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D1 and D2 dopamine receptor mRNA expression in whole hemisphere sections of the human brain
Abstract
Understanding dopamine signaling in human behavior requires knowledge of the distribution of all molecular components involved in dopamine pathways throughout the human brain. In the present study, the relative distributions of D1 and D2 dopamine receptor mRNAs were determined by in situ hybridization histochemistry in whole hemisphere sections from normal human post mortem brains. The findings confirmed information documented from single structure examination that the highest expression of both the D1 and D2 mRNAs were localized to the striatum. The cerebral cortex expressed moderate D1 mRNA in all regions with the highest signal in the medial orbital frontal area (Brodmann areas 11, 14), the paraterminal gyrus (Brodmann area 32) and the insular cortex (Brodmann areas 13-16), whereas the D2 mRNA expression had very low cortical expression. The bed nucleus of the stria terminalis and islands of Calleja had high expression of the D1 mRNA and moderate D2 mRNA levels. Moderate to high expression of the D2 mRNA was evident in the hippocampal formation, parafascicular and paraventricular thalamic nuclei, geniculate bodies, subthalamic nucleus, and pineal gland, all of which were devoid of, or showed only faint, D1 mRNA expression. Brainstem regions, e.g. substantia nigra, red nucleus, inferior colliculus, medial lemniscus, and pontine nuclei expressed D2, but not D1, mRNA. These results emphasize the differential anatomical localization of D1 and D2 dopamine receptor mRNA neuronal populations in the human brain. The restricted expression of the D1 mRNA to the cortical mantle and to a few forebrain structures indicates a strong involvement of the D1 system in cognitive function.
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“Notably, many if not all regions of the interoceptive circuit in Figure 7, are characterized by a high density of dopaminergic receptors and terminals across all cortical layers; this is particularly well-established for visceromotor regions like AIC, ACC, or OFC (Gaspar et al., 1989; Hurd et al., 2001; Lewis et al., 2001).”
From Allostatic Self-efficacy: A Metacognitive Theory of Dyshomeostasis-Induced Fatigue and Depression (2016) · cites this paper as Hurd et al., 2001
In the citing paper
“The role of dopamine for viscerosensory (posterior insula) regions is less well established but in situ hybridisation studies point to the existence of dopamine receptor mRNA in human posterior insula as well (Hurd et al., 2001).”
From Allostatic Self-efficacy: A Metacognitive Theory of Dyshomeostasis-Induced Fatigue and Depression (2016) · cites this paper as Hurd et al., 2001
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Metadata
- Authors
- Hurd, Y. L., Suzuki, M., & Sedvall, G. C.
- Affiliations
- Karolinska University Hospital (SE)
- Corresponding author
- Hurd, Yasmin L.
- Venue
- Journal of Chemical Neuroanatomy
- Publisher
- Elsevier BV
- Published
- 2001-07
- Volume
- 22
- Issue
- 1-2
- Pages
- 127-137
- ISSN
- 0891-0618 (ISSN-L)
- OpenAlex
- W2084024459
- Cited by
- 262
- References
- 47
- Citations by year
- 2026: 8 · 2025: 3 · 2024: 13 · 2023: 16 · 2022: 7 · 2021: 13 · 2020: 11 · 2019: 11 · 2018: 7 · 2017: 13 · 2016: 12 · 2015: 11 · 2014: 11 · 2013: 5 · 2012: 17
- FWCI
- 1.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Chemical Neuroanatomy (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Vetenskapsrådet
- National Institutes of Health (5r01da008914-02)
- National Institute of Mental Health (MH-44814)
- National Institute on Drug Abuse (DA 08914)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- dopamine D1 receptor, dopamine D2 receptor, human brain, striatum, cerebral cortex, insula, bed nucleus of the stria terminalis, islands of Calleja, hippocampal formation, thalamic nuclei, subthalamic nucleus, substantia nigra, brainstem, cognitive function
- MeSH terms
- Brain, Diencephalon, Dopamine, Female, Humans, Male, Mesencephalon, Microtomy, Middle Aged, RNA, Messenger, Telencephalon, Gene Expression, In Situ Hybridization, Receptors, Dopamine D1, Receptors, Dopamine D2, Metencephalon
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