Cited by 201Epilepsy research and treatmentNeuroscience and Neuropharmacology ResearchPharmacological Effects and Toxicity Studies

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Pilocarpine-induced status epilepticus results in mossy fiber sprouting and spontaneous seizures in C57BL/6 and CD-1 mice

Shibley, Heather, Smith, Bret N.·2002·Epilepsy Research

DOI 10.1016/s0920-1211(02)00012-8

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Abstract

Several rodent models are available to study the cellular mechanisms associated with the development of temporal lobe epilepsy (TLE), but few have been successfully transferred to inbred mouse strains commonly used in genetic mutation studies. We examined spontaneous seizure development and correlative axon sprouting in the dentate gyrus of CD-1 and C57BL/6 mice after systemic injection of pilocarpine. Pilocarpine induced seizures and status epilepticus (SE) after systemic injection in both strains, although SE onset latency was greater for C57BL/6 mice. There were also animals of both strains which did not experience SE after pilocarpine treatment. After a period of normal behavior for several days after the pilocarpine treatment, spontaneous tonic-clonic seizures were observed in most CD-1 mice and all C57BL/6 that survived pilocarpine-induced SE. Robust mossy fiber sprouting into the inner molecular layer was observed after 4-8 weeks in mice from both strains which had experienced SE, and cell loss was apparent in the hippocampus. Mossy fiber sprouting and spontaneous seizures were not observed in mice that did not experience a period of SE. These results indicate that pilocarpine induces spontaneous seizures and mossy fiber sprouting in both CD-1 and C57BL/6 mouse strains. Unlike systemic kainic acid treatment, the pilocarpine model offers a potentially useful tool for studying TLE development in genetically modified mice raised on the C57BL/6 background.

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Authors: Shibley, H., & Smith, B. N.
Affiliations: Tulane University (US)
Corresponding author: Smith, Bret N.
ORCID: Smith, Bret N.
Venue: Epilepsy Research
Publisher: Elsevier BV
Published: 2002-04
Volume: 49
Issue: 2
Pages: 109-120
ISSN: 0920-1211 (ISSN-L)
DOI: 10.1016/s0920-1211(02)00012-8
OpenAlex: W2042575144
Cited by: 201
References: 32
Citations by year: 2026: 5 · 2025: 4 · 2024: 3 · 2023: 5 · 2022: 4 · 2021: 11 · 2020: 12 · 2019: 12 · 2018: 10 · 2017: 8 · 2016: 12 · 2015: 10 · 2014: 9 · 2013: 15 · 2012: 15
FWCI: 2.13
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Epilepsy Research (publishedVersion)
PubMed (publishedVersion)
Funders: Louisiana Board of Regents
Tulane University
Topics: Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
Keywords: pilocarpine, status epilepticus, mossy fiber sprouting, temporal lobe epilepsy, spontaneous seizures, dentate gyrus, hippocampal neuronal loss, C57BL/6 mice, ICR mice, mouse strain differences, kainic acid model, inbred mouse models
MeSH terms: Animals, Convulsants, Male, Mice, Inbred C57BL, Mice, Inbred Strains, Neurons, Pilocarpine, Seizures, Status Epilepticus, Cell Death, Dentate Gyrus, Mossy Fibers, Hippocampal, Mice

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Pilocarpine-induced status epilepticus results in mossy fiber sprouting and spontaneous seizures in C57BL/6 and CD-1 mice

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