The effect of weight loss intervention on antihypertensive medication requirements in the hypertension optimal treatment (HOT) study
Abstract
Obesity is a significant risk factor for hypertension and the cardiovascular sequelae of hypertension. Weight loss has been shown to be effective in lowering blood pressure in overweight individuals. The purpose of this study was to show the impact of a weight loss intervention on overall medication requirements for obese, hypertensive patients. This was a substudy of the Hypertension Optimal Treatment (HOT) study. HOT study patients who had a body mass index > or =27 kg/m2 were randomized to receive either the weight loss intervention, which included dietary counseling and group support, or to serve as the control group. Patients' weights and number of medication steps (per HOT protocol) required to achieve target diastolic blood pressure were measured at 3, 6, 12, 18, 24, and 30 months. Patients in the weight loss group lost significantly more weight than the control group only at 6 months (-3.2+/-4.3 v. -1.8+/-2.7 kg [mean +/- SD] for weight loss group versus control, respectively, P = .05). The weight loss group tended to regain weight after the first 6 months of the study. However, patients in the weight loss group used a significantly fewer number of medication steps than the control group at all time intervals except 3 months. Weight loss appears to be a useful tool in blood pressure management in patients who require medication to control their blood pressure.
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Clinical studies indicate that maintenance of a BMI < 25 kg/m2 is effective in primary prevention of hypertension and that weight loss reduces BP in most hypertensive subjects.
“Clinical studies indicate that maintenance of a BMI < 25 kg/m2 is effective in primary prevention of hypertension and that weight loss reduces BP in most hypertensive subjects8,9.”
From Obesity-Induced Hypertension: Interaction of Neurohumoral and Renal Mechanisms (2015) · cites this paper as [8]
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- Authors
- Jones, D.
- Affiliations
- University of Mississippi Medical Center (US)
- Corresponding author
- Jones, D
- ORCID
- Jones, D
- Venue
- American Journal of Hypertension
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-12
- Volume
- 12
- Issue
- 12
- Pages
- 1175-1180
- ISSN
- 0895-7061 (ISSN-L)
- OpenAlex
- W2080953758
- Cited by
- 89
- References
- 16
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 6 · 2023: 2 · 2022: 5 · 2021: 6 · 2020: 4 · 2019: 2 · 2018: 5 · 2017: 3 · 2016: 3 · 2015: 5 · 2014: 1 · 2013: 2 · 2012: 2
- FWCI
- 2.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Hypertension (publishedVersion)
- PubMed (publishedVersion)
- DigitalCommons-Cedarville (Cedarville University) (submittedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- weight loss interventions, hypertension, obesity, overweight, nutrition counseling, group support, weight regain, blood pressure control, body mass index
- MeSH terms
- Adrenergic beta-Antagonists, Angiotensin-Converting Enzyme Inhibitors, Antihypertensive Agents, Blood Pressure, Calcium Channel Blockers, Diet, Drug Therapy, Combination, Enalapril, Female, Humans, Hypertension, Male, Metoprolol, Middle Aged, Obesity, Risk Factors, Weight Loss, Felodipine, Body Mass Index, Treatment Outcome, Disease Progression
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