Peripheral metabolic actions of leptin

Muoio, Deborah M.; Lynis Dohm, G.

doi:10.1053/beem.2002.0223

Cited by 183Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Peripheral metabolic actions of leptin

Muoio, Deborah M., Lynis Dohm, G.·2002·Best Practice & Research Clinical Endocrinology & Metabolism

DOI 10.1053/beem.2002.0223

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Abstract

The adipocyte-derived hormone, leptin, regulates food intake and systemic fuel metabolism; ob /ob mice, which lack functional leptin, exhibit an obesity syndrome that is similar to morbid obesity in humans. Leptin receptors are expressed most abundantly in the brain but are also present in several peripheral tissues. The role of leptin in controlling energy homeostasis has thus far focused on brain receptors and neuroendocrine pathways that regulate feeding behaviour and sympathetic nervous system activity. This chapter focuses on mounting evidence that leptin's effects on energy balance are also mediated by direct peripheral actions on key metabolic organs such as skeletal muscle, liver, pancreas and adipose tissue. Strong evidence indicates that peripheral leptin receptors regulate cellular lipid balance, favouring beta-oxidation over triacylglycerol storage. There are data to indicate that peripheral leptin also modulates glucose metabolism and insulin action; however, its precise role in controlling gluco-regulatory pathways remains uncertain and requires further investigation.

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In obesity with chronic hyperleptinemia, leptin resistance develops, which prevents stimulation of lipolysis and suppression of appetite and leads to insulin resistance.
“However, in obesity with chronic hyperleptinemia, there is a development of leptin resistance, which prevents the stimulation of lipolysis and the suppression of appetite and leads to insulin resistance [19].”
From Beyond Calories: Individual Metabolic and Hormonal Adaptations Driving Variability in Weight Management—A State-of-the-Art Narrative Review (2024) · cites this paper as [19]
Leptin rises in proportion to body fat, increases energy expenditure by stimulating sympathetic outflow and enhancing UCP1 expression in BAT, augments fatty acid oxidation, and reduces lipogenic pathways in peripheral tissues.
“Rising in proportion to body fat, leptin increases energy expenditure by stimulating sympathetic outflow and enhancing UCP1 expression in BAT. Leptin also augments fatty acid oxidation and reduces lipogenic (fat storage) pathways in peripheral tissues, limiting fat accumulation during overfeeding.”
From Beyond Calories: Individual Metabolic and Hormonal Adaptations Driving Variability in Weight Management—A State-of-the-Art Narrative Review (2024) · cites this paper as [19]

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Authors: Muoio, D. M., & Lynis Dohm, G.
Affiliations: Duke Medical Center (US)
ORCID: Muoio, Deborah M.
Venue: Best Practice & Research Clinical Endocrinology & Metabolism
Publisher: Elsevier BV
Published: 2002-12
Volume: 16
Issue: 4
Pages: 653-666
ISSN: 1521-690X (ISSN-L)
DOI: 10.1053/beem.2002.0223
OpenAlex: W2069224161
Cited by: 183
References: 89
Citations by year: 2026: 2 · 2025: 5 · 2024: 6 · 2023: 5 · 2022: 7 · 2021: 5 · 2020: 2 · 2019: 4 · 2018: 9 · 2017: 4 · 2016: 6 · 2015: 12 · 2014: 8 · 2013: 7 · 2012: 6
FWCI: 2.73
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Best Practice & Research Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords: leptin, energy homeostasis, lipid metabolism, fatty acid beta-oxidation, triacylglycerol storage, glucose metabolism, insulin action, skeletal muscle, liver, pancreas, adipose tissue, obesity, ob/ob mice
MeSH terms: Animals, Cholesterol, Energy Metabolism, Fatty Acids, Glucose, Humans, Insulin, Obesity, Receptors, Cell Surface, Leptin, Lipid Metabolism, Receptors, Leptin

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