Cited by 181Treatment of Major DepressionDementia and Cognitive Impairment ResearchNeural and Behavioral Psychology Studies

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Atrophy and High Intensity Lesions Complementary Neurobiological Mechanisms in Late-Life Major Depression

Kumar, A·2000·Neuropsychopharmacology

DOI 10.1016/s0893-133x(99)00124-4

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Abstract

The primary objective of our study was to examine the role of atrophy, high intensity lesions and medical comorbidity in the pathophysiology of major depressive disorder in the elderly (late-life MDD). Our sample was comprised of 51 patients with late-life MDD and 30 non-depressed controls. All subjects were scanned on 1.5 tesla magnetic resonance imaging scanner (MRI) and absolute and normalized measures of brain and lesion volumes were obtained and used for comparison between groups. Patients with MDD had significantly smaller frontal lobe volumes, together with larger whole brain lesion volumes when compared with controls (p < .05). Whole brain lesion volumes correlated significantly (r = 0.41, p = .006) with overall medical comorbidity. The odds ratio (OR) for existing MDD increases significantly with a decrease in frontal lobe volume and an increase in whole brain lesion volumes (p < .05). Our findings suggest that atrophy and high intensity lesions represent relatively independent pathways to late-life MDD. While medical disorders lead to neuropathological changes that are captured on MR imaging as high intensity signals, atrophy may represent a relatively autonomous phenomenon. These findings have broad implications for the pathophysiology of mood disorders and suggest that complementary neurobiological processes may lead to cumulative neuronal injury thereby predisposing to clinical depression.

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Data From the VITA Study Do Not Support the Concept of Vascular Depression
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Aging and brain activation with working memory tasks: an fMRI study of connectivity
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Age of onset of depression and quantitative neuroanatomic measures: absence of specific correlates
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Location of cerebrovascular and degenerative changes, depressive symptoms and cognitive functioning in later life: the SMART-Medea study
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Effects of antidepressive therapy on auditory processing in severely depressed patients: A combined MRS and MEG study
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Authors: Kumar, A.
Affiliations: University of California, Los Angeles (US)
Corresponding author: Kumar, A
Venue: Neuropsychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2000-03
Volume: 22
Issue: 3
Pages: 264-274
ISSN: 0893-133X (ISSN-L)
DOI: 10.1016/s0893-133x(99)00124-4
OpenAlex: W2004128631
Cited by: 181
References: 71
Citations by year: 2025: 3 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 4 · 2018: 3 · 2017: 6 · 2016: 1 · 2015: 3 · 2014: 5 · 2013: 9 · 2012: 9
FWCI: 8.21
Type: journal article
Language: en
Open access: closed
Locations: Neuropsychopharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (MH-52129, P30MH052129, MH-55115, R01MH055115)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: brain atrophy, comorbidities, frontal lobe volume, neurodegeneration, mood disorders, depression pathophysiology, older adults
MeSH terms: Aged, Atrophy, Brain, Depressive Disorder, Female, Humans, Magnetic Resonance Imaging, Male, Reference Values, Regression Analysis, Sex Characteristics, Age of Onset

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Atrophy and High Intensity Lesions Complementary Neurobiological Mechanisms in Late-Life Major Depression

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