Late-Life Depression and Microstructural Abnormalities in Dorsolateral Prefrontal Cortex White Matter
Abstract
OBJECTIVE: The purpose of this study was to determine whether microstructural abnormalities in the white matter of the dorsolateral prefrontal cortex are associated with late-life depression. METHOD: Seventeen elderly depressed subjects were compared with 16 elderly subjects who were not depressed. Diffusion tensor imaging was used to measure the fractional anisotropy of the white matter in the dorsolateral prefrontal cortex's superior and middle frontal gyri bilaterally and in the left occipital lobe as a control region. The authors compared results between groups while controlling for age, sex, and comorbid medical disorders. RESULTS: Even after controlling for age, sex, hypertension, and heart disease, the authors found significantly lower fractional anisotropy values in the right superior frontal gyrus white matter of depressed patients than comparison subjects. CONCLUSIONS: Microstructural changes in the white matter of the right superior frontal gyrus are associated with late-life depression. Further work is needed to determine how these changes contribute to depression outcomes.
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Previous studies using diffusion imaging have demonstrated reduced fractional anisotropy in ACC and prefrontal white matter generally in depressed subjects.
“Previous studies using diffusion imaging have demonstrated reduced fractional anisotropy in ACC and prefrontal white matter generally in depressed subjects (Taylor et al. 2004; Bae et al. 2006; Nobuhara et al. 2006); future studies using diffusion tractography should test the integrity of the specific tracts identified here in patients with mood disorders.”
From Anatomical connectivity of the subgenual cingulate region targeted with deep brain stimulation for treatment-resistant depression (2008) · cites this paper as Taylor et al. 2004
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- Authors
- Taylor, W. D., MacFall, J. R., Payne, M. E., McQuoid, D. R., Provenzale, J. M., Steffens, D. C., & Krishnan, K. R. R.
- Affiliations
- Duke Medical Center (US)
- Venue
- American Journal of Psychiatry
- Published
- 2004-07-01
- Volume
- 161
- Issue
- 7
- Pages
- 1293-1296
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2142902799
- Cited by
- 230
- References
- 35
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 1 · 2023: 4 · 2022: 4 · 2021: 3 · 2020: 5 · 2019: 5 · 2018: 7 · 2017: 7 · 2016: 6 · 2015: 7 · 2014: 15 · 2013: 19 · 2012: 26
- FWCI
- 11.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (K234 MH 65939, R01 MH-54846, R01MH054846, K23MH065939, P50MH60451, P50MH060451)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- geriatric depression, dorsolateral prefrontal cortex, white matter microstructure, fractional anisotropy, superior frontal gyrus, middle frontal gyrus
- MeSH terms
- Aged, Major Depressive Disorder, Depressive Disorder, Major, Female, Frontal Lobe, Heart Diseases, Humans, Hypertension, Image Processing, Computer-Assisted, Functional Laterality, Male, Middle Aged, Neural Pathways, Occipital Lobe, Psychiatric Status Rating Scales, Comorbidity, Anisotropy, Echo-Planar Imaging, Prefrontal Cortex, Diffusion Magnetic Resonance Imaging
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