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Cited by 337Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental DisordersAxon Guidance and Neuronal Signaling

The DOI matches its Crossref record; 101 of the 103 references it cites were found in a registry or an index.

Spine Motility

Open access
Bonhoeffer, Tobias, Yuste, Rafael·2002·Neuron
DOI 10.1016/s0896-6273(02)00906-6
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Abstract

Throughout the history of neuroscience, dendritic spines have been considered stable structures, but in recent years, imaging techniques have revealed that spines are constantly changing shape. Spine motility is difficult to categorize, has different forms, and possibly even represents multiple phenomena. It is influenced by synaptic transmission, intracellular calcium, and a multitude of ions and other molecules. An actin-based cascade mediates this phenomenon, and while the precise signaling pathways are still unclear, the Rho family of GTPases could well be a "common denominator" controlling spine morphology. One role of spine motility might be to enable a searching function during synaptogenesis, allowing for more efficacious neuronal connectivity in the neuronal thicket. This idea revisits concepts originally formulated by Cajal, who proposed over a hundred years ago that spines might help to increase and modify synaptic connections.

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Citations

Cites

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Research works printed but not linked: 2

  1. Gray, 1959, Axo-somatic and axo-dendritic synapses of the cerebral cortex, J. Anat., 83, 420
  2. Ramón y Cajal, 1891, Significación fisiológica de las expansiones protoplásmicas y nerviosas de la sustancia gris, Revista de Ciencias Médicas de Barcelona, 22, 23

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Metadata

Authors
Bonhoeffer, T., & Yuste, R.
Affiliations
  • Max Planck Institute of Neurobiology (DE)
  • Max Planck Society (DE)
Corresponding author
Bonhoeffer, Tobias
ORCID
Venue
Neuron
Publisher
Elsevier BV
Published
2002-09
Volume
35
Issue
6
Pages
1019-1027
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/s0896-6273(02)00906-6
OpenAlex
W151176851
Cited by
337
References
103
Citations by year
2025: 6 · 2024: 5 · 2023: 10 · 2022: 7 · 2021: 10 · 2020: 11 · 2019: 9 · 2018: 10 · 2017: 2 · 2016: 9 · 2015: 16 · 2014: 12 · 2013: 12 · 2012: 18
FWCI
2.72
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • Max Planck Institute for Plasma Physics (submittedVersion)
  • Max Planck Digital Library (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
Funders
  • National Eye Institute (R01EY013237, EY 13237)
  • National Institute of Neurological Disorders and Stroke (NS 40726, R01NS040726)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
Keywords
dendritic spines, spine motility, dendritic spine morphology, synaptic transmission, intracellular calcium, actin cytoskeleton, Rho GTPases, synaptogenesis, neuronal connectivity, Santiago Ramón y Cajal
MeSH terms
Animals, Central Nervous System, Dendrites, Humans, Synaptic Transmission, Neuronal Plasticity, Synapses

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