Cited by 610NF-κB Signaling PathwaysCytokine Signaling Pathways and InteractionsCell death mechanisms and regulation

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TNF receptor subtype signalling: Differences and cellular consequences

MacEwan, David J.·2002·Cellular Signalling

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Abstract

Tumour necrosis factor-alpha (TNF alpha) is a multifunctional cytokine belonging to a family of ligands with an associated family of receptor proteins. The pleiotropic actions of TNF range from proliferative responses such as cell growth and differentiation, to inflammatory effects and the mediation of immune responses, to destructive cellular outcomes such as apoptotic and necrotic cell death mechanisms. Activated TNF receptors mediate the association of distinct adaptor proteins that regulate a variety of signalling processes including kinase or phosphatase activation, lipase stimulation, and protease induction. Moreover, the cytokine regulates the activities of transcription factors, heterotrimeric or monomeric G-proteins and calcium ion homeostasis in order to orchestrate its cellular functions. This review addresses the structural basis of TNF signalling, the pathways employed with their cellular consequences, and focuses on the specific role played by each of the two TNF receptor isotypes, TNFR1 and TNFR2.

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Authors: MacEwan, D. J.
Affiliations: University of Aberdeen (GB)
Corresponding author: MacEwan, David J.
ORCID: MacEwan, David J.
Venue: Cellular Signalling
Publisher: Elsevier BV
Published: 2002-06
Volume: 14
Issue: 6
Pages: 477-492
ISSN: 0898-6568 (ISSN-L)
DOI: 10.1016/s0898-6568(01)00262-5
OpenAlex: W2069681479
Cited by: 610
References: 394
Citations by year: 2026: 1 · 2025: 6 · 2024: 8 · 2023: 11 · 2022: 18 · 2021: 14 · 2020: 17 · 2019: 20 · 2018: 24 · 2017: 18 · 2016: 13 · 2015: 21 · 2014: 20 · 2013: 29 · 2012: 37
FWCI: 2.95
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cellular Signalling (publishedVersion)
PubMed (publishedVersion)
UEA Digital Repository (University of East Anglia) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords: TNF-α, TNFR1, TNFR2, adaptor proteins, apoptosis, necrosis, transcription factors, G proteins, calcium homeostasis
MeSH terms: Animals, Models, Biological, Phospholipases, Phosphoprotein Phosphatases, Protein Kinases, Sphingomyelin Phosphodiesterase, Tumor Necrosis Factor-alpha, Signal Transduction, Antigens, CD, Receptors, Tumor Necrosis Factor, Caspases, Receptors, Tumor Necrosis Factor, Type I, Receptors, Tumor Necrosis Factor, Type II, Mice

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TNF receptor subtype signalling: Differences and cellular consequences

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