The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Alpha tocopherol supplementation decreases serum C-reactive protein and monocyte interleukin-6 levels in normal volunteers and type 2 diabetic patients
Abstract
Type 2 diabetic subjects have an increased propensity to premature atherosclerosis. Alpha tocopherol (AT), a potent antioxidant, has several anti-atherogenic effects. There is scanty data on AT supplementation on inflammation in Type 2 diabetic subjects. The aim of the study was to test the effect of RRR-AT supplementation (1200 IU/d) on plasma C-reactive protein (CRP) and interleukin-6 (IL-6) release from activated monocyte in Type 2 diabetic patients with and without macrovascular complications compared to matched controls. The volunteers comprised Type 2 diabetic subjects with macrovascular disease (DM2-MV, n = 23), Type 2 diabetic subjects without macrovascular complications (DM2, n = 24), and matched controls (C, n = 25). Plasma high sensitive CRP (Hs-CRP) and Monocyte IL-6 were assayed at baseline, following 3 months of supplementation and following a 2 month washout phase. DM2-MV subjects have elevated HsCRP and monocyte IL-6 compared to controls. AT supplementation significantly lowered levels of C-reactive protein and monocyte interleukin-6 in all three groups. In conclusion, AT therapy decreases inflammation in diabetic patients and controls and could be an adjunctive therapy in the prevention of atherosclerosis.
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“Increased consumption of dairy products has been shown to have beneficial effects on plasma CRP and adiponectin concentrations in obese subjects (683) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [683]
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Metadata
- Authors
- Devaraj, S., & Jialal, I.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Jialal, Ishwarlal
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2000-10
- Volume
- 29
- Issue
- 8
- Pages
- 790-792
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W2085598380
- Cited by
- 227
- References
- 9
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 5 · 2021: 5 · 2020: 4 · 2019: 3 · 2018: 7 · 2017: 8 · 2016: 8 · 2015: 9 · 2014: 4 · 2013: 8 · 2012: 5
- FWCI
- 10.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association
- National Center for Complementary and Integrative Health (K-24AT00596, 1 RO1 AT00005-01, R01AT000005, K24AT000596)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Keywords
- alpha-tocopherol, vitamin E supplementation, type 2 diabetes, C-reactive protein, interleukin-6, monocytes, inflammation, macrovascular complications, atherosclerosis, antioxidant therapy
- MeSH terms
- Antioxidants, Arteriosclerosis, C-Reactive Protein, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Humans, Monocytes, Vitamin E, Interleukin-6, Case-Control Studies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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