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Mitochondria: regulators of signal transduction by reactive oxygen and nitrogen species
Abstract
The functional role of mitochondria in cell physiology has previously centered around metabolism, with oxidative phosphorylation playing a pivotal role. Recently, however, this perspective has changed significantly with the realization that mitochondria are active participants in signal transduction pathways, not simply the passive recipients of injunctions from the rest of the cell. In this review the emerging role of the mitochondrion in cell signaling is discussed in the context of cytochrome c release, hydrogen peroxide formation from the respiratory chain, and the nitric oxide-cytochrome c oxidase signaling pathway.
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“The high affinity and rapid binding to ferrous heme are important biologically for the activation of sGC to generate the second messenger cGMP and the regulation of mitochondrial respiration at CcOx (9–16).”
From What Part of NO Don't You Understand? Some Answers to the Cardinal Questions in Nitric Oxide Biology (2010) · cites this paper as [9]
In the citing paper
“The high affinity and rapid binding to ferrous heme are important biologically for the activation of sGC to generate the second messenger cGMP and the regulation of mitochondrial respiration at CcOx (9–16).”
From What Part of NO Don't You Understand? Some Answers to the Cardinal Questions in Nitric Oxide Biology (2010) · cites this paper as [9]
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Self-citation
Metadata
- Authors
- Brookes, P. S., Levonen, A.-L., Shiva, S., Sarti, P., & Darley-Usmar, V. M.
- Affiliations
- University of Alabama at Birmingham (US)
- Sapienza University of Rome (IT)
- Corresponding author
- Darley-Usmar, Victor M.
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2002-09
- Volume
- 33
- Issue
- 6
- Pages
- 755-764
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W1748754899
- Cited by
- 298
- References
- 72
- Citations by year
- 2025: 2 · 2024: 5 · 2023: 1 · 2022: 6 · 2021: 1 · 2020: 3 · 2019: 9 · 2018: 9 · 2017: 10 · 2016: 12 · 2015: 14 · 2014: 13 · 2013: 13 · 2012: 21
- FWCI
- 7.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Funders
- American Heart Association
- National Institutes of Health (1r03aa012613-01)
- National Institute on Alcohol Abuse and Alcoholism (AA 12613)
- National Heart, Lung, and Blood Institute (R01HL058031, HL-58031)
- National Institute of Environmental Health Sciences (R01ES010167, ES-10167)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- mitochondria, signal transduction, reactive oxygen species, reactive nitrogen species, cytochrome c release, hydrogen peroxide, electron transport chain, nitric oxide, cytochrome c oxidase, mitochondrial signaling
- MeSH terms
- Adenosine Triphosphate, Animals, Cytochrome c Group, Electron Transport Complex IV, Free Radicals, Humans, Hydrogen Peroxide, Mitochondria, Models, Biological, Models, Chemical, Nitric Oxide, Oxidation-Reduction, Time Factors, Signal Transduction, Apoptosis, Reactive Oxygen Species, Reactive Nitrogen Species
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