Cited by 262Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchReceptor Mechanisms and Signaling

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D1 and D2 dopamine receptor mRNA expression in whole hemisphere sections of the human brain

Hurd, Yasmin L., Suzuki, Michio, Sedvall, Göran C.·2001·Journal of Chemical Neuroanatomy

DOI 10.1016/s0891-0618(01)00122-3

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Abstract

Understanding dopamine signaling in human behavior requires knowledge of the distribution of all molecular components involved in dopamine pathways throughout the human brain. In the present study, the relative distributions of D1 and D2 dopamine receptor mRNAs were determined by in situ hybridization histochemistry in whole hemisphere sections from normal human post mortem brains. The findings confirmed information documented from single structure examination that the highest expression of both the D1 and D2 mRNAs were localized to the striatum. The cerebral cortex expressed moderate D1 mRNA in all regions with the highest signal in the medial orbital frontal area (Brodmann areas 11, 14), the paraterminal gyrus (Brodmann area 32) and the insular cortex (Brodmann areas 13-16), whereas the D2 mRNA expression had very low cortical expression. The bed nucleus of the stria terminalis and islands of Calleja had high expression of the D1 mRNA and moderate D2 mRNA levels. Moderate to high expression of the D2 mRNA was evident in the hippocampal formation, parafascicular and paraventricular thalamic nuclei, geniculate bodies, subthalamic nucleus, and pineal gland, all of which were devoid of, or showed only faint, D1 mRNA expression. Brainstem regions, e.g. substantia nigra, red nucleus, inferior colliculus, medial lemniscus, and pontine nuclei expressed D2, but not D1, mRNA. These results emphasize the differential anatomical localization of D1 and D2 dopamine receptor mRNA neuronal populations in the human brain. The restricted expression of the D1 mRNA to the cortical mantle and to a few forebrain structures indicates a strong involvement of the D1 system in cognitive function.

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Authors: Hurd, Y. L., Suzuki, M., & Sedvall, G. C.
Affiliations: Karolinska University Hospital (SE)
Corresponding author: Hurd, Yasmin L.
ORCID: Hurd, Yasmin L.
Suzuki, Michio
Venue: Journal of Chemical Neuroanatomy
Publisher: Elsevier BV
Published: 2001-07
Volume: 22
Issue: 1-2
Pages: 127-137
ISSN: 0891-0618 (ISSN-L)
DOI: 10.1016/s0891-0618(01)00122-3
OpenAlex: W2084024459
Cited by: 262
References: 47
Citations by year: 2026: 8 · 2025: 3 · 2024: 13 · 2023: 16 · 2022: 7 · 2021: 13 · 2020: 11 · 2019: 11 · 2018: 7 · 2017: 13 · 2016: 12 · 2015: 11 · 2014: 11 · 2013: 5 · 2012: 17
FWCI: 1.72
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Chemical Neuroanatomy (publishedVersion)
PubMed (publishedVersion)
Funders: Vetenskapsrådet
National Institutes of Health (5r01da008914-02)
National Institute of Mental Health (MH-44814)
National Institute on Drug Abuse (DA 08914)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords: dopamine D1 receptor, dopamine D2 receptor, human brain, striatum, cerebral cortex, insula, bed nucleus of the stria terminalis, islands of Calleja, hippocampal formation, thalamic nuclei, subthalamic nucleus, substantia nigra, brainstem, cognitive function
MeSH terms: Brain, Diencephalon, Dopamine, Female, Humans, Male, Mesencephalon, Microtomy, Middle Aged, RNA, Messenger, Telencephalon, Gene Expression, In Situ Hybridization, Receptors, Dopamine D1, Receptors, Dopamine D2, Metencephalon

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D1 and D2 dopamine receptor mRNA expression in whole hemisphere sections of the human brain

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