Cited by 337Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental DisordersAxon Guidance and Neuronal Signaling

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Spine Motility

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Bonhoeffer, Tobias, Yuste, Rafael·2002·Neuron

DOI 10.1016/s0896-6273(02)00906-6

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Abstract

Throughout the history of neuroscience, dendritic spines have been considered stable structures, but in recent years, imaging techniques have revealed that spines are constantly changing shape. Spine motility is difficult to categorize, has different forms, and possibly even represents multiple phenomena. It is influenced by synaptic transmission, intracellular calcium, and a multitude of ions and other molecules. An actin-based cascade mediates this phenomenon, and while the precise signaling pathways are still unclear, the Rho family of GTPases could well be a "common denominator" controlling spine morphology. One role of spine motility might be to enable a searching function during synaptogenesis, allowing for more efficacious neuronal connectivity in the neuronal thicket. This idea revisits concepts originally formulated by Cajal, who proposed over a hundred years ago that spines might help to increase and modify synaptic connections.

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Authors: Bonhoeffer, T., & Yuste, R.
Affiliations: Max Planck Institute of Neurobiology (DE)
Max Planck Society (DE)
Corresponding author: Bonhoeffer, Tobias
ORCID: Bonhoeffer, Tobias
Yuste, Rafael
Venue: Neuron
Publisher: Elsevier BV
Published: 2002-09
Volume: 35
Issue: 6
Pages: 1019-1027
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/s0896-6273(02)00906-6
OpenAlex: W151176851
Cited by: 337
References: 103
Citations by year: 2025: 6 · 2024: 5 · 2023: 10 · 2022: 7 · 2021: 10 · 2020: 11 · 2019: 9 · 2018: 10 · 2017: 2 · 2016: 9 · 2015: 16 · 2014: 12 · 2013: 12 · 2012: 18
FWCI: 2.72
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
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doi.org/10.15223/policy-017 (stm-asf)
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Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Max Planck Institute for Plasma Physics (submittedVersion)
Max Planck Digital Library (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion)
Funders: National Eye Institute (R01EY013237, EY 13237)
National Institute of Neurological Disorders and Stroke (NS 40726, R01NS040726)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
Keywords: dendritic spines, spine motility, dendritic spine morphology, synaptic transmission, intracellular calcium, actin cytoskeleton, Rho GTPases, synaptogenesis, neuronal connectivity, Santiago Ramón y Cajal
MeSH terms: Animals, Central Nervous System, Dendrites, Humans, Synaptic Transmission, Neuronal Plasticity, Synapses

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