Oxidatively modified proteins in aging and disease1, 2 1Guest Editor: Earl Stadtman 2This article is part of a series of reviews on “Oxidatively Modified Proteins in Aging and Disease” The full list of papers may be found on the homepage of the journal

A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease

Sano, M., Ernesto, C., Thomas, R. G., Klauber, M. R., Schafer, K., Grundman, M., Woodbury, P., Growdon, J., Cotman, C. W., Pfeiffer, E., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704243361704 · Cited by 2,380

Oxidative Damage Linked to Neurodegeneration by Selective α-Synuclein Nitration in Synucleinopathy Lesions

Giasson, B. I., Duda, J. E., Murray, I. V. J., Chen, Q., Souza, J. M., Hurtig, H. I., Ischiropoulos, H., Trojanowski, J. Q., & Lee, V. M. ‐. (2000) · Science · doi:10.1126/science.290.5493.985 · Cited by 1,567

Age-related changes in oxidized proteins.

Oliver, C. N., Ahn, B. W., Moerman, E. J., Goldstein, S., & Stadtman, E. R. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45598-6 · Cited by 1,306

Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease.

Smith, C. D., Carney, J. M., Starke-Reed, P. E., Oliver, C. N., Stadtman, E. R., Floyd, R. A., & Markesbery, W. R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10540 · Cited by 1,296

Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease

Smith, M. A., Richey Harris, P. L., Sayre, L. M., Beckman, J. S., & Perry, G. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02653.1997 · Cited by 1,239

Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease

Liberatore, G. T., Jackson-Lewis, V., Vukosavic, S., Mandir, A. S., Vila, M., McAuliffe, W. G., Dawson, V. L., Dawson, T. M., & Przedborski, S. (1999) · Nature Medicine · doi:10.1038/70978 · Cited by 1,046

Oxidative damage in Alzheimer's

Smith, M. A., Perry, G. L., Richey, P. L., Sayrec, L. M., Anderson, V. E., Beal, M. F., & Kowall, N. W. (1996) · Nature · doi:10.1038/382120b0 · Cited by 897

Oxidative damage and metabolic dysfunction in Huntington's disease: Selective vulnerability of the basal ganglia

Browne, S. E., Bowling, A. C., Macgarvey, U., Baik, M. J., Berger, S. C., Muquit, M. M. K., Bird, E. D., & Beal, M. F. (1997) · Annals of Neurology · doi:10.1002/ana.410410514 · Cited by 885

Evidence of Increased Oxidative Damage in Both Sporadic and Familial Amyotrophic Lateral Sclerosis

Ferrante, R. J., Browne, S. E., Shinobu, L. A., Bowling, A. C., Baik, M. J., MacGarvey, U. M., Kowall, N. W., Brown, R. H., & Beal, M. F. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69052064.x · Cited by 808

Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse

Sohal, R. S., Ku, H.-H., Agarwal, S., Forster, M. J., & Lal, H. (1994) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(94)90104-x · Cited by 788

The role of antioxidants in the chemistry of oxidative stress: A review

Pisoschi, A. M., & Pop, A. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2015.04.040 · Cited by 2,963

Protein carbonyl groups as biomarkers of oxidative stress

Dalle‐Donne, I., Rossi, R., Giustarini, D., Milzani, A., & Colombo, R. (2003) · Clinica Chimica Acta · doi:10.1016/s0009-8981(03)00003-2 · Cited by 2,352

Physiological Implications of Hydrogen Sulfide: A Whiff Exploration That Blossomed

Wang, R. (2012) · Physiological Reviews · doi:10.1152/physrev.00017.2011 · Cited by 1,962

Oxidative DNA damage and disease: induction, repair and significance

Evans, M. D., Dizdaroglu, M., & Cooke, M. S. (2004) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2003.11.001 · Cited by 1,372

Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease

Ngo, V., & Duennwald, M. L. (2022) · Antioxidants · doi:10.3390/antiox11122345 · Cited by 1,130

Glutathione dysregulation and the etiology and progression of human diseases

Ballatori, N., Krance, S. M., Notenboom, S., Shi, S., Tieu, K., & Hammond, C. L. (2009) · Biological Chemistry · doi:10.1515/bc.2009.033 · Cited by 1,145

Mechanism of Oxidative Stress in Neurodegeneration

Gandhi, S., & Abramov, A. Y. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/428010 · Cited by 964

Protein carbonylation in human diseases

Dalle-Donne, I., Giustarini, D., Colombo, R., Rossi, R., & Milzani, A. (2003) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(03)00031-5 · Cited by 961

Oxidative Stress and the Pathogenesis of Alzheimer's Disease

Zhao, Y., & Zhao, B. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/316523 · Cited by 855

Protein carbonylation, cellular dysfunction, and disease progression

Dalle‐Donne, I., Aldini, G., Carini, M., Colombo, R., Rossi, R., & Milzani, A. (2006) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2006.tb00407.x · Cited by 857

Oxidative stress response and Nrf2 signaling in aging

Zhang, H., Davies, K. J. A., & Forman, H. J. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.05.036 · Cited by 804

Oxidative stress in Alzheimer’s disease

Chen, Z., & Zhong, C. (2014) · Neuroscience Bulletin · doi:10.1007/s12264-013-1423-y · Cited by 797

Role of mitochondrial ROS in the brain: from physiology to neurodegeneration

Angelova, P. R., & Abramov, A. Y. (2018) · FEBS Letters · doi:10.1002/1873-3468.12964 · Cited by 789

Mitochondrial creatine kinase in human health and disease

Schlattner, U., Tokarska-Schlattner, M., & Wallimann, T. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2005.09.004 · Cited by 641

Oxidative stress in ALS: Key role in motor neuron injury and therapeutic target

Barber, S. C., & Shaw, P. J. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.11.018 · Cited by 647

The novel neuromodulator hydrogen sulfide: an endogenous peroxynitrite ‘scavenger’?

Whiteman, M., Armstrong, J. S., Chu, S. H., Siau, J. L., Wong, B., Cheung, N. S., Halliwell, B. B., & Moore, P. K. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02617.x · Cited by 604

DJ-1 Is a Redox-Dependent Molecular Chaperone That Inhibits α-Synuclein Aggregate Formation

Shendelman, S., Jonason, A. S., Martinat, C., Leete, T., & Abeliovich, A. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020362 · Cited by 610

Oxidative Modifications and Down-regulation of Ubiquitin Carboxyl-terminal Hydrolase L1 Associated with Idiopathic Parkinson's and Alzheimer's Diseases

Choi, J., Levey, A. I., Weintraub, S. T., Rees, H. D., Gearing, M., Chin, L.-S., & Li, L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m314124200 · Cited by 568

The influence of selenium on immune responses

Hoffmann, P. R., & Berry, M. J. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700330 · Cited by 544

Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse

Itier, J. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg239 · Cited by 523

Oxidative Stress in Neurodegenerative Diseases: From a Mitochondrial Point of View

Cenini, G., Lloret, A., & Cascella, R. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/2105607 · Cited by 521

Quantification of protein modification by oxidants

Hawkins, C. L., Morgan, P. E., & Davies, M. J. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.01.007 · Cited by 489

Oxidative Damage of DJ-1 Is Linked to Sporadic Parkinson and Alzheimer Diseases

Choi, J., Sullards, M. C., Olzmann, J. A., Rees, H. D., Weintraub, S. T., Bostwick, D. E., Gearing, M., Levey, A. I., Chin, L., & Li, L. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m509079200 · Cited by 489

Oxidative stress in ALS: A mechanism of neurodegeneration and a therapeutic target

Barber, S. C., Mead, R. J., & Shaw, P. J. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2006.03.008 · Cited by 489

Rutin as a Potent Antioxidant: Implications for Neurodegenerative Disorders

Enogieru, A. B., Haylett, W. L., Hiss, D. C., Bardien, S., & Ekpo, O. E. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/6241017 · Cited by 496

Protein Disulfide Bond Formation in the Cytoplasm during Oxidative Stress

Cumming, R. C., Andon, N. L., Haynes, P. A., Park, M., Fischer, W. H., & Schubert, D. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312267200 · Cited by 463

L‐tyrosine and L‐dihydroxyphenylalanine as hormone‐like regulators of melanocyte functions

Slominski, A. T., Zmijewski, M. A., & Pawelek, J. M. (2011) · Pigment Cell & Melanoma Research · doi:10.1111/j.1755-148x.2011.00898.x · Cited by 449

Mitochondrial Complex I Activity and Oxidative Damage to Mitochondrial Proteins in the Prefrontal Cortex of Patients With Bipolar Disorder

Andreazza, A. C., Shao, L., Wang, J.-F., & Young, L. T. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.22 · Cited by 448

Proteins as biomarkers of oxidative/nitrosative stress in diseases: The contribution of redox proteomics

Dalle‐Donne, I., Scaloni, A., Giustarini, D., Cavarra, E., Tell, G., Lungarella, G., Colombo, R., Rossi, R., & Milzani, A. (2004) · Mass Spectrometry Reviews · doi:10.1002/mas.20006 · Cited by 461

Detection, identification, and quantification of oxidative protein modifications

Hawkins, C. L., & Davies, M. J. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.rev119.006217 · Cited by 449

Nrf2-induced antioxidant protection: A promising target to counteract ROS-mediated damage in neurodegenerative disease?

de Vries, H. E., Witte, M. E., Hondius, D., Rozemüller, A. J. M., Drukarch, B., Hoozemans, J. J. M., & van Horssen, J. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.09.001 · Cited by 436

Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria

Deng, H., Shi, Y., Furukawa, Y., Zhai, H., Fu, R., Liu, E., Gorrie, G., Khan, M. S., Hung, W.-Y., Bigio, E. H., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602046103 · Cited by 432

Established and Emerging Plasma Biomarkers in the Prediction of First Atherothrombotic Events

Ridker, P. M., Brown, N. J., Vaughan, D. E., Harrison, D. G., & Mehta, J. L. (2004) · Circulation · doi:10.1161/01.cir.0000133444.17867.56 · Cited by 420

Lipofuscin: Formation, Distribution, and Metabolic Consequences

JUNG, T., BADER, N., & GRUNE, T. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1404.008 · Cited by 415

Molecular and cellular mechanisms of skeletal muscle atrophy: an update

Fanzani, A., Conraads, V. M., Penna, F., & Martinet, W. (2012) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1007/s13539-012-0074-6 · Cited by 386

Lipids and proteins—major targets of oxidative modifications in abiotic stressed plants

Anjum, N. A., Sofo, A., Scopa, A., Roychoudhury, A., Gill, S. S., Iqbal, M., Lukatkin, A. S., Pereira, E., Duarte, A. C., & Ahmad, I. (2014) · Environmental Science and Pollution Research · doi:10.1007/s11356-014-3917-1 · Cited by 378

Implications of glial nitric oxide in neurodegenerative diseases

Yuste, J. E., Tarragon, E., Campuzano, C. M., & Ros-Bernal, F. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00322 · Cited by 356

Mechanism of toxicity of pesticides acting at complex I: relevance to environmental etiologies of Parkinson’s disease

Sherer, T., Richardson, J. R., Testa, C. M., Seo, B. B., Panov, A. V., Yagi, T., Matsuno‐Yagi, A., Miller, G. W., & Greenamyre, J. T. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04333.x · Cited by 348

Long-term Intermittent Hypoxia in Mice: Protracted Hypersomnolence with Oxidative Injury to Sleep-Wake Brain Regions

Veasey, S. C., Davis, C. W., Fenik, P., Zhan, G., Hsu, Y.-J., Praticò, D., & Gow, A. J. (2004) · SLEEP · doi:10.1093/sleep/27.2.194 · Cited by 337

Mitochondrial dysfunction in aging: Much progress but many unresolved questions

Payne, B. A. I., & Chinnery, P. F. (2015) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2015.05.022 · Cited by 335

Hydrogen sulphide: a novel inhibitor of hypochlorous acid-mediated oxidative damage in the brain?

Whiteman, M., Cheung, N. S., Zhu, Y. Z., Chu, S. H., Siau, J. L., Wong, B., Armstrong, J. S., & Moore, P. K. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.11.110 · Cited by 331

Mitochondria-targeted peptide antioxidants: Novel neuroprotective agents

Szeto, H. H. (2006) · The AAPS Journal · doi:10.1208/aapsj080362 · Cited by 332

Nrf2—a therapeutic target for the treatment of neurodegenerative diseases

Johnson, D. A., & Johnson, J. A. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.07.147 · Cited by 333

PI3K is a key molecule in the Nrf2‐mediated regulation of antioxidative proteins by hemin in human neuroblastoma cells

Nakaso, K., Yano, H., Fukuhara, Y., Takeshima, T., Wada‐Isoe, K., & Nakashima, K. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00517-9 · Cited by 324

Skeletal Muscle Mitochondria and Aging: A Review

Peterson, C. M., Johannsen, D. L., & Ravussin, É. (2012) · Journal of Aging Research · doi:10.1155/2012/194821 · Cited by 337

Frailty and Protein-Energy Wasting in Elderly Patients with End Stage Kidney Disease

Kim, J. C., Kalantar‐Zadeh, K., & Kopple, J. D. (2012) · Journal of the American Society of Nephrology · doi:10.1681/asn.2012010047 · Cited by 309

Oxidative damage is a potential cause of cone cell death in retinitis pigmentosa

Shen, J., Yang, X., Dong, A., Petters, R. M., Peng, Y., Wong, F., & Campochiaro, P. A. (2005) · Journal of Cellular Physiology · doi:10.1002/jcp.20346 · Cited by 300

Potential role of tryptophan derivatives in stress responses characterized by the generation of reactive oxygen and nitrogen species

Peyrot, F., & Ducrocq, C. (2008) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2008.00580.x · Cited by 292

Oxidative Modifications and Aggregation of Cu,Zn-Superoxide Dismutase Associated with Alzheimer and Parkinson Diseases

Choi, J., Rees, H. D., Weintraub, S. T., Levey, A. I., Chin, L., & Li, L. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414327200 · Cited by 293

Intervention strategies to inhibit protein carbonylation by lipoxidation‐derived reactive carbonyls

Aldini, G., Dalle‐Donne, I., Facino, R. M., Milzani, A., & Carini, M. (2006) · Medicinal Research Reviews · doi:10.1002/med.20073 · Cited by 292

Oxidative damage in neurodegeneration: roles in the pathogenesis and progression of Alzheimer disease

Marzia Perluigi, A., Domenico, F. D., & Butterfield, D. A. (2023) · Physiological Reviews · doi:10.1152/physrev.00030.2022 · Cited by 322

Reduced oxidative damage in ALS by high‐dose enteral melatonin treatment

Weishaupt, J. H., Bartels, C., Pölking, E., Dietrich, J., Rohde, G., Pöeggeler, B., Mertens, N., Sperling, S., Bohn, M., Huether, G., et al. (2006) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2006.00377.x · Cited by 284

Glutathione peroxidase 4: a new player in neurodegeneration?

Cardoso, B. R., Hare, D. J., Bush, A. I., & Roberts, B. R. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.196 · Cited by 287

Role of oxidative stress in paraquat‐induced dopaminergic cell degeneration

McCormack, A. L., Atienza, J. G., Johnston, L. C., Andersen, J. K., Vu, S., & Monte, D. A. D. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03088.x · Cited by 282

Neuroprotective effects and mechanisms of exercise in a chronic mouse model of Parkinson’s disease with moderate neurodegeneration: Exercise neuroprotection in chronic parkinsonism

Lau, Y.-S., Patki, G., Das-Panja, K., Le, W.-D., & Ahmad, S. O. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07626.x · Cited by 275

Iron and Oxidative Stress in Pregnancy

Casanueva, E., & Viteri, F. E. (2003) · The Journal of Nutrition · doi:10.1093/jn/133.5.1700s · Cited by 408

On the Etiology of Contact/Occupational Vitiligo

Boissy, R. E., & Manga, P. (2004) · Pigment Cell Research · doi:10.1111/j.1600-0749.2004.00130.x · Cited by 268

The Ageing Brain: Molecular and Cellular Basis of Neurodegeneration

Azam, S., Haque, M. E., Balakrishnan, R., Kim, I., & Choi, D. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.683459 · Cited by 273

Increased oxidative stress with aging reduces chondrocyte survival: Correlation with intracellular glutathione levels

Carlo, M. D., & Loeser, R. F. (2003) · Arthritis & Rheumatism · doi:10.1002/art.11338 · Cited by 254

Brain iron metabolism and its perturbation in neurological diseases

Crichton, R. R., Dexter, D. T., & Ward, R. J. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0470-z · Cited by 247

Hydrogen Peroxide Is Generated during the Very Early Stages of Aggregation of the Amyloid Peptides Implicated in Alzheimer Disease and Familial British Dementia

Tabner, B. J., El‐Agnaf, O. M. A., Turnbull, S., German, M. J., Paleologou, K. E., Hayashi, Y., Cooper, L. J., Fullwood, N. J., & Allsop, D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.c500238200 · Cited by 243

Markers of oxidant stress that are clinically relevant in aging and age-related disease

Jacob, K. D., Hooten, N. N., Trzeciak, A. R., & Evans, M. K. (2013) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2013.02.008 · Cited by 240

NF-κB Signaling Pathway and Its Therapeutic Implications in Human Diseases

Sarkar, F. H., Li, Y., Wang, Z. P., & Kong, D. (2008) · International Reviews of Immunology · doi:10.1080/08830180802276179 · Cited by 234

Astrocytes and Therapeutics for Parkinson's Disease

Rappold, P. M., & Tieu, K. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.07.001 · Cited by 234

Cerium oxide nanoparticles protect against Aβ-induced mitochondrial fragmentation and neuronal cell death

Dowding, J. M., Song, W., Bossy, K., Karakoti, A., Kumar, A., Kim, A., Bossy, B., Seal, S., Ellisman, M. H., Perkins, G., et al. (2014) · Cell Death & Differentiation · doi:10.1038/cdd.2014.72 · Cited by 221

Age-related changes in brain-derived neurotrophic factor and tyrosine kinase receptor isoforms in the hippocampus and hypothalamus in male rats

Silhol, M., Bonnichon, V., Rage, F., & Tapia‐Arancibia, L. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.01.008 · Cited by 224

Apolipoprotein D is involved in the mechanisms regulating protection from oxidative stress

Ganfornina, M. D., Carmo, S. D., Lora, J. M., Torres‐Schumann, S., Vogel, M., Allhorn, M., González, C., Bastiani, M. J., Rassart, É., & Sánchez, D. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00395.x · Cited by 225

Proteomic identification of 3-nitrotyrosine-containing rat cardiac proteins: effects of biological aging

Kanski, J., Behring, A., Pelling, J., & Schöneich, C. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01030.2003 · Cited by 217

N-acetylcysteine Boosts Brain and Blood Glutathione in Gaucher and Parkinson Diseases

Holmay, M. J., Terpstra, M., Coles, L. D., Mishra, U., Ahlskog, M., Öz, G., Cloyd, J. C., & Tuite, P. J. (2013) · Clinical Neuropharmacology · doi:10.1097/wnf.0b013e31829ae713 · Cited by 216

Oxidative protein damage is associated with poor grip strength among older women living in the community

Howard, C., Ferrucci, L., Sun, K., Fried, L. P., Walston, J., Varadhan, R., Guralnik, J. M., & Semba, R. D. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00133.2007 · Cited by 214

Oxidatively damaged proteins of heart mitochondrial electron transport complexes

Choksi, K. B., Boylston, W. H., Rabek, J. P., Widger, W. R., & Papaconstantinou, J. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2003.11.007 · Cited by 212

Human peroxiredoxin 5 is a peroxynitrite reductase

Dubuisson, M., Stricht, D. V., Clippe, A., Etienne, F., Nauser, T., Kissner, R., Koppenol, W. H., Rees, J., & Knoops, B. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.06.080 · Cited by 212

Glutathione and Parkinson's disease: Is this the elephant in the room?

Zeevalk, G. D., Razmpour, R., & Bernard, L. P. (2008) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2008.01.017 · Cited by 217

Neuroprotection Against Oxidative Stress: Phytochemicals Targeting TrkB Signaling and the Nrf2-ARE Antioxidant System

Hannan, M. A., Dash, R., Sohag, A. A. M., Haque, M. N., & Moon, I. S. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00116 · Cited by 215

Mitochondrial and Cell Death Mechanisms in Neurodegenerative Diseases

Martin, L. J. (2010) · Pharmaceuticals · doi:10.3390/ph3040839 · Cited by 213

Molecular and cellular aspects of protein misfolding and disease

Herczenik, E., & Gebbink, M. F. B. G. (2008) · The FASEB Journal · doi:10.1096/fj.07-099671 · Cited by 211

3-Nitrotyrosine and glutathione antioxidant system in patients in the early and late stages of bipolar disorder

Andreazza, A. C., Kapczinski, F. P., Kauer‐Sant’Anna, M., Walz, J. C., Bond, D. J., Gonçalves, C. A., Young, L. T., & Yatham, L. N. (2009) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0935 · Cited by 199

Effect of alpha‐lipoic acid supplementation on markers of protein oxidation in post‐mitotic tissues of ageing rat

Kayalı, R., Çakatay, U., Akçay, T., & Altuğ, T. (2004) · Cell Biochemistry and Function · doi:10.1002/cbf.1190 · Cited by 199

Histological Evidence of Oxidative Stress and Premature Senescence in Preterm Premature Rupture of the Human Fetal Membranes Recapitulated in Vitro

Menon, R., Boldogh, I. R., Hawkins, H. K., Woodson, M., Polettini, J., Syed, T. A., Fortunato, S. J., Saade, G. R., Papaconstantinou, J., & Taylor, R. N. (2014) · American Journal Of Pathology · doi:10.1016/j.ajpath.2014.02.011 · Cited by 202

DJ-1 induces thioredoxin 1 expression through the Nrf2 pathway

Im, J., Lee, K.-W., Woo, J.-M., Junn, E., & Mouradian, M. M. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds131 · Cited by 197

Pink1 regulates the oxidative phosphorylation machinery via mitochondrial fission

Liu, W., Acín-Peréz, R., Geghman, K. D., Manfredi, G., Lu, B., & Li, C. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107332108 · Cited by 190

Pyridoxamine, an inhibitor of advanced glycation and lipoxidation reactions: a novel therapy for treatment of diabetic complications

Metz, T., Alderson, N. L., Thorpe, S. R., & Baynes, J. (2003) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2003.08.021 · Cited by 190

Neprilysin: An Enzyme Candidate to Slow the Progression of Alzheimer's Disease

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Proteomic Analysis of Protein Expression and Oxidative Modification in R6/2 Transgenic Mice

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