Unraveling peroxynitrite formation in biological systems

Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide

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The L-Arginine-Nitric Oxide Pathway

Epstein, F. H., Moncada, S., & Higgs, A. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312303292706 · Cited by 6,678

Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly

Beckman, J. S., & Koppenol, W. H. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.5.c1424 · Cited by 5,513

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

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Superoxide radical and superoxide dismutases

Fridovich, I. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.000525 · Cited by 3,455

Peroxynitrite oxidation of sulfhydryls.

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Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor

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Peroxynitrite-induced membrane lipid peroxidation: The cytotoxic potential of superoxide and nitric oxide

Radí, R., Beckman, J. S., Bush, K. M., & Freeman, B. Α. (1991) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(91)90224-7 · Cited by 2,201

The reaction of NO with superoxide

Huie, R. E., & Padmaja, S. (1993) · Free Radical Research Communications · doi:10.3109/10715769309145868 · Cited by 2,121

Chemical biology of nitric oxide: insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide

Wink, D. A., & Mitchell, J. B. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00092-6 · Cited by 1,606

Nitric Oxide and Peroxynitrite in Health and Disease

Pacher, P., Beckman, J. S., & Liaudet, L. (2007) · Physiological Reviews · doi:10.1152/physrev.00029.2006 · Cited by 6,390

Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean?

Halliwell, B., & Whiteman, M. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705776 · Cited by 2,238

Peroxynitrite: biochemistry, pathophysiology and development of therapeutics

Szabó, C., Ischiropoulos, H., & Radi, R. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2222 · Cited by 2,134

Redox regulation of cell survival

Trachootham, D., Lu, W., Ogasawara, M. A., Valle, N. R.-D., & Huang, P. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1957 · Cited by 1,781

Chemical biology of peroxynitrite: Kinetics, diffusion, and radicals

Ferrer-Sueta, G., & Radi, R. (2009) · ACS Chemical Biology · doi:10.1021/cb800279q · Cited by 776

Peroxynitrite reactivity with amino acids and proteins

Alvarez, B., & Radi, R. (2003) · Amino Acids · doi:10.1007/s00726-003-0018-8 · Cited by 560

Nitrogen dioxide and carbonate radical anion: two emerging radicals in biology

Augusto, O., Bonini, M. G., Amanso, A. M., Linares, E., Santos, C. C. X., & De Menezes, S. L. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00786-4 · Cited by 555

Fundamentals on the biochemistry of peroxynitrite and protein tyrosine nitration

Bartesaghi, S., & Radi, R. (2018) · Redox Biology · doi:10.1016/j.redox.2017.09.009 · Cited by 485

Peroxynitrite-induced cytotoxicity: mechanism and opportunities for intervention

Virág, L., Szabó, É., Gergely, P., & Szabó, C. (2003) · Toxicology Letters · doi:10.1016/s0378-4274(02)00508-8 · Cited by 460

Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson’s, Huntington’s, Alzheimer’s, prions, bactericides, chemical toxicology and others as examples

Kell, D. B. (2010) · Archives of Toxicology · doi:10.1007/s00204-010-0577-x · Cited by 361

Delayed production of free radicals following noise exposure

Yamashita, D., Jiang, H.-Y., Schacht, J., & Miller, J. M. (2004) · Brain Research · doi:10.1016/j.brainres.2004.05.104 · Cited by 352

Familial Amyloid Polyneuropathy: Receptor for Advanced Glycation End Products-Dependent Triggering of Neuronal Inflammatory and Apoptotic Pathways

Sousa, M. M., Du Yan, S., Fernandes, R., Guimarães, A., Stern, D., & Saraiva, M. J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-19-07576.2001 · Cited by 212

The neglected significance of “antioxidative stress”

Poljsak, B., & Milisav, I. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/480895 · Cited by 177

The Role of Reactive Species on Innate Immunity

Andrés, C., Pérez de la Lastra, J., Juan, C., Plou, F., & Pérez-Lebeña, E. (2022) · Vaccines · doi:10.3390/vaccines10101735 · Cited by 142

Crystal Structure of the Antioxidant Enzyme Glutathione Reductase Inactivated by Peroxynitrite

Savvides, S. N., Scheiwein, M., Böhme, C. C., Arteel, G. E., Karplus, P. A., Becker, K., & Schirmer, R. H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108190200 · Cited by 127

What really happens in the neutrophil phagosome?

Hurst, J. K. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.05.008 · Cited by 124

Influence of vitamin C and vitamin E on redox signaling: implications for exercise adaptations

Cobley, J. N., McHardy, H., Morton, J. P., Nikolaidis, M. G., & Close, G. L. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.03.018 · Cited by 118

Peroxynitrite Detoxification and Its Biologic Implications

Trujillo, M., Ferrer-Sueta, G., & Radi, R. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2008.2060 · Cited by 97

Tyrosine-nitrated proteins: Proteomic and bioanalytical aspects

Batthyány, C., Bartesaghi, S., Mastrogiovanni, M., Lima, A., Demicheli, V., & Radi, R. (2017) · Antioxidants & Redox Signaling · doi:10.1089/ars.2016.6787 · Cited by 86

Inhibition of PTEN by peroxynitrite activates the phosphoinositide‐3‐kinase/Akt neuroprotective signaling pathway

Delgado‐Esteban, M., Martin‐Zanca, D., Andres‐Martin, L., Almeida, A., & Bolaños, J. P. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04450.x · Cited by 78

Lipid Peroxyl Radicals Mediate Tyrosine Dimerization and Nitration in Membranes

Bartesaghi, S., Wenzel, J., Trujillo, M., López, M., Joseph, J., Kalyanaraman, B., & Radi, R. (2010) · Chemical Research in Toxicology · doi:10.1021/tx900446r · Cited by 76

Intragastric nitration by dietary nitrite: implications for modulation of protein and lipid signaling

Rocha, B. S., Gago, B., Barbosa, R. M., Lundberg, J. O., Radi, R., & Laranjinha, J. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.11.011 · Cited by 74

Impact of Reactive Species on Amino Acids—Biological Relevance in Proteins and Induced Pathologies

Andrés, C. M. C., Pérez de la Lastra, J. M., Andrés Juan, C., Plou, F. J., & Pérez-Lebeña, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232214049 · Cited by 71

Phenolic Melatonin-Related Compounds: Their Role as Chemical Protectors against Oxidative Stress

Galano, A., Castañeda-Arriaga, R., Pérez-González, A., Tan, D.-X., & Reiter, R. (2016) · Molecules · doi:10.3390/molecules21111442 · Cited by 60

Modulation of peroxynitrite produced via mitochondrial nitric oxide synthesis during Ca2+ and succinate-induced oxidative stress in cardiac isolated mitochondria

Gerdes, H. J., Yang, M., Heisner, J. S., Camara, A. K. S., & Stowe, D. F. (2020) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2020.148290 · Cited by 19

Prevention of peroxynitrite-induced oxidation and nitration reactions by ellagic acid

Ippoushi, K., Takeuchi, A., & Azuma, K. (2009) · Food Chemistry · doi:10.1016/j.foodchem.2008.05.057 · Cited by 16

Nitric oxide as a regulator of B. anthracis pathogenicity

Popova, T. G., Teunis, A., Vaseghi, H., Zhou, W., Espina, V., Liotta, L. A., & Popov, S. G. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00921 · Cited by 14

Avaliação do sequestro do óxido nítrico (NO) pelo extrato metanólico da alga Bryothamnion triquetrum (Gmelin) Howe

Maia, R. M., Moura, C. W. N., Bispo, V. S., Santos, J. L. A., Santana, R. S., & Matos, H. R. (2010) · Revista Brasileira de Farmacognosia · doi:10.1590/s0102-695x2010000400005 · Cited by 7

On the proton affinity of peroxynitrite and peroxynitrous acid

Kazazić, S., Kazazić, S., Klasinc, L., et al. (2001) · Institutional Repository of the Ruđer Bošković Institute (Ruđer Bošković Institute) · Cited by 2

Superoxide, nitric oxide and peroxynitrite.

Fukuyama, N., & NAKAZAWA, H. (1998) · Folia Pharmacologica Japonica · doi:10.1254/fpj.112.169 · Cited by 2

Identification of Nitration Sites by Peroxynitrite on p16 Protein

Luo, Y., Li, J., Zhang, N., Wang, Y., & Zhong, R. (2012) · The Protein Journal · doi:10.1007/s10930-012-9414-9 · Cited by 3

Nitric Oxide Modulates Superoxide Release and Peroxynitrite Formation in Human Blood Vessels

Guzik, T. J., West, N. E. J., Pillai, R. G., Taggart, D. P., & Channon, K. M. (2002) · Hypertension · doi:10.1161/01.hyp.0000018041.48432.b5 · Cited by 264

Superoxide production by mitochondria in the presence of nitric oxide forms peroxynitrite

Packer, M. A., Porteous, C. M., & Murphy, M. P. (1996) · IUBMB Life · doi:10.1080/15216549600201103 · Cited by 118