Unraveling peroxynitrite formation in biological systems

Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide

Beckman, J. S., Beckman, T. W., Chen, J., Marshall, P. A., & Freeman, B. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1620 · Cited by 7,029

The L-Arginine-Nitric Oxide Pathway

Epstein, F. H., Moncada, S., & Higgs, A. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312303292706 · Cited by 6,678

Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly

Beckman, J. S., & Koppenol, W. H. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.5.c1424 · Cited by 5,513

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

Ignarro, L. J., Buga, G. M., Wood, K. S., Byrns, R. E., & Chaudhuri, G. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.24.9265 · Cited by 5,074

Superoxide radical and superoxide dismutases

Fridovich, I. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.000525 · Cited by 3,455

Peroxynitrite oxidation of sulfhydryls.

Radí, R., Beckman, J. S., Bush, K., & Freeman, B. Α. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)64313-7 · Cited by 2,492

Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor

Gryglewski, R. J., Palmer, R. M. J., & Moncada, S. (1986) · Nature · doi:10.1038/320454a0 · Cited by 2,400

Peroxynitrite-induced membrane lipid peroxidation: The cytotoxic potential of superoxide and nitric oxide

Radí, R., Beckman, J. S., Bush, K. M., & Freeman, B. Α. (1991) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(91)90224-7 · Cited by 2,201

The reaction of NO with superoxide

Huie, R. E., & Padmaja, S. (1993) · Free Radical Research Communications · doi:10.3109/10715769309145868 · Cited by 2,121

Chemical biology of nitric oxide: insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide

Wink, D. A., & Mitchell, J. B. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00092-6 · Cited by 1,606

The chemistry of peroxynitrite: A product from the reaction of nitric oxide with superoxide

Pryor, W. A., & Squadrito, G. L. (1995) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1995.268.5.l699 · Cited by 1,511

Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase

Ischiropoulos, H., Zhu, L., Chen, J., Tsai, M., Martin, J. C., Smith, C. D. L., & Beckman, J. S. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90431-u · Cited by 1,499

Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils

Eiserich, J. P., Hristova, M., Cross, C. E., Jones, A. D., Freeman, B. A., Halliwell, B., & van der Vliet, A. (1998) · Nature · doi:10.1038/34923 · Cited by 1,496

Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives

Rubbo, H., Radí, R., Trujillo, M., Telleri, R., Kalyanaraman, B., Barnes, S., KIRK, M. C., & Freeman, B. Α. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47160-8 · Cited by 1,350

Biosynthesis And Metabolism Of Endothelium-Derived Nitric Oxide

Ignarro, L. J. (1990) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.30.040190.002535 · Cited by 1,300

Evaluation of 2′,7′-Dichlorofluorescin and Dihydrorhodamine 123 as Fluorescent Probes for Intracellular H2O2 in Cultured Endothelial Cells

Royall, J. A., & Ischiropoulos, H. (1993) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1993.1222 · Cited by 1,123

Extensive Nitration of Protein Tyrosines in Human Atherosclerosis Detected by Immunohistochemistry

Beckman, J. S., Ye, Y. Z., Anderson, P. G., Chen, J., Accavitti, M. A., Tarpey, M. M., & White, C. R. (1994) · Biological Chemistry Hoppe-Seyler · doi:10.1515/bchm3.1994.375.2.81 · Cited by 1,122

Peroxynitrite formation from macrophage-derived nitric oxide

Ischiropoulos, H., Zhu, L., & Beckman, J. S. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90433-w · Cited by 1,099

Biological Tyrosine Nitration: A Pathophysiological Function of Nitric Oxide and Reactive Oxygen Species

Ischiropoulos, H. (1998) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1998.0755 · Cited by 1,025

ALS, SOD and peroxynitrite

Beckman, J. S., Carson, M. A., Smith, C. D. L., & Koppenol, W. H. (1993) · Nature · doi:10.1038/364584a0 · Cited by 876

Persistent inhibition of cell respiration by nitric oxide: Crucial role of S -nitrosylation of mitochondrial complex I and protective action of glutathione

Clementi, E., Brown, G. C., Feelisch, M., & Moncada, S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7631 · Cited by 863

Oxidative chemistry of nitric oxide: the roles of superoxide, peroxynitrite, and carbon dioxide

Squadrito, G. L., & Pryor, W. A. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00095-1 · Cited by 800

Formation of reactive nitrogen species during peroxidase-catalyzed oxidation of nitrite

van der Vliet, A., Eiserich, J. P., Halliwell, B., & Cross, C. E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.12.7617 · Cited by 780

Nitration and inactivation of manganese superoxide dismutase in chronic rejection of human renal allografts.

MacMillan-Crow, L.-A., Crow, J. P., Kerby, J. D., Beckman, J. S., & Thompson, J. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11853 · Cited by 769

Kinetics of superoxide dismutase- and iron-catalyzed nitration of phenolics by peroxynitrite

Beckman, J. S., Ischiropoulos, H., Zhu, L., van der Woerd, M., Smith, C. D. L., Chen, J., Harrison, J. G., Martin, J. C., & Tsai, M. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90432-v · Cited by 768

Differential Inhibitory Action of Nitric Oxide and Peroxynitrite on Mitochondrial Electron Transport

Cassina, A., & Radí, R. (1996) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1996.0178 · Cited by 721

Peroxynitrite-mediated oxidation of dihydrorhodamine 123

Kooy, N. W., Royall, J. A., Ischiropoulos, H., & Beckman, J. S. (1994) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)90138-4 · Cited by 720

Evidence for nitric oxide‐mediated oxidative damage in chronic inflammation Nitrotyrosine in serum and synovial fluid from rheumatoid patients

Kaur, H., & Halliwell, B. B. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00722-5 · Cited by 706

Inhibition of Mitochondrial Electron Transport by Peroxynitrite

Radi, R., Rodriguez, M., Castro, L., & Telleri, R. (1994) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1994.1013 · Cited by 693

Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophages

Xia, Y., & Zweier, J. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.13.6954 · Cited by 691

Simulation of the diffusion and reaction of endogenously produced nitric oxide.

Lancaster, J. R. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.17.8137 · Cited by 689

“NONOates” (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: Convenient nitric oxide dosage forms

Keefer, L. K., Nims, R. W., Davies, K. M., & Wink, D. A. (1996) · Methods in Enzymology · doi:10.1016/s0076-6879(96)68030-6 · Cited by 670

Formation and Properties of Peroxynitrite as Studied by Laser Flash Photolysis, High-Pressure Stopped-Flow Technique, and Pulse Radiolysis

Kissner, R., Nauser, T., Bugnon, P., Lye, P. G., & Koppenol, W. H. (1997) · Chemical Research in Toxicology · doi:10.1021/tx970160x · Cited by 629

Dichlorodihydrofluorescein and Dihydrorhodamine 123 Are Sensitive Indicators of Peroxynitritein Vitro:Implications for Intracellular Measurement of Reactive Nitrogen and Oxygen Species

Crow, J. P. (1997) · Nitric Oxide · doi:10.1006/niox.1996.0113 · Cited by 627

Peroxynitrite‐mediated oxidative protein modifications

Ischiropoulos, H., & Al‐Mehdi, A. B. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00307-u · Cited by 605

Increased 3‐nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis

Beal, M. F., Ferrante, R. J., Browne, S. E., Matthews, R. T., Kowall, N. W., & Brown, R. H. (1997) · Annals of Neurology · doi:10.1002/ana.410420416 · Cited by 599

Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutase

Estévez, A. G., Crow, J. P., Sampson, J. B., Reiter, C., Zhuang, Y., Richardson, G. J., Tarpey, M. M., Barbeito, L., & Beckman, J. S. (1999) · Science · doi:10.1126/science.286.5449.2498 · Cited by 596

Quantitation of nitrotyrosine levels in lung sections of patients and animals with acute lung injury.

Haddad, I. Y., Pataki, G., Yu, Y., GALLIANI, C. A., Beckman, J. S., & Matalon, S. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117607 · Cited by 594

Peroxynitrite reaction with carbon dioxide/bicarbonate. Kinetics and influence on peroxynitrite-mediated oxidations

Denicola, A., Freeman, B. A., Trujillo, M., & Radi, R. (1996) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1996.0363 · Cited by 593

Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis

Hooper, D. C., Spitsin, S. V., Kean, R. B., Champion, J. M., Dickson, G. M., Chaudhry, I., & Koprowski, H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.2.675 · Cited by 571

Rapid reaction between peroxonitrite ion and carbon dioxide: Implications for biological activity

Lymar, S. V., & Hurst, J. K. (1995) · Journal of the American Chemical Society · doi:10.1021/ja00139a027 · Cited by 515

Electrochemical Analysis of Protein Nitrotyrosine and Dityrosine in the Alzheimer Brain Indicates Region-Specific Accumulation

Hensley, K., Maidt, M. L., Yu, Z., Sang, H., Markesbery, W. R., & Floyd, R. A. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-20-08126.1998 · Cited by 508

Phenotype of Mice and Macrophages Deficient in Both Phagocyte Oxidase and Inducible Nitric Oxide Synthase

Shiloh, M. U., MacMicking, J. D., Nicholson, S., Brause, J. E., Potter, S. H., Marino, M., Fang, F. C., Dinauer, M. C., & Nathan, C. (1999) · Immunity · doi:10.1016/s1074-7613(00)80004-7 · Cited by 507

Evidence for In Vivo Peroxynitrite Production in Human Acute Lung Injury

Kooy, N. W., Royall, J. A., Ye, Y. Z., Kelly, D. R., & Beckman, J. S. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm/151.4.1250 · Cited by 503

A Nonpeptidyl Mimic of Superoxide Dismutase with Therapeutic Activity in Rats

Salvemini, D., Wang, Z., Zweier, J. L., Samouilov, A., Macarthur, H., Misko, T. P., Currie, M. G., Cuzzocrea, S., Sikorski, J. A., & Riley, D. P. (1999) · Science · doi:10.1126/science.286.5438.304 · Cited by 502

Pathogenesis of influenza virus-induced pneumonia: involvement of both nitric oxide and oxygen radicals.

Akaike, T., Noguchi, Y., Ijiri, S., Setoguchi, K., Suga, M., Zheng, Y., Dietzschold, B., & Maeda, H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.6.2448 · Cited by 490

THE PATHOPHYSIOLOGICAL ROLE OF PEROXYNITRITE IN SHOCK, INFLAMMATION, AND ISCHEMIA-REPERFUSION INJURY

Szabó, C. (1996) · Shock · doi:10.1097/00024382-199608000-00001 · Cited by 481

Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs 1

Stuehr, D. J., Fasehun, O. A., Kwon, N. S., Gross, S. S., Gonzalez, J. A., Levi, R., & Nathan, C. (1991) · The FASEB Journal · doi:10.1096/fasebj.5.1.1703974 · Cited by 465

Effects of peroxynitrite‐induced protein modifications on tyrosine phosphorylation and degradation

Gow, A. J., Duran, D., Malcolm, S., & Ischiropoulos, H. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00347-x · Cited by 449

Inactivation of Human Manganese-superoxide Dismutase by Peroxynitrite Is Caused by Exclusive Nitration of Tyrosine 34 to 3-Nitrotyrosine

Yamakura, F., Taka, H., Fujimura, T., & Murayama, K. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.23.14085 · Cited by 442

Expression of phagocyte NADPH oxidase components in human endothelial cells

Jones, S. A., O’Donnell, V. B., Wood, J. D., Broughton, J. P., Hughes, E. J., & Jones, O. T. (1996) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1996.271.4.h1626 · Cited by 427

Macrophage Microbicidal Mechanisms In Vivo: Reactive Nitrogen versus Oxygen Intermediates in the Killing of Intracellular Visceral Leishmania donovani

Murray, H. W., & Nathan, C. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.4.741 · Cited by 418

Inactivation of tyrosine hydroxylase by nitration following exposure to peroxynitrite and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

Ara, J. E., Przedborski, S., Naini, A., Jackson-Lewis, V. R., Trifiletti, R. R., Horwitz, J., & Ischiropoulos, H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7659 · Cited by 414

Diffusion of peroxynitrite across erythrocyte membranes

Denicola, A., Souza, J. M., & Radi, R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3566 · Cited by 403

The reaction of NO· with O2·− and HO2·−: A pulse radiolysis study

Goldstein, S., & Czapski, G. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)00034-u · Cited by 398

Evidence for free radical formation during the oxidation of 2′-7′-dichlorofluorescin to the fluorescent dye 2′-7′-dichlorofluorescein by horseradish peroxidase:

Rota, C., Chignell, C. F., & Mason, R. P. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00137-9 · Cited by 383

Aromatic hydroxylation and nitration of phenylalanine and tyrosine by peroxynitrite

van der Vliet, A., O’neill, C. A., Halliwell, B. B., Cross, C. E., & Kaur, H. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)80391-9 · Cited by 381

Peroxynitrite-induced luminol chemiluminescence

Radí, R., Cosgrove, T. P., Beckman, J. S., & Freeman, B. Α. (1993) · Biochemical Journal · doi:10.1042/bj2900051 · Cited by 377

Tyrosine Modification by Reactive Nitrogen Species: A Closer Look

Vandervliet, A., Eiserich, J. P., O’Neill, C., Halliwell, B. B., & Cross, C. E. (1995) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1995.1303 · Cited by 373

Permeation of the erythrocyte stroma by superoxide radical

Lynch, R. E., & Fridovich, I. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)30446-5 · Cited by 370

Circulating plasma xanthine oxidase contributes to vascular dysfunction in hypercholesterolemic rabbits.

White, C. R., Darley-Usmar, V, Berrington, W. R., McAdams, M., Gore, J. Z., Thompson, J. A., Parks, D. A., Tarpey, M. M., & Freeman, B. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8745 · Cited by 367

Neuronal Nitric Oxide Synthase Activation and Peroxynitrite Formation in Ischemic Stroke Linked to Neural Damage

Eliasson, M. J. L., Huang, Z., Ferrante, R. J., Sasamata, M., Molliver, M. E., Snyder, S. H., & Moskowitz, M. A. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-14-05910.1999 · Cited by 366

Formation of 8‐nitroguanine in DNA treated with peroxynitrite in vitro and its rapid removal from DNA by depurination

Yermilov, V., Rubio, J., & Ohshima, H. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)01281-6 · Cited by 356

Modulation of Superoxide-dependent Oxidation and Hydroxylation Reactions by Nitric Oxide

Miles, A. M., Bohle, D. S., Glassbrenner, P. A., Hansert, B., Wink, D. A., & Grisham, M. B. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.1.40 · Cited by 350

Nitric Oxide and Superoxide Contribute to Motor Neuron Apoptosis Induced by Trophic Factor Deprivation

Estévez, Á. G., Spear, N., Manuel, S. M., Radí, R., Henderson, C. E., Barbeito, L., & Beckman, J. S. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-03-00923.1998 · Cited by 344

Luminol and lucigenin as detectors for O2ṡ−

Faulkner, K. M., & Fridovich, I. (1993) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(93)90044-u · Cited by 336

Prevention of experimental allergic encephalomyelitis by targeting nitric oxide and peroxynitrite: Implications for the treatment of multiple sclerosis

Hooper, D. C., Bagasra, O., Marini, J. C., Zborek, A., Ohnishi, S. T., Kean, R. B., Champion, J. M., Sarker, A. B., Bobroski, L. E., Farber, J. L., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.6.2528 · Cited by 333

Nitric oxide and peroxynitrite exert distinct effects on mitochondrial respiration which are differentially blocked by glutathione or glucose

Lizasoaín, I., Moro, M. Á., Knowles, R. G., Darley-Usmar, V. M., & Moncada, S. (1996) · Biochemical Journal · doi:10.1042/bj3140877 · Cited by 318

Factors Determining the Selectivity of Protein Tyrosine Nitration

Souza, J. M., Daikhin, E., Yudkoff, M., Raman, C. S., & Ischiropoulos, H. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1480 · Cited by 315

Cytokine-treated human neutrophils contain inducible nitric oxide synthase that produces nitration of ingested bacteria.

Evans, T. J., Buttery, L. D. K., Carpenter, A., Springall, D. R., Polak, J. M., & Cohen, J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9553 · Cited by 311

Peroxynitrite rapidly permeates phospholipid membranes

Marla, S. S., Lee, J., & Groves, J. T. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.26.14243 · Cited by 310

Peroxynitrite Inhibits T Lymphocyte Activation and Proliferation by Promoting Impairment of Tyrosine Phosphorylation and Peroxynitrite-Driven Apoptotic Death

Brito, C., Naviliat, M., Tiscornia, A., Vuillier, F., Gualco, G., Dighiero, G., Radí, R., & Cayota, A. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.6.3356 · Cited by 306

Carbon Dioxide Enhancement of Peroxynitrite-Mediated Protein Tyrosine Nitration

Gow, A. J., Duran, D., Thom, S. R., & Ischiropoulos, H. (1996) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1996.0362 · Cited by 302

Mechanism of carbon dioxide-catalyzed oxidation of tyrosine by peroxynitrite

Lymar, S. V., Jiang, Q., & Hurst, J. K. (1996) · Biochemistry · doi:10.1021/bi960331h · Cited by 299

Direct EPR Detection of the Carbonate Radical Anion Produced from Peroxynitrite and Carbon Dioxide

Bonini, M. G., Radi, R., Ferrer-Sueta, G., Ferreira, A. M. D. C., & Augusto, O. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.16.10802 · Cited by 293

Elevated free nitrotyrosine levels, but not protein-bound nitrotyrosine or hydroxyl radicals, throughout amyotrophic lateral sclerosis (ALS)-like disease implicate tyrosine nitration as an aberrant in vivo property of one familial ALS-linked superoxide dismutase 1 mutant

Bruijn, L. I., Beal, M. F., Bêcher, M. W., Schulz, J. B., Wong, P. C., Price, D. L., & Cleveland, D. W. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.14.7606 · Cited by 290

Nitration of Unsaturated Fatty Acids by Nitric Oxide-Derived Reactive Nitrogen Species Peroxynitrite, Nitrous Acid, Nitrogen Dioxide, and Nitronium Ion

O'Donnell, V. B., Eiserich, J. P., Chumley, P. H., Jablonsky, M. J., Krishna, N. R., Kirk, M., Barnes, S., Darley-Usmar, V. M., & Freeman, B. A. (1999) · Chemical Research in Toxicology · doi:10.1021/tx980207u · Cited by 289

Relationships between nitric oxide, nitroxyl ion, nitrosonium cation and peroxynitrite

Hughes, M. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(99)00019-5 · Cited by 288

2,7‐Dihydrodichlorofluorescein diacetate as a fluorescent marker for peroxynitrite formation

Possel, H., Noack, H., Augustin, W., et al. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01197-6 · Cited by 284

Nitric oxide :principles and actions

Lancaster, J. R. (1996) · Cited by 283

Uric Acid Oxidation by Peroxynitrite: Multiple Reactions, Free Radical Formation, and Amplification of Lipid Oxidation

Santos, C. X. C., Anjos, E. I., & Augusto, O. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1491 · Cited by 275

An activity in rat tissues that modifies nitrotyrosine-containing proteins

Kamisaki, Y., Wada, K., Bian, K., Balabanlı, B., Davis, K. L., Martin, E., Behbod, F., Lee, Y.-C., & Murad, F. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.11584 · Cited by 275

Mass Spectrometric Quantification of 3-Nitrotyrosine, ortho-Tyrosine, and o,o′-Dityrosine in Brain Tissue of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated Mice, a Model of Oxidative Stress in Parkinson's Disease

Pennathur, S., Jackson-Lewis, V. R., Przedborski, S., & Heinecke, J. W. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.49.34621 · Cited by 268

Manganese Superoxide Dismutase Protects nNOS Neurons from NMDA and Nitric Oxide-Mediated Neurotoxicity

Gonzalez‐Zulueta, M., Ensz, L. M., Mukhina, G. L., Lebovitz, R. M., Zwacka, R. M., Engelhardt, J. F., Oberley, L. W., Dawson, V. L., & Dawson, T. M. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-06-02040.1998 · Cited by 265

Eosinophil peroxidase nitrates protein tyrosyl residues

Wu, W., Chen, Y., & Hazen, S. L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.36.25933 · Cited by 265

Downregulation of Cu/Zn superoxide dismutase leads to cell death via the nitric oxide-peroxynitrite pathway

Troy, C. M., Derossi, D., Prochiantz, A., Greene, L., & Shelanski, M. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-01-00253.1996 · Cited by 264

Kinetics and mechanism of the reduction of ferricytochrome c by the superoxide anion.

Butler, J., Koppenol, W. H., & Margoliash, E. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)33886-9 · Cited by 262

Peroxynitrite-Dependent Tryptophan Nitration

Álvarez, B., Rubbo, H., KIRK, M. C., Barnes, S., Freeman, B. Α., & Radí, R. (1996) · Chemical Research in Toxicology · doi:10.1021/tx950133b · Cited by 259

Peroxynitrite decomposition catalysts: Therapeutics for peroxynitrite-mediated pathology

Salvemini, D., Wang, Z.-Q., Stern, M. K., Currie, M. G., & Misko, T. P. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2659 · Cited by 259

The Ortho Effect Makes Manganese(III)Meso-Tetrakis(N-Methylpyridinium-2-yl)Porphyrin a Powerful and Potentially Useful Superoxide Dismutase Mimic

Batinic̈‐Haberle, I., Benov, L., Spasojević, I., & Fridovich, I. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.38.24521 · Cited by 256

Kinetics of Peroxynitrite Reaction with Amino Acids and Human Serum Albumin

Álvarez, B., Ferrer‐Sueta, G., Freeman, B. Α., & Radí, R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.2.842 · Cited by 253

Agonist-Induced Peroxynitrite Production from Endothelial Cells

Kooy, N. W., & Royall, J. A. (1994) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1994.1178 · Cited by 253

Peroxynitrite Increases the Degradation of Aconitase and Other Cellular Proteins by Proteasome

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3-Nitrotyrosine in the proteins of human plasma determined by an ELISA method

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The Cytosolic Antioxidant Copper/Zinc-Superoxide Dismutase Prevents the Early Release of Mitochondrial Cytochrome c in Ischemic Brain after Transient Focal Cerebral Ischemia in Mice

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Ebselen as a Glutathione Peroxidase Mimic and as a Scavenger of Peroxynitrite

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Characterization of the Cytoprotective Action of Peroxynitrite Decomposition Catalysts

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Characterization of Sulfur-centered Radical Intermediates Formed during the Oxidation of Thiols and Sulfite by Peroxynitrite

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Formation of Nitric Oxide–Derived Oxidants by Myeloperoxidase in Monocytes

Hazen, S. L., Zhang, R., Shen, Z., Wu, W., Podrez, E. A., MacPherson, J. C., Schmitt, D. C., Mitra, S. N., Mukhopadhyay, C., Chen, Y., et al. (1999) · Circulation Research · doi:10.1161/01.res.85.10.950 · Cited by 226

Phenoxyl Free Radical Formation during the Oxidation of the Fluorescent Dye 2′,7′-Dichlorofluorescein by Horseradish Peroxidase

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Peroxynitrite‐induced thymocyte apoptosis: the role of caspases and poly (ADP‐ribose) synthetase (PARS) activation

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Reactions of nitric oxide with mitochondrial cytochrome c: a novel mechanism for the formation of nitroxyl anion and peroxynitrite

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On the pH-dependent yield of hydroxyl radical products from peroxynitrite

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The formation of nitric oxide donors from peroxynitrite

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Xanthine Oxidase-mediated Decomposition of S-Nitrosothiols

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[17] Detection and quantitation of nitrotyrosine residues in proteins: In vivo marker of peroxynitrite

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Kinetics of Cytochrome C2+ Oxidation by Peroxynitrite: Implications for Superoxide Measurements in Nitric Oxide-Producing Biological-Systems

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Peroxynitrite Decomposition Catalysts

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Nitric Oxide Diffusion in Membranes Determined by Fluorescence Quenching

Denicola, A., Souza, J. M., Radí, R., & Lissi, E. A. (1996) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1996.0162 · Cited by 183

3-Bromotyrosine and 3,5-Dibromotyrosine Are Major Products of Protein Oxidation by Eosinophil Peroxidase: Potential Markers for Eosinophil-Dependent Tissue Injury in Vivo

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Oxidation of 2′,7′-Dichlorofluorescin by Peroxynitrite

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Glyceraldehyde-3-Phosphate Dehydrogenase Inactivation by Peroxynitrite

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Tyrosine Nitration by Simultaneous Generation of ⋅NO and O⨪2 under Physiological Conditions

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Clinical Evidence of Peroxynitrite Formation in Chronic Renal Failure Patients with Septic Shock

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Vascular Endothelial Cells Generate Peroxynitrite in Response to Carbon Monoxide Exposure

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Peroxynitrite Reactions and Diffusion in Biology

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Kinetic study of the reaction of ebselen with peroxynitrite

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Inflammation and NO x -induced nitration: Assay for 3-nitrotyrosine by HPLC with electrochemical detection

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Spin-Trapping Studies of Peroxynitrite Decomposition and of 3-Morpholinosydnonimine N-Ethylcarbamide Autooxidation: Direct Evidence for Metal-Independent Formation of Free-Radical Intermediates

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Nitric Oxide Trapping of the Tyrosyl Radical of Prostaglandin H Synthase-2 Leads to Tyrosine Iminoxyl Radical and Nitrotyrosine Formation

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Mercaptoethylguanidine and Guanidine Inhibitors of Nitric-oxide Synthase React with Peroxynitrite and Protect against Peroxynitrite-induced Oxidative Damage

Szabó, C., Ferrer‐Sueta, G., Zingarelli, B., Southan, G. J., Salzman, A. L., & Radí, R. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.14.9030 · Cited by 168

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Effects of carbon dioxide/bicarbonate on induction of DNA single‐strand breaks and formation of 8‐nitroguanine, 8‐oxoguanine and base‐propenal mediated by peroxynitrite

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The Nitric Oxide/Superoxide Assay

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Chemiluminescent Detection of Oxidants in Vascular Tissue

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Mechanisms of Iron Porphyrin Reactions with Peroxynitrite

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Base Modification and Strand Breakage in Isolated Calf Thymus DNA and in DNA from Human Skin Epidermal Keratinocytes Exposed to Peroxynitrite or 3-Morpholinosydnonimine

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Peroxynitrite-mediated modification of proteins at physiological carbon dioxide concentration: pH dependence of carbonyl formation, tyrosine nitration, and methionine oxidation

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Dityrosine Formation Outcompetes Tyrosine Nitration at Low Steady-state Concentrations of Peroxynitrite

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Nitration and Hydroxylation of Phenolic Compounds by Peroxynitrite

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Catalytic Scavenging of Peroxynitrite by Isomeric Mn(III) N -Methylpyridylporphyrins in the Presence of Reductants

Ferrer‐Sueta, G., Batinic̈‐Haberle, I., Spasojević, I., Fridovich, I., & Radí, R. (1999) · Chemical Research in Toxicology · doi:10.1021/tx980245d · Cited by 157

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Manganese Porphyrins as Redox-Coupled Peroxynitrite Reductases

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Analysis of free and protein-bound nitrotyrosine in human plasma by a gas chromatography/mass spectrometry method that avoids nitration artifacts

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Peroxynitrite‐mediated oxidation of albumin to the protein‐thiyl free radical

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S-Nitroglutathione, a Product of the Reaction between Peroxynitrite and Glutathione That Generates Nitric Oxide

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CO2-Catalyzed One-Electron Oxidations by Peroxynitrite: Properties of the Reactive Intermediate

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Reactions of Nitric Oxide with Metalloproteins

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Nitrotyrosine in plasma of celiac disease patients as detected by a new sandwich ELISA

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Spin Trapping of Superoxide Radicals and Peroxynitrite by 1-Hydroxy-3-carboxy-pyrrolidine and 1-Hydroxy-2,2,6,6-tetramethyl-4-oxo-piperidine and the Stability of Corresponding Nitroxyl Radicals Towards Biological Reductants

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[39] Immunohistochemical methods to detect nitrotyrosine

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Analytical Methods for 3-Nitrotyrosine as a Marker of Exposure to Reactive Nitrogen Species: A Review

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Nitrosation of Uric Acid by Peroxynitrite

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Peroxynitrite Scavenging by Different Antioxidants. Part I: Convenient Assay

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Hydrogen Peroxide Formation by Reaction of Peroxynitrite with HEPES and Related Tertiary Amines

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[16] Nitrotyrosine as biomarker for reactive nitrogen species

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Desferrioxamine inhibition of the hydroxyl radical-like reactivity of peroxynitrite: Role of the hydroxamic groups

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Ca2+-Independent Permeabilization of the Inner Mitochondrial Membrane by Peroxynitrite Is Mediated by Membrane Protein Thiol Cross-Linking and Lipid Peroxidation

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Nitric Oxide Synthase Inhibitors Preclinical Studies of Potential Use for Treatment of Opioid Withdrawal

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Diffusion of Peroxynitrite in the Presence of Carbon Dioxide

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Design of isoform-selective inhibitors of nitric oxide synthase

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Free Radical Formation in the Peroxynitrous Acid (ONOOH)/Peroxynitrite (ONOO-) System

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[37] Peroxynitrite reactions with carbon dioxide-bicarbonate

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In Vivo Aspects of Nitric Oxide (NO) Chemistry: Does Peroxynitrite (-OONO) Play a Major Role in Cytotoxicity?

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Nitric oxide and peroxynitrite-dependent aconitase inactivation and iron-regulatory protein-1 activation in mammalian fibroblasts

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Evidence for iNOS-dependent peroxynitrite production in diabetic platelets

Tannous, M., Rabini, R. A., Vignini, A., Moretti, N., Fumelli, P., Zielinski, B. S., Mazzanti, L., & Mutus, B. (1999) · Diabetologia · doi:10.1007/s001250051192 · Cited by 97

Direct and Indirect Oxidations by Peroxynitrite

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Nitration of surfactant protein A results in decreased ability to aggregate lipids

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Requirements for heme and thiols for the nonenzymatic modification of nitrotyrosine

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Quantitation of Protein-Bound 3-Nitrotyrosine and 3,4-Dihydroxyphenylalanine by High-Performance Liquid Chromatography with Electrochemical Array Detection

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Sensitive determination of nitrotyrosine in human plasma by isocratic high-performance liquid chromatography

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Isotope Dilution Mass Spectrometric Quantification of 3-Nitrotyrosine in Proteins and Tissues Is Facilitated by Reduction to 3-Aminotyrosine

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Gas Chromatographic–Tandem Mass Spectrometric Quantification of Free 3-Nitrotyrosine in Human Plasma at the Basal State

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Erratum: Elevated free nitrotyrosine levels, but not protein-bound nitrotyrosine or hydroxyl radicals, throughout amyotrophic lateral sclerosis (ALS)-like disease implicate tyrosine nitration as an aberrant in vivo property of one familial ALS-linked superoxide dismutase 1 mutant (Proceedings of the Nat. Acad. of Sci. of the USA (July 8, 1997) 94:14 (7606-7611))

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Nitration of Proteins in Bronchoalveolar Lavage Fluid from Patients with Acute Respiratory Distress Syndrome Receiving Inhaled Nitric Oxide

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Formation of Spin Trap Adducts during the Decomposition of Peroxynitrite

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[16] Measurement and significance of free and protein-bound 3-nitrotyrosine, 3-chlorotyrosine, and free 3-nitro-4-hydroxyphenylacetic acid in biologic samples: A high-performance liquid chromatography method using electrochemical detection

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Peroxynitrite production by human neutrophils, monocytes and lymphocytes challenged with lipopolysaccharide

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The Effect of Bicarbonate on Oxidation by Peroxynitrite: Implication for Its Biological Activity

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Quantification of Superoxide Radicals and Peroxynitrite in Vascular Cells Using Oxidation of Sterically Hindered Hydroxylamines and Electron Spin Resonance

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Suppression of Intracellular Superoxide Dismutase Activity by Antisense Oligonucleotides Causes Inhibition of Progesterone Production by Rat Luteal Cells1

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Modulatory Role of Nitric Oxide on Superoxide-Dependent Luminol Chemiluminescence

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Molecular Actions of a Mn(III)Porphyrin Superoxide Dismutase Mimetic and Peroxynitrite Scavenger: Reaction with Nitric Oxide and Direct Inhibition of NO Synthase and Soluble Guanylyl Cyclase

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New Aspects in the Reaction Mechanism of Phenol with Peroxynitrite: The Role of Phenoxy Radicals

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Reactions of Oxymyoglobin with NO, NO2, and NO2- under Argon and in Air

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Liposome-delivered superoxide dismutase prevents nitric oxide–dependent motor neuron death induced by trophic factor withdrawal

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