Diffusion MRI of complex neural architecture.
Open accessAbstract
While functional brain imaging methods can locate the cortical regions subserving particular cognitive functions, the connectivity between the functional areas of the human brain remains poorly understood. Recently, investigators have proposed a method to image neural connectivity noninvasively using a magnetic resonance imaging method called diffusion tensor imaging (DTI). DTI measures the molecular diffusion of water along neural pathways. Accurate reconstruction of neural connectivity patterns from DTI has been hindered, however, by the inability of DTI to resolve more than a single axon direction within each imaging voxel. Here, we present a novel magnetic resonance imaging technique that can resolve multiple axon directions within a single voxel. The technique, called q-ball imaging, can resolve intravoxel white matter fiber crossing as well as white matter insertions into cortex. The ability of q-ball imaging to resolve complex intravoxel fiber architecture eliminates a key obstacle to mapping neural connectivity in the human brain noninvasively.
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The conventional interpretation that higher FA values generally reflect greater white matter density is problematic in the presence of crossing fibers.
“this makes the conventional “if some is good, more is better” interpretation of FA values much more problematic than originally thought.”
From Potential Pitfalls of Using Fractional Anisotropy, Axial Diffusivity, and Radial Diffusivity as Biomarkers of Cerebral White Matter Microstructure (2022) · cites this paper as Tuch et al., 2003
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- Authors
- Tuch, D. S., Reese, T. G., Wiegell, M. R., & Wedeen, V. J.
- Affiliations
- Massachusetts General Hospital (US)
- Corresponding author
- Tuch, David S.
- ORCID
- Reese, Timothy G.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2003-12
- Volume
- 40
- Issue
- 5
- Pages
- 885-895
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1997161422
- Cited by
- 698
- References
- 3
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 14 · 2023: 13 · 2022: 27 · 2021: 17 · 2020: 24 · 2019: 32 · 2018: 25 · 2017: 32 · 2016: 28 · 2015: 43 · 2014: 41 · 2013: 45 · 2012: 43
- FWCI
- 24.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 3516 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Massachusetts General Hospital
- National Institute of Mental Health (MH64044)
- National Institute of Neurological Disorders and Stroke (K25NS046532, NS46532)
- National Center for Research Resources (RR 14075, P41RR014075)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- Q-ball imaging, diffusion tensor imaging, fiber tractography, human brain connectivity
- MeSH terms
- Cerebral Cortex, Humans, Nerve Net, Diffusion Magnetic Resonance Imaging
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