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Cited by 285

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Neuropsychological evidence supporting a neurodevelopmental model of schizophrenia: a longitudinal study

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Censits, David M., Daniel Ragland, J., Gur, Ruben C., Gur, Raquel E.·1997·Schizophrenia Research

Abstract

The stability of neuropsychological performance in schizophrenia and its relationship to clinical change was contrasted between 60 patients with schizophrenia (30 first-episode, 30 previously treated) and 38 healthy controls using a comprehensive neuropsychological battery and clinical scales administered at intake and at a 19-month follow-up. Consistent with the neurodevelopmental model of schizophrenia, patients demonstrated deficits in cognitive performance at initial testing and did not show decline at follow-up. There were no differences in neuropsychological performance over time between first-episode and previously treated patients, nor between male and female patients or controls. As expected, patients improved clinically with treatment with respect to both positive and negative symptoms. First-episode patients improved more on the positive symptoms of hallucination and delusion; male and female patients showed equivalent clinical improvement. Clinical improvement correlated positively with neuropsychological change, with improved negative symptomatology accounting for most of the significant correlations.

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Metadata

Authors
Censits, D. M., Daniel Ragland, J., Gur, R. C., & Gur, R. E.
Venue
Schizophrenia Research
Publisher
Elsevier BV
Published
1997-04
Volume
24
Issue
3
Pages
289-298
ISSN
0920-9964 (ISSN-L)
OpenAlex
W2090874551
Cited by
285
References
1
FWCI
7.61
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Neuropsychological evidence supporting a neurodevelopmental model of schizophrenia: a longitudinal study. https://app.cochat.ai/papers/10.1016/s0920-9964(96)00091-6
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Censits, D. M., Daniel Ragland, J., Gur, R. C., & Gur, R. E. (1997). Neuropsychological evidence supporting a neurodevelopmental model of schizophrenia: a longitudinal study. Schizophrenia Research. https://doi.org/10.1016/s0920-9964(96)00091-6

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