Cited by 176Estrogen and related hormone effectsSystemic Lupus Erythematosus ResearchRheumatoid Arthritis Research and Therapies

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DIFFERENT ROLES FOR ANDROGENS AND ESTROGENS IN THE SUSCEPTIBILITY TO AUTOIMMUNE RHEUMATIC DISEASES

Cutolo, Maurizio, Wilder, Ronald L.·2000·Rheumatic Disease Clinics of North America

DOI 10.1016/s0889-857x(05)70171-x

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Abstract

It is now documented that androgens and estrogens modulate susceptibility and progression to autoimmune rheumatic diseases. At any concentration, androgens seem to be primarily suppressive on cellular and humoral immunity, whereas at physiologic concentrations, estrogens seem to enhance humoral immunity. Further research should focus on the different and frequently opposite effects exerted by physiologic and pharmacologic doses of estrogens (dose-related effects). In addition to the influence of endogenous estrogen fluctuations (i.e., during pregnancy, postpartum, menstrual periods, menopause), estrogen replacement therapy, and the use of oral contraceptives, the susceptibility to autoimmunity might be increased by the environmental estrogens (xenobiotics). Further studies must be directed to the inflammatory mediators (i.e., cytokines) that seem to alter the peripheral metabolism of sex hormones and complicate the effects of sex hormones on susceptibility to autoimmunity. Finally, genetic factors might further interfere with the roles of androgens and estrogens in selected individuals.

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Preface
Cutolo, M., Bijlsma, J. W. J., Lahita, R. G., Masi, A. T., Straub, R. H., & Bradlow, H. L. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04195.x · Cited by 16
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Authors: Cutolo, M., & Wilder, R. L.
Affiliations: University of Genoa (IT)
National Institutes of Health (US)
ORCID: Cutolo, Maurizio
Venue: Rheumatic Disease Clinics of North America
Publisher: Elsevier BV
Published: 2000-11
Volume: 26
Issue: 4
Pages: 825-839
ISSN: 0889-857X (ISSN-L)
DOI: 10.1016/s0889-857x(05)70171-x
OpenAlex: W1996899099
Cited by: 176
References: 71
Citations by year: 2026: 3 · 2025: 3 · 2024: 3 · 2023: 5 · 2022: 7 · 2021: 3 · 2020: 5 · 2019: 5 · 2018: 4 · 2017: 5 · 2016: 5 · 2015: 11 · 2014: 4 · 2013: 10 · 2012: 10
FWCI: 1.37
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Rheumatic Disease Clinics of North America (publishedVersion)
PubMed (publishedVersion)
CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
Keywords: androgens, estrogen, sex hormones, autoimmune rheumatic diseases, disease susceptibility, humoral immunity, cell-mediated immunity, estrogen replacement therapy, oral contraceptives, xenoestrogens, xenobiotics, cytokines, sex steroid metabolism, genetic factors, pregnancy, menopause
MeSH terms: Androgens, Animals, Autoimmune Diseases, Estrogens, Female, Humans, Immunity, Cellular, Male, Rheumatic Diseases, Risk Factors, Mice

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DIFFERENT ROLES FOR ANDROGENS AND ESTROGENS IN THE SUSCEPTIBILITY TO AUTOIMMUNE RHEUMATIC DISEASES

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