Signalling aspects of insulin resistance in skeletal muscle

Mechanism of free fatty acid-induced insulin resistance in humans.

Roden, M., Price, T. B., Perseghin, G., Petersen, K. F., Rothman, D. L., Cline, G. W., & Shulman, G. I. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118742 · Cited by 1,539

The c-Jun NH2-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser307

Aguirre, V., Uchida, T., Yenush, L., Davis, R., & White, M. F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.12.9047 · Cited by 1,487

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.

Griffin, M. E., Marcucci, M. J., Cline, G. W., Bell, K., Barucci, N., Lee, D., Goodyear, L. J., Kraegen, E. W., White, M. F., & Shulman, G. I. (1999) · Diabetes · doi:10.2337/diabetes.48.6.1270 · Cited by 1,267

Fatty acid-induced β cell apoptosis: A link between obesity and diabetes

Shimabukuro, M., Zhou, Y.-T., Levi, M., & Unger, R. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2498 · Cited by 1,142

Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle

Cusi, K., Maezono, K., Osman, A., Pendergrass, M., Patti, M. E., Pratipanawatr, T., DeFronzo, R. A., Kahn, C. R., & Mandarino, L. J. (2000) · Journal of Clinical Investigation · doi:10.1172/jci7535 · Cited by 1,139

Protein–protein interaction in insulin signaling and the molecular mechanisms of insulin resistance

Virkamäki, A., Ueki, K., & Kahn, C. R. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6609 · Cited by 854

Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes

Kim, Y.-B., Nikoulina, S. E., Ciaraldi, T. P., Henry, R. R., & Kahn, B. B. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6928 · Cited by 487

Characterization of signal transduction and glucose transport in skeletal muscle from type 2 diabetic patients

Krook, A., Björnholm, M., Galuska, D., Jiang, X. J., Fahlman, R., Myers, M. G., Wallberg-Henriksson, H., & Zierath, J. R. (2000) · Diabetes · doi:10.2337/diabetes.49.2.284 · Cited by 375

Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes.

Nikoulina, S. E., Ciaraldi, T. P., Mudaliar, S., Mohideen, P., Carter, L., & Henry, R. R. (2000) · Diabetes · doi:10.2337/diabetes.49.2.263 · Cited by 357

Alterations in the Expression and Cellular Localization of Protein Kinase C Isozymes ε and θ Are Associated With Insulin Resistance in Skeletal Muscle of the High-Fat–Fed Rat

Schmitz-Peiffer, C., Browne, C. L., Oakes, N. D., Watkinson, A., Chisholm, D. J., Kraegen, E. W., & Biden, T. J. (1997) · Diabetes · doi:10.2337/diab.46.2.169 · Cited by 314

Oxidative Stress and Stress-Activated Signaling Pathways: A Unifying Hypothesis of Type 2 Diabetes

Evans, J. L., Goldfine, I. D., Maddux, B. A., & Grodsky, G. M. (2002) · Endocrine Reviews · doi:10.1210/er.2001-0039 · Cited by 2,232

Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance

Holland, W. L., Brozinick, J. T., Wang, L.-P., Hawkins, E. D., Sargent, K. M., Liu, Y., Narra, K., Hoehn, K. L., Knotts, T. A., Siesky, A., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.01.002 · Cited by 1,232

A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids

Chavez, J. A., Knotts, T. A., Wang, L.-P., Li, G., Dobrowsky, R. T., Florant, G. L., & Summers, S. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212307200 · Cited by 617

Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes

Chavez, J. A., & Summers, S. A. (2003) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2003.08.020 · Cited by 498

Skeletal Muscle Lipid Metabolism in Exercise and Insulin Resistance

Kiens, B. (2006) · Physiological Reviews · doi:10.1152/physrev.00023.2004 · Cited by 478

Oxidative Capacity, Lipotoxicity, and Mitochondrial Damage in Type 2 Diabetes

Schrauwen, P., & Hesselink, M. K. C. (2004) · Diabetes · doi:10.2337/diabetes.53.6.1412 · Cited by 408

Regulation of Insulin Action by Ceramide

Stratford, S., Hoehn, K. L., Liu, F., & Summers, S. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406499200 · Cited by 410

Dose-Response Effect of Elevated Plasma Free Fatty Acid on Insulin Signaling

Belfort, R., Mandarino, L., Kashyap, S., Wirfel, K., Pratipanawatr, T., Berria, R., DeFronzo, R. A., & Cusi, K. (2005) · Diabetes · doi:10.2337/diabetes.54.6.1640 · Cited by 404

Cell signaling, the essential role of O-GlcNAc

Zachara, N. E., & Hart, G. W. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2006.04.007 · Cited by 386

Skeletal muscle lipid deposition and insulin resistance: effect of dietary fatty acids and exercise

Corcoran, M. P., Lamon-Fava, S., & Fielding, R. A. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.3.662 · Cited by 341

What is lipotoxicity?

Engin, A. B. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-48382-5_8 · Cited by 260

Oestrogen alters adipocyte biology and protects female mice from adipocyte inflammation and insulin resistance

Stubbins, R. E., Najjar, K., Holcomb, V. B., Hong, J., & Núñez, N. P. (2012) · Diabetes, Obesity and Metabolism · doi:10.1111/j.1463-1326.2011.01488.x · Cited by 204

Type 2 Diabetes Mellitus and Skeletal Muscle Metabolic Function

Phielix, E., & Mensink, M. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.01.020 · Cited by 198

Peripheral metabolic actions of leptin

Muoio, D. M., & Lynis Dohm, G. (2002) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1053/beem.2002.0223 · Cited by 183

Exercise training increases intramyocellular lipid and oxidative capacity in older adults

Pruchnic, R., Katsiaras, A., He, J., Kelley, D. E., Winters, C., & Goodpaster, B. H. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00459.2003 · Cited by 177

Increased Efficiency of Fatty Acid Uptake Contributes to Lipid Accumulation in Skeletal Muscle of High Fat-Fed Insulin-Resistant Rats

Hegarty, B. D., Cooney, G. J., Kraegen, E. W., & Furler, S. M. (2002) · Diabetes · doi:10.2337/diabetes.51.5.1477 · Cited by 166

Skeletal muscle triglyceride: marker or mediator of obesity-induced insulin resistance in type 2 diabetes mellitus?

Goodpaster, B. H., & Kelley, D. E. (2002) · Current Diabetes Reports · doi:10.1007/s11892-002-0086-2 · Cited by 155

Increased β-Oxidation in Muscle Cells Enhances Insulin-stimulated Glucose Metabolism and Protects against Fatty Acid-induced Insulin Resistance Despite Intramyocellular Lipid Accumulation

Perdomo, G., Commerford, S. R., Richard, A.-M. T., Adams, S. H., Corkey, B. E., O'Doherty, R. M., & Brown, N. F. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403566200 · Cited by 158

Plasma Free Fatty Acid Uptake and Oxidation Are Already Diminished in Subjects at High Risk for Developing Type 2 Diabetes

Mensink, M., Blaak, E. E., van Baak, M. A., Wagenmakers, A. J. M., & Saris, W. H. M. (2001) · Diabetes · doi:10.2337/diabetes.50.11.2548 · Cited by 128

Reduced insulin-mediated citrate synthase activity in cultured skeletal muscle cells from patients with type 2 diabetes: evidence for an intrinsic oxidative enzyme defect

Ørtenblad, N., Mogensen, M., Petersen, I., Højlund, K., Levin, K., Sahlin, K., Beck-Nielsen, H., & Gaster, M. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2005.04.001 · Cited by 101

Impaired skeletal muscle substrate oxidation in glucose-intolerant men improves after weight loss

Corpeleijn, E., Mensink, M., Kooi, M. E., Roekaerts, P. M. H. J., Saris, W. H. M., & Blaak, E. E. (2008) · Obesity · doi:10.1038/oby.2008.24 · Cited by 104

Discordant effects of a chronic physiological increase in plasma FFA on insulin signaling in healthy subjects with or without a family history of type 2 diabetes

Kashyap, S. R., Belfort, R., Berria, R., Suraamornkul, S., Pratipranawatr, T., Finlayson, J., Barrentine, A., Bajaj, M., Mandarino, L., DeFronzo, R., et al. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00541.2003 · Cited by 103

Eicosapentaenoic acid (20:5 n-3) increases fatty acid and glucose uptake in cultured human skeletal muscle cells

Aas, V., Rokling-Andersen, M. H., Kase, E. T., Thoresen, G. H., & Rustan, A. C. (2006) · Journal of Lipid Research · doi:10.1194/jlr.m500300-jlr200 · Cited by 101

DHA at nutritional doses restores insulin sensitivity in skeletal muscle by preventing lipotoxicity and inflammation

Capel, F., Acquaviva, C., Pitois, E., Laillet, B., Rigaudière, J.-P., Jouve, C., Pouyet, C., Gladine, C., Comte, B., Vianey Saban, C., et al. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.04.003 · Cited by 86

Effects of acute lipid overload on skeletal muscle insulin resistance, metabolic flexibility, and mitochondrial performance

Dubé, J. J., Coen, P. M., DiStefano, G., Chacon, A. C., Helbling, N. L., Desimone, M. E., Stafanovic-Racic, M., Hames, K. C., Despines, A. A., Toledo, F. G. S., et al. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00257.2014 · Cited by 83

Fatty acid‐induced defects in insulin signalling, in myotubes derived from children, are related to ceramide production from palmitate rather than the accumulation of intramyocellular lipid

Sabin, M. A., Stewart, C. E. H., Crowne, E. C., Turner, S. J., Hunt, L. P., Welsh, G. I., Grohmann, M. J., Holly, J. M. P., & Shield, J. P. H. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.20922 · Cited by 71

Exercise training and calorie restriction increase SREBP-1 expression and intramuscular triglyceride in skeletal muscle

Nadeau, K. J., Ehlers, L. B., Aguirre, L. E., Moore, R. L., Jew, K. N., Ortmeyer, H. K., Hansen, B. C., Reusch, J. E. B., & Draznin, B. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00543.2005 · Cited by 57

Effects of a High-Protein Diet Including Whole Eggs on Muscle Composition and Indices of Cardiometabolic Health and Systemic Inflammation in Older Adults with Overweight or Obesity: A Randomized Controlled Trial

Wright, C. S., Zhou, J., Sayer, R. D., Kim, J. E., & Campbell, W. W. (2018) · Nutrients · doi:10.3390/nu10070946 · Cited by 43

Role of lipid-derived mediators in skeletal muscle insulin resistance

Taube, A., Eckardt, K., & Eckel, J. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00241.2009 · Cited by 40

Mitochondrial function: use it or lose it.

Hawley, J. A., & Lessard, S. J. (2007) · Diabetologia · doi:10.1007/s00125-007-0595-2 · Cited by 32

Reduced malonyl-CoA content in recovery from exercise correlates with improved insulin-stimulated glucose uptake in human skeletal muscle

Frøsig, C., Roepstorff, C., Brandt, N., Maarbjerg, S. J., Birk, J. B., Wojtaszewski, J. F. P., Richter, E. A., & Kiens, B. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90556.2008 · Cited by 21