Complementary use of tai chi chih augments escitalopram treatment of geriatric depression: a randomized controlled trial
Open accessAbstract
Background Nearly two-thirds of elderly patients treated for depression fail to achieve symptomatic remission and functional recovery with first-line pharmacotherapy. In this study, we ask whether a mind-body exercise, Tai Chi Chih (TCC), added to escitalopram will augment the treatment of geriatric depression designed to achieve symptomatic remission and improvements in health functioning and cognitive performance.Methods : One hundred twelve older adults with major depression age 60 years and older were recruited and treated with escitalopram for approximately 4 weeks. Seventy-three partial responders to escitalopram continued to receive escitalopram daily and were randomly assigned to 10 weeks of adjunct use of either 1) TCC for 2 hours per week or 2) health education (HE) for 2 hours per week. All participants underwent evaluations of depression, anxiety, resilience, health-related quality of life, cognition, and inflammation at baseline and during 14-week follow-up.Results Subjects in the escitalopram and TCC condition were more likely to show greater reduction of depressive symptoms and to achieve a depression remission as compared with those receiving escitalopram and HE. Subjects in the escitalopram and TCC condition also showed significantly greater improvements in 36-Item Short Form Health Survey physical functioning and cognitive tests and a decline in the inflammatory marker, C-reactive protein, compared with the control group.Conclusion : Complementary use of a mind-body exercise, such as TCC, may provide additional improvements of clinical outcomes in the pharmacologic treatment of geriatric depression.
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Adverse events were reported only by three trials.
“Adverse events were reported only by three trials [62,70,76].”
From The effects of exercise on sleep in unipolar depression: a systematic review and network meta-analysis (2021) · cites this paper as [70]
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- Authors
- Lavretsky, H., Alstein, L. L., Olmstead, R. E., Ercoli, L. M., Riparetti-Brown, M., St. Cyr, N., & Irwin, M. R.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Lavretsky, Helen
- Venue
- The American Journal of Geriatric Psychiatry
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 19
- Issue
- 10
- Pages
- 839-850
- ISSN
- 1064-7481 (ISSN-L)
- PMC
- PMC3136557
- OpenAlex
- W2001281470
- Cited by
- 268
- References
- 71
- Citations by year
- 2026: 22 · 2025: 21 · 2024: 21 · 2023: 14 · 2022: 15 · 2021: 27 · 2020: 18 · 2019: 13 · 2018: 19 · 2017: 15 · 2016: 6 · 2015: 22 · 2014: 19 · 2013: 22 · 2012: 9
- FWCI
- 12.89
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Geriatric Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (1ul1rr033176-01, UL1TR000124)
- National Institute on Aging (AG 026364, R01AG026364, P30AG028748)
- National Heart, Lung, and Blood Institute (HL 079955, R01HL079955)
- National Institute of Mental Health (K24MH086481, R01MH077650, T32MH019925, MH077650, MH86481, T32 MH 19925)
- National Cancer Institute (R01CA116778, CA-10014152, CA-116778)
- National Center for Research Resources (UL1-RR-033176, RR00827, M01RR000827)
- National Center for Advancing Translational Sciences
- National Center for Complementary and Integrative Health (AT003480, R21AT003480)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Keywords
- geriatric depression, escitalopram, mind-body exercise, complementary therapy, antidepressant augmentation, health education, depression remission, cognitive function, physical function, health-related quality of life, C-reactive protein, inflammation, resilience, older adults
- MeSH terms
- Aged, Anxiety, C-Reactive Protein, Cognition, Combined Modality Therapy, Major Depressive Disorder, Female, Health Education, Humans, Male, Psychiatric Status Rating Scales, Quality of Life, Severity of Illness Index, Citalopram, Tai Ji, Resilience, Psychological
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