Cited by 882Schizophrenia research and treatmentNeuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

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Molecular Characterization of Schizophrenia Viewed by Microarray Analysis of Gene Expression in Prefrontal Cortex

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Mirnics, Károly, Middleton, Frank A., Marquez, Adriana, Lewis, David A., Levitt, Pat·2000·Neuron

DOI 10.1016/s0896-6273(00)00085-4

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Abstract

Microarray expression profiling of prefrontal cortex from matched pairs of schizophrenic and control subjects and hierarchical data analysis revealed that transcripts encoding proteins involved in the regulation of presynaptic function (PSYN) were decreased in all subjects with schizophrenia. Genes of the PSYN group showed a different combination of decreased expression across subjects. Over 250 other gene groups did not show altered expression. Selected PSYN microarray observations were verified by in situ hybridization. Two of the most consistently changed transcripts in the PSYN functional gene group, N-ethylmaleimide sensitive factor and synapsin II, were decreased in ten of ten and nine of ten subjects with schizophrenia, respectively. The combined data suggest that subjects with schizophrenia share a common abnormality in presynaptic function. We set forth a predictive, testable model.

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Alizadeh, A. A., Eisen, M. B., Davis, R. E., Ma, C., Lossos, I. S., Rosenwald, A., Boldrick, J. C., Sabet, H., Tran, T., Yu, X., et al. (2000) · Nature · doi:10.1038/35000501 · Cited by 9,925
Self-citation
Synaptic density in human frontal cortex —Developmental changes and effects of aging
Peter R., H. (1979) · Brain Research · doi:10.1016/0006-8993(79)90349-4 · Cited by 2,645
Exploring the new world of the genome with DNA microarrays
Brown, P. O., & Botstein, D. (1999) · Nature Genetics · doi:10.1038/4462 · Cited by 2,430
Physiologic Dysfunction of Dorsolateral Prefrontal Cortex in Schizophrenia
Weinberger, D. R. (1986) · Archives of General Psychiatry · doi:10.1001/archpsyc.1986.01800020020004 · Cited by 2,025
The synaptic vesicle cycle: a cascade of protein–protein interactions
Südhof, T. C. (1995) · Nature · doi:10.1038/375645a0 · Cited by 1,991
Searching for genetic determinants in the new millennium
Risch, N. J. (2000) · Nature · doi:10.1038/35015718 · Cited by 1,839
The neuropathology of schizophrenia
Harrison, P. J. (1999) · Brain · doi:10.1093/brain/122.4.593 · Cited by 1,677
Expression profiling using cDNA microarrays
Duggan, D. J., Bittner, M. L., Chen, Y., Meltzer, P. S., & Trent, J. M. (1999) · Nature Genetics · doi:10.1038/4434 · Cited by 1,660
Decreased Dendritic Spine Density on Prefrontal Cortical Pyramidal Neurons in Schizophrenia
Glantz, L. A., & Lewis, D. A. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.1.65 · Cited by 1,636
Self-citation

Show all 105 references

Research works printed but not linked: 3

Lewis, 2000, Catching up with schizophrenia, Neuron, in press
Volk, 2000, Decreased GAD67 mRNA expression in a subset of prefrontal cortical GABA neurons in schizophrenia, Arch. Gen. Psychiatry, in press
Weinberger, 1999, Schizophrenia, Biol. Psychiatry, 46, 3

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Kerns, R. T., Ravindranathan, A., Hassan, S., Cage, M. P., York, T., Sikela, J. M., Williams, R. W., & Miles, M. F. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4372-04.2005 · Cited by 232
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Siegert, S., Seo, J., Kwon, E. J., Rudenko, A., Cho, S., Wang, W., Flood, Z., Martorell, A. J., Ericsson, M., Mungenast, A. E., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4023 · Cited by 221
Variations in myelin and oligodendrocyte-related gene expression across multiple brain regions in schizophrenia: A gene ontology study
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Consistent gene signature of schizophrenia identified by a novel feature selection strategy from comprehensive sets of transcriptomic data
Yang, Q., Li, B., Tang, J., Cui, X., Wang, Y., Li, X., Hu, J., Chen, Y., Xue, W., Lou, Y., et al. (2019) · Briefings in Bioinformatics · doi:10.1093/bib/bbz049 · Cited by 217
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Morris, H. M., Hashimoto, T., & Lewis, D. A. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhm186 · Cited by 216
Self-citation
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Tang, Y., Lu, A., Aronow, B. J., Wagner, K. R., & Sharp, F. R. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02030.x · Cited by 213
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Jarskog, L. F., Glantz, L. A., Gilmore, J. H., & Lieberman, J. A. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.03.010 · Cited by 219
Neuroscience in the era of functional genomics and systems biology
Geschwind, D. H., & Konopka, G. (2009) · Nature · doi:10.1038/nature08537 · Cited by 213
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Thakker, D. R., Natt, F., Hüsken, D., Maier, R., Müller, M., van der Putten, H., Hoyer, D., & Cryan, J. F. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406214101 · Cited by 209
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Preece, P., & Cairns, N. J. (2003) · Molecular Brain Research · doi:10.1016/s0169-328x(03)00337-1 · Cited by 206
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Narayan, S., Tang, B., Head, S. R., Gilmartin, T. J., Sutcliffe, J. G., Dean, B., & Thomas, E. A. (2008) · Brain Research · doi:10.1016/j.brainres.2008.08.023 · Cited by 207
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Innocenti, G. M., Ansermet, F., & Parnas, J. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001205 · Cited by 207
Gene Expression Profiling in Postmortem Rett Syndrome Brain: Differential Gene Expression and Patient Classification
Colantuoni, C., Jeon, O., Hyder, K., Chenchik, A. A., Khimani, A. H., Narayanan, V., Hoffman, E. P., Kaufmann, W. E., Naidu, S., & Pevsner, J. (2001) · Neurobiology of Disease · doi:10.1006/nbdi.2001.0428 · Cited by 205
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Martins‐de‐Souza, D., Gattaz, W. F., Schmitt, A., Rewerts, C., Maccarrone, G., Dias‐Neto, E., & Turck, C. W. (2009) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-008-0847-2 · Cited by 203
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Lewis, D. A. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00393-1 · Cited by 201
Self-citation
Advances in schizophrenia
Thaker, G. K., & Carpenter, W. T. (2001) · Nature Medicine · doi:10.1038/89040 · Cited by 203
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Konradi, C. L., & Heckers, S. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01267-7 · Cited by 201
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Hof, P. R., Haroutunian, V., Copland, C., Davis, K. L., & Buxbaum, J. D. (2002) · Neurochemical Research · doi:10.1023/a:1020981510759 · Cited by 199
Analysis of gene expression in two large schizophrenia cohorts identifies multiple changes associated with nerve terminal function
Maycox, P. R., Kelly, F., Taylor, A. R., Bates, S., Reid, J. L., Logendra, R., Barnes, M. R., Larminie, C. G. C., Jones, N. A., Lennon, M. G., et al. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.18 · Cited by 200

Authors: Mirnics, K., Middleton, F. A., Marquez, A., Lewis, D. A., & Levitt, P.
Affiliations: University of Pittsburgh (US)
Corresponding author: Mirnics, Károly
ORCID: Mirnics, Károly
Middleton, Frank A.
Lewis, David A.
Levitt, Pat
Venue: Neuron
Publisher: Elsevier BV
Published: 2000-10
Volume: 28
Issue: 1
Pages: 53-67
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/s0896-6273(00)00085-4
OpenAlex: W2032208151
Cited by: 882
References: 105
Citations by year: 2026: 5 · 2025: 1 · 2024: 3 · 2023: 7 · 2022: 8 · 2021: 11 · 2020: 10 · 2019: 13 · 2018: 16 · 2017: 14 · 2016: 19 · 2015: 32 · 2014: 19 · 2013: 29 · 2012: 37
FWCI: 48.20
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4672 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (T32 MH18273, MH 45156, T32MH018273, P50MH045156)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: schizophrenia, prefrontal cortex, gene expression profiling, presynaptic function, N-ethylmaleimide-sensitive factor, synapsin II, transcriptome
MeSH terms: Animals, Carrier Proteins, Female, Humans, Macaca fascicularis, Male, Middle Aged, Synaptic Transmission, RNA, Messenger, Schizophrenia, Synapses, Antipsychotic Agents, Genetic Variation, Gene Expression, Confounding Factors, Epidemiologic, Synapsins, Prefrontal Cortex, In Situ Hybridization, Presynaptic Terminals, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Vesicular Transport Proteins, N-Ethylmaleimide-Sensitive Proteins

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Molecular Characterization of Schizophrenia Viewed by Microarray Analysis of Gene Expression in Prefrontal Cortex

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