Oxidatively modified proteins in aging and disease1, 2 1Guest Editor: Earl Stadtman 2This article is part of a series of reviews on “Oxidatively Modified Proteins in Aging and Disease” The full list of papers may be found on the homepage of the journal

A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease

Sano, M., Ernesto, C., Thomas, R. G., Klauber, M. R., Schafer, K., Grundman, M., Woodbury, P., Growdon, J., Cotman, C. W., Pfeiffer, E., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704243361704 · Cited by 2,380

Oxidative Damage Linked to Neurodegeneration by Selective α-Synuclein Nitration in Synucleinopathy Lesions

Giasson, B. I., Duda, J. E., Murray, I. V. J., Chen, Q., Souza, J. M., Hurtig, H. I., Ischiropoulos, H., Trojanowski, J. Q., & Lee, V. M. ‐. (2000) · Science · doi:10.1126/science.290.5493.985 · Cited by 1,567

Age-related changes in oxidized proteins.

Oliver, C. N., Ahn, B. W., Moerman, E. J., Goldstein, S., & Stadtman, E. R. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45598-6 · Cited by 1,306

Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease.

Smith, C. D., Carney, J. M., Starke-Reed, P. E., Oliver, C. N., Stadtman, E. R., Floyd, R. A., & Markesbery, W. R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10540 · Cited by 1,296

Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease

Smith, M. A., Richey Harris, P. L., Sayre, L. M., Beckman, J. S., & Perry, G. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02653.1997 · Cited by 1,239

Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease

Liberatore, G. T., Jackson-Lewis, V., Vukosavic, S., Mandir, A. S., Vila, M., McAuliffe, W. G., Dawson, V. L., Dawson, T. M., & Przedborski, S. (1999) · Nature Medicine · doi:10.1038/70978 · Cited by 1,046

Oxidative damage in Alzheimer's

Smith, M. A., Perry, G. L., Richey, P. L., Sayrec, L. M., Anderson, V. E., Beal, M. F., & Kowall, N. W. (1996) · Nature · doi:10.1038/382120b0 · Cited by 897

Oxidative damage and metabolic dysfunction in Huntington's disease: Selective vulnerability of the basal ganglia

Browne, S. E., Bowling, A. C., Macgarvey, U., Baik, M. J., Berger, S. C., Muquit, M. M. K., Bird, E. D., & Beal, M. F. (1997) · Annals of Neurology · doi:10.1002/ana.410410514 · Cited by 885

Evidence of Increased Oxidative Damage in Both Sporadic and Familial Amyotrophic Lateral Sclerosis

Ferrante, R. J., Browne, S. E., Shinobu, L. A., Bowling, A. C., Baik, M. J., MacGarvey, U. M., Kowall, N. W., Brown, R. H., & Beal, M. F. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69052064.x · Cited by 808

Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse

Sohal, R. S., Ku, H.-H., Agarwal, S., Forster, M. J., & Lal, H. (1994) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(94)90104-x · Cited by 788

Mass spectrometric characterization of photooxidative protein modifications in Arabidopsis thaliana thylakoid membranes

Galetskiy, D., Lohscheider, J. N., Kononikhin, A. S., Popov, I. A., Николаев, Е. Н., & Adamska, I. (2010) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.4855 · Cited by 49

Tyrosine nitration as mediator of cell death

Franco, M. C., & Estévez, Á. G. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1662-8 · Cited by 50

Oxidative stress in the brain at early preclinical stages of mouse scrapie

Yun, S., Gerlach, M., Riederer, P. F., & Klein, M. A. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2006.03.025 · Cited by 52

Genetic association between Ubiquitin Carboxy-terminal Hydrolase-L1 gene S18Y polymorphism and sporadic Alzheimer's disease in a Chinese Han population

Xue, S., & Jia, J. (2006) · Brain Research · doi:10.1016/j.brainres.2006.02.121 · Cited by 49

Evidence for chronically elevated serum protein oxidation in systemic lupus erythematosus patients

Morgan, P. E., Sturgess, A. D., & Davies, M. J. (2009) · Free Radical Research · doi:10.1080/10715760802623896 · Cited by 48

Cause of death: suicide

Kajstura, J., Bolli, R., Sonnenblick, E. H., Anversa, P., & Leri, A. (2006) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2005.12.013 · Cited by 49

Protein Nitration in Biological Aging: Proteomic and Tandem Mass Spectrometric Characterization of Nitrated Sites

Kański, J., & Schöneich, C. (2005) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(05)96016-3 · Cited by 48

3-Hydroxy-3-methylglutaryl coenzyme A reductase deregulation and age-related hypercholesterolemia: A new role for ROS

Pallottini, V., Martini, C., Pascolini, A., Cavallini, G., Gori, Z., Bergamini, E., Incerpi, S., & Trentalance, A. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.02.009 · Cited by 48

Peroxynitrite transforms nerve growth factor into an apoptotic factor for motor neurons

Pehar, M., Vargas, M. R., Robinson, K. M., Cassina, P., England, P., Beckman, J. S., Alzari, P. M., & Barbeito, L. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.08.010 · Cited by 50

Rapid Purification and Mass Spectrometric Characterization of Mitochondrial NADH Dehydrogenase (Complex I) from Rodent Brain and a Dopaminergic Neuronal Cell Line

Schilling, B., Bharath, S., Row, R. H., Murray, J. M., Cusack, M. P., Capaldi, R., Freed, C. R., Prasad, K. N., Andersen, J. K., & Gibson, B. W. (2005) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m400143-mcp200 · Cited by 48

Rapid and sensitive determination of protein-nitrotyrosine by ELISA: Application to human plasma

Weber, D., Kneschke, N., Grimm, S., Bergheim, I., Breusing, N., & Grune, T. (2012) · Free Radical Research · doi:10.3109/10715762.2011.652627 · Cited by 47

Oxidative Stress in a Model of Toxic Demyelination in Rat Brain: The Effect of Piracetam and Vinpocetine

Abdel‐Salam, O. M. E., Khadrawy, Y. A., Salem, N. A., & Sleem, A. A. (2011) · Neurochemical Research · doi:10.1007/s11064-011-0450-1 · Cited by 47

Attenuation of genotoxicity, oxidative stress, apoptosis and inflammation by rutin in benzo(a)pyrene exposed lungs of mice: plausible role of NF-κB, TNF-α and Bcl-2

Shahid, A., Ali, R., Ali, N., Hasan, S. K., Rashid, S., Majed, F., & Sultana, S. (2016) · Journal of Complementary and Integrative Medicine · doi:10.1515/jcim-2015-0078 · Cited by 47

Expression of mitochondrial genes MT-ND1, MT-ND6, MT-CYB, MT-COI, MT-ATP6, and 12S/MT-RNR1 in colorectal adenopolyps

Wallace, L. M., Mehrabi, S., Bacanamwo, M., Yao, X., & Aikhionbare, F. O. (2016) · Tumor Biology · doi:10.1007/s13277-016-5101-3 · Cited by 49

Chronic exposure to acephate triggers ROS-mediated injuries at organismal and sub-organismal levels ofDrosophila melanogaster

Rajak, P., Khatun, S., Dutta, M., Mandi, M., & Roy, S. (2018) · Toxicology Research · doi:10.1039/c8tx00052b · Cited by 47

Elevated levels of protein carbonyls in sera of chronic fatigue syndrome patients

Smirnova, I. V., & Pall, M. L. (2003) · Molecular and Cellular Biochemistry · doi:10.1023/a:1024176016962 · Cited by 46

Alteration of cytosolic free calcium homeostasis by SIN‐1: high sensitivity of L‐type Ca2+ channels to extracellular oxidative/nitrosative stress in cerebellar granule cells

Gutiérrez-Martı́n, Y., Martı́n-Romero, F. J., Henao, F., & Gutiérrez‐Merino, C. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02964.x · Cited by 46

Increased neuronal glutathione and neuroprotection in GTRAP3-18-deficient mice

Aoyama, K., Wang, F., Matsumura, N., Kiyonari, H., Shioi, G., Tanaka, K., Kinoshita, C., Kikuchi-Utsumi, K., Watabe, M., & Nakaki, T. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.12.016 · Cited by 45

Toll-Like Receptor 4–Mediated Nuclear Factor Kappa B Activation Is Essential for Sensing Exogenous Oxidants to Propagate and Maintain Oxidative/Nitrosative Cellular Stress

Karki, R., & Igwe, O. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073840 · Cited by 47

Computational Study on the Attack of .OH Radicals on Aromatic Amino Acids

Mujika, J. I., Uranga, J., & Matxain, J. M. (2013) · Chemistry – A European Journal · doi:10.1002/chem.201203862 · Cited by 45

Influence of feeding thermally peroxidized soybean oil on oxidative status in growing pigs

Lindblom, S. C., Gabler, N. K., Dilger, R. N., Olson, Z. F., Loving, C. L., & Kerr, B. J. (2018) · Journal of Animal Science · doi:10.1093/jas/sky005 · Cited by 45

Mechanism of non-enzymatic antiglycation action by coumarin: a biophysical study

Qais, F. A., & Ahmad, I. (2019) · New Journal of Chemistry · doi:10.1039/c9nj01490j · Cited by 45

Potential beneficial effect of naringenin on lipid peroxidation and antioxidant status in rats with ethanol-induced hepatotoxicity

Jayaraman, J., Veerappan, M., & Nalini, N. (2009) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.61.10.0016 · Cited by 45

The Role of Bioenergetics in Neurodegeneration

Strope, T. A., Birky, C. J., & Wilkins, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169212 · Cited by 44

Maternal Thimerosal Exposure Results in Aberrant Cerebellar Oxidative Stress, Thyroid Hormone Metabolism, and Motor Behavior in Rat Pups; Sex- and Strain-Dependent Effects

Sulkowski, Z. L., Chen, T., Midha, S., Zavacki, A. M., & Sajdel, E. M. (2011) · The Cerebellum · doi:10.1007/s12311-011-0319-5 · Cited by 45

Protective effects of Peroxiredoxin 6 overexpression on amyloid β-induced apoptosis in PC12 cells

Kim, I.-K., Lee, K. J., Rhee, S., Seo, S., & Pak, J. H. (2013) · Free Radical Research · doi:10.3109/10715762.2013.833330 · Cited by 44

Effect of aging on the expression of BDNF and TrkB isoforms in rat pituitary

Rage, F., Silhol, M., Binamé, F., Arancibia, S., & Tapia‐Arancibia, L. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.05.013 · Cited by 44

Differential cell death regulation between adult-unloaded and aged rat soleus muscle

Ogata, T., Machida, S., Oishi, Y., Higuchi, M., & Muraoka, I. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.02.001 · Cited by 44

Phosphorylation and nitration levels of photosynthetic proteins are conversely regulated by light stress

Galetskiy, D., Lohscheider, J. N., Kononikhin, A. S., Popov, I. A., Николаев, Е. Н., & Adamska, I. (2011) · Plant Molecular Biology · doi:10.1007/s11103-011-9824-7 · Cited by 44

Nitric oxide-related species-induced protein oxidation: Reversible, irreversible, and protective effects on enzyme function of papain

Väänänen, A. J., Kankuri, E. M., & Rauhala, P. V. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.01.007 · Cited by 44

Misfolding of short-chain acyl-CoA dehydrogenase leads to mitochondrial fission and oxidative stress

Schmidt, S. P., Corydon, T. J., Pedersen, C. B., Bross, P., & Gregersen, N. V. (2010) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2010.03.009 · Cited by 45

Prevention of Oxidative Stress and Diseases by Antioxidant Supplementation

Martemucci, G., Portincasa, P., Centonze, V., Mariano, M., Khalil, M., & D‘Alessandro, A. G. (2022) · Medicinal Chemistry · doi:10.2174/1573406419666221130162512 · Cited by 48

Potential beneficial effect of naringenin on lipid peroxidation and antioxidant status in rats with ethanol-induced hepatotoxicity

Jayaraman, J., Veerappan, M., & Nalini, N. (2009) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp/61.10.0016 · Cited by 43

Cell Stress Induced by the Parkinsonian Mimetic, 6-Hydroxydopamine, is Concurrent with Oxidation of the Chaperone, ERp57, and Aggresome Formation

Kim‐Han, J. S., & O’Malley, K. L. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1791 · Cited by 43

Stress-responsive expression of a glutathione S-transferase (delta) gene in waterflea Daphnia magna challenged by microcystin-producing and microcystin-free Microcystis aeruginosa

Lyu, K., Gu, L., Li, B., Lu, Y., Wu, C., Guan, H., & Yang, Z. (2016) · Harmful Algae · doi:10.1016/j.hal.2016.04.009 · Cited by 43

Protective Effect of Tert-Butylhydroquinone on the Quinolinic-Acid-Induced Toxicity in Rat Striatal Slices: Role of the Nrf2-Antioxidant Response Element Pathway

Tasset, I., Cruz, V. P.-D. L., Elinos, D., Carrillo-Mora, P. U., González-Herrera, I. G., Luna-López, A., Königsberg, M., Pedraza-Chaverrí, J., Maldonado, P. D., Ali, S. F., et al. (2009) · Neurosignals · doi:10.1159/000243650 · Cited by 42

Protective effect of quercetin on homocysteine-induced oxidative stress

Çelik, N., Vurmaz, A., & Kahraman, A. (2016) · Nutrition · doi:10.1016/j.nut.2016.07.014 · Cited by 42

Diseases Related to Types of Free Radicals

Maddu, N. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.82879 · Cited by 42

Neuroprotective Effects ofHypericum perforatumon Trauma Induced by Hydrogen Peroxide in PC12 Cells

Lü, Y., Du, C., Liu, J., Hong, W., & Wei, D. (2004) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x04002053 · Cited by 42

Investigation of tyrosine nitration and nitrosylation of angiotensin II and bovine serum albumin with electrospray ionization mass spectrometry

Lee, S. J., Lee, J. R., Kim, Y. H., Park, Y. S., Park, S. I., Park, H. S., & Kim, K. P. (2007) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.3145 · Cited by 42

Saffron (Crocus sativus L.) and Its By-Products: Healthy Effects in Internal Medicine

Marrone, G., Urciuoli, S., Lauro, M. D., Cornali, K., Montalto, G., Masci, C., Vanni, G., Tesauro, M., Vignolini, P., & Noce, A. (2024) · Nutrients · doi:10.3390/nu16142319 · Cited by 41

Mitochondrial dysfunction in cellular senescence: a bridge to neurodegenerative disease

Hruby, A. J., & Higuchi‐Sanabria, R. (2025) · npj Aging · doi:10.1038/s41514-025-00291-4 · Cited by 52

Salivary Gland Dysfunction, Protein Glycooxidation and Nitrosative Stress in Children with Chronic Kidney Disease

Maciejczyk, M., Szulimowska, J., Taranta‐Janusz, K., Wasilewska, A. M., & Zalewska, A. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9051285 · Cited by 41

Standardization of a Fluorometric Assay for Measuring Oxidative Stress in Irradiated Cells

Wan, X. S., Zhou, Z., Ware, J. H., & Kennedy, A. R. (2005) · Radiation Research · doi:10.1667/rr3299 · Cited by 40

Impact of Peroxynitrite Modification on Structure and Immunogenicity of H2A Histone

Khan, M. A., Dixit, K., Jabeen, S., Moinuddin, & Alam, K. (2009) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2008.02200.x · Cited by 39

Improvement of oxidative stress and immunity by melatonin: An age dependent study in golden hamster

Vishwas, D. K., Mukherjee, A., Haldar, C., Dash, D., & Nayak, M. K. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.11.012 · Cited by 39

Signal Transduction, Ageing and Disease

Zhang, L. J., Yousefzadeh, M. J., Suh, Y., Niedernhofer, L. J., & Robbins, P. D. (2019) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-981-13-3681-2_9 · Cited by 40

Gender difference as regards myocardial protein oxidation in aged rats: male rats have increased oxidative protein damage

Kayalı, R., Çakatay, U., Uzun, H., & Genç, H. (2007) · Biogerontology · doi:10.1007/s10522-007-9107-5 · Cited by 39

Anti-Tumor Effects of Liposome-Encapsulated Titanium Dioxide in Nude Mice

Chihara, Y., Fujimoto, K., Kondo, H., Moriwaka, Y., Sasahira, T., Hirao, Y., & Kuniyasu, H. (2007) · Pathobiology · doi:10.1159/000110029 · Cited by 39

Effect of dimethylsulphoxide and curcumin on protein carbonyls and reactive oxygen species of cerebral hemispheres of mice as a function of age

Dkhar, P., & Sharma, R. (2010) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2010.04.005 · Cited by 39

Age‐dependent modulation of hippocampal long‐term potentiation by antioxidant enzymes

Watson, J. B., Arnold, M. M., Ho, Y., & O’Dell, T. J. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.21040 · Cited by 39

Determining cysteine oxidation status using differential alkylation

Schilling, B., Yoo, C. B., Collins, C. J., & Gibson, B. W. (2004) · International Journal of Mass Spectrometry · doi:10.1016/j.ijms.2004.06.004 · Cited by 40

Antioxidant Effect of Sericin in Brain and Peripheral Tissues of Oxidative Stress Induced Hypercholesterolemic Rats

Deori, M., Devi, D., Kumari, S., Hazarika, A., Kalita, H., Sarma, R., & Devi, R. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00319 · Cited by 38

Enzyme Complexes Important for the Glutamate–Glutamine Cycle

McKenna, M. C., & Ferreira, G. C. (2016) · Advances in neurobiology · doi:10.1007/978-3-319-45096-4_4 · Cited by 35

Disability in multiple sclerosis is associated with age and inflammatory, metabolic and oxidative/nitrosative stress biomarkers: results of multivariate and machine learning procedures

Flauzino, T., Simão, A. N. C., Pereira, W. L. D. C. J., Alfieri, D. F., Oliveira, S. R., Kallaur, A. P., Lozovoy, M. A. B., Kaimen-Maciel, D. R., Maes, M. H. J., & Reiche, E. M. V. (2019) · Metabolic Brain Disease · doi:10.1007/s11011-019-00456-7 · Cited by 40

Effect of Curcumin on Protein Damage Induced by Rotenone in Dopaminergic PC12 Cells

Buratta, S., Chiaradia, E., Tognoloni, A., Gambelunghe, A., Meschini, C., Palmieri, L., Muzi, G., Urbanelli, L., Emiliani, C., & Tancini, B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21082761 · Cited by 40

A DFT study on reaction of eupatilin with hydroxyl radical in solution

Li, M., Liu, W., Peng, C., Ren, Q., Lu, W., & Deng, W. (2012) · International Journal of Quantum Chemistry · doi:10.1002/qua.24060 · Cited by 38

Brewing complications: the effect of acute ethanol exposure on wound healing

Radek, K. A., Ranzer, M. J., & DiPietro, L. A. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0209103 · Cited by 38

Age-related oxidative changes in pancreatic islets are predominantly located in the vascular system

Kehm, R., König, J., Nowotny, K., Jung, T., Deubel, S., Gohlke, S., Schulz, T. J., & Höhn, A. (2017) · Redox Biology · doi:10.1016/j.redox.2017.12.015 · Cited by 41

Chromolaena odorata (Siam weed): A natural reservoir of bioactive compounds with potent anti-fibrillogenic, antioxidative, and cytocompatible properties

Eze, F. N., & Jayeoye, T. J. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111811 · Cited by 37

Bioactive Compounds from Ephedra fragilis: Extraction Optimization, Chemical Characterization, Antioxidant and AntiGlycation Activities

Guenaou, I., Irahal, I. N., Errami, A., Lahlou, F. A., Hmimid, F., & Bourhim, N. (2021) · Molecules · doi:10.3390/molecules26195998 · Cited by 40

GABAA-receptor mRNA expression in the prefrontal and temporal cortex of ALS patients

Petri, S., Kollewe, K., Grothe, C., Hori, A., Dengler, R., Bufler, J., & Krampfl, K. (2006) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2006.08.005 · Cited by 37

Pinpointing oxidative modifications in proteins—recent advances in analytical methods

Törnvall, U. (2010) · Analytical Methods · doi:10.1039/c0ay00375a · Cited by 37

Serum protein oxidation and apolipoprotein CIII levels in people with systemic lupus erythematosus with and without nephritis

Morgan, P. E., Sturgess, A. D., Hennessy, A., & Davies, M. J. (2007) · Free Radical Research · doi:10.1080/10715760701684809 · Cited by 37

Products of Cu(II)-catalyzed oxidation of the N-terminal fragments of α-synuclein in the presence of hydrogen peroxide

Kowalik‐Jankowska, T., Rajewska, A., Jankowska, E., Wiśniewska, K., & Grzonka, Z. (2006) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2006.05.010 · Cited by 37

Oxidative stress, hemoglobin content, superoxide dismutase and catalase activity influenced by sulphur baths and mud packs in patients with osteoarthritis

Jokic, A., Sremcevic, N., Karagülle, Z., Pekmezovic, T. D., & Davidović, V. (2010) · Vojnosanitetski pregled · doi:10.2298/vsp1007573j · Cited by 36

Polyphenolic extract of Blighia sapida arilli prevents N-nitrosodiethylamine-mediated oxidative onslaught on microsomal protein, lipid and DNA

Oloyede, H. O. B., Ajiboye, T. O., Komolafe, Y. O., & Salau, A. K. (2013) · Food Bioscience · doi:10.1016/j.fbio.2013.03.003 · Cited by 36

Impairment of the proteasome is crucial for glucose-induced lifespan reduction in the mev-1 mutant of Caenorhabditis elegans

Fitzenberger, E., Boll, M., & Wenzel, U. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.01.012 · Cited by 36

Combining redox-proteomics and epigenomics to explain the involvement of oxidative stress in psychiatric disorders

Andreazza, A. C. (2012) · Molecular BioSystems · doi:10.1039/c2mb25118c · Cited by 36

Xanthine Oxidase/Dehydrogenase Activity as a Source of Oxidative Stress in Prostate Cancer Tissue

Veljković, A., Hadži-Djokić, J., Sokolovic, D. T., Bašić, D., Veličković, L. J., Stojanović, M., Popović, D., & Kocic, G. M. (2020) · Diagnostics · doi:10.3390/diagnostics10090668 · Cited by 36

Evidence for oxidative stress in the developing cerebellum of the rat after chronic mild carbon monoxide exposure (0.0025% in air)

López, I. A., Acuña, D., Beltrán‐Parrazal, L., Lopez, I. E., Amarnani, A., Cortes, M., & Edmond, J. (2009) · BMC Neuroscience · doi:10.1186/1471-2202-10-53 · Cited by 35

Increased nitration and carbonylation of proteins in MRL +/+ mice exposed to trichloroethene: Potential role of protein oxidation in autoimmunity

Wang, G., Wang, J., Ma, H., & Khan, M. F. (2009) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2009.03.010 · Cited by 37

Potential cosmetic application of essential oil extracted fromLitsea cubebafruits from China

Huang, X., Feng, Y., Huang, Y., & Li, H. (2013) · Journal of Essential Oil Research · doi:10.1080/10412905.2012.755479 · Cited by 36

DNA repair capacities of cutaneous fibroblasts: effect of sun exposure, age and smoking on response to an acute oxidative stress

Sauvaigo, S., Bonnet, M., Odin, F., Hazane‐Puch, F., Lachmann, N., Bonté, F., Kurfürst, R., & Favier, A. E. (2007) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2007.07890.x · Cited by 36

Identification of oxidative stress-related genes differentially expressed in Alzheimer’s disease and construction of a hub gene-based diagnostic model

Zhang, Y., & Kiryu, H. (2023) · Scientific Reports · doi:10.1038/s41598-023-34021-1 · Cited by 37

Amyotrophic Lateral Sclerosis: Insights and New Prospects in Disease Pathophysiology, Biomarkers and Therapies

Al-Khayri, J. M., Ravindran, M., Banadka, A., Devaiah, V. C., Priya, K., Nagella, P., & Kukkemane, K. (2024) · Pharmaceuticals · doi:10.3390/ph17101391 · Cited by 42

Hyperglycemia induced structural and functional changes in human serum albumin of diabetic patients: a physico-chemical study

Neelofar, K., Arif, Z., Alam, K., & Ahmad, J. (2016) · Molecular BioSystems · doi:10.1039/c6mb00324a · Cited by 35

Lipid and protein oxidation in female patients with chronic fatigue syndrome

Tomić, S., Brkic, S. V., Marić, D., & Mikić, A. N. (2012) · Archives of Medical Science · doi:10.5114/aoms.2012.31620 · Cited by 34

Natural antioxidants in prevention and management of Alzheimer's disease

Zhao, Y. (2011) · Frontiers in Bioscience-Elite · doi:10.2741/419 · Cited by 35

d-Ribose induced glycoxidative insult to hemoglobin protein: An approach to spot its structural perturbations

Siddiqui, Z., Ishtikhar, M., Moinuddin, M., & Ahmad, S. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.01.161 · Cited by 35

In vitro–in vivo study of CoQ10-loaded lipid nanoparticles in comparison with nanocrystals

Piao, H., Ouyang, M., Xia, D., Quan, P., Xiao, W., Song, Y., & Cui, F. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.07.016 · Cited by 34

Ameliorative effects ofBacopa monnieraon lead-induced oxidative stress in different regions of rat brain

Velaga, M. K., Basuri, C. K., Taylor, K. S. R., Yallapragada, P. R., Rajanna, S., & Rajanna, B. (2013) · Drug and Chemical Toxicology · doi:10.3109/01480545.2013.866137 · Cited by 34

Inhibitory effect of vitamin B 3 against glycation and reactive oxygen species production in HSA: An in vitro approach

Abdullah, K. M., Qais, F. A., Ahmad, I., & Naseem, I. (2017) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2017.06.009 · Cited by 34

Increased plasma levels of advanced oxidation protein products (AOPP) as a marker for oxidative stress in patients with active ulcerative colitis

Alagözlü, H., Görgül, A., Bi̇lgi̇han, A., Tunçer, C., & Ünal, S. (2012) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2012.03.034 · Cited by 34

Protein carbonyl levels in the aqueous humour and serum of patients with pseudoexfoliation syndrome

Yağcı, R., Ersöz, İ., Erdurmuş, M., Gürel, A., & Duman, S. (2007) · Eye · doi:10.1038/sj.eye.6702751 · Cited by 33

Mercury Abolishes Neurotrophic Factor-Stimulated Jak-STAT Signaling in Nerve Cells by Oxidative Stress

Monroe, R. K., & Halvorsen, S. W. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfl073 · Cited by 33

Fast repair of protein radicals by urate

Domazou, A. S., Zhu, H., & Koppenol, W. H. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.02.045 · Cited by 33

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Wu, F., Xue, Y., Tang, Q., Xu, J., Du, L., Xue, C., Takahashi, K., & Wang, Y. (2013) · Journal of Oleo Science · doi:10.5650/jos.62.717 · Cited by 33

The effects of A. senticosus supplementation on serum lipid profiles, biomarkers of oxidative stress, and lymphocyte DNA damage in postmenopausal women

Lee, Y. J., Chung, H.-Y., Kwak, H., & Yoon, S. O. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.07.097 · Cited by 32

Rat hippocampal responses up to 90 days after a single nanoceria dose extends a hierarchical oxidative stress model for nanoparticle toxicity

Hardas, S. S., Rukhsana Sultana, A., Warrier, G., Dan, M., Wu, P., Grulke, E. A., Tseng, M. T., Unrine, J. M., Graham, U. M., Yokel, R. A., et al. (2013) · Nanotoxicology · doi:10.3109/17435390.2013.868059 · Cited by 32

AAV-Nrf2 Promotes Protection and Recovery in Animal Models of Oxidative Stress

Liang, K. J., Woodard, K., Weaver, M. A., Gaylor, J. P., Weiss, E. R., & Samulski, R. J. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2016.12.016 · Cited by 32

Effect of Aging on Brain-Derived Neurotrophic Factor, proBDNF, and Their Receptors in the Hippocampus of Lou/C Rats

Silhol, M., Arancibia, S., Perrin, D., Maurice, T., Alliot, J., & Tapia‐Arancibia, L. (2008) · Rejuvenation Research · doi:10.1089/rej.2008.0791 · Cited by 36

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Manikandan, P., Murugan, R. S., Abbas, H. Y., Abraham, S. K., & Nagini, S. (2007) · Journal of Medicinal Food · doi:10.1089/jmf.2006.125 · Cited by 32

Protective effect of Phyllanthus fraternus against allyl alcohol-induced oxidative stress in liver mitochondria

Sailaja, R., & Setty, O. H. (2005) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2005.10.019 · Cited by 34

The Ameliorating Effects of Luteolin on Beta-Amyloid-Induced Impairment of Water Maze Performance and Passive Avoidance in Rats

Tsai, F., Cheng, H., Hsieh, M., Wu, C., Lin, Y.-C., & Peng, W. (2010) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x10007841 · Cited by 32

Strategies for clinical approach to neurodegeneration in Amyotrophic lateral sclerosis.

Carlesi, C., Pasquali, L., Piazza, S., Gerfo, A. L., Ienco, E. C., Alessi, R., Fornai, F., & Siciliano, G. (2011) · PubMed · doi:10.4449/aib.v149i1.1267 · Cited by 33

Biological Markers in Older People at Risk of Mobility Limitations

Lippi, G., Sanchis‐Gomar, F., & Montagnana, M. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113196660697 · Cited by 32

Tocopherol-mediated modulation of age-related changes in microglial cells: Turnover of extracellular oxidized protein material

Stolzing, A., Widmer, R., Jung, T., Voß, P., & Grune, T. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.02.011 · Cited by 32

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Canet, G., Zussy, C., Hernandez, C., Maurice, T., Desrumaux, C. M., & Givalois, L. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108398 · Cited by 34

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Kerasioti, E., Stagos, D., Georgatzi, V. V., Bregou, E., Priftis, A., Kafantaris, I., & Kouretas, D. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/6585737 · Cited by 31

Free radical processes in aging, neurodegenerative diseases and other pathological states

Dubinina, E. E., & Васильевна, П. А. (2007) · Biochemistry (Moscow) Supplement Series B Biomedical Chemistry · doi:10.1134/s1990750807040026 · Cited by 15

Protein oxidative modifications in the ageing brain: Consequence for the onset of neurodegenerative disease

Grimm, S., Höhn, A., Davies, K. J. A., & Grune, T. (2010) · Free Radical Research · doi:10.3109/10715762.2010.512040 · Cited by 112

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Butterfield, D. A., Marzia Perluigi, A., Reed, T. T., Muharib, T., Hughes, C. P., Robinson, R. A. S., & Rukhsana Sultana, A. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4109 · Cited by 171

Human studies related to protein oxidation: protein carbonyl content as a marker of damage.

Chevion, M., Berenshtein, E., & Stadtman, E. R. (2000) · PubMed · Cited by 400

Protein Oxidation in Aging and Age‐Related Diseases

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