The DOI matches its Crossref record; 105 of the 105 references it cites were found in a registry or an index.
Molecular Characterization of Schizophrenia Viewed by Microarray Analysis of Gene Expression in Prefrontal Cortex
Open accessAbstract
Microarray expression profiling of prefrontal cortex from matched pairs of schizophrenic and control subjects and hierarchical data analysis revealed that transcripts encoding proteins involved in the regulation of presynaptic function (PSYN) were decreased in all subjects with schizophrenia. Genes of the PSYN group showed a different combination of decreased expression across subjects. Over 250 other gene groups did not show altered expression. Selected PSYN microarray observations were verified by in situ hybridization. Two of the most consistently changed transcripts in the PSYN functional gene group, N-ethylmaleimide sensitive factor and synapsin II, were decreased in ten of ten and nine of ten subjects with schizophrenia, respectively. The combined data suggest that subjects with schizophrenia share a common abnormality in presynaptic function. We set forth a predictive, testable model.
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“Our observation that the degree of correlation between pathways across disorders is higher than expected by chance builds on the observation of shared genetics between these disorders4 and, importantly, indicates that polygenic overlap is nonrandom at a molecular or pathway level.”
From Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways (2015) · cites this paper as [4]
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Research works printed but not linked: 3
- Lewis, 2000, Catching up with schizophrenia, Neuron, in press
- Volk, 2000, Decreased GAD67 mRNA expression in a subset of prefrontal cortical GABA neurons in schizophrenia, Arch. Gen. Psychiatry, in press
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Cortical inhibitory neurons and schizophrenia
Lewis, D. A., Hashimoto, T., & Volk, D. W. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1648 · Cited by 2,297
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Metadata
- Authors
- Mirnics, K., Middleton, F. A., Marquez, A., Lewis, D. A., & Levitt, P.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Mirnics, Károly
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2000-10
- Volume
- 28
- Issue
- 1
- Pages
- 53-67
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2032208151
- Cited by
- 882
- References
- 105
- Citations by year
- 2026: 5 · 2025: 1 · 2024: 3 · 2023: 7 · 2022: 8 · 2021: 11 · 2020: 10 · 2019: 13 · 2018: 16 · 2017: 14 · 2016: 19 · 2015: 32 · 2014: 19 · 2013: 29 · 2012: 37
- FWCI
- 48.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (T32 MH18273, MH 45156, T32MH018273, P50MH045156)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- schizophrenia, prefrontal cortex, gene expression profiling, presynaptic function, N-ethylmaleimide-sensitive factor, synapsin II, transcriptome
- MeSH terms
- Animals, Carrier Proteins, Female, Humans, Macaca fascicularis, Male, Middle Aged, Synaptic Transmission, RNA, Messenger, Schizophrenia, Synapses, Antipsychotic Agents, Genetic Variation, Gene Expression, Confounding Factors, Epidemiologic, Synapsins, Prefrontal Cortex, In Situ Hybridization, Presynaptic Terminals, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Vesicular Transport Proteins, N-Ethylmaleimide-Sensitive Proteins
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