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Cited by 227Antioxidant Activity and Oxidative StressAdipokines, Inflammation, and Metabolic DiseasesExercise and Physiological Responses

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Alpha tocopherol supplementation decreases serum C-reactive protein and monocyte interleukin-6 levels in normal volunteers and type 2 diabetic patients

Devaraj, Sridevi, Jialal, Ishwarlal·2000·Free Radical Biology and Medicine
DOI 10.1016/s0891-5849(00)00420-2
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Abstract

Type 2 diabetic subjects have an increased propensity to premature atherosclerosis. Alpha tocopherol (AT), a potent antioxidant, has several anti-atherogenic effects. There is scanty data on AT supplementation on inflammation in Type 2 diabetic subjects. The aim of the study was to test the effect of RRR-AT supplementation (1200 IU/d) on plasma C-reactive protein (CRP) and interleukin-6 (IL-6) release from activated monocyte in Type 2 diabetic patients with and without macrovascular complications compared to matched controls. The volunteers comprised Type 2 diabetic subjects with macrovascular disease (DM2-MV, n = 23), Type 2 diabetic subjects without macrovascular complications (DM2, n = 24), and matched controls (C, n = 25). Plasma high sensitive CRP (Hs-CRP) and Monocyte IL-6 were assayed at baseline, following 3 months of supplementation and following a 2 month washout phase. DM2-MV subjects have elevated HsCRP and monocyte IL-6 compared to controls. AT supplementation significantly lowered levels of C-reactive protein and monocyte interleukin-6 in all three groups. In conclusion, AT therapy decreases inflammation in diabetic patients and controls and could be an adjunctive therapy in the prevention of atherosclerosis.

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Crossref · 10.1016/s0891-5849(00)00420-2

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Metadata

Authors
Devaraj, S., & Jialal, I.
Affiliations
The University of Texas Southwestern Medical Center (US)
Corresponding author
Jialal, Ishwarlal
ORCID
Venue
Free Radical Biology and Medicine
Publisher
Elsevier BV
Published
2000-10
Volume
29
Issue
8
Pages
790-792
ISSN
0891-5849 (ISSN-L)
DOI
10.1016/s0891-5849(00)00420-2
OpenAlex
W2085598380
Cited by
227
References
9
Citations by year
2026: 3 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 5 · 2021: 5 · 2020: 4 · 2019: 3 · 2018: 7 · 2017: 8 · 2016: 8 · 2015: 9 · 2014: 4 · 2013: 8 · 2012: 5
FWCI
10.69
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Free Radical Biology and Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • American Heart Association
  • National Center for Complementary and Integrative Health (K-24AT00596, 1 RO1 AT00005-01, R01AT000005, K24AT000596)
Topics
  • Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Keywords
alpha-tocopherol, vitamin E supplementation, type 2 diabetes, C-reactive protein, interleukin-6, monocytes, inflammation, macrovascular complications, atherosclerosis, antioxidant therapy
MeSH terms
Antioxidants, Arteriosclerosis, C-Reactive Protein, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Humans, Monocytes, Vitamin E, Interleukin-6, Case-Control Studies

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