The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Rapid Actin-Based Plasticity in Dendritic Spines
Open accessAbstract
Dendritic spines have been proposed as primary sites of synaptic plasticity in the brain. Consistent with this hypothesis, spines contain high concentrations of actin, suggesting that they might be motile. To investigate this possibility, we made video recordings from hippocampal neurons expressing actin tagged with green fluorescent protein (GFP-actin). This reagent incorporates into actin-containing structures and allows the visualization of actin dynamics in living neurons. In mature neurons, recordings of GFP fluorescence revealed large actin-dependent changes in dendritic spine shape, similar to those inferred from previous studies using fixed tissues. Visible changes occurred within seconds, suggesting that anatomical plasticity at synapses can be extremely rapid. As well as providing a molecular basis for structural plasticity, the presence of motile actin in dendritic spines implicates the postsynaptic element as a primary site of this phenomenon.
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In the citing paper
“A recent study demonstrated that, in cultured hippocampal neurons, actin distribution in spines changes on a time scale of seconds to minutes in a manner that is perturbed by latrunculin A (Fischer et al., 1998).”
From Regulation of F-Actin Stability in Dendritic Spines by Glutamate Receptors and Calcineurin (1998) · cites this paper as Fischer et al., 1998
In the citing paper
“Morphological alterations of dendritic spines have been shown to have profound effects on the efficacy of synaptic transmission43.”
In the citing paper
“The concentrations of latrunculin A and cytochalasins used here (0.01–1 μM) are similar to those that have been shown previously to alter actin filament organization in cultured cells, prevent lamellipodial ruffling in fibroblasts, inhibit motility and retrograde flow in neuronal growth cones, and arrest dendritic spine motility in hippocampal neurons (3, 4, 7, 10).”
From Dynamic actin filaments are required for stable long-term potentiation (LTP) in area CA1 of the hippocampus (2000) · cites this paper as [10]
Citations
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Competitive binding of α-actinin and calmodulin to the NMDA receptor
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Danbolt, N. C. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00067-8 · Cited by 4,227
Structural basis of long-term potentiation in single dendritic spines
Matsuzaki, M., Honkura, N., Ellis-Davies, G. C. R., & Kasai, H. (2004) · Nature · doi:10.1038/nature02617 · Cited by 2,483
Experience-dependent structural synaptic plasticity in the mammalian brain
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Kaech, S., & Banker, G. A. (2006) · Nature Protocols · doi:10.1038/nprot.2006.356 · Cited by 1,766
Self-citationDendritic spine changes associated with hippocampal long-term synaptic plasticity
Engert, F., & Bonhoeffer, T. (1999) · Nature · doi:10.1038/19978 · Cited by 1,412
Metadata
- Authors
- Fischer, M., Kaech, S., Knutti, D., & Matus, A.
- Affiliations
- Friedrich Miescher Institute (CH)
- Corresponding author
- Matus, Andrew
- ORCID
- Kaech, Stefanie
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1998-05
- Volume
- 20
- Issue
- 5
- Pages
- 847-854
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2111916392
- Cited by
- 905
- References
- 40
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 5 · 2023: 12 · 2022: 16 · 2021: 21 · 2020: 18 · 2019: 17 · 2018: 22 · 2017: 17 · 2016: 33 · 2015: 28 · 2014: 31 · 2013: 30 · 2012: 34
- FWCI
- 20.16
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- dendritic spines, actin dynamics, synaptic plasticity, structural plasticity, hippocampal neurons, spine motility, postsynaptic elements
- MeSH terms
- Actins, Animals, Cell Line, Dendrites, Fibroblasts, Hippocampus, Indicators and Reagents, Luminescent Proteins, Neuronal Plasticity, Neurons, Synapses, Thiazoles, Cytochalasin D, Microscopy, Video, Bridged Bicyclo Compounds, Heterocyclic, Nucleic Acid Synthesis Inhibitors, Cell Size, Green Fluorescent Proteins, Rats, Thiazolidines
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