Oxidatively modified proteins in aging and disease1, 2 1Guest Editor: Earl Stadtman 2This article is part of a series of reviews on “Oxidatively Modified Proteins in Aging and Disease” The full list of papers may be found on the homepage of the journal

A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease

Sano, M., Ernesto, C., Thomas, R. G., Klauber, M. R., Schafer, K., Grundman, M., Woodbury, P., Growdon, J., Cotman, C. W., Pfeiffer, E., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704243361704 · Cited by 2,380

Oxidative Damage Linked to Neurodegeneration by Selective α-Synuclein Nitration in Synucleinopathy Lesions

Giasson, B. I., Duda, J. E., Murray, I. V. J., Chen, Q., Souza, J. M., Hurtig, H. I., Ischiropoulos, H., Trojanowski, J. Q., & Lee, V. M. ‐. (2000) · Science · doi:10.1126/science.290.5493.985 · Cited by 1,567

Age-related changes in oxidized proteins.

Oliver, C. N., Ahn, B. W., Moerman, E. J., Goldstein, S., & Stadtman, E. R. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45598-6 · Cited by 1,306

Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease.

Smith, C. D., Carney, J. M., Starke-Reed, P. E., Oliver, C. N., Stadtman, E. R., Floyd, R. A., & Markesbery, W. R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10540 · Cited by 1,296

Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease

Smith, M. A., Richey Harris, P. L., Sayre, L. M., Beckman, J. S., & Perry, G. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02653.1997 · Cited by 1,239

Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease

Liberatore, G. T., Jackson-Lewis, V., Vukosavic, S., Mandir, A. S., Vila, M., McAuliffe, W. G., Dawson, V. L., Dawson, T. M., & Przedborski, S. (1999) · Nature Medicine · doi:10.1038/70978 · Cited by 1,046

Oxidative damage in Alzheimer's

Smith, M. A., Perry, G. L., Richey, P. L., Sayrec, L. M., Anderson, V. E., Beal, M. F., & Kowall, N. W. (1996) · Nature · doi:10.1038/382120b0 · Cited by 897

Oxidative damage and metabolic dysfunction in Huntington's disease: Selective vulnerability of the basal ganglia

Browne, S. E., Bowling, A. C., Macgarvey, U., Baik, M. J., Berger, S. C., Muquit, M. M. K., Bird, E. D., & Beal, M. F. (1997) · Annals of Neurology · doi:10.1002/ana.410410514 · Cited by 885

Evidence of Increased Oxidative Damage in Both Sporadic and Familial Amyotrophic Lateral Sclerosis

Ferrante, R. J., Browne, S. E., Shinobu, L. A., Bowling, A. C., Baik, M. J., MacGarvey, U. M., Kowall, N. W., Brown, R. H., & Beal, M. F. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69052064.x · Cited by 808

Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse

Sohal, R. S., Ku, H.-H., Agarwal, S., Forster, M. J., & Lal, H. (1994) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(94)90104-x · Cited by 788

Spatial localisation of oxidative and inflammatory markers within advanced atherosclerotic plaques

Crone, E. M. (2008) · UC Research Repository (University of Canterbury) · doi:10.26021/6121 · Cited by 2

The Age-Related Proinflammatory State and Eye Disease

(2007) · Humana Press eBooks · doi:10.1007/978-1-59259-979-0_10 · Cited by 2

A metabolic and mitochondrial angle on aging

Duarte, A. I., Sadowska‐Bartosz, I., Karkucińska‐Więckowska, A., Lebiedzińska, M., Palmeira, C. M., Rolo, A. P., Kabiri, Y., Zavan, B., Pinton, P., Borges, F., et al. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823761-8.00024-0 · Cited by 3

Relationships between pesticides, polychlorinated biphenyls, blood parameters and oxidative stress of white stork Ciconia ciconia chicks in Poland

Siekiera, J., Jankowiak, Ł., Siekiera, A., Ostaszewska, M., Jerzak, L., Kasprzak, M., Ciepliński, M., Kamiński, P., Frątczak, M., & Tryjanowski, P. (2024) · Environmental Science and Pollution Research · doi:10.1007/s11356-024-34072-5 · Cited by 1

Ameliorating the toxicity induced by L-arginine through iris germanica methanolic extract in an experimental model of acute pancreatitis

Bakhoda, M. R., Kheiripour, N., Samani, K. G., Taheri, M. A., Najarzadeh, F., Lari, M. M. H., & Shahaboddin, M. E. (2025) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2025.2541699 · Cited by 1

Characterization of novel lactic acid bacteria from Algerian ecosystems with probiotic potential and antioxidant-antidiabetic properties

Mahrouk, A., Mosbah, A., Chaouche, N. K., Hamdi, M., Slimani, A., Badaoui, M. Y. Z., Amrani, Y., & Akkal, S. (2025) · Folia Microbiologica · doi:10.1007/s12223-025-01386-x · Cited by 1

Inhibition of Glucose-Induced Glycation of HSA by Pioglitazone: Multi-Spectroscopic and Bioinformatic Evidence

Alrehaili, J. A., & Anwer, R. (2026) · Molecules · doi:10.3390/molecules31091519 · Cited by 1

Peroxiredoxins and Neurodegeneration

Ahmed, R. G., ., Y. Y. M., & ., S. H. L. (2006) · International Journal of Zoological Research · doi:10.3923/ijzr.2006.226.241 · Cited by 1

Effect of Oxidatively Modified and Non-Modified Human Serum Albumin on Luminol-Dependent Chemiluminescence of Human Peripheral Blood Leukocytes Stimulated with Opsonized Zymosan

Piryazev, A. P., Azizova, A. P., Асейчев, А. В., & Сергиенко, В. И. (2014) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-014-2561-6 · Cited by 1

The influence of oxidized fibrinogen on apoptosis of endothelial cells

Aseychev, A. V., Azizova, O. A., Scheglovitova, O. N., Sklyankina, N. N., & Borisenko, G. G. (2011) · Biomeditsinskaya Khimiya · doi:10.18097/pbmc20115702210 · Cited by 1

Oxidative Stress in Bipolar Disorder

Scola, G., & Andreazza, A. C. (2014) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-1-4939-0440-2_3 · Cited by 1

Skeletal muscle atrophy

Pierre-Jerome, C. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13328-2.00008-8 · Cited by 1

Wpływ palenia papierosów oraz narażenia na wdychanie dymu tytoniowego w aspekcie stanu noworodka po urodzeniu

Krzyścin, M. (2013) · Cited by 1

Combinação de monensina, virginiamicina, micros minerais e leveduras sobre o perfil bioquímico no sangue e stress oxidativo no plasma, fígado e músculo de bovinos alimentados com dieta de alto grão

Tagiariolli, M. A., Duarte, V., Matos, A. M., Carvalho, V. M., Bonin, E., do Prado, R. M., Maróstica, H. V. P., Comar, J. F., Silva, L. F. C. E., & do Prado, I. N. (2020) · Research Society and Development · doi:10.33448/rsd-v9i11.9918 · Cited by 1

Crosstalk Between Autophagy and Nutrigenomics in Neurodegenerative Diseases

Russell, A. E., Badr, A., Rai, A., Carafice, C., Rai, A., Daily, K. P., Whitham, O. D., Amer, A. O., Brown, C. M., & Dakhlallah, D. A. (2022) · Nutritional neurosciences · doi:10.1007/978-981-16-9205-5_13 · Cited by 1

Neurotoxicity of Manufactured Nanoparticles

Hatcher-Martin, J. M., Jones, D. P., Miller, G. W., & Pennell, K. D. (2008) · Wiley eBooks · doi:10.1002/9780470396612.ch16 · Cited by 1

Recent progress in histochemistry and cell biology: the state of the art 2005

Taatjes, D. J., & Roth, J. (2005) · Histochemistry and Cell Biology · doi:10.1007/s00418-005-0110-0 · Cited by 1

Qualidade sanitária e nutricional de hortícolas organicas

Arbos, K. A. (2009) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) · Cited by 1

Protein markers of oxidative stress damage: Applications to experimental research and effects of fatty acids

Danielsen, T. (2015) · NORA - Norwegian Open Research Archives · Cited by 1

Enhanced Urinary Excretion of Lipid Metabolites Following Exposure to Structurally Diverse Toxicants: A Unique Experimental Model for the Assessment of Oxidative Stress

Lau, F. C., Bagchi, M., Zafra‐Stone, S., & Bagchi, D. (2011) · Humana Press eBooks · doi:10.1007/978-1-60761-956-7_22

PROTEIN FOLDING AND DISEASE THE MITOCHONDRIAL PROTEIN FRATAXIN

Correia, A. R. (2010) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)

THE ROLE OF DOPAMINE OXIDATION IN DOPAMINE-INDUCED TOXICITY, INITIATION OF ENDOPLASMIC RETICULUM STRESS, AND POTENTIATION OF ROTENONE-INDUCED TOXICITY IN DIFFERENTIATED PC12 CELLS

Dukes, A. A. (2007) · D-Scholarship@Pitt (University of Pittsburgh)

Cytokine genetics and expression : implications of an immunogenetic pathogenesis in autism spectrum disorders.

Mott, M. C. (2011) · ThinkIR: The University of Louisville's Institutional Repository (University of Louisville) · doi:10.18297/etd/1016

Oxidatively Modified Biomolecules: An Early Biomarker for Acute Coronary Artery Disease

Kumphune, S. (2012) · InTech eBooks · doi:10.5772/32503

Do cartilage and subchondral bone act together in development and disease

van der Harst, M. R. (2005) · Utrecht University Repository (Utrecht University)

PROTEİN OKSİDASYONUNUN KLİNİK ÖNEMİ

Çakatay, U., & Kayalı, R. (2014) · DergiPark (Istanbul University)

Current and potential treatments of Parkinson's disease

Shults, C. W. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511544873.043

Trichloroethylene-Induced Oxidative Stress and Autoimmunity

Khan, M. F., & Wang, G. (2014) · Molecular and integrative toxicology · doi:10.1007/978-1-4471-6311-4_4

Alterations of mitochondrial biogenesis and alterations of mitochondrial antioxidant defense in Friedreich's ataxia

Marmolino, D., & Pandolfo, M. (2011) · Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles)

Influence of diagnostic categories, age, and gender on antioxidative defense and lipid peroxidation in skeletal muscle of patients with neuromuscular diseases

Stuerenburg, H. J., Stangneth, B., Kohlschütter, A., & Finckh, B. (2003) · AGE · doi:10.1007/s11357-003-0004-9

HPLC-MS aided PC12cell systems: to quantitatively monitor the conversion of nitronyl nitroxide in biological systems with and without NO

Wang, Y., Jiang, X., Liu, J., Zhao, M., Kang, G., Wu, J., Li, P., & Peng, S. (2011) · Molecular BioSystems · doi:10.1039/c1mb05037k

Green tea polyphenols prevent Parkinson's disease: in vitro and in vivo studies

Chen, D. (2013) · doi:10.31274/etd-180810-3371

Antioxidants and Anti-Inflammatory Drugs in the Treatment of Motor Neuron Disease

Esmaeili, M. A., & Kiaei, M. (2014) · Springer eBooks · doi:10.1007/978-3-642-30018-9_132

Gaseous Signaling: Nitric Oxide and Carbon Monoxide as Messenger Molecules

Chung, K. K. K., Dawson, V. L., & Dawson, T. M. (2007) · Wiley eBooks · doi:10.1002/9780470101001.hcn017

ANTIOXIDANT PROPERTIES AND CHEMOPREVENTIVE POTENTIAL OF THE BIOACTIVE CONSTITUENTS OF THE ROOTS OF DECALEPIS HAMILTONII

SRIVASTAVA, A. (2006) · Open Access Repository of Indian Theses

posttranslational modifications in mice Antioxidant network expression abrogates oxidative

Ziolo, T., Dwyer, K. M., D'Apice, A. J. F., Zweier, J. L., He, G., Cowan, P. J., Mital, R., Zhang, W., Cai, M., Huttinger, Z. M., et al. (2011)

antioxidant therapy defense after burn injury: the beneficial effects of Cardiac mitochondrial damage and loss of ROS

Zang, Q. S., Maass, D. L., White, J., Horton, J. W., Fischman, A. J., Yo, K., Yu, Y., Zhao, G., Bonab, A. A., Aikawa, N., et al. (2015)

Concentration and Time - Antioxidant Effect Relationship of Anthocyanins in Sodium Nitrite and Azo Compounds-Induced Hemoglobin Oxidation and Erythrocytes Membrane Damage; In Vitro and In Vivo Studies

Sulaiman, A. A. (2012)

Toxicologia reprodutiva: padrão de ligação e efeitos delectinas do gênero Canavalia em espermatozoides bovinos

Kaefer, C. (2012) · Americanae (AECID Library)

Sengmaek-san-mediated Enhancement of Axonal Regeneration after Sciatic Nerve Injury in the Rat

Baek, K.-M., Kim, Y. S., Ryu, H. R., Jo, H. K., An, J. J., Namgung, U., & Seol, I.-C. (2008) · 동의생리병리학회지

AVALIAÇÃO DOS EFEITOS DO EXTRATO DE Baccharis trimera (CARQUEJA) SOBRE PARÂMETROS METABÓLICOS E DE ESTRESSE OXIDATIVO EM MODELO DE DIABETES MELITO TIPO 1 INDUZIDO POR ALOXANO EM RATAS

Metabólica, L. D. B. (2013)

The Neuroprotective Role of Micronutrients in Parkinson’s Disease

Malkus, K. A., Tsika, E., & Ischiropoulos, H. (2009) · doi:10.1201/9781420073522-7

Mass spectrometry-based high throughput approach for identification of molecular modification of oxidative process in respiratory diseases.

Song, W. (2008) · EngagedScholarship @ Cleveland State University (Cleveland State University)

The Downstream Targets of Complex I Dysfunction in Bipolar Disorder

Kim, H. K. (2015) · TSpace (University of Toronto)

Oxidative Stress and Global DNA Methylation in Patients with Bipolar Disorder and an Excellent Response to Lithium

Huzayyin, A. A. S. (2013) · TSpace (University of Toronto)

Polimorfismo da Ala16Val MnSOD na hipercolesterolemia e sua associação com biomarcadores de inflamação e estresse oxidativo

Duarte, M. M. M. F. (2010) · Americanae (AECID Library)

Oxidative Thiol Modifications in Pro- And Eukaryotic Organisms

Brandes, N. (2010) · Online Publication Service of Würzburg University (Würzburg University)

Elucidation of alteration in biological rhythmicity at weekly intervals in clinicopathological attributes following interplay nexus of deltamethrin with colibacillosis in broiler chicks

Tiwari, S., Jhakar, K. K., Sharma, V. K., Jangir, B., & Shukla, A. K. (2019) · Biological Rhythm Research · doi:10.1080/09291016.2019.1613082

Genetic Syndromes and Aging

Mangalhara, K. C., & Bamezai, R. N. K. (2019) · Springer eBooks · doi:10.1007/978-981-13-3585-3_11

CORRELATION BETWEEN DILATATION OF THE BILE DUCTS AND OXIDATIVE STRESS IN PATIENTS WITH CHOLEDOCHOLITHIASIS

Damnjanović, Z., Jovanović, M., Radojković, M., Sokolovic, D. T., Karanikolić, A., Ignjatović, N., Stepanović, N., Damnjanović, G., & Gmijovic, M. D. (2020) · Acta Medica Medianae · doi:10.5633/amm.2020.0206

Inhibitory Dysfunction in the SOD1-ALS Motor Cortex

Khademullah, C. S. (2018) · TSpace (University of Toronto)

Role of pleural fluid-serum protein carbonyl gradient in differentiating exudative and transudative effusions

Ghosh, R., Mukherjee, K., Maiti, S., Bhattacharjee, D., & Chowdhuri, S. (2020) · Asian Journal of Medical Sciences · doi:10.3126/ajms.v11i6.30579

Neuronal Differentiation of Cartilage-derived Stem Cells In Vitro and their Delivery to the Spinal Cord in a Mouse Model of ALS Using MRI-guided Focused Ultrasound

Shah, K. (2020) · TSpace (University of Toronto)

Envolvimento do dano ao DNA e estresse oxidativo no transtorno bipolar e no uso de metilfenidato

Andreazza, A. C. (2008) · Americanae (AECID Library)

The Neuroprotective Role of Micronutrients in Parkinson’s Disease

Tsika, E., Ischiropoulos, H., & Malkus, K. A. (2009) · Oxidative stress and disease · doi:10.1201/9781420073522.ch2

The pathophysiology of neurodegenerative diseases: The back effects of oxidative stress and antioxidants system

Bikri, S., Aboussaleh, Y., & Fouad, F. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15702-8.00011-7

Formation of protein-derived electrophiles in ribonuclease A by biologically relevant oxidants

López, A. C., Acosta, S., Mastrogiovanni, M., Porcal, W., Portela, M. M., Durán, R., Radí, R., Denicola, A., & Möller, M. N. (2025) · Redox Biochemistry and Chemistry · doi:10.1016/j.rbc.2025.100048

Animal Models for the Study of Neurological Diseases and Their Link to Sleep

Rubio, C., González-Sánchez, E., Lee, Á., Ponce-Juárez, A., Serrano‐García, N., & Rubio‐Osornio, M. (2025) · Biomedicines · doi:10.3390/biomedicines13082005

Perfil oxidativo e bioquímico em pacientes que apresentam anemia falciforme ou traço falciforme

Manfredini, V. (2008) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)

Role of PGC-1β and TIF2 co-regulators in mouse skeletal muscle function

Ramamoorthy, T. G. (2013) · theses.fr (ABES) · doi:10.70675/e05002c4z4806z4363z90b1z0e406b6c0e4c

Pseudoalteromonas sp. NC201, un probiotique isolé en Nouvelle-Calédonie pour l'élevage de la crevette Litopenaeus stylirostris : Caractérisation et impact sur l’état physiologique de la crevette

Sorieul, L. (2017) · doi:10.70675/bcfde8cdz99edz4e06z8e39z6db0c65c71c0

Quantitative MRI Measurements of The Brainstem and Spinal Cord in Predicting Motor and Respiratory Capacity in Amyotrophic Lateral Sclerosis

Khamaysa, M. (2023) · theses.fr (ABES) · doi:10.70675/4e78f41ezb3fcz4940z9dcczfebf233cdc2d

Methionine oxidation alters both helical assembly and disordered contacts in human TDP-43 C-terminal domain phase separation

Ozguney, B., Puterbaugh, R. Z., Viswanathan, R., Shenoy, J., Mohanty, P., Mittal, J., & Fawzi, N. L. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2537431123 · Cited by 3

Free radical processes in aging, neurodegenerative diseases and other pathological states

Dubinina, E. E., & Васильевна, П. А. (2007) · Biochemistry (Moscow) Supplement Series B Biomedical Chemistry · doi:10.1134/s1990750807040026 · Cited by 15

Protein oxidative modifications in the ageing brain: Consequence for the onset of neurodegenerative disease

Grimm, S., Höhn, A., Davies, K. J. A., & Grune, T. (2010) · Free Radical Research · doi:10.3109/10715762.2010.512040 · Cited by 112

Redox Proteomics in Selected Neurodegenerative Disorders: From Its Infancy to Future Applications

Butterfield, D. A., Marzia Perluigi, A., Reed, T. T., Muharib, T., Hughes, C. P., Robinson, R. A. S., & Rukhsana Sultana, A. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4109 · Cited by 171

Human studies related to protein oxidation: protein carbonyl content as a marker of damage.

Chevion, M., Berenshtein, E., & Stadtman, E. R. (2000) · PubMed · Cited by 400

Protein Oxidation in Aging and Age‐Related Diseases

Stadtman, E. R. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb05632.x · Cited by 660