Overview on the Antihypertensive and Anti-Obesity Effects of Secondary Metabolites from Seaweeds

Seca, Ana M. L.; Pinto, Diana C. G. A.

doi:10.3390/md16070237

Cited by 123Seaweed-derived Bioactive CompoundsMarine and coastal plant biologyEchinoderm biology and ecology

Overview on the Antihypertensive and Anti-Obesity Effects of Secondary Metabolites from Seaweeds

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Seca, Ana M. L., Pinto, Diana C. G. A.·2018·Marine Drugs

DOI 10.3390/md16070237PMC PMC6070913

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Abstract

Hypertension and obesity are two significant factors that contribute to the onset and exacerbation of a cascade of mechanisms including activation of the sympathetic and renin-angiotensin systems, oxidative stress, release of inflammatory mediators, increase of adipogenesis and thus promotion of systemic dysfunction that leads to clinical manifestations of cardiovascular diseases. Seaweeds, in addition to their use as food, are now unanimously acknowledged as an invaluable source of new natural products that may hold noteworthy leads for future drug discovery and development, including in the prevention and/or treatment of the cardiovascular risk factors. Several compounds including peptides, phlorotannins, polysaccharides, carotenoids, and sterols, isolated from brown, red and green macroalgae exhibit significant anti-hypertensive and anti-obesity properties. This review will provide a comprehensive overview of the recent advances on bioactive pure compounds isolated from different seaweed sources focusing on their potential use as drugs to treat or prevent hypertension and obesity. On the other hand, although it is obvious that macroalgae represent promising sources of antihypertensive and anti-obesity compounds, it is also clear that further efforts are required to fully understand their cellular mechanisms of action, to establish structure-inhibition relationships and mainly to evaluate them in pre-clinical and clinical trials.

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Seaweed-derived peptides from Undaria pinnatifida, Neopyropia yezoensis, Ulva rigida, and Ulva clathrata have shown ACE inhibitory activity.
“Among seaweed-derived peptides, species such as Undaria pinnatifida (Phaeophyceae), Neopyropia yezoensis (formerly Porphyra yezoensis) (Rhodophyta), Ulva rigida, and Ulva clathrata (formerly Enteromorpha clathrata) have shown ACE inhibitory activity [53–57].”
From Navigating the potential of algal peptides: health effects, market applications, and scientific challenges (2026) · cites this paper as [54]
Section 2.1 reports ACE I-inhibitory peptides from Undaria pinnatifida, Porphyra yezoensis (listed there as Pyropia yezoensis), and Ulva rigida. It also reports an inhibitory peptide attributed to Enteromorpha clathrata, but explicitly says that seaweed was not properly identified and only notes a suggested equivalence between Enteromorpha and Ulva. The source therefore does not firmly establish the claim for Ulva clathrata. (LLM, conf=0.85)
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Ko, S., Kang, M. C., Kang, N., Kim, H.-S., Lee, S., Ahn, G., Jung, W., & Jeon, Y. (2017) · Process Biochemistry · doi:10.1016/j.procbio.2017.04.014 · Cited by 41 · see citing works
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Antihypertensive Effect of Oligopeptides Derived from Nori (Porphyra yezoensis) and Ala-Lys-Tyr-Ser-Tyr in Rats
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Anti-obesity effects of enzymatically-digested alginate oligomer in mice model fed a high-fat-diet
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“Porphyra yezoensis), called Nori-peptides, have proven their potent ACE I inhibitory activity in rats [37] and even when tested in humans [38].”
Influential
Xanthigen attenuates high-fat diet-induced obesity through down-regulation of PPARγ and activation of the AMPK pathway
Choi, K.-M., Jeon, Y. S., Kim, W., Lee, A., Kim, Y., Lee, J. H., Kang, Y. E., Jung, J., Lee, J., Min, B., et al. (2014) · Food Science and Biotechnology · doi:10.1007/s10068-014-0125-1 · Cited by 17 · see citing works
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Global seaweed farming and processing in the past 20 years
Zhang, L., Liao, W., Huang, Y., Wen, Y., Chu, Y., & Zhao, C. (2022) · Food Production Processing and Nutrition · doi:10.1186/s43014-022-00103-2 · Cited by 199 · see citing works
Potential Use of Marine Seaweeds as Prebiotics: A Review
López-Santamarina, A., Miranda, J. M., Mondragón, A. D. C., Lamas, A., Cardelle‐Cobas, A., Franco, C. M., & Cepeda, A. (2020) · Molecules · doi:10.3390/molecules25041004 · Cited by 162 · see citing works
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Seaweed Secondary Metabolites with Beneficial Health Effects: An Overview of Successes in In Vivo Studies and Clinical Trials
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Seaweed-Derived Proteins and Peptides: Promising Marine Bioactives
Echave, J., Otero, P., Garcia‐Oliveira, P., Munekata, P. E. S., Pateiro, M., Lorenzo, J. M., Simal‐Gándara, J., & Prieto, M. A. (2022) · Antioxidants · doi:10.3390/antiox11010176 · Cited by 143 · see citing works
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Nutraceutical characteristics of the brown seaweed carotenoid fucoxanthin
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Seaweed Secondary Metabolites In Vitro and In Vivo Anticancer Activity
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Red seaweed proteins: Valuable marine-origin compounds with encouraging applications
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Variation in Lipid Components from 15 Species of Tropical and Temperate Seaweeds
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Bensy, A. D. V., Christobel, G. J., Muthusamy, K., Alfarhan, A., & Anantharaman, P. (2022) · Journal of King Saud University - Science · doi:10.1016/j.jksus.2022.101888 · Cited by 59 · see citing works
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Marine pharmacology in 2018: Marine compounds with antibacterial, antidiabetic, antifungal, anti-inflammatory, antiprotozoal, antituberculosis and antiviral activities; affecting the immune and nervous systems, and other miscellaneous mechanisms of action
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Therapeutic Potential of Seaweed-Derived Bioactive Compounds for Cardiovascular Disease Treatment
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Amino Acid Imprinted UiO-66s for Highly Recognized Adsorption of Small Angiotensin-Converting-Enzyme-Inhibitory Peptides
Liu, L., Qiao, Z., Cui, X., Pang, C., Liang, H., Xie, P., Luo, X., Huang, Z., Zhang, Y., & Zhao, Z. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b07453 · Cited by 44 · see citing works
Red and brown seaweeds extracts: A source of biologically active compounds
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Potential Anti-Aging Substances Derived from Seaweeds
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Pyrogallol-Phloroglucinol-6,6’-Bieckol from Ecklonia cava Improved Blood Circulation in Diet-Induced Obese and Diet-Induced Hypertension Mouse Models
Son, M., Oh, S., Lee, H. S., Ryu, B., Jiang, Y., Jang, J. T., Jeon, Y., & Byun, K. (2019) · Marine Drugs · doi:10.3390/md17050272 · Cited by 36 · see citing works
Anti-Obesity Effects of Macroalgae
Gómez‐Zorita, S., González-Arceo, M., Trepiana, J., Eseberri, I., Fernández‐Quintela, A., Milton‐Laskibar, I., Aguirre, L., González, M. A., & Portillo, M. P. (2020) · Nutrients · doi:10.3390/nu12082378 · Cited by 36 · see citing works
Identification of Bioactive Peptides from a Laminaria digitata Protein Hydrolysate Using In Silico and In Vitro Methods to Identify Angiotensin-1-Converting Enzyme (ACE-1) Inhibitory Peptides
Purcell, D., Packer, M. A., & Hayes, M. (2023) · Marine Drugs · doi:10.3390/md21020090 · Cited by 36 · see citing works
Twice daily oral administration of Palmaria palmata protein hydrolysate reduces food intake in streptozotocin induced diabetic mice, improving glycaemic control and lipid profiles
McLaughlin, C. M., Sharkey, S. J., Harnedy‐Rothwell, P. A., Parthsarathy, V., Allsopp, P. J., McSorley, E. M., Fitzgerald, R. J., & O'Harte, F. P. M. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104101 · Cited by 32 · see citing works
Advances in oligosaccharides production from brown seaweeds: extraction, characterization, antimetabolic syndrome, and other potential applications
Perumal, P. K., Huang, C.-Y., Chen, C., Anisha, G. S., Singhania, R. R., Dong, C., & Patel, A. K. (2023) · Bioengineered · doi:10.1080/21655979.2023.2252659 · Cited by 31 · see citing works
Nordic Seaweed and Diabetes Prevention: Exploratory Studies in KK-Ay Mice
Sørensen, L. E., Jeppesen, P. B., Christiansen, C., Hermansen, K., & Gregersen, S. (2019) · Nutrients · doi:10.3390/nu11061435 · Cited by 30 · see citing works
Angiotensin-I-Converting Enzyme Inhibitory Activity of Protein Hydrolysates Generated from the Macroalga Laminaria digitata (Hudson) JV Lamouroux 1813
Purcell, D., Packer, M. A., & Hayes, M. (2022) · Foods · doi:10.3390/foods11121792 · Cited by 30 · see citing works
Aqueous–ethanol extracts of some South African seaweeds inhibit beta‐amyloid aggregation, cholinesterases, and beta‐secretase activities in vitro
Olasehinde, T. A., Olaniran, A. O., & Okoh, A. I. (2019) · Journal of Food Biochemistry · doi:10.1111/jfbc.12870 · Cited by 28 · see citing works
Fucoxanthin attenuates behavior deficits and neuroinflammatory response in 1-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine-induced parkinson's disease in mice
Pang, Q., Sun, G., Xin, T., Zhang, R., & Liu, C. (2020) · Pharmacognosy Magazine · doi:10.4103/pm.pm_318_19 · Cited by 28 · see citing works
Therapeutic Effect of Seaweed Derived Xanthophyl Carotenoid on Obesity Management; Overview of the Last Decade
Ojulari, O. V., Lee, S. G., & Nam, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072502 · Cited by 32 · see citing works
pH-Dependent Extraction of Antioxidant Peptides from Red Seaweed Palmaria palmata: A Sequential Approach
Ghelichi, S., Sørensen, A. M., Náthia-Neves, G., & Jacobsen, C. (2024) · Marine Drugs · doi:10.3390/md22090413 · Cited by 27 · see citing works
Effects of brown seaweed polyphenols, a class of phlorotannins, on metabolic disorders via regulation of fat function
Chen, L., Liu, R., He, X., Pei, S., & Li, D. (2021) · Food & Function · doi:10.1039/d0fo02886j · Cited by 27 · see citing works
Seaweeds: Bioactive Components and Properties, Potential Risk Factors, Uses, Extraction and Purification Methods
Amlani, M. Q., & Yetgın, S. (2022) · Marine Science and Technology Bulletin · doi:10.33714/masteb.1021121 · Cited by 26 · see citing works
Effect of Dietary Nori (Dried Laver) on Blood Pressure in Young Japanese Children: An Intervention Study
Wada, K., Tsuji, M., Nakamura, K., Oba, S., Nishizawa, S., Yamamoto, K., Watanabe, K., Ando, K., & Nagata, C. (2020) · Journal of Epidemiology · doi:10.2188/jea.je20190176 · Cited by 25 · see citing works
Prevention of cardiovascular disease through modulation of endothelial cell function by dietary seaweed intake
Yamagata, K. (2021) · Phytomedicine Plus · doi:10.1016/j.phyplu.2021.100026 · Cited by 24 · see citing works
Challenges to the future domestication of seaweeds as cultivated species: understanding their physiological processes for large-scale production
Hayashi, L., Cantarino, S. D. J., & Critchley, A. T. (2019) · Advances in botanical research · doi:10.1016/bs.abr.2019.11.010 · Cited by 24 · see citing works
Ecklonia cava Extract and Its Derivative Dieckol Promote Vasodilation by Modulating Calcium Signaling and PI3K/AKT/eNOS Pathway in In Vitro and In Vivo Models
Lu, Y., Je, J.-G., Hwang, J., Jeon, Y., & Ryu, B. (2021) · Biomedicines · doi:10.3390/biomedicines9040438 · Cited by 23 · see citing works
Mitochondrial Damage in Myocardial Ischemia/Reperfusion Injury and Application of Natural Plant Products
Su, X., Zhou, M., Li, Y., An, N., Yang, F., Zhang, G., Xu, L., Chen, H., Wu, H., & Xing, Y. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/8726564 · Cited by 24 · see citing works
The bioactivities and biotechnological production approaches of carotenoids derived from microalgae and cyanobacteria
Huang, J. J., Xu, W., Lin, S., & Cheung, P. C. K. (2024) · Critical Reviews in Biotechnology · doi:10.1080/07388551.2024.2359966 · Cited by 23 · see citing works
Anti-glycation effects of brown algae extracts and its phenolic compounds
Park, J. J., & Lee, W. (2021) · Food Bioscience · doi:10.1016/j.fbio.2021.101042 · Cited by 21 · see citing works
Chemical space and diversity of seaweed metabolite database (SWMD): A cheminformatics study
Sharie, A. H. A., El‐Elimat, T., Zu’bi, Y. O. A., Aleshawi, A. J., & Medina‐Franco, J. L. (2020) · Journal of Molecular Graphics and Modelling · doi:10.1016/j.jmgm.2020.107702 · Cited by 20 · see citing works
Algal proteins for sustainable nutrition and functional food innovation
Saeed, F., Tul Zohra, K., Naveed, K., Zia, A., Khaliq, M., Noor, Z., Khaliq, K., & Ali, M. A. (2025) · Applied Food Research · doi:10.1016/j.afres.2025.100752 · Cited by 19 · see citing works
Potentials of food-derived peptides as novel antihypertensive agents and their acting mechanisms
Guo, R.-X., & Liang, S. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.146183 · Cited by 19 · see citing works
Durvillaea antarctica: A Seaweed for Enhancing Immune and Cardiometabolic Health and Gut Microbiota Composition Modulation
Guerrero‐Wyss, M., Yans, C., Boscan, A., Durán, P., Parra-Soto, S. L., & Angarita, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310779 · Cited by 19 · see citing works
Advances in the Study of Marine Products with Lipid-Lowering Properties
Zhao, J., Cao, Q., Xing, M., Han, X., Cheng, Z., Song, S., & Ji, A. (2020) · Marine Drugs · doi:10.3390/md18080390 · Cited by 18 · see citing works
Molecular Mechanisms of the Anti-obesity Properties of Agardhiella subulata in Mice Fed a High-Fat Diet
Hsiao, Y., Wang, Y., Lin, W., Cheng, Y.-C., Nagabhushanam, K., Ho, C., & Pan, M. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c01117 · Cited by 17 · see citing works
Effect of Deployment and Harvest Date on Growth and High-Value Compounds of Farmed Alaria esculenta
Blanco, S., Sapatinha, M., Mackey, M., Maguire, J., Paolacci, S., Gonçalves, S., Lourenço, H. M., Mendes, R. O., Bandarra, N. M., & Pires, C. (2023) · Marine Drugs · doi:10.3390/md21050305 · Cited by 18 · see citing works
Advanced Pharmacological Uses of Marine Algae as an Anti-Diabetic Therapy
Gunathilaka, M. D. T. L., Keertihirathna, L. R., & Peiris, L. D. C. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.96807 · Cited by 16 · see citing works
Recent advances in the extraction, purification, structural-property correlations, and antiobesity mechanism of traditional Chinese medicine-derived polysaccharides: a review
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Potential Prebiotic and Anti-Obesity Effects of Codium fragile Extract
Oh, S. W., Kim, S., Jung, K.-J., Pham, T. N. A., Yang, S. H., & Ahn, B.-J. (2022) · Applied Sciences · doi:10.3390/app12030959 · Cited by 12 · see citing works
Novel Therapeutic Approach for Obesity: Seaweeds as an Alternative Medicine with the Latest Conventional Therapy
Yadav, R., Nigam, A., Mishra, R., Gupta, S. K., Chaudhary, A. A., Khan, S.-U.-D., Almuqri, E. A., Ahmed, Z. H., Rustagi, S., Singh, D. P., et al. (2024) · Medical Sciences · doi:10.3390/medsci12040055 · Cited by 12 · see citing works
Production and Characterization of Durvillaea antarctica Enzyme Extract for Antioxidant and Anti-Metabolic Syndrome Effects
Shih, M., Hou, C., Dong, C., Patel, A. K., Tsai, Y., Lin, M., Xu, Z.-Y., Perumal, P. K., Kuo, C., & Huang, C.-Y. (2022) · Catalysts · doi:10.3390/catal12101284 · Cited by 12 · see citing works
Impact of Seaweed-derived Xanthophyll Carotenoid on Obesity Management: Overview of the Last DecadePreprint
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Combined Potential of Orlistat with Natural Sources and Their Bioactive Compounds Against Obesity: A Review
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Exploring a New Natural Treating Agent for Primary Hypertension: Recent Findings and Forthcoming Perspectives
Lin, S., Lin, S., Chen, C.-C., Fu, Y., & Weng, C. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8112003 · Cited by 11 · see citing works
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Ivane, N. M. A., Ozoh, C. F., & Michelle, D. T. F. (2025) · Aquaculture International · doi:10.1007/s10499-025-01844-w · Cited by 8 · see citing works
Canary Seed (Phalaris canariensis L.) Peptides Prevent Obesity and Glucose Intolerance in Mice Fed a Western Diet
Urbizo-Reyes, U., Liceaga, A. M., Reddivari, L., Li, S., Kim, K., Cox, A. D., & Anderson, J. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314927 · Cited by 8 · see citing works
Nutraceutical Properties of Seaweed Vitamins
Pathan, A. S., Mahajan, M. M., Jain, P. G., Zambad, S. P., Bhandari, G. S., Darak, A., Ahire, E. D., Rajora, A. K., & Surana, K. R. (2023) · doi:10.1002/9781394175543.ch7 · Cited by 8 · see citing works
Protein dan Asam Amino pada Edible Sargassum aquifolium, Ulva lactuca, dan Gracilariopsis longissima
Pratiwi, A. R., Fadlilah, I., Ananingsih, V. K., & Meiliana, M. (2021) · Jurnal Pengolahan Hasil Perikanan Indonesia · doi:10.17844/jphpi.v24i3.37085 · Cited by 7 · see citing works
Evaluation of Pretreatment and GABA Production Using Levilactobacillus brevis Fermentation of the Seaweed Saccharina japonica
Lee, S. Y., & Ra, C. H. (2023) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-023-0073-9 · Cited by 7 · see citing works
In-silico study of seaweed secondary metabolites as AXL kinase inhibitors
Nagamalla, L., Kumar, J. V. S., Chintakindi, S., Al-Samhan, A. M., & Shaik, M. R. (2021) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2021.11.054 · Cited by 7 · see citing works
Revolutionizing Diabetes Care: The Role of Marine Bioactive Compounds and Microorganisms
Reddy, K. T. K., Rakesh, K., Prathyusha, S., Gupta, J. K., Nagasree, K., Ravikumar, L., Elumalai, S., Prasad, P. D., & Kolli, D. (2024) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-024-01508-1 · Cited by 7 · see citing works
Secret heroes of the sea: brown macroalgae and their bioactive powers—a narrative review
Başak, C. A. N., & Şanlıer, N. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1766041 · Cited by 6 · see citing works
Effect of Macro and Microalgae Addition on Nutritional, Physicochemical, Sensorial, and Functional Properties of a Vegetable Cream
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Authors: Seca, A. M. L., & Pinto, D. C. G. A.
Affiliations: Universidade dos Açores (PT)
University of Aveiro (PT)
Corresponding author: Seca, Ana M. L.
ORCID: Seca, Ana M. L.
Pinto, Diana C. G. A.
Venue: Marine Drugs
Publisher: MDPI AG
Published: 2018-07-14
Volume: 16
Issue: 7
Pages: 237
ISSN: 1660-3397 (ISSN-L)
DOI: 10.3390/md16070237
PMC: PMC6070913
OpenAlex: W2885018850
Cited by: 123
References: 101
Citations by year: 2026: 11 · 2025: 15 · 2024: 13 · 2023: 12 · 2022: 22 · 2021: 13 · 2020: 23 · 2019: 13 · 2018: 1
FWCI: 1.17
Type: journal article
Language: en
Open access: gold
dx.doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Marine Drugs (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Fundação para a Ciência e a Tecnologia (UID/QUI/00062/2013, UID/BIA/00329/2013)
Topics: Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
Physical Sciences › Earth and Planetary Sciences › Oceanography › Marine and coastal plant biology
Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Echinoderm biology and ecology
Keywords: seaweed, antihypertensive compounds, anti-obesity compounds, hypertension, obesity, phlorotannins, seaweed polysaccharides, carotenoids, sterols, cardiovascular disease prevention, renin-angiotensin system, adipogenesis, drug discovery
MeSH terms: Antihypertensive Agents, Carotenoids, Humans, Hypertension, Obesity, Peptides, Polysaccharides, Renin-Angiotensin System, Seaweed, Sterols, Structure-Activity Relationship, Oxidative Stress, Anti-Obesity Agents, Adipogenesis, Drug Discovery

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Overview on the Antihypertensive and Anti-Obesity Effects of Secondary Metabolites from Seaweeds

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