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Cited by 169Stress Responses and CortisolChild Abuse and TraumaChild and Adolescent Psychosocial and Emotional Development

The DOI matches its Crossref record; 52 of the 53 references it cites were found in a registry or an index.

Environmental stress and psychiatric illness

Agid, O., Kohn, Y., Lerer, B.·2000·Biomedicine & Pharmacotherapy
DOI 10.1016/s0753-3322(00)89046-0
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Abstract

It has long been recognized that environmental stress plays a pivotal role in the pathogenesis of psychiatric disorders. The relationship is complex and the neurobiological mechanisms that mediate the contribution of stressful experiences to the manifestation of illness are not well understood. In considering this relationship, it is important to differentiate between the role of environmental stressors as vulnerability factors that predispose the individual to psychiatric illness and may be temporally distant from its clinical onset, and their role as direct precipitants of the illness. Furthermore, environmental stressors must be considered in the context of constitutional vulnerability factors, such as genetic predisposition, with which such stressors may interact. Genetic predisposition may influence not only vulnerability to illness but also the nature of the individual's response to stress and the likelihood of exposure to stressful events. In this paper, we focus on two areas that illustrate the complexity of the field and the important findings that have emerged--the role of early parental loss (EPL) in adult psychopathology, particularly major depression, and the relationship between recent significant life events and depressive episodes. We conclude with a preliminary conceptual framework for considering the relationship between genetic susceptibility and environmental stress in the pathogenesis of psychiatric illness.

Overview

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Crossref · 10.1016/s0753-3322(00)89046-0

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Metadata

Authors
Agid, O., Kohn, Y., & Lerer, B.
Affiliations
Hebrew University of Jerusalem (IL)
Corresponding author
Agid, O.
ORCID
Venue
Biomedicine & Pharmacotherapy
Publisher
Elsevier BV
Published
2000-04
Volume
54
Issue
3
Pages
135-141
ISSN
0753-3322 (ISSN-L)
DOI
10.1016/s0753-3322(00)89046-0
OpenAlex
W2157974953
Cited by
169
References
53
Citations by year
2026: 6 · 2025: 8 · 2024: 7 · 2023: 6 · 2022: 7 · 2021: 6 · 2020: 2 · 2019: 4 · 2018: 11 · 2017: 3 · 2016: 9 · 2015: 10 · 2014: 10 · 2013: 8 · 2012: 5
FWCI
1.08
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Biomedicine & Pharmacotherapy (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Keywords
environmental stress, mental illness, major depressive disorder, major life events, genetic susceptibility, vulnerability factors, stress response
MeSH terms
Animals, Mental Disorders, Depressive Disorder, Environment, Humans, Stress, Psychological

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