The DOI matches its Crossref record; 394 of the 394 references it cites were found in a registry or an index.
TNF receptor subtype signalling: Differences and cellular consequences
Abstract
Tumour necrosis factor-alpha (TNF alpha) is a multifunctional cytokine belonging to a family of ligands with an associated family of receptor proteins. The pleiotropic actions of TNF range from proliferative responses such as cell growth and differentiation, to inflammatory effects and the mediation of immune responses, to destructive cellular outcomes such as apoptotic and necrotic cell death mechanisms. Activated TNF receptors mediate the association of distinct adaptor proteins that regulate a variety of signalling processes including kinase or phosphatase activation, lipase stimulation, and protease induction. Moreover, the cytokine regulates the activities of transcription factors, heterotrimeric or monomeric G-proteins and calcium ion homeostasis in order to orchestrate its cellular functions. This review addresses the structural basis of TNF signalling, the pathways employed with their cellular consequences, and focuses on the specific role played by each of the two TNF receptor isotypes, TNFR1 and TNFR2.
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“TNF-α has been reported to bind to tumor necrosis factor (TNFR1), leading to neuronal apoptosis [155,156].”
From Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation (2022) · cites this paper as [156]
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Cites
Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics
Kerr, J. F. R., Wyllie, A. H., & Currie, A. R. (1972) · British Journal of Cancer · doi:10.1038/bjc.1972.33 · Cited by 15,673
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J., & Greenberg, M. E. (1995) · Science · doi:10.1126/science.270.5240.1326 · Cited by 5,273
Caspases: the executioners of apoptosis
Cohen, G. M. (1997) · Biochemical Journal · doi:10.1042/bj3260001 · Cited by 4,737
Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C
Nishizuka, Y. (1992) · Science · doi:10.1126/science.1411571 · Cited by 4,472
The TNF and TNF Receptor Superfamilies
Locksley, R. M., Killeen, N., & Lenardo, M. J. (2001) · Cell · doi:10.1016/s0092-8674(01)00237-9 · Cited by 3,650
Muzio, M., Chinnaiyan, A. M., Kischkel, F. C., O'Rourke, K., Shevchenko, A., Ni, J., Scaffidi, C., Bretz, J. D., Zhang, M., Gentz, R., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81266-0 · Cited by 3,046
Hotamisligil, G. S., Peraldi, P., Budavari, A., Ellis, R., White, M. F., & Spiegelman, B. M. (1996) · Science · doi:10.1126/science.271.5249.665 · Cited by 2,630
Inhibition of death receptor signals by cellular FLIP
Irmler, M., Thome, M., Hahne, M., Schneider, P., Hofmann, K., Steiner, V., Bodmer, J.-L., Schröter, M., Burns, K., Mattmann, C., et al. (1997) · Nature · doi:10.1038/40657 · Cited by 2,548
Chinnaiyan, A. M., O'Rourke, K., Tewari, M., & Dixit, V. M. (1995) · Cell · doi:10.1016/0092-8674(95)90071-3 · Cited by 2,431
Research works printed but not linked: 39
- Hass, 1985, Fed Proc, 44, 1686
- Vitt, 1987, Fed Proc, 46, 2117
- Adam, 1996, J Inflammation, 47, 61
- Kreder, 1998, J Interferon Cytokine Res, 18, A-54
- Wyllie, 1997, Eur J Cell Biol, 73, 189
- Kinloch, 1999, TIPS, 20, 35
- Squier, 1996, Cell Death Differ, 3, 275
- Marquet, 1987, Immunobiology, 175, 54
- Beyaert, 1987, Immunobiology, 175, 3
- Clark, 1987, Fed Proc, 46, 1946
- Kronke, 1990, Lymphokine Res, 9, 549
- Pyne, 2000, Biochem J, 349, 385, 10.1042/bj3490385 · DOI
- Wu, 1998, Cancer Res, 58, 633
- Fiers, 1996, J Inflammation, 47, 67
- Bermudez, 1987, J Leukocyte Biol, 42, 598
- Matsubara, 1991, Immunology, 73, 457
- Davis, 1999, Cell Resp Stress, 1
- Nakada, 2001, Anticancer Res, 21, 167
- Kunz, 2001, Cell Growth Differ, 12, 137
- Wang, 2000, Arthritis Rheum, 43, 1989
- Hiraoka, 2001, Am J Physiol: Heart Circ Physiol, 280, H1861
- Totpal, 1992, Cancer Res, 52, 2557
- Mishra, 1994, Lymphokine Cytokine Res, 13, 77
- Peraldi, 1996, Diabetes, 45, 161
- Ermakova, 1999, Diabetologia, 42, 529
- Klein, 1994, Clin Res, 42, A331
- Scherzer, 1993, Clin Res, 41, A241
- Klein, 1992, Clin Res, 40, A745
- Yan, 2001, Cancer Res, 61, 963
- Hunter, 2001, FASEB J, 15, A163
- Bick, 1997, Am J Physiol: Heart Circ Physiol, 41, H1937
- Amrani, 1993, C R Acad Sci, Ser III, 316, 1489
- Amrani, 1996, Rev Mal Respir, 13, 539
- Grell, 1993, Lymphokine Cytokine Res, 12, 143
- Moosmayer, 1994, Lymphokine Cytokine Res, 13, 295
- Ledgerwood, 1999, Lab Invest, 79, 1041
- Vanderpoll, 1996, Blood, 88, 922
- Rothe, 1994, Circ Shock, 44, 51
- Aggarwal, 1993, Lymphokine Cytokine Res, 12, 149
Cited by
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Items 601–610 of 610
Paul, R., Sohtun, L. P., & Aguan, K. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-33590-7.00014-9
Ceramide transporters in neuroinflammation and neurodegenerative diseases
Mencarelli, C. (2012) · Research Publications (Maastricht University) · doi:10.26481/dis.20120627cm
Álvarez-Guardia, D. (2011) · Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)
Adaptor Proteins in Death Receptor Signaling
Chen, N., & Yeh, W. (2005) · Humana Press eBooks · doi:10.1385/1-59259-851-x:093
Thornley, T. B. (2006) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/dwrq-5545
Experimental Models of Cytokines and Cancer Prevention
Smyth, M. J., Cretney, E., Street, S. E. A., & Hayakawa, Y. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-455-1_12
Immunopathogenesis of Liver Injury
Shata, M. T. M. (2011) · Springer eBooks · doi:10.1007/978-1-4419-1712-6_7
Metadata
- Authors
- MacEwan, D. J.
- Affiliations
- University of Aberdeen (GB)
- Corresponding author
- MacEwan, David J.
- ORCID
- MacEwan, David J.
- Venue
- Cellular Signalling
- Publisher
- Elsevier BV
- Published
- 2002-06
- Volume
- 14
- Issue
- 6
- Pages
- 477-492
- ISSN
- 0898-6568 (ISSN-L)
- OpenAlex
- W2069681479
- Cited by
- 610
- References
- 394
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 8 · 2023: 11 · 2022: 18 · 2021: 14 · 2020: 17 · 2019: 20 · 2018: 24 · 2017: 18 · 2016: 13 · 2015: 21 · 2014: 20 · 2013: 29 · 2012: 37
- FWCI
- 2.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cellular Signalling (publishedVersion)
- PubMed (publishedVersion)
- UEA Digital Repository (University of East Anglia) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- TNF-α, TNFR1, TNFR2, adaptor proteins, apoptosis, necrosis, transcription factors, G proteins, calcium homeostasis
- MeSH terms
- Animals, Models, Biological, Phospholipases, Phosphoprotein Phosphatases, Protein Kinases, Sphingomyelin Phosphodiesterase, Tumor Necrosis Factor-alpha, Signal Transduction, Antigens, CD, Receptors, Tumor Necrosis Factor, Caspases, Receptors, Tumor Necrosis Factor, Type I, Receptors, Tumor Necrosis Factor, Type II, Mice
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