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The Mammalian Brain rsec6/8 Complex
Open accessAbstract
rsec6 and rsec8 are two components of a 17S complex in mammalian brain that is homologous to the yeast 834 kDa Sec6/8/15 complex which is essential for exocytosis. Purification and partial amino acid sequencing of the mammalian rsec6/8 complex reveals that it is composed of eight novel proteins with a combined molecular weight of 743 kDa. The complex is broadly expressed in brain and displays a plasma membrane localization in nerve terminals. Membrane associated rsec6/8 complex coimmunoprecipitates with syntaxin, a plasma membrane protein critical for neurotransmission. These data suggest a role for the mammalian rsec6/8 complex in neurotransmitter release via interactions with the core vesicle docking and fusion apparatus.
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Citations
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Metadata
- Authors
- Hsu, S.-C., Ting, A. E., Hazuka, C. D., Davanger, S., Kenny, J. W., Kee, Y., & Scheller, R. H.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1996-12
- Volume
- 17
- Issue
- 6
- Pages
- 1209-1219
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1965522502
- Cited by
- 267
- References
- 0
- FWCI
- 4.04
- Type
- journal article
- Language
- en
- Open access
- hybrid
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