Oxidatively modified proteins in aging and disease1, 2 1Guest Editor: Earl Stadtman 2This article is part of a series of reviews on “Oxidatively Modified Proteins in Aging and Disease” The full list of papers may be found on the homepage of the journal

A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease

Sano, M., Ernesto, C., Thomas, R. G., Klauber, M. R., Schafer, K., Grundman, M., Woodbury, P., Growdon, J., Cotman, C. W., Pfeiffer, E., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704243361704 · Cited by 2,380

Oxidative Damage Linked to Neurodegeneration by Selective α-Synuclein Nitration in Synucleinopathy Lesions

Giasson, B. I., Duda, J. E., Murray, I. V. J., Chen, Q., Souza, J. M., Hurtig, H. I., Ischiropoulos, H., Trojanowski, J. Q., & Lee, V. M. ‐. (2000) · Science · doi:10.1126/science.290.5493.985 · Cited by 1,567

Age-related changes in oxidized proteins.

Oliver, C. N., Ahn, B. W., Moerman, E. J., Goldstein, S., & Stadtman, E. R. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45598-6 · Cited by 1,306

Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease.

Smith, C. D., Carney, J. M., Starke-Reed, P. E., Oliver, C. N., Stadtman, E. R., Floyd, R. A., & Markesbery, W. R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10540 · Cited by 1,296

Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease

Smith, M. A., Richey Harris, P. L., Sayre, L. M., Beckman, J. S., & Perry, G. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02653.1997 · Cited by 1,239

Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease

Liberatore, G. T., Jackson-Lewis, V., Vukosavic, S., Mandir, A. S., Vila, M., McAuliffe, W. G., Dawson, V. L., Dawson, T. M., & Przedborski, S. (1999) · Nature Medicine · doi:10.1038/70978 · Cited by 1,046

Oxidative damage in Alzheimer's

Smith, M. A., Perry, G. L., Richey, P. L., Sayrec, L. M., Anderson, V. E., Beal, M. F., & Kowall, N. W. (1996) · Nature · doi:10.1038/382120b0 · Cited by 897

Oxidative damage and metabolic dysfunction in Huntington's disease: Selective vulnerability of the basal ganglia

Browne, S. E., Bowling, A. C., Macgarvey, U., Baik, M. J., Berger, S. C., Muquit, M. M. K., Bird, E. D., & Beal, M. F. (1997) · Annals of Neurology · doi:10.1002/ana.410410514 · Cited by 885

Evidence of Increased Oxidative Damage in Both Sporadic and Familial Amyotrophic Lateral Sclerosis

Ferrante, R. J., Browne, S. E., Shinobu, L. A., Bowling, A. C., Baik, M. J., MacGarvey, U. M., Kowall, N. W., Brown, R. H., & Beal, M. F. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69052064.x · Cited by 808

Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse

Sohal, R. S., Ku, H.-H., Agarwal, S., Forster, M. J., & Lal, H. (1994) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(94)90104-x · Cited by 788

Oxidative Stress Response to Aerobic Exercise

Bloomer, R. J., Goldfarb, A. H., & MCKENZIE, M. J. (2006) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000222839.51144.3e · Cited by 154

Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes

Katyal, S., Lee, Y., Nitiss, K. C., Downing, S. M., Li, Y., Shimada, M., Zhao, J., Russell, H. R., Petrini, J. H. J., Nitiss, J. L., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3715 · Cited by 152

Anti-inflammatory and ameliorative effects of gallic acid on fluoxetine-induced oxidative stress and liver damage in rats

Karimi-Khouzani, O., Heidarian, E., & Amini, S. A. (2017) · Pharmacological Reports · doi:10.1016/j.pharep.2017.03.011 · Cited by 154

Peroxiredoxin 6 in human brain: molecular forms, cellular distribution and association with Alzheimer’s disease pathology

Power, J. H. T., Asad, S., Chataway, T., Chegini, F., Manavis, J., Temlett, J. A., Jensen, P. H., Blumbergs, P. C., & Gai, W. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0373-3 · Cited by 152

Oxidative damage in age-related macular degeneration.

Shen, J., Dong, A., Hackett, S. F., Bell, W. R., Green, W. R., & Campochiaro, P. A. (2007) · PubMed · doi:10.14670/hh-22.1301 · Cited by 152

Malondialdehyde, carbonyl proteins and albumin-disulphide as useful oxidative markers in mild cognitive impairment and Alzheimer's disease

Greilberger, J., Koidl, C., Greilberger, M., Lamprecht, M., Schroecksnadel, K., Leblhuber, F., Fuchs, D., & Oettl, K. (2008) · Free Radical Research · doi:10.1080/10715760802255764 · Cited by 151

Linking Alzheimer's disease to insulin resistance: the FoxO response to oxidative stress

Manolopoulos, K. N., Klotz, L.-O., Korsten, P., Bornstein, S. R., & Barthel, A. (2010) · Molecular Psychiatry · doi:10.1038/mp.2010.17 · Cited by 150

Antioxidants do not explain the disparate longevity between mice and the longest-living rodent, the naked mole-rat

Andziak, B., O’Connor, T. P., & Buffenstein, R. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.06.009 · Cited by 150

Maillard reaction in food allergy: Pros and cons

Gupta, R. K., Gupta, K., Sharma, A., Das, M., Ansari, I. A., & Dwivedi, P. D. (2016) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2016.1152949 · Cited by 154

Carbonylation of ER chaperone proteins in aged mouse liver

Rabek, J. P., Boylston, W. H., & Papaconstantinou, J. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00826-x · Cited by 148

Specific subcellular changes in oxidative stress in prefrontal cortex from patients with bipolar disorder

Andreazza, A. C., Wang, J., Salmasi, F., Shao, L., & Young, L. T. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12316 · Cited by 146

PPAR: a therapeutic target in Parkinson’s disease

Chaturvedi, R. K., & Beal, M. F. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05388.x · Cited by 151

Diet supplementation with acai (Euterpe oleracea Mart.) pulp improves biomarkers of oxidative stress and the serum lipid profile in rats

de Souza, M. O., Silva, M., Silva, M. E., Oliveira, R. D. P., & Pedrosa, M. L. (2009) · Nutrition · doi:10.1016/j.nut.2009.09.007 · Cited by 143

Inactivation of Parkin by Oxidative Stress and C-terminal Truncations

Winklhofer, K. F., Henn, I. H., Kay-Jackson, P. C., Heller, U., & Tatzelt, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306769200 · Cited by 143

Brain Region-Specific Changes in Oxidative Stress and Neurotrophin Levels in Autism Spectrum Disorders (ASD)

Sajdel, E. M., Xu, M. Q., McGinnis, W. R., & Koibuchi, N. (2010) · The Cerebellum · doi:10.1007/s12311-010-0223-4 · Cited by 147

8-Oxoguanine DNA Glycosylase-1 Augments Proinflammatory Gene Expression by Facilitating the Recruitment of Site-Specific Transcription Factors

Ba, X., Bácsi, A., Luo, J., Aguilera-Aguirre, L., Zeng, X., Radak, Z. O., Brasier, A. R., & Boldogh, I. R. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302472 · Cited by 144

Protein carbonyl levels in serum and gingival crevicular fluid in patients with chronic periodontitis

Baltacıoğlu, E., Akalın, F. A., Alver, A., Değer, O., & Karabulut, E. (2008) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2008.02.002 · Cited by 138

High sensitivity enzyme-linked immunosorbent assay (ELISA) method for measuring protein carbonyl in samples with low amounts of protein

Alamdari, D. H., Kostidou, E., Paletas, K., Sarigianni, M., Konstas, A. G. P., KARAPIPERIDOU, A., & Koliakos, G. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.06.023 · Cited by 138

Oxidant/antioxidant imbalance and the risk of Alzheimer's disease

Moneim, A. (2015) · Current Alzheimer Research · doi:10.2174/1567205012666150325182702 · Cited by 136

Mitochondrial dysfunction in amyotrophic lateral sclerosis – a valid pharmacological target?

Muyderman, H., & Chen, T. H. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12476 · Cited by 138

Comparison of oxidative stress biomarker profiles between acute and chronic wound environments

Moseley, R., Hilton, J. R., Waddington, R. J., Harding, K. G., Stephens, P., & Thomas, D. W. (2004) · Wound Repair and Regeneration · doi:10.1111/j.1067-1927.2004.12406.x · Cited by 134

Clinical oxidation parameters of aging

Voß, P., & Siems, W. (2006) · Free Radical Research · doi:10.1080/10715760600953859 · Cited by 134

Current Trends in Neurodegeneration: Cross Talks between Oxidative Stress, Cell Death, and Inflammation

Behl, T., Makkar, R., Sehgal, A., Singh, S., Sharma, N., Zengin, G., BUNGAU, S. G., Andronie-Cioară, F. L., Munteanu, M. A., Brisc, M. C., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147432 · Cited by 134

Oxidative Stress and Severe Walking Disability among Older Women

Semba, R. D., Ferrucci, L., Sun, K., Walston, J. D., Varadhan, R., Guralnik, J. M., & Fried, L. P. (2007) · The American Journal of Medicine · doi:10.1016/j.amjmed.2007.07.028 · Cited by 132

Fluoxetine prevents MPTP-induced loss of dopaminergic neurons by inhibiting microglial activation

Chung, Y. C., Kim, S. R., Park, J. Y., Chung, E. S., Park, K. W., Won, S.-Y., Bok, E., Jin, M., Park, E. S., & Yoon, S.-H. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.01.043 · Cited by 126

Oxidative stress‐triggered unfolded protein response is upstream of intrinsic cell death evoked by parkinsonian mimetics

Holtz, W. A., Turetzky, J. M., Jong, Y.-J. I., & O’Malley, K. L. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04025.x · Cited by 126

Oxidative damage during chagasic cardiomyopathy development: role of mitochondrial oxidant release and inefficient antioxidant defense

Wen, J.-J., Vyatkina, G., & Garg, N. J. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.08.018 · Cited by 124

Cannabinoid Receptor Type 1 Protects Nigrostriatal Dopaminergic Neurons against MPTP Neurotoxicity by Inhibiting Microglial Activation

Chung, Y. C., Bok, E., Huh, S. H., Park, J., Yoon, S., Kim, S. R., Kim, Y., Maeng, S., Park, S. H., & Jin, B. K. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1102435 · Cited by 123

Antioxidant and Probiotic Properties of Lactobacilli and Bifidobacteria of Human Origins

Kim, H., Kim, J.-S., Kim, Y., Jeong, Y., Kim, J.-E., Paek, N.-S., & Kang, C.-H. (2020) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-020-0147-x · Cited by 121

In Vitro Model of Neuroinflammation: Efficacy of Cannabigerol, a Non-Psychoactive Cannabinoid

Gugliandolo, A., Pollastro, F., Grassi, G., Bramanti, P., & Mazzon, E. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19071992 · Cited by 119

Mitochondrial ROS and mitochondria-targeted antioxidants in the aged heart

Bou‐Teen, D., Kaludercic, N., Weissman, D., Turan, B., Maack, C., Lisa, F. D., & Ruiz‐Meana, M. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.02.043 · Cited by 119

Effects of Panax ginseng and ginsenosides on oxidative stress and cardiovascular diseases: pharmacological and therapeutic roles

Hyun, S. H., Bhilare, K. D., In, G., Park, C.-K., & Kim, J. (2021) · Journal of Ginseng Research · doi:10.1016/j.jgr.2021.07.007 · Cited by 118

Polymers and Sulfur: what are Organic Polysulfides Good For? Preparative Strategies and Biological Applications

Vo, C., Kilcher, G., & Tirelli, N. (2009) · Macromolecular Rapid Communications · doi:10.1002/marc.200800740 · Cited by 121

Protein aggregation, metals and oxidative stress in neurodegenerative diseases

Tabner, B. J., El-Agnaf, O. M. A., German, M. J., Fullwood, N. J., & Allsop, D. (2005) · Biochemical Society Transactions · doi:10.1042/bst20051082 · Cited by 118

Protective effects of hyperoside (quercetin-3-o-galactoside) to PC12 cells against cytotoxicity induced by hydrogen peroxide and tert-butyl hydroperoxide.

Liu, Z., Tao, X.-Y., Zhang, C., Lu, Y.-H., & Wei, D. (2005) · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · doi:10.1016/j.biopha.2005.06.009 · Cited by 118

Repeated treatment with a low dose of reserpine as a progressive model of Parkinson's disease

Fernandes, V. S., dos Santos, J. R., Leão, A. H. F. F., Medeiros, A. M., Melo, T. G., Izídio, G. S., Cabral, A., Ribeiro, R. A., Abílio, V. C., Ribeiro, A. M., et al. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.03.008 · Cited by 116

Selectivity of protein carbonylation in the apoptotic response to oxidative stress associated with photodynamic therapy: a cell biochemical and proteomic investigation

Magi, B., Ettorre, A., Liberatori, S., Bini, L., Andreassi, M. G., Frosali, S., Neri, P., PALLINI, V., & Stefano, A. D. (2004) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401427 · Cited by 114

Circadian Rhythm and Alzheimer’s Disease

Homolak, J., Mudrovčić, M., Vukić, B., & Toljan, K. (2018) · Medical Sciences · doi:10.3390/medsci6030052 · Cited by 120

Inhibition of thrombin‐induced microglial activation and NADPH oxidase by minocycline protects dopaminergic neurons in the substantia nigra in vivo

Choi, S. H., Lee, D. Y., Chung, E. S., Hong, Y. B., Kim, S. U., & Jin, B. K. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03503.x · Cited by 112

Impairment of mitochondrial calcium handling in a mtSOD1 cell culture model of motoneuron disease

Jaiswal, M. K., Zech, W., Goos, M., Leutbecher, C., Ferri, A., Zippelius, A., Carrı̀, M. T., Nau, R., & Keller, B. U. (2009) · BMC Neuroscience · doi:10.1186/1471-2202-10-64 · Cited by 111

Dysregulation of the Ubiquitin-Proteasome System in Human Carotid Atherosclerosis

Versari, D., Herrmann, J., Gössl, M., Mannheim, D., Sattler, K., Meyer, F. B., Lerman, L. O., & Lerman, A. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000232501.08576.73 · Cited by 111

Role of mitochondria in mutant SOD1 linked amyotrophic lateral sclerosis

Tan, W., Pasinelli, P., & Trotti, D. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.02.009 · Cited by 117

Role of Nrf2 in Synaptic Plasticity and Memory in Alzheimer’s Disease

Davies, D. A., Adlimoghaddam, A., & Albensi, B. C. (2021) · Cells · doi:10.3390/cells10081884 · Cited by 112

Proteomic identification of age-dependent protein nitration in rat skeletal muscle

Kański, J., Alterman, M. A., & Schöneich, C. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00500-8 · Cited by 108

The anti-amnesic effects of luteolin against amyloid β25–35 peptide-induced toxicity in mice involve the protection of neurovascular unit

Liu, R., Gao, M., Qiang, G., Zhang, T.-T., Lan, X., Ying, J., & Du, G.-H. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.05.009 · Cited by 107

Carbonyl scavenger and antiatherogenic effects of hydrazine derivatives

Galvani, S., Coatrieux, C., Elbaz, M., Grazide, M.-H., Thiers, J., Parini, A., Uchida, K., Kamar, N., Rostaing, L. P. E., Baltas, M., et al. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.08.026 · Cited by 105

What We Know About Oxidative Stress in Patients with Chronic Kidney Disease on Dialysis—Clinical Effects, Potential Treatment, and Prevention

Vecchio, L. D., Locatelli, F., & Carini, M. (2011) · Seminars in Dialysis · doi:10.1111/j.1525-139x.2010.00819.x · Cited by 104

Evidence for Early Cytotoxic Aggregates in Transgenic Mice for Human Transthyretin Leu55Pro

Sousa, M. M., Fernandes, R., Palha, J. A., Taboada, A., Vieira, P., & Saraiva, M. J. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64469-0 · Cited by 108

The Aging Mitochondria

Theurey, P., & Pizzo, P. (2018) · Genes · doi:10.3390/genes9010022 · Cited by 108

Development of Mitochondria‐targeted Aromatic‐cationic Peptides for Neurodegenerative Diseases

Szeto, H. H. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.013 · Cited by 100

Cinnamon and Its Metabolite Sodium Benzoate Attenuate the Activation of p21rac and Protect Memory and Learning in an Animal Model of Alzheimer’s Disease

Modi, K. K., Roy, A., Brahmachari, S., Rangasamy, S. B., & Pahan, K. (2015) · PLoS ONE · doi:10.1371/journal.pone.0130398 · Cited by 100

Oxidative Stress in Autism: Elevated Cerebellar 3-nitrotyrosine Levels

Sajdel, E. M., Lipiński, B., Windom, H., AUDHYA, T. K., & McGinnis, W. R. (2008) · American journal of biochemistry & biotechnology/American journal of biochemistry and biotechnology · doi:10.3844/ajbbsp.2008.73.84 · Cited by 101

Protein carbonyls are acutely elevated following single set anaerobic exercise in resistance trained men

Bloomer, R. J., Fry, A. C., Falvo, M. J., & Moore, C. A. (2006) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2006.07.014 · Cited by 99

The solution chemistry of nitric oxide and other reactive nitrogen species

Ford, P. C., & Miranda, K. M. (2020) · Nitric Oxide · doi:10.1016/j.niox.2020.07.004 · Cited by 104

Role of Oxidative Stress in the Pathogenesis of Amyotrophic Lateral Sclerosis: Antioxidant Metalloenzymes and Therapeutic Strategies

Hemerková, P., & Vališ, M. (2021) · Biomolecules · doi:10.3390/biom11030437 · Cited by 100

Cu/Zn Superoxide Dismutase Typical for Familial Amyotrophic Lateral Sclerosis Increases the Vulnerability of Mitochondria and Perturbs Ca2+ Homeostasis in SOD1G93A Mice

Jaiswal, M. K., & Keller, B. U. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.050831 · Cited by 98

The protective effect of eicosapentaenoic acid-enriched phospholipids from sea cucumber Cucumaria frondosa on oxidative stress in PC12 cells and SAMP8 mice

Wu, F., Xue, Y., Liu, X., Xue, C., Wang, J., Du, L., Takahashi, K., & Wang, Y. (2013) · Neurochemistry International · doi:10.1016/j.neuint.2013.10.015 · Cited by 99

Identification of specific protein carbonylation sites in model oxidations of human serum albumin

Temple, A., Yen, T., & Gronert, S. (2006) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2006.04.030 · Cited by 96

Oxidative and nitrosative stress markers in bus drivers

Rössner, P., Švecová, V., Milcová, A., Lnenickova, Z., Solanský, I., Santella, R. M., & Šrám, R. J. (2007) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2006.11.033 · Cited by 96

Exercise-Induced Neuroprotection and Recovery of Motor Function in Animal Models of Parkinson’s Disease

Palasz, E., Niewiadomski, W., Gasiorowska, A., Wysocka, A., Stepniewska, A., & Niewiadomska, G. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.01143 · Cited by 95

Inducers of oxidative stress block ciliary neurotrophic factor activation of Jak/STAT signaling in neurons

Kaur, N., Lu, B.-J., Monroe, R. K., Ward, S. M., & Halvorsen, S. W. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02990.x · Cited by 98

Antioxidant effects of Etlingera elatior flower extract against lead acetate - induced perturbations in free radical scavenging enzymes and lipid peroxidation in rats

Jackie, T., Haleagrahara, N., & Chakravarthi, S. (2011) · BMC Research Notes · doi:10.1186/1756-0500-4-67 · Cited by 103

A Method for Selective Enrichment and Analysis of Nitrotyrosine-Containing Peptides in Complex Proteome Samples

Zhang, Q., Qian, W., Knyushko, T. V., Clauss, T. R., Purvine, S. O., Moore, R. J., Sacksteder, C. A., Chin, M. H., Smith, D., Camp, D., et al. (2007) · Journal of Proteome Research · doi:10.1021/pr0606934 · Cited by 95

Inducible nitric oxide synthase (iNOS) in muscle wasting syndrome, sarcopenia, and cachexia

Hall, D. T., Ma, J. F., Marco, S. D., & Gallouzi, I. (2011) · Aging · doi:10.18632/aging.100358 · Cited by 98

Relevance of oxidative injury in the pathogenesis of motor neuron diseases

Agar, J. N., & Durham, H. D. (2003) · Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders · doi:10.1080/14660820310011278 · Cited by 95

Assessment of the antioxidant and antimutagenic activity of extracts from goji berry of Greek cultivation

Skenderidis, P., Kerasioti, E., Karkanta, E., Stagos, D., Kouretas, D., Petrotos, K., Hadjichristodoulou, C. S., & Tsakalof, A. K. (2018) · Toxicology Reports · doi:10.1016/j.toxrep.2018.02.001 · Cited by 96

Oxidative stress markers, C-reactive protein and heat shock protein 70 levels in subjects with metabolic syndrome

Armutçu, F., Ataymen, M., Atmaca, H., & Gürel, A. (2008) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2008.166 · Cited by 93

Retinal degeneration from oxidative damage

Cingolani, C., Rogers, B. S., Lu, L., Kachi, S., Shen, J., & Campochiaro, P. A. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.09.032 · Cited by 93

Attenuation of tamoxifen-induced hepatotoxicity by taurine in mice

Tabassum, H., Rehman, H., Banerjee, B. D., Raisuddin, S., & Parvez, S. (2006) · Clinica Chimica Acta · doi:10.1016/j.cca.2006.02.006 · Cited by 91

PGC‐1α activation as a therapeutic approach in mitochondrial disease

Wenz, T. (2009) · IUBMB Life · doi:10.1002/iub.261 · Cited by 91

Spatial memory training modifies the expression of brain-derived neurotrophic factor tyrosine kinase receptors in young and aged rats

Silhol, M., Arancibia, S., Maurice, T., & Tapia‐Arancibia, L. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.02.013 · Cited by 93

An Orally Active Catalytic Metalloporphyrin Protects against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine NeurotoxicityIn Vivo

Liang, L., Huang, J., Fulton, R. E., Day, B. J., & Patel, M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0019-07.2007 · Cited by 91

Understanding the mechanism of non-enzymatic glycation inhibition by cinnamic acid: an in vitro interaction and molecular modelling study

Qais, F. A., Alam, M. M., Naseem, I., & Ahmad, I. (2016) · RSC Advances · doi:10.1039/c6ra12321j · Cited by 90

Ginger (Zingiber officinale Roscoe) in the Prevention of Ageing and Degenerative Diseases: Review of Current Evidence

Sahardi, N. F. N. M., & Makpol, S. (2019) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2019/5054395 · Cited by 101

Involvement of Nrf2 in Ocular Diseases

Batliwala, S. Y., Xavier, C., Liu, Y., Wu, H., & Pang, I.-H. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/1703810 · Cited by 93

The oxidative damage theory of aging

Lin, M. T., & Flint Beal, M. (2003) · Clinical Neuroscience Research · doi:10.1016/s1566-2772(03)00007-0 · Cited by 89

Mitochondria in ageing: there is metabolism beyond the ROS

Breitenbach, M., Rinnerthaler, M., Hartl, J., Stincone, A., Vowinckel, J., Breitenbach‐Koller, H., & Ralser, M. (2013) · FEMS Yeast Research · doi:10.1111/1567-1364.12134 · Cited by 93

Selectivity of the ubiquitin pathway for oxidatively modified proteins: relevance to protein precipitation diseases

Dudek, E. J., Shang, F., Liu, Q. L., Valverde, P., Hobbs, M., & Taylor, A. (2005) · The FASEB Journal · doi:10.1096/fj.05-4049fje · Cited by 86

Mitochondrial Dysfunction in Neurodegenerative Diseases

Yang, H. (2025) · Cells · doi:10.3390/cells14040276 · Cited by 95

Antioxidative defense mechanisms controlled by Nrf2: state-of-the-art and clinical perspectives in neurodegenerative diseases

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