., & Lauer, M. R. (2005) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2005.50021.x · Cited by 11
Dąbrowski, R., Sosnowski, C., Jankowska, A., Religa, G., Kowalik, I., & Szwed, H. (2007) · PubMed · Cited by 11
Okawa, K., Miyoshi, T., Sogo, M., Hara, S., Sudo, Y., Ugawa, S., Takahashi, M., Doi, M., Morita, H., & Ito, H. (2020) · Journal of Cardiology · doi:10.1016/j.jjcc.2020.07.002 · Cited by 11
Pathophysiology and therapeutic relevance of PI3K(p110α) protein in atrial fibrillation
Ezeani, M., & Prabhu, S. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2020.105415 · Cited by 11
Hirayama, Y., Atarashi, H., Kobayashi, Y., & Takano, T. (2004) · Japanese Heart Journal · doi:10.1536/jhj.45.93 · Cited by 11
Proteomics in myocardial diseases
Bukowska, A., Lendeckel, U., Kähne, T., & Goette, A. (2004) · Pathology - Research and Practice · doi:10.1016/j.prp.2004.02.004 · Cited by 11
Fuster, V., Rydén, L., Cannom, D. S., Crijns, H. J. G. M., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Heuzey, J. Y. L., Kay, G. N., Lowe, J. E., et al. (2007) · Rational Pharmacotherapy in Cardiology · doi:10.20996/1819-6446-2007-3-3-84-111 · Cited by 11
Atrial fibrillation and fibrosis: role of connective tissue growth factor
Lendeckel, U., Wolke, C., & Goette, A. (2012) · EP Europace · doi:10.1093/europace/eus147 · Cited by 11
Atrial remodeling in persistent atrial fibrillation: the potential role of aldosterone
Korantzopoulos, P. G. (2004) · European Heart Journal · doi:10.1016/j.ehj.2003.12.033 · Cited by 11
Induction of heat shock proteins prevents the arrhythmogenic substrate for atrial fibrillation
Takahashi, N., Wakisaka, O., Yoshimatsu, H., & Saikawa, T. (2009) · International Journal of Hyperthermia · doi:10.3109/02656730903070949 · Cited by 10
Embryology and Anatomy of the Left Atrial Appendage
Kanmanthareddy, A., Reddy, Y. M., Vallakati, A., Earnest, M., Nath, J., Ferrell, R., Dawn, B., & Lakkireddy, D. (2014) · Interventional Cardiology Clinics · doi:10.1016/j.iccl.2013.11.002 · Cited by 10
The M235T polymorphism in the angiotensinogen gene and atrial fibrillation: A meta-analysis
Wang, H., Teng, Y., Wang, K., Xia, Z., Tian, Y., & Li, C. (2014) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/1470320313513482 · Cited by 10
Eisen, A., Haim, M., Hoshen, M., Balicer, R. D., Reges, O., Leibowitz, M., Iakobishvili, Z., & Hasdai, D. (2016) · European Journal of Preventive Cardiology · doi:10.1177/2047487316676132 · Cited by 10
Hirayama, Y., Atarashi, H., Kobayashi, Y., Iwasaki, Y., Miyauchi, Y., Ohara, T., Yashima, M., Katoh, T., & Mizuno, K. (2009) · International Heart Journal · doi:10.1536/ihj.50.141 · Cited by 10
Geidel, S., Lass, M., & Ostermeyer, J. (2008) · Interactive Cardiovascular and Thoracic Surgery · doi:10.1510/icvts.2008.179622 · Cited by 10
RetractedImpaired Transport Function of the Left Atrium in Patients with Lone Paroxysmal Atrial Fibrillation
Shin, S. Y., Lim, H. E., Choi, U.-J., Choi, C. U., Kim, S. H., Kim, J. W., Kim, E. J., Rha, S., Park, C. G., Seo, H. S., et al. (2010) · Echocardiography · doi:10.1111/j.1540-8175.2010.01271.x · Cited by 10
Bank, U., Tadje, J., Täger, M., Wolke, C., Bukowska, A., Ittenson, A., Reinhold, D., Helmuth, M., Ansorge, S., Shakespeare, A. P., et al. (2007) · International Journal of Molecular Medicine · doi:10.3892/ijmm.20.4.483 · Cited by 10
Williams, S. G., Connelly, D. T., JACKSON, M., BENNETT, A., Albouaini, K., & Todd, D. (2005) · EP Europace · doi:10.1016/j.eupc.2005.06.003 · Cited by 10
The Promise of Resynchronization Therapy. Who (and How Many) Will Benefit?
Auricchio, A., & Spinelli, J. C. (2003) · Cardiac Electrophysiology Review · doi:10.1023/a:1023674519769 · Cited by 10
Huiskes, F. G., Creemers, E. E., & Brundel, B. J. J. M. (2023) · Cells · doi:10.3390/cells12182242 · Cited by 11
Atrial Fibrillation and the Renin-Angiotensin-Aldosterone System
Perlini, S., Belluzzi, F., Salinaro, F., & Musc, F. (2013) · InTech eBooks · doi:10.5772/53917 · Cited by 9
Cong, H., Li, X., Ma, L., Jiang, H., Mao, Y., & Xu, M. (2010) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2009.10.035 · Cited by 7
Feng, O., Rao, N., Jiang, X., Qian, M., Feng, W., Yin, L., & Xu, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076166 · Cited by 9
Cardioversion for Atrial Fibrillation: Does Inflammation Matter?
Watson, T., Kakar, P., & Lip, G. Y. H. (2007) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2006.12.089 · Cited by 9
Atrial fibrillation and arterial hypertension
Баранова, Е. И. (2011) · Arterial’naya Gipertenziya (Arterial Hypertension) · doi:10.18705/1607-419x-2011--4- · Cited by 9
Use of Cardiac Electric Near-Field Measurements to Determine Activation Times
Plank, G., & Hofer, E. (2003) · Annals of Biomedical Engineering · doi:10.1114/1.1603258 · Cited by 9
New drugs for atrial fibrillation
Hammwöhner, M., Smid, J., Lendeckel, U., & Goette, A. (2008) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-008-9278-2 · Cited by 9
Osaka, T., Yamazaki, M., Yokoyama, E., Ito, A., & Kodama, I. (2004) · Journal of Cardiovascular Electrophysiology · doi:10.1046/j.1540-8167.2004.03671.x · Cited by 9
Aldosterone Antagonism as an Antiarrhythmic Approach for Atrial Arrhythmias in Heart Failure
Ram, R., & Wagoner, D. R. V. (2006) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2006.00477.x · Cited by 9
Smokeless tobacco country: from nicotine dependency to oral problems and cancer.
Christen, A. G., & McDonald, J. L. (1987) · PubMed · Cited by 9
Chronic kidney disease and atrial fibrillation
Linz, D., & Neuberger, H. (2012) · Heart Rhythm · doi:10.1016/j.hrthm.2012.08.024 · Cited by 9
Clinical effect of vein of Marshall ethanol infusion on mitral isthmus ablation
Ge, W., Lu, Y.-F., Li, T., Wang, Y., Yin, J., Li, X., Jiang, J., Mi, Y., Tung, T., & Yan, S. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1253554 · Cited by 8
Adjuvant Therapy for Atrial Fibrillation
Mohammed, K., Kowey, P. R., & Musco, S. (2009) · Future Cardiology · doi:10.2217/fca.09.57 · Cited by 8
Effects of Angiotensin II on the Action Potential Durations of Atrial Myocytes in Hypertensive Rats
Sonoyama, K., Igawa, O., Miake, J., Yamamoto, Y., Sugihara, S., Sasaki, N., Shimoyama, M., Hamada, T., Taniguchi, S., Yoshida, A., et al. (2005) · Hypertension Research · doi:10.1291/hypres.28.173 · Cited by 8
Moon, J., Rim, S., Cho, I., Lee, S., Choi, S., Chung, W., Byun, Y. S., Ryu, S. K., Pyun, W. B., & Kim, J. (2010) · Clinical and Experimental Hypertension · doi:10.3109/10641963.2010.496522 · Cited by 8
Polyunsaturated Fatty Acids in Atrial Fibrillation: Looking for the Proper Candidates
Salvador, O., Gómez-Gallanti, A., Garófalo, D., Noujaim, S. F., Peinado, R., & Rama, D. F. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00370 · Cited by 8
Goette, A. (2003) · Cardiac Electrophysiology Review · doi:10.1023/a:1027415600883 · Cited by 8
Yongjun, Q., Ying, L., Hong, T., Wenxia, Z., Jiang, L., Yong-bo, L., Li, N., Li, M., & Xijun, X. (2012) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/1470320312460897 · Cited by 8
Upstream Therapy for Atrial Fibrillation in Heart Failure
Goette, A. (2013) · Heart Failure Clinics · doi:10.1016/j.hfc.2013.07.010 · Cited by 8
Aizawa, Y., Sato, T., & Akazawa, K. (2018) · Journal of Electrocardiology · doi:10.1016/j.jelectrocard.2018.12.008 · Cited by 8
Cihak, R. J., Heinc, P., Haman, L., Fiala, M., Neužil, P., & Toman, O. (2011) · Cor et Vasa · doi:10.33678/cor.2011.193 · Cited by 8
Neue Antiarrhythmika in der Therapie des Vorhofflimmerns
Hammwöhner, M., D’Alessandro, A., Dobrev, D., Kirchhof, P. F., & Goette, A. (2006) · Herzschrittmachertherapie + Elektrophysiologie · doi:10.1007/s00399-006-0513-1 · Cited by 8
Mello, W. C. D. (2002) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1001351 · Cited by 8
Laszlo, R., Eick, C., Rüb, N., Weretka, S., Weig, H., Schreieck, J., & BOSCH, R. F. (2008) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/1470320308095262 · Cited by 8
Neue Antiarrhythmika in der Therapie des Vorhofflimmerns
Ravens, U., Wettwer, E., Schotten, U., Wessel, R. E., & Dobrev, D. (2006) · Herzschrittmachertherapie + Elektrophysiologie · doi:10.1007/s00399-006-0512-2 · Cited by 8
ARBs, ACE‐Is, or Statins After Catheter Ablation of Atrial Fibrillation?
Deneke, T. (2007) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2007.00917.x · Cited by 8
Boos, C. J., & Lip, G. Y. H. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.11.033 · Cited by 8
Determinanten des paroxysmalen Vorhofflimmerns bei Patienten mit arterieller Hypertonie
Hennersdorf, M., Hafke, G. J., Steiner, S., Dierkes, S., Jansen, A., Perings, C. A., & Strauer, B. E. (2003) · Zeitschrift für Kardiologie · doi:10.1007/s00392-003-0924-5 · Cited by 8
Inflammation and Atrial Fibrillation
Endoh, Y., Endoh, I., Geczy, C. L., Nakagomi, A., Kusama, Y., & Atarashi, H. (2011) · Journal of Arrhythmia · doi:10.1016/s1880-4276(11)80017-7 · Cited by 7
Alterations in cytoskeletal and Ca2+ cycling regulators in atria lacking the obscurin Ig58/59 module
Grogan, A., Huang, W., Brong, A., Kane, M. A., & Kontrogianni‐Konstantopoulos, A. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1085840 · Cited by 7
Fukaya, H., Niwano, S., Niwano, H., Masaki, Y., Kiryu, M., Hirasawa, S., Satoh, D., Moriguchi, M., & Izumi, T. (2010) · International Journal of Cardiology · doi:10.1016/j.ijcard.2010.12.008 · Cited by 7
Elevated potassium outward currents in hyperoxia treated atrial cardiomyocytes
Vysotskaya, Z. V., Chidipi, B., Rodgers, J. L., Tang, X., Samal, E., Kolliputi, N., Mohapatra, S., Bennett, E. S., & Panguluri, S. K. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26263 · Cited by 7
Prasitlumkum, N., Kanitsoraphan, C., Kittipibul, V., Rattanawong, P., Chongsathidkiet, P., & Cheungpasitporn, W. (2018) · Clinical Cardiology · doi:10.1002/clc.23100 · Cited by 7
Modifiable Risk Factors and Atrial Fibrillation: the Quest for a Personalized Approach
Matei, L.-L., Silişte, C., & Vinereanu, D. (2021) · MAEDICA – a Journal of Clinical Medicine · doi:10.26574/maedica.2020.16.1.88 · Cited by 8
Čarná, Z., & Osmancik, P. P. (2021) · Physiological Research · doi:10.33549//physiolres.934744 · Cited by 38
Ruf, L., Bukowska, A., Gardemann, A., & Goette, A. (2023) · Cells · doi:10.3390/cells12242849 · Cited by 7
Upstream Therapy for Atrial Fibrillation
Kumagai, K. (2007) · Circulation Journal · doi:10.1253/circj.71.a75 · Cited by 7
Doğan, A., Akçay, S., Karabacak, M., Türker, Y., Özaydın, M., & Erdoğan, D. (2009) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2009.01997.x · Cited by 7
Angiotensin‐(1–7) Prevent Atrial Tachycardia Induced Sodium Channel Remodeling
Wang, X., & Li, G. (2014) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.12427 · Cited by 7
Ramirez, A., Pacchia, C. F., Sanders, N. A., Wasmund, S. L., & Hamdan, M. H. (2012) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-012-9716-z · Cited by 7
Ducharme, A., & Schiffrin, E. L. (2010) · Canadian Journal of Cardiology · doi:10.1016/s0828-282x(10)71170-3 · Cited by 7
Goette, A., Röcken, C., Nepple, K., & Lendeckel, U. (2003) · Springer eBooks · doi:10.1007/978-1-4419-9082-2_9 · Cited by 8
Morphologisches Remodeling bei Vorhofflimmern
Goette, A., & Lendeckel, U. (2006) · Herz · doi:10.1007/s00059-006-2788-8 · Cited by 7
New Antiarrhythmic Agents for the Prevention and Treatment of Atrial Fibrillation
Padanilam, B. J., & Prystowsky, E. N. (2006) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2006.00634.x · Cited by 7
Stockburger, M. A., BARTELS, R., Gerhardt, L., & Butter, C. (2007) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2007.00572.x · Cited by 7
Non-antiarrhythmic drugs to prevent atrial fibrillation
Folkeringa, R., Tieleman, R. G., & Crijns, H. J. G. M. (2004) · Heart Rhythm · doi:10.1016/j.hrthm.2004.02.019 · Cited by 7
Gouissem, I., Midani, F., Soualmia, H., Bouchemi, M., Ouali, S., Kallele, A., Romdhane, N. B., Mourali, M. S., & Feki, M. (2021) · Biological Research For Nursing · doi:10.1177/10998004211029376 · Cited by 6
Yang, L., Chen, Y., & Huang, W. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.920399 · Cited by 6
Sang, W., Wang, L., Yan, X., Sun, H., Han, Y., Wang, F., Tang, B., & Li, Y. (2023) · Journal of Inflammation Research · doi:10.2147/jir.s415410 · Cited by 6
Lan, X., Su, L., Ling, Z., Liu, Z., Wu, J., Yang, X., Zrenner, B., & Yin, Y. (2009) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2009.02160.x · Cited by 6
During ablation for atrial fibrillation, is simultaneous renal artery ablation appropriate?
Hogarth, A. J., Dobson, L. E., & Tayebjee, M. H. (2013) · Journal of Human Hypertension · doi:10.1038/jhh.2013.75 · Cited by 5
Yoon, N., Kim, K. H., Park, K. H., Sim, D. S., Youn, H. J., Hong, Y. J., Park, H. W., Kim, J. H., Ahn, Y., Jeong, M. H., et al. (2013) · Korean Circulation Journal · doi:10.4070/kcj.2013.43.10.686 · Cited by 6
Metadata
- Authors
- Goette, A., Staack, T., Röcken, C., Arndt, M., Geller, J. C., Huth, C., Ansorge, S., Klein, H. U., & Lendeckel, U.
- Affiliations
- University Hospital Magdeburg (DE)
- Corresponding author
- Goette, Andreas
- ORCID
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2000-05
- Volume
- 35
- Issue
- 6
- Pages
- 1669-1677
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2038843437
- Cited by
- 583
- References
- 47
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 14 · 2023: 10 · 2022: 17 · 2021: 17 · 2020: 15 · 2019: 17 · 2018: 10 · 2017: 17 · 2016: 20 · 2015: 17 · 2014: 23 · 2013: 24 · 2012: 27
- FWCI
- 10.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- atrial fibrillation, extracellular signal-regulated kinase, ERK1/ERK2, angiotensin-converting enzyme, atrial fibrosis, MEK1/2, interstitial cells, chronic atrial fibrillation, paroxysmal atrial fibrillation, ACE inhibitors, MAPK signaling
- MeSH terms
- Aged, Atrial Fibrillation, Endomyocardial Fibrosis, Female, Heart Atria, Humans, Peptidyl-Dipeptidase A, Male, Middle Aged, RNA, Messenger, Gene Expression Regulation, Enzymologic, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinases, Mitogen-Activated Protein Kinase 3
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review