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Cited by 267

The DOI matches its Crossref record.

The Mammalian Brain rsec6/8 Complex

Open access
Hsu, Shu-Chan, Ting, Anthony E, Hazuka, Christopher D, Davanger, Svend, Kenny, James W, Kee, Yun, Scheller, Richard H·1996·Neuron
DOI 10.1016/s0896-6273(00)80251-2
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Abstract

rsec6 and rsec8 are two components of a 17S complex in mammalian brain that is homologous to the yeast 834 kDa Sec6/8/15 complex which is essential for exocytosis. Purification and partial amino acid sequencing of the mammalian rsec6/8 complex reveals that it is composed of eight novel proteins with a combined molecular weight of 743 kDa. The complex is broadly expressed in brain and displays a plasma membrane localization in nerve terminals. Membrane associated rsec6/8 complex coimmunoprecipitates with syntaxin, a plasma membrane protein critical for neurotransmission. These data suggest a role for the mammalian rsec6/8 complex in neurotransmitter release via interactions with the core vesicle docking and fusion apparatus.

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Metadata

Authors
Hsu, S.-C., Ting, A. E., Hazuka, C. D., Davanger, S., Kenny, J. W., Kee, Y., & Scheller, R. H.
Venue
Neuron
Publisher
Elsevier BV
Published
1996-12
Volume
17
Issue
6
Pages
1209-1219
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/s0896-6273(00)80251-2
OpenAlex
W1965522502
Cited by
267
References
0
FWCI
4.04
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: The Mammalian Brain rsec6/8 Complex. https://app.cochat.ai/papers/10.1016/s0896-6273(00)80251-2
The paper
Hsu, S.-C., Ting, A. E., Hazuka, C. D., Davanger, S., Kenny, J. W., Kee, Y., & Scheller, R. H. (1996). The Mammalian Brain rsec6/8 Complex. Neuron. https://doi.org/10.1016/s0896-6273(00)80251-2

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.