Cited by 381Heart Rate Variability and Autonomic ControlCardiovascular and exercise physiologyCardiac Health and Mental Health

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Improvements in heart rate variability with exercise therapy

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Routledge, Faye S., Campbell, Tavis S., McFetridge-Durdle, Judith A., Bacon, Simon L.·2010·Canadian Journal of Cardiology

DOI 10.1016/s0828-282x(10)70395-0PMC PMC2903986

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Abstract

Heart rate variability (HRV) is a noninvasive, practical and reproducible measure of autonomic nervous system function. A heart rate that is variable and responsive to demands is believed to bestow a survival advantage, whereas reduced HRV may be associated with poorer cardiovascular health and outcomes. In recent years, many researchers have investigated the prognostic implications of HRV in a variety of clinical populations. Evidence suggests that reduced HRV has prognostic significance for individuals with myocardial infarction, chronic heart failure, unstable angina and diabetes mellitus. Interventions to increase HRV, such as exercise therapy, have also been examined. The findings of the present review suggest that exercise therapy may improve HRV in myocardial infarction, chronic heart failure and revascularization patients by increasing vagal tone and decreasing sympathetic activity. One hypothesis is that a shift toward greater vagal modulation may positively affect the prognosis of these individuals. While the underlying mechanisms by which exercise training improves vagal modulation are speculative at present, angiotensin II and nitric oxide may be potential mediators.

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Heart Rate Variability: Standards of Measurement, Physiological Interpretation, and Clinical Use
Electrophysiology, T. F. O. T. E. S. O. C. T. N. A. (1996) · Circulation · doi:10.1161/01.cir.93.5.1043 · Cited by 17,159
Heart rate variability: Standards of measurement, physiological interpretation, and clinical use
Malik, M., Bigger, J. T., Camm, A. J., Kleiger, R. E., Malliani, A., Moss, A. J., & Schwartz, P. J. (1996) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a014868 · Cited by 15,289
Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction
Rovere, M. T. L., Bigger, J. T., Marcus, F. I., Mortara, A., & Schwartz, P. J. (1998) · The Lancet · doi:10.1016/s0140-6736(97)11144-8 · Cited by 3,120
Heart rate variability. Standards of measurement, physiological interpretation, and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology.
(1996) · PubMed · Cited by 2,718
Frequency domain measures of heart period variability and mortality after myocardial infarction
Bigger, J. T., Fleiss, J. L., Steinman, R. C., Rolnitzky, L. M., Kleiger, R. E., & Rottman, J. N. (1992) · Circulation · doi:10.1161/01.cir.85.1.164 · Cited by 1,712
Prophylactic use of an implantable cardioverter-defibrillator after acute myocardial infarction
Hohnloser, S. H., Kuck, K. H., Dorian, P., Roberts, R. S., Hampton, J. R., Hatala, R., Fain, E., Gent, M., & Connolly, S. J. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa041489 · Cited by 1,519
Effect of Exercise on Coronary Endothelial Function in Patients with Coronary Artery Disease
Hambrecht, R., Wolf, A., Gielen, S., Linke, A., Hofer, J., Erbs, S., Schoene, N., & Schuler, G. (2000) · New England Journal of Medicine · doi:10.1056/nejm200002173420702 · Cited by 1,340
Heart rate variability: measurement and clinical utility.
Kleiger, R. E., Stein, P. K., & Bigger, J. T. (2005) · Annals of Noninvasive Electrocardiology · doi:10.1111/j.1542-474x.2005.10101.x · Cited by 1,290
Heart Rate Monitoring
Achten, J., & Jeukendrup, A. E. (2003) · Sports Medicine · doi:10.2165/00007256-200333070-00004 · Cited by 1,286
Prospective Study of Heart Rate Variability and Mortality in Chronic Heart Failure: Results of the United Kingdom Heart Failure Evaluation and Assessment of Risk Trial (UK-Heart)
Nolan, J., Batin, P. D., Andrews, R., Lindsay, S. J., Brooksby, P., Mullen, M., Baig, W., Flapan, A. D., Cowley, A., Prescott, R. J., et al. (1998) · Circulation · doi:10.1161/01.cir.98.15.1510 · Cited by 1,179
Short-Term Heart Rate Variability Strongly Predicts Sudden Cardiac Death in Chronic Heart Failure Patients
La Rovere, M. T., Pinna, G. D., Maestri, R., Mortara, A., Capomolla, S., Febo, O., Ferrari, R., Franchini, M., Gnemmi, M., Opasich, C., et al. (2003) · Circulation · doi:10.1161/01.cir.0000047275.25795.17 · Cited by 917
Baroreflex Sensitivity and Heart Rate Variability in the Identification of Patients at Risk for Life-Threatening Arrhythmias: Implications for Clinical Trials
La Rovere, M. T., Pinna, G. D., Hohnloser, S. H., Marcus, F. I., Mortara, A., Nohara, R., Bigger, J. T., Camm, A. J., & Schwartz, P. J. (2001) · Circulation · doi:10.1161/01.cir.103.16.2072 · Cited by 697
Assessment of Autonomic Function in Cardiovascular Disease
Lahiri, M. K., Kannankeril, P. J., & Goldberger, J. J. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.01.038 · Cited by 571
Depressed Heart Rate Variability as an Independent Predictor of Death in Chronic Congestive Heart Failure Secondary to Ischemic or Idiopathic Dilated Cardiomyopathy
Ponikowski, P. P., Anker, S. D., Chua, T. P., Szełemej, R., Piepoli, M. F., Adamopoulos, S. N., Webb-Peploe, K., Harrington, D., Banasiak, W., Wrabec, K., et al. (1997) · The American Journal of Cardiology · doi:10.1016/s0002-9149(97)00215-4 · Cited by 497
Complex systems and the technology of variability analysis
SEELY, A. J. E., & Macklem, P. T. (2004) · Critical Care · doi:10.1186/cc2948 · Cited by 456
Correlations among time and frequency domain measures of heart period variability two weeks after acute myocardial infarction
Bigger, J. T., Fleiss, J. L., Steinman, R. C., Rolnitzky, L. M., Kleiger, R. E., & Rottman, J. N. (1992) · The American Journal of Cardiology · doi:10.1016/0002-9149(92)90788-z · Cited by 371
Decreased spontaneous heart rate variability in congestive heart failure
Casolo, G., Balli, E., Taddei, T., Amuhasi, J., & Gori, C. (1989) · The American Journal of Cardiology · doi:10.1016/0002-9149(89)90871-0 · Cited by 344
Neural regulation of heart rate variability in endurance athletes and sedentary controls
Dixon, E. M., Kamath, M. V., McCartney, N., & Fallen, E. L. (1992) · Cardiovascular Research · doi:10.1093/cvr/26.7.713 · Cited by 307
Early and late effects of exercise and athletic training on neural mechanisms controlling heart rate
Furlan, R., Piazza, S., Dell’Orto, S., Gentile, E., Cerutti, S., Pagani, M., & Malliani, A. (1993) · Cardiovascular Research · doi:10.1093/cvr/27.3.482 · Cited by 296
Autonomic Nervous System Interaction With the Cardiovascular System During Exercise
Freeman, J. V., Dewey, F. E., Hadley, D., MYERS, J. N., & Froelicher, V. F. (2006) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2005.11.003 · Cited by 288
Prognostic value of heart rate variability in chronic congestive heart failure (Veterans Affairs’ Survival Trial of Antiarrhythmic Therapy in Congestive Heart Failure)
Bilchick, K. C., Fetics, B., Djoukeng, R., Gross Fisher, S., Fletcher, R. D., Singh, S. N., Nevo, E., & Berger, R. D. (2002) · The American Journal of Cardiology · doi:10.1016/s0002-9149(02)02380-9 · Cited by 288
Depressed low frequency power of heart rate variability as an independent predictor of sudden death in chronic heart failure
Galinier, M. (2000) · European Heart Journal · doi:10.1053/euhj.1999.1875 · Cited by 285
Traditional and Nonlinear Heart Rate Variability Are Each Independently Associated with Mortality after Myocardial Infarction
Stein, P. K., Domitrovich, P. P., Huikuri, H. V., Kleiger, R. E., & Cast Investigators (2005) · Journal of Cardiovascular Electrophysiology · doi:10.1046/j.1540-8167.2005.04358.x · Cited by 283
Fractal analysis and time- and frequency-domain measures of heart rate variability as predictors of mortality in patients with heart failure
Mäkikallio, T. H., Huikuri, H. V., Hintze, U., Videbæk, J., Mitrani, R. D., Castellanos, A., Myerburg, R. J., & Møller, M. (2001) · The American Journal of Cardiology · doi:10.1016/s0002-9149(00)01312-6 · Cited by 252
Moderate-intensity resistance exercise training in patients with chronic heart failure improves strength, endurance, heart rate variability, and forearm blood flow*1
Selig, S. E., Carey, M., Menzies, D. G., PATTERSON, J., Geerling, R. H., Williams, A. D., Bamroongsuk, V., Toia, D., Krum, H., & Hare, D. L. (2004) · Journal of Cardiac Failure · doi:10.1016/s1071-9164(03)00583-9 · Cited by 248
Fractal analysis of heart rate variability and mortality after an acute myocardial infarction
Tapanainen, J. M., Thomsen, P. E. B., Køber, L., Torp-Pedersen, C. T., Mäkikallio, T. H., Still, A.-M., Lindgren, K. S., & Huikuri, H. V. (2002) · The American Journal of Cardiology · doi:10.1016/s0002-9149(02)02488-8 · Cited by 239
Muscarinic cholinergic receptor modulation of beta-adrenergic receptor affinity for catecholamines.
Watanabe, A. M., McConnaughey, M. M., Strawbridge, R. A., Fleming, J. W., Jones, L. R., & Besch, H. R. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34620-3 · Cited by 224
Effects of a Residential Exercise Training on Baroreflex Sensitivity and Heart Rate Variability in Patients With Coronary Artery Disease
Iellamo, F., Legramante, J. M., Massaro, M., Raimondi, G., & Galante, A. (2000) · Circulation · doi:10.1161/01.cir.102.21.2588 · Cited by 213
Exercise training improves baroreflex sensitivity in type 2 diabetes
Loimaala, A., Huikuri, H. V., Kööbi, T., Rinne, M., Nenonen, A., & Vuori, I. (2003) · Diabetes · doi:10.2337/diabetes.52.7.1837 · Cited by 207 · cited 3×
“Loimaala et al (74) Men with type 2 DM Exercise group: 24 (53.”
BackgroundInfluential
Reversal of autonomic derangements by physical training in chronic heart failure assessed by heart rate variability
Kiilavuori, K., Toivonen, L., Näveri, H., & Leinonen, H. (1995) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a060941 · Cited by 206
Heart rate variability measurements and the prediction of ventricular arrhythmias
Reed, M. J., Robertson, C. E., & Addison, P. S. (2005) · QJM · doi:10.1093/qjmed/hci018 · Cited by 188
Role of nitric oxide in the regulation of cardiovascular autonomic control
Chowdhary, S., & Townend, J. (1999) · Clinical Science · doi:10.1042/cs0970005 · Cited by 176
The Effect of Age and Gender on Heart Rate Variability after Endurance Training
Carter, J. B., Banister, E. W., & Blaber, A. P. (2003) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000079046.01763.8f · Cited by 167
Effects of cardiac rehabilitation and exercise training on autonomic regulation in patients with coronary artery disease
Lucini, D., Milani, R. V., Costantino, G., Lavie, C. J., Porta, A., & Pagani, M. (2002) · American Heart Journal · doi:10.1067/mhj.2002.123117 · Cited by 159
Mortality, cardiac vagal control and physical training — what's the link?
Buch, A. N., Coote, J. H., & Townend, J. (2002) · Experimental Physiology · doi:10.1111/j.1469-445x.2002.tb00055.x · Cited by 158
Short and long term effects of exercise training on the tonic autonomic modulation of heart rate variability after myocardial infarction
Malfatto, G., Facchini, M., Bragato, R., Branzi, G., Sala, L., & Leonetti, G. (1996) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a014905 · Cited by 139
Effects of Cardiac Rehabilitation and Beta-Blocker Therapy on Heart Rate Variability After First Acute Myocardial Infarction
Malfatto, G., Facchini, M., Sala, L., Branzi, G., Bragato, R., & Leonetti, G. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)00021-6 · Cited by 135
Prognostic role of heart rate variability in patients with a recent acute myocardial infarction
Lanza, G. A., Guido, V., Galeazzi, M. M., Mustilli, M., Natali, R., Ierardi, C., Milici, C., Burzotta, F., Pasceri, V., Tomassini, F., et al. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)00635-3 · Cited by 133
Circadian rhythm of the autonomic nervous system in insulin resistant subjects with normoglycemia, impaired fasting glycemia, impaired glucose tolerance, type 2 diabetes mellitus
Perciaccante, A., Fiorentini, A., Paris, A., Serra, P., & Tubani, L. (2006) · BMC Cardiovascular Disorders · doi:10.1186/1471-2261-6-19 · Cited by 118
Endurance training improves post-exercise cardiac autonomic modulation in obese women with and without type 2 diabetes
Figueroa, A., Baynard, T., Fernhall, B., Carhart, R., & Kanaley, J. A. (2007) · European Journal of Applied Physiology · doi:10.1007/s00421-007-0446-3 · Cited by 117
EXPLAINING FATIGUE IN CONGESTIVE HEART FAILURE
Drexler, H., & Coats, A. J. S. (1996) · Annual Review of Medicine · doi:10.1146/annurev.med.47.1.241 · Cited by 114
Non-linear heart rate variability and risk stratification in cardiovascular disease.
Stein, P. K., & Reddy, A. (2005) · PubMed · Cited by 109
Interval training in elderly men increases both heart rate variability and baroreflex activity
Pichot, V., Roche, F., Denis, C., Garet, M., Duverney, D., Costes, F. R., & Barthélemy, J. (2005) · Clinical Autonomic Research · doi:10.1007/s10286-005-0251-1 · Cited by 107
Predictors of mortality in patients with type 2 diabetes with or without diabetic nephropathy: a follow-up study
Astrup, A. S., Nielsen, F. S., Rossing, P. R., Ali, S., Kastrup, J., Smidt, U., & Parving, H. (2007) · Journal of Hypertension · doi:10.1097/hjh.0b013e3282f06428 · Cited by 105
Autonomic Nervous System Adaptations to Short-term Exercise Training
Rovere, M. T. L., Mortara, A., Sandrone, G., & Lombardi, F. (1992) · CHEST Journal · doi:10.1378/chest.101.5_supplement.299s · Cited by 103
Decreased heart rate variability may predict the progression of carotid atherosclerosis in type 2 diabetes
Gottsäter, A., Ahlgren, Å. R., Taimour, S., & Sundkvist, G. (2006) · Clinical Autonomic Research · doi:10.1007/s10286-006-0345-4 · Cited by 98
Relation of Heart Rate Variability to Serum Levels of C-Reactive Protein in Patients With Unstable Angina Pectoris
Lanza, G. A., Sgueglia, G. A., Cianflone, D., Rebuzzi, A. G., Angeloni, G., Sestito, A., Infusino, F., Crea, F., & Maseri, A. (2006) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2006.01.029 · Cited by 97
Role of Heart Rate Variability in the Early Diagnosis of Diabetic Autonomic Neuropathy in Children
Chessa, M., Butera, G., Lanza, G. A., Bossone, E., Delogu, A. B., Rosa, G. D., Marietti, G., Rosti, L., & Carminati, M. (2002) · Herz · doi:10.1007/s00059-002-2340-4 · Cited by 96
Nitric Oxide As A Metabolic Regulator During Exercise: Effects Of Training In Health And Disease
Kingwell, B. A. (2000) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2000.03232.x · Cited by 92
Prospective study of autonomic neuropathy as a predictor of mortality in patients with diabetes
Wheeler, S., Ahroni, J. H., & Boyko, E. J. (2002) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(02)00128-6 · Cited by 88
Prevalent Low-Frequency Oscillation of Heart Rate
Wichterle, D., Šimek, J., Rovere, M. T. L., Schwartz, P. J., Camm, A. J., & Malik, M. (2004) · Circulation · doi:10.1161/01.cir.0000140765.71014.1c · Cited by 88
Measures of heart period variability as predictors of mortality in hospitalized patients with decompensated congestive heart failure
Aronson, D., Mittleman, M. A., & Burger, A. J. (2003) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2003.09.013 · Cited by 86
Low heart rate variability is a risk factor for sudden cardiac death in type 2 diabetes
Kataoka, M., Ito, C., Sasaki, H., Yamane, K., & Kohno, N. (2003) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2003.10.009 · Cited by 85
Get moving! Physical activity counseling in primary care
Peterson, J. A. (2007) · Journal of the American Academy of Nurse Practitioners · doi:10.1111/j.1745-7599.2007.00239.x · Cited by 85
Modulation of Cardiac Autonomic Control in Humans by Angiotensin II
Townend, J., Al-Ani, M., West, J. N. W., Littler, W. A., & Coote, J. H. (1995) · Hypertension · doi:10.1161/01.hyp.25.6.1270 · Cited by 85
Randomized Trial of a Hospital-Based Exercise Training Program After Acute Myocardial Infarction: Cardiac Autonomic Effects
Leitch, J. W., Newling, R., Basta, M., Inder, K., Dear, K. B. G., & Fletcher, P. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00050-8 · Cited by 84
THE FETAL ELECTROCARDIOGRAM. IV. UNUSUAL VARIATIONS IN THE QRS COMPLEX DURING LABOR.
Lee, S. T., & Hon, E. H. (1965) · PubMed · Cited by 78
Five-minute recording of heart rate variability in severe chronic heart failure: Correlates with right ventricular function and prognostic implications
Lucreziotti, S., Gavazzi, A., Scelsi, L., Inserra, C. A., Klersy, C., Campana, C., Ghio, S., Vanoli, E., & Tavazzi, L. (2000) · American Heart Journal · doi:10.1067/mhj.2000.106168 · Cited by 74
Recovery of Cardiac Autonomic Responsiveness with Low-Intensity Physical Training in Patients with cHronic Heart Failure
Malfatto, G., Branzi, G., Riva, B., Sala, L., Leonetti, G., & Facchini, M. (2002) · European Journal of Heart Failure · doi:10.1016/s1388-9842(01)00221-5 · Cited by 72
Prognostic value of heart rate variability after acute myocardial infarction.
Balanescu, S. M., Corlan, A. D., Dorobanţu, M., & Gherasim, L. (2004) · PubMed · Cited by 72
Novel spectral indexes of heart rate variability as predictors of sudden and non‐sudden cardiac death after an acute myocardial infarction
Kiviniemi, A. M., Tulppo, M. P., Wichterle, D., Hautala, A. J., Tiinanen, S., Seppänen, T., Mäkikallio, T. H., & Huikuri, H. V. (2007) · Annals of Medicine · doi:10.1080/07853890600990375 · Cited by 69
Clinical and demographic determinants of heart rate variability in patients post myocardial infarction: Insights from the cardiac arrhythmia suppression trial (CAST)
Stein, P. K., Kleiger, R. E., Domitrovich, P. P., Schechtman, K. B., & Rottman, J. N. (2000) · Clinical Cardiology · doi:10.1002/clc.4960230311 · Cited by 69
Changes in short-term measures of heart rate variability after eight weeks of cardiac rehabilitation
SANDERCOCK, G. R. H., Grocott-Mason, R. M., & Brodie, D. A. (2007) · Clinical Autonomic Research · doi:10.1007/s10286-007-0392-5 · Cited by 62
Prognostic value of ventricular arrhythmias and heart rate variability in patients with unstable angina
LANZA, G., Cianflone, D., Rebuzzi, A. G., Angeloni, G., Sestito, A., Ciriello, G., Torre, G. L., Crea, F., & Maseri, A. (2005) · Heart · doi:10.1136/hrt.2005.070714 · Cited by 61
Usefulness of the Addition of Heart Rate Variability to Holter Monitoring in Predicting In-Hospital Cardiac Events in Patients With Unstable Angina Pectoris
Lanza, G. A., Pedrotti, P., Rebuzzi, A. G., Pasceri, V., Quaranta, G., & Maseri, A. (1997) · The American Journal of Cardiology · doi:10.1016/s0002-9149(97)00343-3 · Cited by 61
Prognostic Value of Iodine-123-Metaiodobenzylguanidine Myocardial Uptake and Heart Rate Variability in Chronic Congestive Heart Failure Secondary to Ischemic or Idiopathic Dilated Cardiomyopathy
ANASTASIOU‐NANA, M. I., Terrovitis, J. V., Athanasoulis, T., Karaloizos, L., Geramoutsos, A., Pappa, L., Tsagalou, E. P., Efentakis, S., & Nanas, J. N. (2005) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2005.03.093 · Cited by 58
Effects of Physical Training on the Recovery of the Autonomic Nervous Activity During Exercise After Coronary Artery Bypass Grafting
Takeyama, J., Itoh, H., Katô, M., Koike, A., Aoki, K., Fu, L.-T., Watanabe, H., Nagayama, M., & Katagiri, T. (2000) · Japanese Circulation Journal-english Edition · doi:10.1253/jcj.64.809 · Cited by 57
Effect of moderate aerobic exercise on sympatho‐vagal balance in Type 2 diabetic patients
Zoppini, G., Cacciatori, V., Gemma, M. L., Moghetti, P., Targher, G., Zamboni, C., Thomaseth, K., Bellavere, F., & Muggeo, M. (2007) · Diabetic Medicine · doi:10.1111/j.1464-5491.2007.02076.x · Cited by 56
Effects of Exercise Training on the Recovery of the Autonomic Nervous System and Exercise Capacity After Acute Myocardial Infarction
Oya, M., Itoh, H., Kato, K., Tanabe, K., & Murayama, M. (1999) · Japanese Circulation Journal-english Edition · doi:10.1253/jcj.63.843 · Cited by 56
Early assessment of heart rate variability is predictive of in-hospital death and major complications after acute myocardial infarction
Carpeggiani, C., L’Abbate, A., Landi, P., Michelassi, C., Raciti, M., Macerata, A., & Emdin, M. (2004) · International Journal of Cardiology · doi:10.1016/j.ijcard.2003.07.023 · Cited by 55
Exercise training in chronic heart failure: beneficial effects on cardiac (11)C-hydroxyephedrine PET, autonomic nervous control, and ventricular repolarization.
Pietilä, M., Malminiemi, K., Vesalainen, R. K., Jartti, T. T., Teräs, M., Någren, K., Lehikoinen, P., & Voipio‐Pulkki, L. (2002) · PubMed · Cited by 54
Autonomic function testing in children and adolescents with diabetes mellitus
Boysen, A., Lewin, M. A. G., Hecker, W., Leichter, H. E., & Uhlemann, F. (2007) · Pediatric Diabetes · doi:10.1111/j.1399-5448.2007.00254.x · Cited by 54
The value of the electrocardiogram in risk assessment in primary prevention: Experience from the West of Scotland Coronary Prevention Study
Macfarlane, P. W., & Norrie, J. D. (2006) · Journal of Electrocardiology · doi:10.1016/j.jelectrocard.2006.05.003 · Cited by 51
Parasympathetic versus sympathetic control of the cardiovascular system in young patients with type 1 diabetes mellitus
Javorka, M., Javorkova, J., Tonhajzerová, I., & Javorka, K. (2005) · Clinical Physiology and Functional Imaging · doi:10.1111/j.1475-097x.2005.00623.x · Cited by 48
Effects of Exercise Training on Heart Rate Variability After Coronary Angioplasty
Tsai, M., Chie, W., Kuo, T. B. J., Chen, M.-F., Liu, J., Chen, T. H.-H., & Wu, Y.-T. (2006) · Physical Therapy · doi:10.1093/ptj/86.5.626 · Cited by 46
Is heart rate variability a reliable method to assess autonomic modulation in left ventricular dysfunction and heart failure?
Scalvini, S., Volterrani, M., Zanelli, E., Pagani, M., MAZZUERO, G., Coats, A. J. S., & Giordano, A. (1998) · International Journal of Cardiology · doi:10.1016/s0167-5273(98)00252-6 · Cited by 45
Interpreting Heart Rate Variability Sleep/Wake Patterns in Cardiac Patients
McMillan, D. E. (2002) · The Journal of Cardiovascular Nursing · doi:10.1097/00005082-200210000-00007 · Cited by 41
Marked abnormalities in heart rate variability are associated with progressive deterioration of renal function in type I diabetic patients with overt nephropathy
Burger, A. J., D’Elia, J. A., Weinrauch, L. A., Lerman, I. G., & Gaur, A. (2002) · International Journal of Cardiology · doi:10.1016/s0167-5273(02)00346-7 · Cited by 40
Handbook of autonomic nervous system dysfunction
Korczyn, A. D. (1995) · M. Dekker eBooks · Cited by 38
Heart rate variability and ischaemia in patients with coronary heart disease and stable angina pectoris Influence of drug therapy and prognostic value
Weber, F. (1999) · European Heart Journal · doi:10.1053/euhj.1998.1272 · Cited by 38
Handbook of autonomic nervous system dysfunction
Polinsky, R. J. (1995) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(95)90292-9 · Cited by 38
Age-adjustment of HRV measures and its prognostic value for risk assessment in patients late after myocardial infarction
Sosnowski, M., Macfarlane, P. W., Czyż, Z., Skrzypek-Wańha, J., Boczkowska-Gaik, E., & Tendera, M. (2002) · International Journal of Cardiology · doi:10.1016/s0167-5273(02)00301-7 · Cited by 36
Including patients with diabetes mellitus or coronary artery bypass grafting decreases the association between heart rate variability and mortality after myocardial infarction
Stein, P. K., Domitrovich, P. P., & Kleiger, R. E. (2004) · American Heart Journal · doi:10.1016/s0002-8703(03)00520-9 · Cited by 35
Comparison of the prognostic value of RR-interval variability after acute myocardial infarction in patients with versus those without diabetes mellitus
Whang, W., & Bigger, J. T. (2003) · The American Journal of Cardiology · doi:10.1016/s0002-9149(03)00618-0 · Cited by 32
Long-term adaptation of 24-h heart rate variability after myocardial infarction. The EAMI Study Group. Exercise Training in Anterior Myocardial Infarction
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Authors: Routledge, F. S., Campbell, T. S., McFetridge-Durdle, J. A., & Bacon, S. L.
Affiliations: Dalhousie University (CA)
University of Calgary (CA)
Concordia University (CA)
Corresponding author: Routledge, Faye S.
ORCID: Campbell, Tavis S.
Bacon, Simon L.
Venue: Canadian Journal of Cardiology
Publisher: Elsevier BV
Published: 2010-06
Volume: 26
Issue: 6
Pages: 303-312
ISSN: 0828-282X (ISSN-L)
DOI: 10.1016/s0828-282x(10)70395-0
PMC: PMC2903986
OpenAlex: W2057649886
Cited by: 381
References: 96
Citations by year: 2026: 9 · 2025: 26 · 2024: 24 · 2023: 23 · 2022: 24 · 2021: 41 · 2020: 23 · 2019: 43 · 2018: 22 · 2017: 28 · 2016: 24 · 2015: 25 · 2014: 19 · 2013: 18 · 2012: 20
FWCI: 2.59
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Canadian Journal of Cardiology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
Keywords: heart rate variability, exercise therapy, autonomic nervous system, vagal tone, sympathetic activity, myocardial infarction, chronic heart failure, revascularization, prognosis, angiotensin II, nitric oxide
MeSH terms: Cardiac Rehabilitation, Autonomic Nervous System, Cardiovascular Diseases, Exercise Therapy, Heart Rate, Humans, Prognosis

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Improvements in heart rate variability with exercise therapy

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