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Cited by 137Axon Guidance and Neuronal SignalingNeurogenesis and neuroplasticity mechanismsNerve injury and regeneration

Semaphorins in Adult Nervous System Plasticity and Disease

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Carulli, Daniela, de Winter, Fred, Verhaagen, Joost·2021·Frontiers in Synaptic Neuroscience
DOI 10.3389/fnsyn.2021.672891PMC PMC8148045
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Abstract

Semaphorins, originally discovered as guidance cues for developing axons, are involved in many processes that shape the nervous system during development, from neuronal proliferation and migration to neuritogenesis and synapse formation. Interestingly, the expression of many Semaphorins persists after development. For instance, Semaphorin 3A is a component of perineuronal nets, the extracellular matrix structures enwrapping certain types of neurons in the adult CNS, which contribute to the closure of the critical period for plasticity. Semaphorin 3G and 4C play a crucial role in the control of adult hippocampal connectivity and memory processes, and Semaphorin 5A and 7A regulate adult neurogenesis. This evidence points to a role of Semaphorins in the regulation of adult neuronal plasticity. In this review, we address the distribution of Semaphorins in the adult nervous system and we discuss their function in physiological and pathological processes.

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  • Sema3A is associated with PNNs around Purkinje cell terminals and may influence remodelling of synapses and in turn the impact of ChABC on eyeblink conditioning.

    “Sema3A is associated with PNNs around Purkinje cell terminals and may influence remodelling of synapses and in turn the impact of ChABC on eyeblink conditioning [56] (Fig. 2A).”

    From The extracellular matrix and perineuronal nets in memory (2022) · cites this paper as [56]

    The “Class 3 Semaphorins in Perineuronal Nets” section reports Sema3A in PNNs of the cerebellar nuclei and links changes in its labeling to synaptic-terminal remodeling after loss of Purkinje-cell inputs. It also reports that chondroitinase ABC releases Sema3A from PNNs. The paper does not connect those findings to an effect of ChABC on eyeblink conditioning, so that final link remains unsupported. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • Absence of semaphorin 4C prevents the increase in spine number during fear learning.

    “absence of semaphorin 4C (sema4C) prevents the increase in spine number during fear learning [55, 56].”

    From The extracellular matrix and perineuronal nets in memory (2022) · cites this paper as [56]

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Authors
Carulli, D., de Winter, F., & Verhaagen, J.
Affiliations
Netherlands Institute for Neuroscience (NL)
Corresponding author
Carulli, Daniela
ORCID
Venue
Frontiers in Synaptic Neuroscience
Publisher
Frontiers Media SA
Published
2021-05-11
Volume
13
Pages
672891-672891
ISSN
1663-3563 (ISSN-L)
DOI
10.3389/fnsyn.2021.672891
PMC
PMC8148045
OpenAlex
W3163835391
Cited by
137
References
30
Citations by year
2026: 17 · 2025: 38 · 2024: 27 · 2023: 28 · 2022: 25 · 2021: 2
FWCI
3.10
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Synaptic Neuroscience (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • KNAW research portal (Royal Academy of Art and Sciences (KNAW)) (publishedVersion, other-oa)
  • Institutional Research Information System University of Turin (University of Turin) (submittedVersion, other-oa)
  • Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Nederlandse Organisatie voor Wetenschappelijk Onderzoek
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Keywords
semaphorins, adult neuroplasticity, perineuronal nets, critical period, hippocampal connectivity, memory, adult neurogenesis, axon guidance, extracellular matrix, brain development, neurological disorders

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