Developmental Excitation of Corticothalamic Neurons by Nicotinic Acetylcholine Receptors
Open accessAbstract
In this study, we show robust nicotinic excitation of pyramidal neurons in layer VI of prefrontal cortex. This layer contains the corticothalamic neurons, which gate thalamic activity and play a critical role in attention. Our experiments tested nicotinic excitation across postnatal development, using whole-cell recordings in prefrontal brain slices from rats. These experiments showed that layer VI neurons have peak nicotinic currents during the first postnatal month, a time period of intensive cortical development in rodents. We demonstrate that these currents are mediated directly by postsynaptic nicotinic receptors and can be suppressed by a competitive antagonist of α 4 β 2 * nicotinic receptors. To record from identified corticothalamic neurons, we performed stereotaxic surgery to label the neurons projecting to medial dorsal thalamus. As hypothesized, recordings from these retrogradely labeled neurons in layer VI showed prominent nicotinic currents. Finally, we examined the effects of the drug nicotine on layer VI neurons and probed for the potential involvement of the accessory subunit, α 5 , in their receptors. A level of nicotine similar to that found in the blood of smokers elicits a stable inward current in layer VI neurons, yet this exposure desensitizes ∼50% of the subsequent current elicited by acetylcholine. An allosteric modulator of α 4 β 2 α 5 receptors resulted in a 2.5-fold potentiation of submaximal nicotinic currents. This result is consistent with the expression of the relatively rare α 5 nicotinic subunit in layer VI. In summary, we show that layer VI corticothalamic neurons can be strongly excited during development by an unusual subtype of nicotinic receptor.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Currents mediated through α5/β2 nAChRs are maximal in the early postnatal period.
“Electrophysiological studies have shown that currents mediated through α5/β2 Ã nAChRs are maximal in the early postnatal period (Kassam et al. 2008).”
From Mechanisms of Nicotine Addiction (2021) · cites this paper as Kassam et al. 2008
The section “Nicotinic currents in layer VI pyramidal neurons change across development” reports that currents in rat prefrontal cortical neurons were highest in the first postnatal month. The paper separately says pharmacological results suggest involvement of α5-containing α4β2 receptors; it does not establish that the measured developmental peak was specifically a peak in currents mediated by that receptor subtype. (LLM, conf=0.84)
Experimental — accuracy not yet measuredLayer VI neurons are modulated by β2* nAChRs responsible for strong activation of the layer VI neuronal population.
“These neurons are modulated by β2* nAChRs that are responsible for the strong activation of the layer VI neuronal population (Kassam et al. 2008; Poorthuis et al. 2012).”
From Short- and Long-Term Consequences of Nicotine Exposure during Adolescence for Prefrontal Cortex Neuronal Network Function (2012) · cites this paper as Kassam et al. 2008
Lynx may bind to non-agonist interfaces, such as the α4-α4 interface in (α4)3(β2)2 receptors, or the allosterically important α4-α5 interface if the complex includes an α5 subunit.
“A modest and obvious extension of this idea is that lynx may bind to non-agonist interfaces, such as the α4–α4 interface in (α4)3(β2)2 receptors, or the allosterically important α4–α5 interface if the complex includes an α5 subunit (113,126).”
From Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery (2009) · cites this paper as [126]
There is evidence of nicotine-exposure induced alterations in the electrophysiological characteristics of corticothalamic projection neurons.
“This is supported by evidence of nicotine-exposure induced alterations in the electrophysiological characteristics of corticothalamic projection neurons [67].”
From Impaired auditory discrimination learning following perinatal nicotine exposure or β2 nicotinic acetylcholine receptor subunit deletion (2012) · cites this paper as [67]
The later period (postnatal weeks 2 and 3) coincides with the peak nAChR-mediated currents exhibited by corticothalamic neurons projecting from medial prefrontal cortex.
“This later period coincides with the peak nAChR-mediated currents exhibited by corticothalamic neurons projecting from medial prefrontal cortex [67].”
From Impaired auditory discrimination learning following perinatal nicotine exposure or β2 nicotinic acetylcholine receptor subunit deletion (2012) · cites this paper as [67]
The corticothalamic projections between rodent prefrontal cortex and the medial dorsal thalamic nucleus can be altered by nicotine administration in a slice preparation, suggesting that activity in this higher cortical area can be affected directly by nicotine exposure.
“For instance, the corticothalamic projections between rodent prefrontal cortex and the medial dorsal thalamic nucleus can be altered by nicotine administration in a slice preparation [67], suggesting that activity in this higher cortical area can be affected directly by nicotine exposure.”
From Impaired auditory discrimination learning following perinatal nicotine exposure or β2 nicotinic acetylcholine receptor subunit deletion (2012) · cites this paper as [67]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
AChE-stained horizontal sections of the rat brain in stereotaxic coordinates
Paxinos, G., WATSON, C. R. R., & Emson, P. C. (1980) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(80)90021-7 · Cited by 4,497 · see citing works
Grouping of brain rhythms in corticothalamic systems
Steriade, M. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.10.029 · Cited by 1,296 · see citing works
Steinlein, O. K., Mulley, J. C., Propping, P., Wallace, R. H., Phillips, H. A., Sutherland, G. R., Scheffer, I. E., & Berkovic, S. F. (1995) · Nature Genetics · doi:10.1038/ng1095-201 · Cited by 1,134 · see citing works
Physiological Diversity of Nicotinic Acetylcholine Receptors Expressed by Vertebrate Neurons
McGehee, D. S., & Role, L. W. (1995) · Annual Review of Physiology · doi:10.1146/annurev.ph.57.030195.002513 · Cited by 1,022 · see citing works
Saccone, S. F., Hinrichs, A. L., Saccone, N. L., Chase, G. A., Konvicka, K., Madden, P. A. F., Breslau, N., Johnson, E. O., Hatsukami, D., Pomerleau, O., et al. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddl438 · Cited by 850 · see citing works
Synaptic mechanisms underlie nicotine-induced excitability of brain reward areas
Mansvelder, H. D., Keath, J. R., & McGehee, D. S. (2002) · Neuron · doi:10.1016/s0896-6273(02)00625-6 · Cited by 701 · see citing works
Variants in Nicotinic Receptors and Risk for Nicotine Dependence
Bierut, L. J., Stitzel, J. A., Wang, J. C., Hinrichs, A. L., Grucza, R. A., Xuei, X., Saccone, N. L., Saccone, S. F., Bertelsen, S., Fox, L., et al. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.07111711 · Cited by 648 · see citing works
The maternal and fetal physiologic effects of nicotine
Lambers, D. S., & Clark, K. E. (1996) · Seminars in Perinatology · doi:10.1016/s0146-0005(96)80079-6 · Cited by 577 · see citing works
Romijn, H. J., Hofman, M. A., & Gramsbergen, A. (1991) · Early Human Development · doi:10.1016/0378-3782(91)90044-4 · Cited by 553 · see citing works
Nicotine binding and nicotinic receptor subunit RNA after chronic nicotine treatment
Marks, M., Pauly, Jr., Gross, S., Deneris, E., Hermans-Borgmeyer, I., Heinemann, S., & Collins, A. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-07-02765.1992 · Cited by 551 · see citing works
Slotkin, T. A. (2004) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2003.06.001 · Cited by 544 · see citing works
Rezvani, A. H., & Levin, E. D. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01094-5 · Cited by 519 · see citing works
α-5/α-3 nicotinic receptor subunit alleles increase risk for heavy smoking
Berrettini, W., Yuan, X., Tozzi, F., Song, K., Francks, C., Chilcoat, H., Waterworth, D., Muglia, P., & Mooser, V (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002154 · Cited by 465 · see citing works
Desensitization of neuronal nicotinic receptors
Quick, M. W., & Lester, R. A. J. (2002) · Journal of Neurobiology · doi:10.1002/neu.10109 · Cited by 456 · see citing works
The nicotinic receptor β2 subunit is mutant in nocturnal frontal lobe epilepsy
Fusco, M. D., Becchetti, A., Patrignani, A., Annesi, G., Gambardella, A., Quattrone, A., Ballabio, A., Wanke, E., & Casari, G. (2000) · Nature Genetics · doi:10.1038/81566 · Cited by 447 · see citing works
Cholinergic Switching Within Neocortical Inhibitory Networks
Xiang, Z., Huguenard, J. R., & Prince, D. A. (1998) · Science · doi:10.1126/science.281.5379.985 · Cited by 438 · see citing works
Sofouglu, M., Herman, A. I., Robinson, C. D., & Waters, A. J. (2014) · Lincoln (University of Nebraska) · Cited by 417 · see citing works
Functional contributions of α5 subunit to neuronal acetylcholine receptor channels
Ramírez-Latorre, J. A., Yu, C., Qu, X., Perin, F., Karlin, A., & Role, L. W. (1996) · Nature · doi:10.1038/380347a0 · Cited by 397 · see citing works
Cholinergic Activity in Autism: Abnormalities in the Cerebral Cortex and Basal Forebrain
Perry, E. K., Lee, M., Martin-Ruiz, C. M., COURT, J. A., Volsen, S. G., Merrit, J., Folly, E. A., Iversen, P. E., Bauman, M. L., Perry, R. H., et al. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.7.1058 · Cited by 390 · see citing works
Higher levels of nicotine in arterial than in venous blood after cigarette smoking
Henningfield, J. E. (1993) · Drug and Alcohol Dependence · doi:10.1016/0376-8716(93)90030-t · Cited by 370 · see citing works
Cigarette Smoking Saturates Brain α4β2 Nicotinic Acetylcholine Receptors
Brody, A. L., Mandelkern, M. A., London, E. D., Olmstead, R. E., Farahi, J., Scheibal, D., Jou, J., Allen, V., Tiongson, E., Chefer, S. I., et al. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.8.907 · Cited by 367 · see citing works
Wooltorton, J. R. A., Pidoplichko, V. I., Broide, R. S., & Dani, J. A. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03176.2003 · Cited by 363 · see citing works
Abnormal Regulation of High Affinity Nicotinic Receptors in Subjects with Schizophrenia
Breese, C. R. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00121-4 · Cited by 343 · see citing works
Are maternal smoking and stress during pregnancy related to ADHD symptoms in children?
Rodriguez, A., & Bohlin, G. (2004) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2004.00359.x · Cited by 333 · see citing works
Moroni, M., Zwart, R., Sher, E., Cassels, B. K., & Bermúdez, I. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.023044 · Cited by 286 · see citing works
Wada, E., McKinnon, D. H., Heinemann, S., Patrick, J., & Swanson, L. W. (1990) · Brain Research · doi:10.1016/0006-8993(90)90248-a · Cited by 254 · see citing works
Couey, J. J., Meredith, R. M., Spijker, S., Poorthuis, R. B., Smit, A. B., Brussaard, A. B., & Mansvelder, H. D. (2007) · Neuron · doi:10.1016/j.neuron.2007.03.006 · Cited by 253 · see citing works
Postnatal growth and morphological development of the brain: a species comparison
Watson, R. E., DeSesso, J. M., Hurtt, M. E., & Cappon, G. D. (2006) · Birth Defects Research Part B Developmental and Reproductive Toxicology · doi:10.1002/bdrb.20090 · Cited by 229 · see citing works
Langley, K., Rice, F. J., van den Bree, M. B. M., & Thapar, A. (2005) · PubMed · Cited by 225 · see citing works
Nicotinic modulation of neuronal networks: from receptors to cognition
Mansvelder, H. D., van Aerde, K. I., Couey, J. J., & Brussaard, A. B. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0070-z · Cited by 201 · see citing works
The Nicotinic Acetylcholine Receptor Subunit α5 Mediates Short-Term Effects of Nicotine in Vivo
Salas, R., Orr‐Urtreger, A., Broide, R. S., Beaudet, A. L., Paylor, R. E., & Biasi, M. D. (2003) · Molecular Pharmacology · doi:10.1124/mol.63.5.1059 · Cited by 200 · see citing works
Tribollet, E., Bertrand, D., Marguerat, A., & Raggenbass, M. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2003.09.028 · Cited by 199 · see citing works
Navarro, H. A., Seidler, F. J., Eylers, J. P., Baker, F. E., Dobbins, S. S., Lappi, S. E., & Ta, S. (1989) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)21095-3 · Cited by 198 · see citing works
Tapia, L., Kuryatov, A., & Lindstrom, J. M. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.030445 · Cited by 196 · see citing works
Roles of Accessory Subunits in α4β2* Nicotinic Receptors
Kuryatov, A., Onksen, J., & Lindstrom, J. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.046789 · Cited by 195 · see citing works
Gioanni, Y., Rougeot, C., Clarke, P. B. S., Lepousé, C., Thierry, A. M., & Vidal, C. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00403.x · Cited by 191 · see citing works
Schlaepfer, I. R., Hoft, N. R., Collins, A. C., Corley, R. P., Hewitt, J. K., Hopfer, C. J., Lessem, J. M., McQueen, M. B., Rhee, S. H., & Ehringer, M. A. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.10.024 · Cited by 186 · see citing works
Nicotinic receptors in human brain: topography and pathology
Court, J. A., Martin-Ruiz, C., Graham, A., & Perry, E. (2000) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(00)00110-1 · Cited by 180 · see citing works
Laminar distribution of nicotinic receptor subtypes in cortical regions in schizophrenia
Marutle, A., Zhang, X., Court, J., Piggott, M., Johnson, M., Perry, R., Perry, E., & Nordberg, A. (2001) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(01)00117-x · Cited by 175 · see citing works
Nicotinic control of axon excitability regulates thalamocortical transmission
Kawai, H., Lazar, R., & Metherate, R. (2007) · Nature Neuroscience · doi:10.1038/nn1956 · Cited by 171 · cited 1× · see citing works
“This observation more closely parallels the nicotinic currents in the thalamus and thalamocortical axons and terminals (Gioanni et al., 1999; Lambe et al., 2005; Kawai et al., 2007).”
BackgroundAlteration of the in vivo nicotinic receptor density in ADNFLE patients: a PET study
Picard, F., Bruel, D., Servent, D., Saba, W., Fruchart‐Gaillard, C., Peyronneau, M., Roumenov, D., Brodtkorb, E., Zuberi, S. M., Gambardella, A., et al. (2006) · Brain · doi:10.1093/brain/awl156 · Cited by 168 · see citing works
Executive and social behaviors under nicotinic receptor regulation
Granon, S., Fauré, P., & Changeux, J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1533498100 · Cited by 166 · see citing works
Brown, R. W., & Kolb, B. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02201-6 · Cited by 156 · see citing works
Molecular analysis of nicotinic receptor expression in autism
Martin-Ruiz, C. M., Lee, M., Perry, R. H., Baumann, M., Court, J. A., & Perry, E. K. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.01.003 · Cited by 141 · see citing works
Lambe, E. K., Olausson, P., Horst, N. K., Taylor, J. R., & Aghajanian, G. K. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0719-05.2005 · Cited by 135 · see citing works
Self-citationPerinatal exposure to nicotine causes deficits associated with a loss of nicotinic receptor function
Cohen, G., Roux, J.-C., Grailhe, R., Malcolm, G., Changeux, J.-P., & Lagercrantz, H. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409782102 · Cited by 134 · see citing works
Schmitz, M. D., Denardin, D., da Silva, T. L., Pianca, T. G., Hutz, M. H., Faraone, S. V., & Rohde, L. A. (2006) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/s0890-8567(09)61916-x · Cited by 121 · see citing works
Mercer, A., West, D. C., Morris, O. T., Kirchhecker, S., Kerkhoff, J. E., & Thomson, A. M. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhi027 · Cited by 118 · see citing works
The role of the nicotinic acetylcholine receptors in sleep-related epilepsy
Marini, C., & Guerrini, R. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.06.030 · Cited by 103 · see citing works
West, D. C., Mercer, A., Kirchhecker, S., Morris, O. T., & Thomson, A. M. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhi098 · Cited by 103 · see citing works
Liang, K., Poytress, B. S., Chen, Y., Leslie, F. M., Weinberger, N. M., & Metherate, R. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04945.x · Cited by 89 · see citing works
Brown, R. W. B., Collins, A. C., Lindstrom, J. M., & Whiteaker, P. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04700.x · Cited by 88 · cited 1× · see citing works
“Inclusion of the 5 accessory subunit is also thought to alter several parameters of 4 2* nicotinic receptors (Brown et al., 2007; Tapia et al., 2007; Kuryatov et al., 2008).”
BackgroundKing, S. L., Marks, M. J., Grady, S. R., Caldarone, B. J., Koren, A. O., Mukhin, A. G., Collins, A. C., & Picciotto, M. R. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-09-03837.2003 · Cited by 82 · see citing works
Winzer‐Serhan, U. H., & Leslie, F. M. (2004) · The Journal of Comparative Neurology · doi:10.1002/cne.20357 · Cited by 79 · see citing works
Sleep Oscillations Developing into Seizures in Corticothalamic Systems
Steriade, M., & Amzica, F. (2003) · Epilepsia · doi:10.1111/j.0013-9580.2003.12006.x · Cited by 78 · see citing works
Attention-deficit/hyperactivity disorder: A plausible mouse model?
Granon, S., & Changeux, J. (2006) · Acta Paediatrica · doi:10.1080/08035250600719747 · Cited by 49 · see citing works
Autosomal dominant nocturnal frontal lobe epilepsy with a mutation in the CHRNB2 gene
Díaz‐Otero, F., Quesada, M. M., Morales‐Corraliza, J., Martínez-Parra, C., Gómez‐Garre, P., & Serratosa, J. M. (2007) · Epilepsia · doi:10.1111/j.1528-1167.2007.01328.x · Cited by 46 · see citing works
Belluardo, N., Mudò, G., Blum, M., Cheng, Q., Caniglia, G., Dell’Albani, P., & Fuxé, K. (1999) · Molecular Brain Research · doi:10.1016/s0169-328x(99)00266-1 · Cited by 34 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior
Picciotto, M. R., Higley, M. J., & Mineur, Y. S. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.036 · Cited by 1,404 · see citing works
The dynamic effects of nicotine on the developing brain
Dwyer, J. B., McQuown, S. C., & Leslie, F. M. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.02.003 · Cited by 559 · see citing works
Goriounova, N. A., & Mansvelder, H. D. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a012120 · Cited by 307 · see citing works
“These neurons are modulated by b2 nAChRs that are responsible for the strong activation of the layer VI neuronal population (Kassam et al. 2008; Poorthuis et al. 2012).”
BackgroundNicotinic acetylcholine receptor β2 subunits in the medial prefrontal cortex control attention
Guillem, K., Bloem, B., Poorthuis, R. B., Loos, M., Smit, A. B., Maskos, U., Spijker, S., & Mansvelder, H. D. (2011) · Science · doi:10.1126/science.1207079 · Cited by 191 · see citing works
Lester, H. A., Xiao, C., Srinivasan, R., Son, C. D., Miwa, J., Pantoja, R., Banghart, M. R., Dougherty, D. A., Goate, A. M., & Wang, J. C. (2009) · The AAPS Journal · doi:10.1208/s12248-009-9090-7 · Cited by 163 · see citing works
Mechanisms of Nicotine Addiction
Picciotto, M. R., & Kenny, P. J. (2021) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a039610 · Cited by 157 · see citing works
The Nicotinic Acetylcholine Receptor 5 Subunit Plays a Key Role in Attention Circuitry and Accuracy
Bailey, C. D. C., De Biasi, M., Fletcher, P. J., & Lambe, E. K. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2258-10.2010 · Cited by 146 · see citing works
Self-citationNicotine on the developing brain.
Castro, E. M., Lotfipour, S., & Leslie, F. M. (2023) · Pharmacological research · doi:10.1016/j.phrs.2023.106716 · Cited by 140 · see citing works
“In this case, descending corticothalamic projections from layer VI cortical neurons, that critically regulate attention, have peak currents in the first postnatal month that are mediated by α5- and β2-containing heteromeric nAChRs [99].”
BackgroundNicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits
Mansvelder, H. D., Mertz, M., & Role, L. W. (2009) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2009.01.007 · Cited by 126 · see citing works
Nicotinic actions on neuronal networks for cognition: General principles and long-term consequences
Poorthuis, R. B., Goriounova, N. A., Couey, J. J., & Mansvelder, H. D. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.04.031 · Cited by 102 · see citing works
Adolescent neurodevelopment and substance use: receptor expression and behavioral consequences
Thorpe, H. H. A., Hamidullah, S., Jenkins, B. W., & Khokhar, J. Y. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.107431 · Cited by 97 · see citing works
Obermayer, J., Luchicchi, A., Heistek, T. S., de Kloet, S. F., Terra, H., Bruinsma, B., Mnie-Filali, O., Kortleven, C., Galakhova, A. A., Khalil, A. J., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13244-9 · Cited by 83 · see citing works
Bailey, C. D. C., Alves, N. C., Nashmi, R., De Biasi, M., & Lambe, E. K. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.09.011 · Cited by 69 · see citing works
Self-citationCholinergic modulation of dopamine pathways through nicotinic acetylcholine receptors
de Kloet, S. F., Mansvelder, H. D., & De Vries, T. J. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.07.014 · Cited by 69 · see citing works
Heath, C. J., King, S. L., Gotti, C., Marks, M. J., & Picciotto, M. R. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.130 · Cited by 59 · see citing works
Goriounova, N. A., & Mansvelder, H. D. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5502-11.2012 · Cited by 51 · see citing works
Galvin, V. C., Arnsten, A. F. T., & Wang, M. (2018) · Frontiers in Neural Circuits · doi:10.3389/fncir.2018.00067 · Cited by 25 · see citing works
Horst, N. K., Heath, C. J., Neugebauer, N. M., Kimchi, E. Y., Laubach, M., & Picciotto, M. R. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.03.002 · Cited by 17 · see citing works
Obermayer, J., Luchicchi, A., de Kloet, S. F., Terra, H., Bruinsma, B., Heistek, T. S., Mnie-Filali, O., Kortleven, C., Kroon, T., Jonker, A. J., et al. (2018) · doi:10.1101/461723 · Cited by 83 · see citing works
- Authors
- Kassam, S. M., Herman, P. M., Goodfellow, N. M., Alves, N. C., & Lambe, E. K.
- Affiliations
- University of Toronto (CA)
- Corresponding author
- Lambe, Evelyn K.
- ORCID
- Lambe, Evelyn K.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2008-08-27
- Volume
- 28
- Issue
- 35
- Pages
- 8756-8764
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2909269
- OpenAlex
- W2022503151
- Cited by
- 100
- References
- 59
- Citations by year
- 2025: 5 · 2024: 5 · 2023: 3 · 2022: 1 · 2021: 5 · 2020: 5 · 2019: 7 · 2018: 6 · 2017: 3 · 2016: 7 · 2015: 6 · 2014: 12 · 2013: 10 · 2012: 8
- FWCI
- 2.33
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- Canada Research Chairs
- Canadian Institutes of Health Research (89825_1, 83422_1, 82660, 82660_1)
- Natural Sciences and Engineering Research Council of Canada
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- corticothalamic neurons, nicotinic acetylcholine receptors, alpha4beta2 nicotinic receptor, postnatal development, allosteric modulation, mediodorsal thalamus, attention
- MeSH terms
- Acetylcholine, Age Factors, Analysis of Variance, Animals, Animals, Newborn, Dose-Response Relationship, Drug, Electric Stimulation, Male, Membrane Potentials, Neural Pathways, Neurons, Receptors, Nicotinic, Rhodamines, Tetrodotoxin, Thalamus, Prefrontal Cortex, Patch-Clamp Techniques, Cholinergic Agents, Excitatory Amino Acid Antagonists, Statistics, Nonparametric, Sodium Channel Blockers, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
