The DOI matches its Crossref record; 206 of the 206 references it cites were found in a registry or an index.
Unraveling peroxynitrite formation in biological systems
Abstract
Peroxynitrite promotes oxidative damage and is implicated in the pathophysiology of various diseases that involve accelerated rates of nitric oxide and superoxide formation. The unambiguous detection of peroxynitrite in biological systems is, however, difficult due to the combination of a short biological half-life, limited diffusion, multiple target molecule reactions, and participation of alternative oxidation/nitration pathways. In this review, we provide the conceptual framework and a comprehensive analysis of the current experimental strategies that can serve to unequivocally define the existence and quantitation of peroxynitrite in biological systems of different levels of organization and complexity.
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“Peroxynitrite ONOO— is a potent oxidizing and nitrating agent, with a short half-life of about 10−2 s [26].”
From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [26]
Citations
Cites
Items 201–206 of 206
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Antioxidant Properties of Nitric Oxide
Radí, R., & Rubbo, H. (2001) · CRC Press eBooks · doi:10.1201/9780203904046.pt10 · Cited by 12
Waldvogel (1999) · doi:10.1002/1531-8249(199907)46:1
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Research works printed but not linked: 2
- Pryor, 1995, The chemistry of peroxynitrite, Am. J. Physiol., 268, L699
- Virag, 1998, Peroxynitrite-induced thymocyte apoptosis, Immunology, 94, 345
Cited by
Sorted by citations
Nitric Oxide and Peroxynitrite in Health and Disease
Pacher, P., Beckman, J. S., & Liaudet, L. (2007) · Physiological Reviews · doi:10.1152/physrev.00029.2006 · Cited by 6,390
Halliwell, B., & Whiteman, M. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705776 · Cited by 2,238
Peroxynitrite: biochemistry, pathophysiology and development of therapeutics
Szabó, C., Ischiropoulos, H., & Radi, R. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2222 · Cited by 2,134
Redox regulation of cell survival
Trachootham, D., Lu, W., Ogasawara, M. A., Valle, N. R.-D., & Huang, P. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1957 · Cited by 1,781
Chemical biology of peroxynitrite: Kinetics, diffusion, and radicals
Ferrer-Sueta, G., & Radi, R. (2009) · ACS Chemical Biology · doi:10.1021/cb800279q · Cited by 776
Metadata
- Authors
- Radi, R., Peluffo, G., Alvarez, M. N., Naviliat, M., & Cayota, A.
- Affiliations
- Universidad de la República de Uruguay (UY)
- ORCID
- Cayota, Alfonso
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2001-03
- Volume
- 30
- Issue
- 5
- Pages
- 463-488
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W1967729440
- Cited by
- 735
- References
- 206
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 15 · 2023: 20 · 2022: 20 · 2021: 12 · 2020: 18 · 2019: 22 · 2018: 19 · 2017: 22 · 2016: 20 · 2015: 28 · 2014: 27 · 2013: 27 · 2012: 36
- FWCI
- 17.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- peroxynitrite, nitric oxide, superoxide, oxidative damage, peroxynitrite detection, nitration, biological half-life
- MeSH terms
- Animals, Carbon Dioxide, Cytochrome c Group, Electron Spin Resonance Spectroscopy, Fluorescent Dyes, Free Radicals, Humans, Hydroxylation, Immunohistochemistry, Indicators and Reagents, Luminescent Measurements, Nitrates, Phenols, Tyrosine, Oxidants, Oxidative Stress
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