Cited by 298Mitochondrial Function and PathologyRedox biology and oxidative stressCell death mechanisms and regulation

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Mitochondria: regulators of signal transduction by reactive oxygen and nitrogen species

Brookes, Paul S., Levonen, Anna-Liisa, Shiva, Sruti, Sarti, Paolo, Darley-Usmar, Victor M.·2002·Free Radical Biology and Medicine

DOI 10.1016/s0891-5849(02)00901-2

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Abstract

The functional role of mitochondria in cell physiology has previously centered around metabolism, with oxidative phosphorylation playing a pivotal role. Recently, however, this perspective has changed significantly with the realization that mitochondria are active participants in signal transduction pathways, not simply the passive recipients of injunctions from the rest of the cell. In this review the emerging role of the mitochondrion in cell signaling is discussed in the context of cytochrome c release, hydrogen peroxide formation from the respiratory chain, and the nitric oxide-cytochrome c oxidase signaling pathway.

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The Role of Mitochondria in Hypertension
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Authors: Brookes, P. S., Levonen, A.-L., Shiva, S., Sarti, P., & Darley-Usmar, V. M.
Affiliations: University of Alabama at Birmingham (US)
Sapienza University of Rome (IT)
Corresponding author: Darley-Usmar, Victor M.
ORCID: Brookes, Paul S.
Levonen, Anna-Liisa
Shiva, Sruti
Sarti, Paolo
Darley-Usmar, Victor M.
Venue: Free Radical Biology and Medicine
Publisher: Elsevier BV
Published: 2002-09
Volume: 33
Issue: 6
Pages: 755-764
ISSN: 0891-5849 (ISSN-L)
DOI: 10.1016/s0891-5849(02)00901-2
OpenAlex: W1748754899
Cited by: 298
References: 72
Citations by year: 2025: 2 · 2024: 5 · 2023: 1 · 2022: 6 · 2021: 1 · 2020: 3 · 2019: 9 · 2018: 9 · 2017: 10 · 2016: 12 · 2015: 14 · 2014: 13 · 2013: 13 · 2012: 21
FWCI: 7.09
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Free Radical Biology and Medicine (publishedVersion)
PubMed (publishedVersion)
IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Funders: American Heart Association
National Institutes of Health (1r03aa012613-01)
National Institute on Alcohol Abuse and Alcoholism (AA 12613)
National Heart, Lung, and Blood Institute (R01HL058031, HL-58031)
National Institute of Environmental Health Sciences (R01ES010167, ES-10167)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords: mitochondria, signal transduction, reactive oxygen species, reactive nitrogen species, cytochrome c release, hydrogen peroxide, electron transport chain, nitric oxide, cytochrome c oxidase, mitochondrial signaling
MeSH terms: Adenosine Triphosphate, Animals, Cytochrome c Group, Electron Transport Complex IV, Free Radicals, Humans, Hydrogen Peroxide, Mitochondria, Models, Biological, Models, Chemical, Nitric Oxide, Oxidation-Reduction, Time Factors, Signal Transduction, Apoptosis, Reactive Oxygen Species, Reactive Nitrogen Species

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Mitochondria: regulators of signal transduction by reactive oxygen and nitrogen species

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