Antihypertensive effect of Nori-peptides derived from red alga porphyra yezoensis in hypertensive patients
Abstract
Nori-peptides have a potent angiotensin I converting enzyme (ACE) inhibitory activity. It has been fractionated from red alga porphyrayezoensis(Nori) by using iron-exchange and gel-filtration. Previous report showed that amino acid sequences of ACE inhibitory Nori-peptides were Ile-Tyr, Met-Lys-Tyr, Ala-Lys-Thy-Ser-Thyr, and Leu-Arg-Tyr, and 200mg/kg of Nori-peptides induced a significant blood pressure reduction in spontaneously hypertensive rats (Suetuna K. J Mar Biotechnol 1998; 6:163–167). We examined the efficacy and safety of Nori-peptides in humans. The subjects enrolled in this study were 64 hypertensive patients (36 men and 28 women, 59.9±2.0 years) and 29 normotensive subjects (15 men and 14 women, 51.9±3.6 years). Nori-peptides 1.8g/day was administered and change of blood pressure was followed for 35 days. Nori-peptide induced a significant blood pressure reduction in hypertensive patients (157.9±14.4/95.1±11.1 to 142.3±16.0/86.8±10.2 mmHg, p<0.001), but did not showed a significant depressor effect in normotensive Subjects (121.1±10.5/80.2 to 118.0 ±15.0/76.6±9.4 mmHg). There was no significant changes in clinical laboratory findings included blood count, serum creatinine, electrolyte, liver function test or blood glucose. It can be concluded that Nori-peptides have a significant antihypertensive effect in hypertensive patients as well as spontaneously hypertensive rats.
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Seaweed-derived peptides from Undaria pinnatifida, Neopyropia yezoensis, Ulva rigida, and Ulva clathrata have shown ACE inhibitory activity.
“Among seaweed-derived peptides, species such as Undaria pinnatifida (Phaeophyceae), Neopyropia yezoensis (formerly Porphyra yezoensis) (Rhodophyta), Ulva rigida, and Ulva clathrata (formerly Enteromorpha clathrata) have shown ACE inhibitory activity [53–57].”
From Navigating the potential of algal peptides: health effects, market applications, and scientific challenges (2026) · cites this paper as [56]
Enzymatically derived nori peptides reduced blood pressure in hypertensive patients without affecting normotensive individuals.
“while enzymatically derived nori peptides reduced blood pressure in hypertensive patients without affecting normotensive individuals [56].”
From Navigating the potential of algal peptides: health effects, market applications, and scientific challenges (2026) · cites this paper as [56]
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- Authors
- SAITO, M.
- Corresponding author
- SAITO, M
- Venue
- American Journal of Hypertension
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-04
- Volume
- 15
- Issue
- 4
- Pages
- A210
- ISSN
- 0895-7061 (ISSN-L)
- OpenAlex
- W2032139220
- Cited by
- 22
- References
- 0
- Citations by year
- 2026: 5 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 3 · 2018: 1 · 2013: 1 · 2012: 2
- FWCI
- 0.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Hypertension (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Hydrolysis and Bioactive Peptides
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- Porphyra yezoensis, red algae, antihypertensive effect, angiotensin-converting enzyme inhibition, blood pressure reduction, hypertensive patients, safety, amino acid sequence, dietary peptides
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