The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Defining clinically meaningful change in health-related quality of life
Abstract
This article reviews current approaches to defining clinically meaningful change in health-related quality of life (HRQOL) and provides guidelines for their use. Definitions of clinically meaningful change are discussed. Two broad methods for identifying clinically meaningful change are contrasted: anchor-based methods and distribution-based methods. Anchor-based methods include cross-sectional approaches and longitudinal approaches. Distribution-based methods include those based on statistical significance, sample variability, and measurement precision. Anchor-based and distribution-based methods have advantages and limitations, and neither seems to be superior to the other. An integrated system for defining clinically meaningful change is recommended that combines anchor-based and distribution-based methods. We propose a new terminology for describing meaningful change derived from anchor-based and distribution-based methods.
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Citations
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Cited by
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Metadata
- Authors
- Crosby, R. D., Kolotkin, R. L., & Williams, G. R.
- Venue
- Journal of Clinical Epidemiology
- Publisher
- Elsevier BV
- Published
- 2003-05
- Volume
- 56
- Issue
- 5
- Pages
- 395-407
- ISSN
- 0895-4356 (ISSN-L)
- OpenAlex
- W2078378191
- Cited by
- 1,332
- References
- 15
- FWCI
- 61.24
- Type
- journal article
- Language
- en
- Open access
- closed
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