Cited by 381Heart Rate Variability and Autonomic ControlCardiovascular and exercise physiologyCardiac Health and Mental Health

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Improvements in heart rate variability with exercise therapy

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Routledge, Faye S., Campbell, Tavis S., McFetridge-Durdle, Judith A., Bacon, Simon L.·2010·Canadian Journal of Cardiology

DOI 10.1016/s0828-282x(10)70395-0PMC PMC2903986

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Abstract

Heart rate variability (HRV) is a noninvasive, practical and reproducible measure of autonomic nervous system function. A heart rate that is variable and responsive to demands is believed to bestow a survival advantage, whereas reduced HRV may be associated with poorer cardiovascular health and outcomes. In recent years, many researchers have investigated the prognostic implications of HRV in a variety of clinical populations. Evidence suggests that reduced HRV has prognostic significance for individuals with myocardial infarction, chronic heart failure, unstable angina and diabetes mellitus. Interventions to increase HRV, such as exercise therapy, have also been examined. The findings of the present review suggest that exercise therapy may improve HRV in myocardial infarction, chronic heart failure and revascularization patients by increasing vagal tone and decreasing sympathetic activity. One hypothesis is that a shift toward greater vagal modulation may positively affect the prognosis of these individuals. While the underlying mechanisms by which exercise training improves vagal modulation are speculative at present, angiotensin II and nitric oxide may be potential mediators.

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Authors: Routledge, F. S., Campbell, T. S., McFetridge-Durdle, J. A., & Bacon, S. L.
Affiliations: Dalhousie University (CA)
University of Calgary (CA)
Concordia University (CA)
Corresponding author: Routledge, Faye S.
ORCID: Campbell, Tavis S.
Bacon, Simon L.
Venue: Canadian Journal of Cardiology
Publisher: Elsevier BV
Published: 2010-06
Volume: 26
Issue: 6
Pages: 303-312
ISSN: 0828-282X (ISSN-L)
DOI: 10.1016/s0828-282x(10)70395-0
PMC: PMC2903986
OpenAlex: W2057649886
Cited by: 381
References: 96
Citations by year: 2026: 9 · 2025: 26 · 2024: 24 · 2023: 23 · 2022: 24 · 2021: 41 · 2020: 23 · 2019: 43 · 2018: 22 · 2017: 28 · 2016: 24 · 2015: 25 · 2014: 19 · 2013: 18 · 2012: 20
FWCI: 2.59
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Canadian Journal of Cardiology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
Keywords: heart rate variability, exercise therapy, autonomic nervous system, vagal tone, sympathetic activity, myocardial infarction, chronic heart failure, revascularization, prognosis, angiotensin II, nitric oxide
MeSH terms: Cardiac Rehabilitation, Autonomic Nervous System, Cardiovascular Diseases, Exercise Therapy, Heart Rate, Humans, Prognosis

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Improvements in heart rate variability with exercise therapy

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