Seizures accelerate functional integration of adult-generated granule cells
Open accessAbstract
In humans and experimental animals, structural and functional changes in neural circuits can accompany the development of epilepsy. In the dentate gyrus, seizures enhance adult neurogenesis, but it is unclear to what extent newborn granule cells participate in seizure-induced synaptic reorganization. During the first weeks of their existence, mouse newborn granule cells labeled with enhanced green fluorescent protein have only short dendrites that lack excitatory input. We report that pilocarpine-induced seizures accelerated the morphological development of labeled granule cells, causing their dendrites to extend through the molecular layer. In whole-cell recordings 5-16 d after seizure induction, perforant-path stimulation now evoked glutamatergic input to newborn granule cells. These synaptic responses were mediated by monosynaptic as well as recurrent polysynaptic input. Thus, seizures facilitated functional integration of adult-generated granule cells. One month later, subsequent generations of newborn cells also showed alterations in dendrite morphology, suggesting persistent effects of seizures on granule cell maturation. The sensitivity of newborn granule cells to seizures could contribute to hyperexcitability during the latent period.
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Seizures induce faster maturation of new granule neurons including early and more extensive mossy fiber sprouting and dendritic outgrowth as well as aberrant basal dendritic trees extending into the hilus.
“In fact, seizures induce faster maturation of new granule neurons including early and more extensive mossy fiber sprouting and dendritic outgrowth as well as aberrant basal dendritic trees extending into the hilus, which receive recurrent excitatory drive from mossy fibers (Overstreet-Wadiche et al., 2006; Shapiro and Ribak, 2006) (Table 1).”
From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Overstreet-Wadiche et al., 2006
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- Authors
- Overstreet-Wadiche, L. S., Bromberg, D. A., Bensen, A. L., & Westbrook, G. L.
- Affiliations
- Oregon Health & Science University (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2006-04-12
- Volume
- 26
- Issue
- 15
- Pages
- 4095-4103
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6673901
- OpenAlex
- W2067128446
- Cited by
- 266
- References
- 61
- Citations by year
- 2026: 10 · 2025: 6 · 2024: 7 · 2023: 3 · 2022: 4 · 2021: 6 · 2020: 9 · 2019: 18 · 2018: 7 · 2017: 12 · 2016: 10 · 2015: 18 · 2014: 15 · 2013: 15 · 2012: 12
- FWCI
- 6.50
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (#NS 26494)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- adult neurogenesis, dentate gyrus granule cells, pilocarpine-induced seizures, epilepsy, synaptic remodeling, dendrite formation, glutamatergic synapses, granule cell maturation, molecular layer
- MeSH terms
- Animals, Animals, Newborn, Cell Division, Crosses, Genetic, Dendrites, Female, Humans, Male, Mice, Transgenic, Pilocarpine, Seizures, Green Fluorescent Proteins, Mice
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