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TNF receptor subtype signalling: Differences and cellular consequences
Abstract
Tumour necrosis factor-alpha (TNF alpha) is a multifunctional cytokine belonging to a family of ligands with an associated family of receptor proteins. The pleiotropic actions of TNF range from proliferative responses such as cell growth and differentiation, to inflammatory effects and the mediation of immune responses, to destructive cellular outcomes such as apoptotic and necrotic cell death mechanisms. Activated TNF receptors mediate the association of distinct adaptor proteins that regulate a variety of signalling processes including kinase or phosphatase activation, lipase stimulation, and protease induction. Moreover, the cytokine regulates the activities of transcription factors, heterotrimeric or monomeric G-proteins and calcium ion homeostasis in order to orchestrate its cellular functions. This review addresses the structural basis of TNF signalling, the pathways employed with their cellular consequences, and focuses on the specific role played by each of the two TNF receptor isotypes, TNFR1 and TNFR2.
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“TNF-α has been reported to bind to tumor necrosis factor (TNFR1), leading to neuronal apoptosis [155,156].”
From Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation (2022) · cites this paper as [156]
Citations
Cites
Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics
Kerr, J. F. R., Wyllie, A. H., & Currie, A. R. (1972) · British Journal of Cancer · doi:10.1038/bjc.1972.33 · Cited by 15,673
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J., & Greenberg, M. E. (1995) · Science · doi:10.1126/science.270.5240.1326 · Cited by 5,273
Caspases: the executioners of apoptosis
Cohen, G. M. (1997) · Biochemical Journal · doi:10.1042/bj3260001 · Cited by 4,737
Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C
Nishizuka, Y. (1992) · Science · doi:10.1126/science.1411571 · Cited by 4,472
The TNF and TNF Receptor Superfamilies
Locksley, R. M., Killeen, N., & Lenardo, M. J. (2001) · Cell · doi:10.1016/s0092-8674(01)00237-9 · Cited by 3,650
Muzio, M., Chinnaiyan, A. M., Kischkel, F. C., O'Rourke, K., Shevchenko, A., Ni, J., Scaffidi, C., Bretz, J. D., Zhang, M., Gentz, R., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81266-0 · Cited by 3,046
Hotamisligil, G. S., Peraldi, P., Budavari, A., Ellis, R., White, M. F., & Spiegelman, B. M. (1996) · Science · doi:10.1126/science.271.5249.665 · Cited by 2,630
Inhibition of death receptor signals by cellular FLIP
Irmler, M., Thome, M., Hahne, M., Schneider, P., Hofmann, K., Steiner, V., Bodmer, J.-L., Schröter, M., Burns, K., Mattmann, C., et al. (1997) · Nature · doi:10.1038/40657 · Cited by 2,548
Chinnaiyan, A. M., O'Rourke, K., Tewari, M., & Dixit, V. M. (1995) · Cell · doi:10.1016/0092-8674(95)90071-3 · Cited by 2,431
Research works printed but not linked: 39
- Hass, 1985, Fed Proc, 44, 1686
- Vitt, 1987, Fed Proc, 46, 2117
- Adam, 1996, J Inflammation, 47, 61
- Kreder, 1998, J Interferon Cytokine Res, 18, A-54
- Wyllie, 1997, Eur J Cell Biol, 73, 189
- Kinloch, 1999, TIPS, 20, 35
- Squier, 1996, Cell Death Differ, 3, 275
- Marquet, 1987, Immunobiology, 175, 54
- Beyaert, 1987, Immunobiology, 175, 3
- Clark, 1987, Fed Proc, 46, 1946
- Kronke, 1990, Lymphokine Res, 9, 549
- Pyne, 2000, Biochem J, 349, 385, 10.1042/bj3490385 · DOI
- Wu, 1998, Cancer Res, 58, 633
- Fiers, 1996, J Inflammation, 47, 67
- Bermudez, 1987, J Leukocyte Biol, 42, 598
- Matsubara, 1991, Immunology, 73, 457
- Davis, 1999, Cell Resp Stress, 1
- Nakada, 2001, Anticancer Res, 21, 167
- Kunz, 2001, Cell Growth Differ, 12, 137
- Wang, 2000, Arthritis Rheum, 43, 1989
- Hiraoka, 2001, Am J Physiol: Heart Circ Physiol, 280, H1861
- Totpal, 1992, Cancer Res, 52, 2557
- Mishra, 1994, Lymphokine Cytokine Res, 13, 77
- Peraldi, 1996, Diabetes, 45, 161
- Ermakova, 1999, Diabetologia, 42, 529
- Klein, 1994, Clin Res, 42, A331
- Scherzer, 1993, Clin Res, 41, A241
- Klein, 1992, Clin Res, 40, A745
- Yan, 2001, Cancer Res, 61, 963
- Hunter, 2001, FASEB J, 15, A163
- Bick, 1997, Am J Physiol: Heart Circ Physiol, 41, H1937
- Amrani, 1993, C R Acad Sci, Ser III, 316, 1489
- Amrani, 1996, Rev Mal Respir, 13, 539
- Grell, 1993, Lymphokine Cytokine Res, 12, 143
- Moosmayer, 1994, Lymphokine Cytokine Res, 13, 295
- Ledgerwood, 1999, Lab Invest, 79, 1041
- Vanderpoll, 1996, Blood, 88, 922
- Rothe, 1994, Circ Shock, 44, 51
- Aggarwal, 1993, Lymphokine Cytokine Res, 12, 149
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Kroetsch, J. T., Levy, A. S., Zhang, H., Aschar‐Sobbi, R., Lidington, D., Offermanns, S., Nedospasov, S. A., Backx, P. H., Heximer, S. P., & Bolz, S. (2017) · Nature Communications · doi:10.1038/ncomms14805 · Cited by 55
Xu, D., Zhao, H., Gao, H. T., Zhao, H., Liu, D., & Li, J. (2018) · Molecular Pain · doi:10.1177/1744806918783535 · Cited by 56
Bette, M., Kaut, O., Schäfer, M. K.-H., & Weihe, E. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10877 · Cited by 56
Contact-dependent signaling during the late events of platelet activation
Prévost, N., Woulfe, D. S., Tognolini, M., & Brass, L. F. (2003) · Journal of Thrombosis and Haemostasis · doi:10.1046/j.1538-7836.2003.00327.x · Cited by 56
Costagliola, G., Depietri, G., Michev, A., Riva, A., Foiadelli, T., Savasta, S., Bonuccelli, A., Peroni, D. G., Consolini, R., Marseglia, G. L., et al. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.741244 · Cited by 56
Church, L. D., Hessler, G., Goodall, J. E., Rider, D. A., Workman, C. J., Vignali, D. A. A., BACON, P. A., Gulbins, E., & Young, S. P. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.1003456 · Cited by 55
Proinflammatory Factors Mediate Paclitaxel-Induced Impairment of Learning and Memory
Zhao, L., Zhao, S., Zhang, H., Liu, P., Liu, F., Guo, Y., & Wang, X. (2018) · Mediators of Inflammation · doi:10.1155/2018/3941840 · Cited by 55
The therapeutic effect of TNFR1-selective antagonistic mutant TNF-α in murine hepatitis models
Shibata, H., Yoshioka, Y., Ohkawa, A., Abe, Y., Nomura, T., Mukai, Y., Nakagawa, S., Taniai, M., Ohta, T., Mayumi, T., et al. (2008) · Cytokine · doi:10.1016/j.cyto.2008.07.003 · Cited by 55
Schlaepfer, D. D., Hou, S., Lim, S., Tomar, A., Yu, H.-G., Lim, Y., Hanson, D. A., Uryu, S. A., Molina, J., & Mitra, S. K. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610672200 · Cited by 54
Donaldson, A. R., Tanase, C. E., Awuah, D., Bathrinarayanan, P. V., Hall, L., Nikkhah, M., Khademhosseini, A., Rose, F. R. A. J., Alexander, C., & Ghaemmaghami, A. M. (2018) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2018.00116 · Cited by 54
Kafrouni, M. I., Brown, G., & Thiele, D. L. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0103035 · Cited by 54
Tolosa, L., Morlá, M., Iglesias, A., Busquets, X., Lladó, J., & Olmos, G. (2005) · Cellular Signalling · doi:10.1016/j.cellsig.2005.02.001 · Cited by 54
Lüschen, S., Scherer, G., Ussat, S., Ungefroren, H., & Adam‐Klages, S. (2003) · Experimental Cell Research · doi:10.1016/j.yexcr.2003.10.009 · Cited by 54
Leo, M., Argalski, S., Schäfers, M., & Hagenacker, T. (2015) · Mediators of Inflammation · doi:10.1155/2015/124942 · Cited by 52
Martinez, T. N., Chen, X., Bandyopadhyay, S., Merrill, A. H., & Tansey, M. G. (2012) · Molecular Neurodegeneration · doi:10.1186/1750-1326-7-45 · Cited by 52
Neuroinflammation and central PI3K/Akt/mTOR signal pathway contribute to bone cancer pain
Zhang, J., Wang, L., Wang, H., Su, Z., & Pang, X. (2019) · Molecular Pain · doi:10.1177/1744806919830240 · Cited by 52
Rockel, J. S., Bernier, S. M., & Leask, A. (2009) · Arthritis Research & Therapy · doi:10.1186/ar2595 · Cited by 52
Obesity and airway responsiveness: Role of TNFR2
Williams, A. S., Chen, L., Kasahara, D. I., Si, H., Wurmbrand, A. P., & Shore, S. A. (2012) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2012.05.001 · Cited by 53
Regulation of c-Rel Nuclear Localization by Binding of Ca2+/Calmodulin
Antonsson, Å., Hughes, K. A., Edin, S., & Grundstrüm, T. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.4.1418-1427.2003 · Cited by 51
Adult hippocampal neurogenesis: regulation by HIV and drugs of abuse
Venkatesan, A., Nath, A., Ming, G., & Song, H. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7063-5 · Cited by 52
Connexin Channels at the Glio-Vascular Interface: Gatekeepers of the Brain
Bock, M. D., Leybaert, L., & Giaume, C. (2017) · Neurochemical Research · doi:10.1007/s11064-017-2313-x · Cited by 54
Morceau, F., Duvoix, A., Delhalle, S., Schnekenburger, M., Dicato, M. A., & Diederich, M. F. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2003.10.036 · Cited by 50
Zhu, G., Dai, H.-P., Shen, Q., Ji, O., Zhang, Q., & Zhai, Y. (2015) · Pharmaceutical Biology · doi:10.3109/13880209.2015.1060508 · Cited by 49
Cytokines in Neuropathic Pain and Associated Depression
Lees, J. G., Fivelman, B., Duffy, S. S., Makker, P. G. S., Perera, C. J., & Moalem‐Taylor, G. (2015) · Modern trends in psychiatry · doi:10.1159/000435932 · Cited by 49
Liu, D., Zhao, D., Zhao, Y., Wang, Y., Zhao, Y., & Wen, C. (2019) · Current Alzheimer Research · doi:10.2174/1567205016666190503145207 · Cited by 49
An, S., Hishikawa, Y., Liu, J., & Koji, T. (2007) · APOPTOSIS · doi:10.1007/s10495-007-0125-1 · Cited by 48
Pietri, M., Schneider, B., Mouillet‐Richard, S., Ermonval, M., Mutel, V., Launay, J., & Kellermann, O. (2005) · The FASEB Journal · doi:10.1096/fj.04-3631com · Cited by 49
Bao, H., Zhang, Z., Liang, Y., Joshua, J. S., Eaton, D. C., & Ma, H. (2007) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00153.2007 · Cited by 47
Qi, Z., Shen, L., Zhou, H., Jiang, Y., Lan, L., Luo, L., & Yin, Z. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2014.03.015 · Cited by 47
Zhang, A., Wang, Y., Zhou, Y., Xie, H., Zhou, L., & Zheng, S. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22729 · Cited by 47
Chowers, Y., Sturm, A., Sans, M., Papadakis, K. A., Gazouli, M., Harbord, M., Jahnel, J., Mantzaris, G. J., Meier, J., Mottet, C., et al. (2010) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2010.05.011 · Cited by 47
Bouhaha, R., Baroudi, T., Ennafaa, H., Vaillant, E., Abid, H., Sassi, R., Vatin, V., Froguel, P., Gaaied, A. B.-E., Meyre, D., et al. (2010) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2010.01.008 · Cited by 48
Ida, H. (2004) · British journal of rheumatology · doi:10.1093/rheumatology/keh320 · Cited by 46
Hobbs, S. S., Goettel, J. A., Liang, D., Yan, F., Edelblum, K. L., Frey, M. R., Mullane, M. T., & Polk, D. B. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00383.2010 · Cited by 45
Liddle, D. M., Hutchinson, A. L., Wellings, H. R., Power, K. A., Robinson, L. E., & Monk, J. M. (2017) · Nutrients · doi:10.3390/nu9121289 · Cited by 47
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Harrington, J. F., Messier, A. A., Levin, A. R., Szmydynger‐Chodobska, J., & Chodobski, A. (2005) · Journal of Neurotrauma · doi:10.1089/neu.2005.22.919 · Cited by 44
Papaneophytou, C. P., & Kontopidis, G. A. (2012) · Protein Expression and Purification · doi:10.1016/j.pep.2012.09.002 · Cited by 43
Liu, W., & Chang, L. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.06.007 · Cited by 43
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Heidinger, M., Kolb, H. J., Krell, H., Jochum, M., & Ries, C. (2006) · Biological Chemistry · doi:10.1515/bc.2006.010 · Cited by 43
Wang, Z., Aris, V. M., Ogburn, K. D., Soteropoulos, P., & Figueiredo‐Pereira, M. E. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601201200 · Cited by 42
Mizgerd, J. P., Lupa, M. M., Hjoberg, J., Vallone, J., Warren, H. B., Butler, J. P., & Silverman, E. S. (2004) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00353.2003 · Cited by 42
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Smith, R. C., Eappen, A. G., Radtke, A. J., & Jacobs‐Lorena, M. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002965 · Cited by 41
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Wang, T., Rumbaugh, J. A., & Nath, A. (2006) · Clinical Science · doi:10.1042/cs20050278 · Cited by 42
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Myles, I. A., & Datta, S. K. (2012) · Seminars in Immunopathology · doi:10.1007/s00281-011-0301-9 · Cited by 48
Quintão, N. L. M., Balz, D., Santos, A. R. S., Campos, M. M., & Calixto, J. Β. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.11.007 · Cited by 40
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Keeton, R., Allie, N., Dambuza, I. M., Abel, B., Hsu, N., Sebesho, B., Randall, P. J., Burger, P. E., Fick, E., Quesniaux, V. F. J., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci45005 · Cited by 40
Rae, C. J., Langa, S., Tucker, S. J., & MacEwan, D. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701437104 · Cited by 40
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O'Connor, J. J. (2013) · Irish Journal of Medical Science (1971 -) · doi:10.1007/s11845-013-0911-4 · Cited by 37
The MAP kinase pathway mediates transcytosis induced by TNF‐α in anin vitroblood–brain barrier model
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Ezpeleta, J., Boudet-Devaud, F., Pietri, M., Baudry, A., Baudouin, V., Alleaume‐Butaux, A., Dagoneau, N., Kellermann, O., Launay, J., & Schneider, B. (2017) · Scientific Reports · doi:10.1038/s41598-017-08110-x · Cited by 38
Profound lymphopenia and bacteraemia
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Carámbula, S. F., Pru, J. K., Lynch, M. P., Matikainen, T., Gonçalves, P. B. D., Flavell, R. A., Tilly, J. L., & Rueda, B. R. (2003) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-1-15 · Cited by 38
Satou, R., Miyata, K., Katsurada, A., Navar, L. G., & Kobori, H. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00078.2010 · Cited by 37
Batti, L., & O'Connor, J. J. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.11.002 · Cited by 37
Turner, M. D., Chaudhry, A., & Nedjai, B. (2011) · Bioscience Reports · doi:10.1042/bsr20110089 · Cited by 38
Huang, R. (2004) · Humana Press eBooks · doi:10.1385/1-59259-759-9:215 · Cited by 37
Pradines, E., Loubet, D., Mouillet‐Richard, S., Manivet, P., Launay, J., Kellermann, O., & Schneider, B. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06176.x · Cited by 37
Koh, G., & Lee, D. (2011) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2011.04.017 · Cited by 51
Negm, O. H., Mannsperger, H., McDermott, E. M., Drewe, E., Powell, R. J., Todd, I., Fairclough, L. C., & Tighe, P. J. (2014) · European Journal of Immunology · doi:10.1002/eji.201344328 · Cited by 36
Opposite Role of Tumor Necrosis Factor Receptors in Dextran Sulfate Sodium-Induced Colitis in Mice
Wang, K., Han, G., Dou, Y., Wang, Y., Liu, G., Wang, R., He, X., Li, X., Hou, C., Shen, B., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052924 · Cited by 36
Wang, Y., Han, G., Chen, Y., Wang, K., Liu, G., Wang, R., He, X., Li, X., Hou, C., Shen, B., et al. (2013) · Laboratory Investigation · doi:10.1038/labinvest.2013.89 · Cited by 36
Peritoneal mesothelial cells produce inflammatory related cytokines
Yao, V., Platell, C. F. E., & Hall, J. C. (2004) · ANZ Journal of Surgery · doi:10.1111/j.1445-1433.2004.03220.x · Cited by 36
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Schneider, J., Seibold, I., Saxer‐Sekulic, N., Paredes, B. E., Saurer, L., & Mueller, C. (2009) · European Journal of Immunology · doi:10.1002/eji.200839132 · Cited by 35
Mazor, R., Itzhaki, O., Sela, S., Yagil, Y., Cohen-Mazor, M., Yagil, C., & Kristal, B. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.144154 · Cited by 35
García-Vallejo, J. J., van Dijk, W., van Die, I., & Gringhuis, S. I. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m410093200 · Cited by 34
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Tripsianis, G., Papadopoulou, E. G., Romanidis, Κ., Katotomichelakis, M., Anagnostopoulos, K., Kontomanolis, E. N., Botaitis, S., Tentes, I. K., & Kortsaris, A. (2013) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2013.14.11.6813 · Cited by 33
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Garcia, I., Olleros, M. L., Quesniaux, V. F. J., Jacobs, M., Allie, N., Nedospasov, S. A., Szymkowski, D. E., & Ryffel, B. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-6612-4_20 · Cited by 33
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Sethu, S., & Melendez, A. J. (2010) · Bioscience Reports · doi:10.1042/bsr20100040 · Cited by 33
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Ktori, C., Shepherd, P. R., & O’Rourke, L. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00933-1 · Cited by 36
Patel, J. R., & Brewer, G. J. (2008) · Journal of Neuroscience Research · doi:10.1002/jnr.21663 · Cited by 32
Albrecht, M., Frungieri, M. B., Kunz, L., Rämsch, R., Meineke, V., Köhn, F. M., & Mayerhofer, A. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5289-7 · Cited by 32
TNF-α as an Autocrine Mediator and its Role in the Activation of Schwann Cells
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Cytokines and Inflammatory Response in the Fetus and Neonate
Srinivasan, L., Harris, M. C., & Kilpatrick, L. E. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-35214-7.00128-1 · Cited by 31
Tanaka, T., KAMIYAMA, T., Daikoku, T., Takahashi, K., NOMURA, N., Kurokawa, M., & Shiraki, K. (2017) · Acta Virologica · doi:10.4149/av_2017_01_48 · Cited by 31
Yu, K., Yu, K., Chen, B., Liao, Z., Liang, J., Yao, Q., Qin, Z., Wang, H. E., & Yu, J. (2021) · Coral Reefs · doi:10.1007/s00338-021-02182-y · Cited by 31
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Metadata
- Authors
- MacEwan, D. J.
- Affiliations
- University of Aberdeen (GB)
- Corresponding author
- MacEwan, David J.
- ORCID
- MacEwan, David J.
- Venue
- Cellular Signalling
- Publisher
- Elsevier BV
- Published
- 2002-06
- Volume
- 14
- Issue
- 6
- Pages
- 477-492
- ISSN
- 0898-6568 (ISSN-L)
- OpenAlex
- W2069681479
- Cited by
- 610
- References
- 394
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 8 · 2023: 11 · 2022: 18 · 2021: 14 · 2020: 17 · 2019: 20 · 2018: 24 · 2017: 18 · 2016: 13 · 2015: 21 · 2014: 20 · 2013: 29 · 2012: 37
- FWCI
- 2.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cellular Signalling (publishedVersion)
- PubMed (publishedVersion)
- UEA Digital Repository (University of East Anglia) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- TNF-α, TNFR1, TNFR2, adaptor proteins, apoptosis, necrosis, transcription factors, G proteins, calcium homeostasis
- MeSH terms
- Animals, Models, Biological, Phospholipases, Phosphoprotein Phosphatases, Protein Kinases, Sphingomyelin Phosphodiesterase, Tumor Necrosis Factor-alpha, Signal Transduction, Antigens, CD, Receptors, Tumor Necrosis Factor, Caspases, Receptors, Tumor Necrosis Factor, Type I, Receptors, Tumor Necrosis Factor, Type II, Mice
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