Neurocognitive predictors of work outcome in recent-onset schizophrenia.
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While the role of neurocognitive impairment in predicting functional outcome in chronic schizophrenia is now widely accepted, the results that have examined this relationship in the early phase of psychosis are surprisingly rather mixed. The predictive role of cognitive impairment early in the illness is of particular interest because interventions during this initial period may help to prevent the development of chronic disability. In a University of California, Los Angeles (UCLA) longitudinal study, we assessed schizophrenia patients with a recent first episode of psychosis using a neurocognitive battery at an initial clinically stabilized outpatient point and then followed them during continuous treatment over the next 9 months. Three orthogonal cognitive factors were derived through principal components analysis: working memory, attention and early perceptual processing, and verbal memory and processing speed. All patients were provided a combination of maintenance antipsychotic medication, case management, group skills training, and family education in a UCLA research clinic. A modified version of the Social Adjustment Scale was used to assess work outcome. Multiple regression analyses indicate that the combination of the 3 neurocognitive factors predicts 52% of the variance in return to work or school by 9 months after outpatient clinical stabilization. These data strongly support the critical role of neurocognitive factors in recovery of work functioning after an onset of schizophrenia. Cognitive remediation and other interventions targeting these early cognitive deficits are of major importance to attempts to prevent chronic disability.
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Cognitive dysfunction in human patients with schizophrenia is considered amongst the most debilitating aspects of schizophrenia, and its severity is a key determinant of functional outcome following treatment.
“Cognitive dysfunction in human patients with schizophrenia is rapidly being considered amongst the most debilitating aspects of schizophrenia (Nuechterlein et al., 2011) and the severity of cognitive dysfunction is a key determinant of the functional outcome following treatment (Goldberg and Green, 2002).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Nuechterlein et al., 2011
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Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
Diagnostic and Statistical Manual of Mental Disorders (DSM-IV)
Hu, R. J. (2003) · Elsevier eBooks · doi:10.1016/b0-12-226870-9/01070-4 · Cited by 9,167 · see citing works
VALIDITY OF THE TRAIL MAKING TEST AS AN INDICATOR OF ORGANIC BRAIN DAMAGE
Reitan, R. M. (1958) · Perceptual and Motor Skills · doi:10.2466/pms.1958.8.3.271 · Cited by 7,925 · see citing works
Spitzer, R. L. (1978) · Archives of General Psychiatry · doi:10.1001/archpsyc.1978.01770300115013 · Cited by 6,946 · see citing works
What are the functional consequences of neurocognitive deficits in schizophrenia?
(1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.3.321 · Cited by 3,516 · see citing works
Green, M. F., Kern, R. S., Braff, D. L., & Mintz, J. (2000) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a033430 · Cited by 2,999 · see citing works
Self-citationThe MATRICS Consensus Cognitive Battery, part 1: test selection, reliability, and validity
Nuechterlein, K. H., Green, M. F., Kern, R. S., Baade, L. E., Barch, D. M., Cohen, J. D., Essock, S., Fenton, W. S., Frese, F. J., Gold, J. M., et al. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07010042 · Cited by 2,342 · see citing works
Fett, A.-K. J., Viechtbauer, W., Dominguez, M.-D.-G., Penn, D. L., van Os, J., & Krabbendam, L. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.07.001 · Cited by 1,833 · see citing works
Assessment of social adjustment by patient self report.
Weissman, M. M. (1976) · Archives of General Psychiatry · doi:10.1001/archpsyc.1976.01770090101010 · Cited by 1,782 · see citing works
A Meta-Analysis of Cognitive Remediation for Schizophrenia: Methodology and Effect Sizes
Wykes, T., Huddy, V., Cellard, C., McGurk, S. R., & Czobor, P. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.10060855 · Cited by 1,693 · see citing works
Longitudinal studies of cognition and functional outcome in schizophrenia: implications for MATRICS
Green, M. F., Kern, R. S., & Heaton, R. K. (2004) · Schizophrenia Research · doi:10.1016/j.schres.2004.09.009 · Cited by 1,422 · see citing works
Identification of separable cognitive factors in schizophrenia
Nuechterlein, K. H., Barch, D. M., Gold, J. M., Goldberg, T. E., Green, M. F., & Heaton, R. K. (2004) · Schizophrenia Research · doi:10.1016/j.schres.2004.09.007 · Cited by 1,304 · see citing works
A Meta-Analysis of Cognitive Remediation in Schizophrenia
McGurk, S. R., Twamley, E. W., Sitzer, D. I., McHugo, G. J., & Mueser, K. T. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07060906 · Cited by 1,214 · see citing works
Nuechterlein, K. H., & Dawson, M. E. (1984) · Schizophrenia Bulletin · doi:10.1093/schbul/10.2.160 · Cited by 1,141 · see citing works
Neurocognition in first-episode schizophrenia: a meta-analytic review.
Mesholam-Gately, R. I., Giuliano, A. J., Goff, K. P., Faraone, S. V., & Seidman, L. J. (2009) · Neuropsychology · doi:10.1037/a0014708 · Cited by 1,130 · see citing works
VALIDITY OF THE TRAIL MAKING TEST AS AN INDICATOR OF ORGANIC BRAIN DAMAGE
Reitan, R. M. (1958) · Perceptual and Motor Skills · doi:10.2466/pms.8.7.271-276 · Cited by 1,088 · see citing works
Green, M. F., Nuechterlein, K. H., Gold, J. M., Barch, D. M., Cohen, J., Essock, S., Fenton, W. S., Frese, F., Goldberg, T. E., Heaton, R. K., et al. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.06.023 · Cited by 919 · see citing works
Snitz, B. E. (2005) · Schizophrenia Bulletin · doi:10.1093/schbul/sbi048 · Cited by 714 · see citing works
Training and quality assurance with the structured clinical interview for DSM-iV (SCID-I/P)
Ventura, J., Liberman, R. P., Green, M. F., Shaner, A., & Mintz, J. (1998) · Psychiatry Research · doi:10.1016/s0165-1781(98)00038-9 · Cited by 591 · see citing works
Ventura, J., Hellemann, G., Thames, A. D., Koellner, V., & Nuechterlein, K. H. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.03.035 · Cited by 564 · see citing works
Bowie, C. R., Depp, C. A., McGrath, J. A., Wolyniec, P. S., Mausbach, B. T., Thornquist, M. H., Luke, J. R., Patterson, T. L., Harvey, P. D., & Pulver, A. E. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09101406 · Cited by 468 · see citing works
Developmental Processes in Schizophrenic Disorders: Longitudinal Studies of Vulnerability and Stress
Nuechterlein, K. H., Dawson, M. E., Gitlin, M. J., Ventura, J., Goldstein, M. J., Snyder, K. S., Yee, C. M., & Mintz, J. (1992) · Schizophrenia Bulletin · doi:10.1093/schbul/18.3.387 · Cited by 467 · see citing works
Visual Sustained Attention: Image Degradation Produces Rapid Sensitivity Decrement Over Time
Nuechterlein, K. H., Parasuraman, R., & Jiang, Q. (1983) · Science · doi:10.1126/science.6836276 · Cited by 426 · see citing works
Marder, S. R., & Fenton, W. S. (2004) · Schizophrenia Research · doi:10.1016/j.schres.2004.09.010 · Cited by 419 · see citing works
Seidman, L. J. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.66 · Cited by 410 · see citing works
Longitudinal Neuropsychological Follow-Up Study of Patients With First-Episode Schizophrenia
Hoff, A. L., Sakuma, M., Wieneke, M. H., Horon, R., Kushner, M., & DeLisi, L. E. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.9.1336 · Cited by 363 · see citing works
The functional significance of symptomatology and cognitive function in schizophrenia
Velligan, D. I., Mahurin, R. K., Diamond, P., Hazleton, B. C., Eckert, S. L., & Miller, A. L. (1997) · Schizophrenia Research · doi:10.1016/s0920-9964(97)00010-8 · Cited by 345 · see citing works
Harvey, P. D., Howanitz, E. M., Parrella, M. J., WHITE, L. E., Davidson, M., Mohs, R. C., Hoblyn, J. C., & Davis, K. L. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.8.1080 · Cited by 337 · see citing works
Sergi, M. J., Rassovsky, Y., Nuechterlein, K. H., & Green, M. F. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.3.448 · Cited by 336 · see citing works
Attentional Vulnerability Indicators, Thought Disorder, and Negative Symptoms
Nuechterlein, K. H., Edell, W., Norris, M., & Dawson, M. E. (1986) · Schizophrenia Bulletin · doi:10.1093/schbul/12.3.408 · Cited by 300 · see citing works
Killackey, E. J., Jackson, H. J., & McGorry, P. D. (2008) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.107.043109 · Cited by 294 · see citing works
Censits, D. M., Ragland, J. D., Gur, R. C., & Gur, R. E. (1997) · Schizophrenia Research · doi:10.1016/s0920-9964(96)00091-6 · Cited by 285 · see citing works
McGurk, S. R., Mueser, K. T., DeRosa, T., & Wolfe, R. S. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn182 · Cited by 271 · see citing works
Residual performance deficit in clinically remitted schizophrenics: A marker of schizophrenia?
Asarnow, R. F., & MacCrimmon, D. J. (1978) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.87.6.597 · Cited by 255 · see citing works
Overall, J. E. (1967) · Archives of General Psychiatry · doi:10.1001/archpsyc.1967.01730200014003 · Cited by 253 · see citing works
Oltmanns, T. F., & Neale, J. M. (1975) · Journal of Abnormal Psychology · doi:10.1037/h0076721 · Cited by 246 · see citing works
Neurocognitive performance and functional disability in the psychosis prodrome
Niendam, T. A., Bearden, C. E., Johnson, J. K., McKinley, M., Loewy, R. L., O’Brien, M. P., Nuechterlein, K. H., Green, M. F., & Cannon, T. D. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2006.02.005 · Cited by 244 · see citing works
Backward Masking in Schizophrenia and Mania
Green, M. F. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950120017004 · Cited by 209 · see citing works
Nuechterlein, K. H., Subotnik, K. L., Turner, L. R., Ventura, J., Becker, D. R., & Drake, R. E. (2008) · Psychiatric Rehabilitation Journal · doi:10.2975/31.4.2008.340.349 · Cited by 200 · see citing works
Residual performance deficit in clinically remitted schizophrenics: A marker of schizophrenia?
Asarnow, R. F., & MacCrimmon, D. J. (1978) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.87.6.597 · Cited by 192 · see citing works
Self-citationAllott, K., Liu, P., Proffitt, T., & Killackey, E. J. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.11.001 · Cited by 165 · see citing works
Neuropsychology, Psychophysiology and Information Processing
Steinhauer, S. R., Gruzelier, J. H., Zubin, J., & Nasrallah, H. A. (1992) · Medical Entomology and Zoology · Cited by 158 · see citing works
Stability of cognitive functioning early in the course of schizophrenia
Nopoulos, P., Flashman, L. A., Flaum, M. A., Arndt, S. V., & Andreasen, N. C. (1994) · Schizophrenia Research · doi:10.1016/0920-9964(94)90006-x · Cited by 126 · see citing works
Remission and recovery during the first outpatient year of the early course of schizophrenia
Ventura, J., Subotnik, K. L., Guzik, L. H., Hellemann, G., Gitlin, M. J., Wood, R. C., & Nuechterlein, K. H. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.06.025 · Cited by 107 · see citing works
Rinaldi, M., Mcneil, K., Firn, M., Koletsi, M., Perkins, R., & Singh, S. P. (2004) · Psychiatric Bulletin · doi:10.1192/pb.28.8.281 · Cited by 98 · see citing works
Cognitive functioning in first-episode schizophrenia
Addington, J., & Addington, D. E. (2002) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0222 · Cited by 97 · see citing works
Nuechterlein, K., Miklowitz, D., Ventura, J., Gitlin, M., Stoddard, M., & Lukoff, D. (2006) · Psychiatry Research · doi:10.1016/j.psychres.2004.04.018 · Cited by 50 · see citing works
Breaking the log-jam in treatment development for cognition in schizophrenia: NIMH perspective
Fenton, W. S., Stover, E. L., & Insel, T. R. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1564-1 · Cited by 33 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Overall JE, Hollister LE, Pichot P. Major psychiatric disor- der: a four-dimensional model. Arch Gen Psychiatry. 1967;16:146-151.
Cited by
Sorted by citations
Cognition in schizophrenia: core psychological and neural mechanisms
Barch, D. M., & Ceaser, A. E. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.11.015 · Cited by 752 · see citing works
Barnes, T. R. E., Drake, R., Paton, C., Cooper, S. J., Deakin, J. F. W., Ferrier, I. N., Gregory, C. J., Haddad, P. M., Howes, O. D., Jones, I. R., et al. (2019) · Journal of Psychopharmacology · doi:10.1177/0269881119889296 · Cited by 607 · see citing works
Firth, J., Stubbs, B., Rosenbaum, S., Vancampfort, D., Malchow, B., Schuch, F., Elliott, R., Nuechterlein, K. H., & Yung, A. R. (2016) · Schizophrenia Bulletin · doi:10.1093/schbul/sbw115 · Cited by 488 · see citing works
Recent Advances in Social Skills Training for Schizophrenia
Kopelowicz, A. J. (2006) · Schizophrenia Bulletin · doi:10.1093/schbul/sbl023 · Cited by 342 · see citing works
Neurocognition: Clinical and Functional Outcomes in Schizophrenia
Lepage, M., Bodnar, M. D., & Bowie, C. R. (2014) · The Canadian Journal of Psychiatry · doi:10.1177/070674371405900103 · Cited by 268 · see citing works
Kimhy, D., Vakhrusheva, J., Jobson-Ahmed, L., Tarrier, N., Malaspina, D., & Gross, J. J. (2012) · Psychiatry Research · doi:10.1016/j.psychres.2012.05.029 · Cited by 199 · see citing works
Dissecting psychiatric spectrum disorders by generative embedding
Brodersen, K. H., Deserno, L., Schlagenhauf, F., Lin, Z., Penny, W. D., Buhmann, J. M., & Stephan, K. E. (2014) · NeuroImage: Clinical · doi:10.1016/j.nicl.2013.11.002 · Cited by 173 · see citing works
Ventura, J., Subotnik, K. L., Gitlin, M. J., Gretchen‐Doorly, D., Ered, A., Villa, K. F., Hellemann, G., & Nuechterlein, K. H. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.10.043 · Cited by 158 · see citing works
Fervaha, G., Foussias, G., Agid, O., & Remington, G. J. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.04.040 · Cited by 158 · see citing works
The Importance of Social Cognition in Improving Functional Outcomes in Schizophrenia
Javed, A., & Charles, A. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00157 · Cited by 158 · see citing works
Kandola, A., Hendrikse, J., Lucassen, P. J., & Yücel, M. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00373 · Cited by 155 · see citing works
“…paradigms, AE has been reliably demonstrated to improve task performance in animal models (van Praag, 2009; Voss et al., 2013a), although this does also depend on others aspects of AE such as the duration and intensity of AE (Naylor et al., 2005; Ploughman et al., 2007; O’Callaghan et al., 2009).”
Cognitive impairments in psychotic disorders: common mechanisms and measurement
Barch, D. M., & Sheffield, J. M. (2014) · World Psychiatry · doi:10.1002/wps.20145 · Cited by 154 · see citing works
Meyer, E. C., Carrión, R. E., Cornblatt, B. A., Addington, J., Cadenhead, K. S., Cannon, T. D., McGlashan, T. H., Perkins, D. O., Tsuang, M. T., Walker, E. F., et al. (2014) · Schizophrenia Bulletin · doi:10.1093/schbul/sbt235 · Cited by 153 · see citing works
Cowman, M., Holleran, L., Lonergan, E., O’Connor, K., Birchwood, M. J., & Donohoe, G. J. (2021) · Schizophrenia Bulletin · doi:10.1093/schbul/sbab033 · Cited by 144 · see citing works
Therapeutic Potential of α7 Nicotinic Acetylcholine Receptors
Bertrand, D., Lee, C., Flood, D. G., Marger, F., & Donnelly‐Roberts, D. L. (2015) · Pharmacological Reviews · doi:10.1124/pr.113.008581 · Cited by 139 · see citing works
Cognition, Function, and Disability in Patients with Schizophrenia: A Review of Longitudinal Studies
Rajji, T. K., Miranda, D., & Mulsant, B. H. (2014) · The Canadian Journal of Psychiatry · doi:10.1177/070674371405900104 · Cited by 129 · see citing works
The assessment of quality of life in clinical practice in patients with schizophrenia
Karow, A., Wittmann, L., Schöttle, D., Schäfer, I., & Lambert, M. (2014) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2014.16.2/akarow · Cited by 123 · see citing works
Is Altered BDNF Biosynthesis a General Feature in Patients with Cognitive Dysfunctions?
Carlino, D., Vanna, M. D., & Tongiorgi, E. (2012) · The Neuroscientist · doi:10.1177/1073858412469444 · Cited by 113 · see citing works
Firth, J., Stubbs, B., Vancampfort, D., Firth, J. A., Large, M., Rosenbaum, S., Hallgren, M., Ward, P. B., Sarris, J., & Yung, A. R. (2018) · Schizophrenia Bulletin · doi:10.1093/schbul/sby034 · Cited by 105 · see citing works
European Psychiatric Association guidance on assessment of cognitive impairment in schizophrenia
Vita, A., Gäebel, W., Mucci, A., Sachs, G., Erfurth, A., Barlati, S., Zanca, F., Giordano, G. M., Glenthøj, L. B., Nordentoft, M., et al. (2022) · European Psychiatry · doi:10.1192/j.eurpsy.2022.2316 · Cited by 99 · see citing works
Nuechterlein, K. H., Ventura, J., McEwen, S. C., Gretchen‐Doorly, D., Vinogradov, S., & Subotnik, K. L. (2016) · Schizophrenia Bulletin · doi:10.1093/schbul/sbw007 · Cited by 93 · see citing works
Social skills programmes for schizophrenia
Almerie, M. Q., Marhi, M. O. A., Jawoosh, M., Alsabbagh, M., Matar, H. E., Maayan, N., & Bergman, H. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009006.pub2 · Cited by 96 · see citing works
Blokland, G. A. M., Mesholam‐Gately, R. I., Toulopoulou, T., del Re, E. C., Lam, M., DeLisi, L. E., Donohoe, G. J., Walters, J., Seidman, L. J., & Petryshen, T. L. (2016) · Schizophrenia Bulletin · doi:10.1093/schbul/sbw146 · Cited by 93 · see citing works
Volatility Estimates Increase Choice Switching and Relate to Prefrontal Activity in Schizophrenia
Deserno, L., Boehme, R., Mathys, C. D., Katthagen, T., Kaminski, J. A., Stephan, K. E., Heinz, A., & Schlagenhauf, F. (2019) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2019.10.007 · Cited by 80 · see citing works
Estrogens and the cognitive symptoms of schizophrenia: Possible neuroprotective mechanisms
McGregor, C., Riordan, A. J., & Thornton, J. E. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.06.003 · Cited by 88 · see citing works
Processing speed impairment in schizophrenia is mediated by white matter integrity
Karbasforoushan, H., Duffy, B., Blackford, J. U., & Woodward, N. D. (2014) · Psychological Medicine · doi:10.1017/s0033291714001111 · Cited by 85 · see citing works
Gutman, B. A., van Erp, T. G. M., Alpert, K. I., Ching, C. R. K., Isaev, D., Ragothaman, A., Jahanshad, N., Saremi, A., Zavaliangos‐Petropulu, A., Glahn, D. C., et al. (2021) · Human Brain Mapping · doi:10.1002/hbm.25625 · Cited by 76 · see citing works
Ventura, J., Subotnik, K. L., Ered, A., Gretchen‐Doorly, D., Hellemann, G., Vaskinn, A., & Nuechterlein, K. H. (2014) · Schizophrenia Bulletin · doi:10.1093/schbul/sbu002 · Cited by 75 · see citing works
Gut Microbiota in Neurological Disorders
Grochowska, M., Laskus, T., & Radkowski, M. (2019) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-019-00561-6 · Cited by 73 · see citing works
Voineskos, A. N., Hawco, C. S., Neufeld, N. H., Turner, J. A., Ameis, S. H., Anticevic, A., Buchanan, R. W., Cadenhead, K. S., Dazzan, P., Dickie, E. W., et al. (2024) · World Psychiatry · doi:10.1002/wps.21159 · Cited by 73 · see citing works
Wang, P., Yang, J., Yin, Z., Duan, J., Zhang, R., Sun, J., Xu, Y., Liu, L., Chen, X., Li, H., et al. (2019) · BMC Psychiatry · doi:10.1186/s12888-018-1992-4 · Cited by 71 · see citing works
Tanaka‐Koshiyama, K., Koshiyama, D., Miyakoshi, M., Joshi, Y. B., Molina, J. L., Sprock, J., BRAFF, D. L., & Light, G. A. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00832 · Cited by 67 · see citing works
The Early Longitudinal Course of Cognitive Deficits in Schizophrenia
Nuechterlein, K. H., Ventura, J., Subotnik, K. L., & Bartzokis, G. (2014) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.13065su1.06 · Cited by 69 · see citing works
Palaniyappan, L. K., Al‐Radaideh, A., Mougin, O. E., Gowland, P. A., & Liddle, P. F. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.80 · Cited by 68 · see citing works
Starc, M., Murray, J. D., Santamauro, N. P., Savić, A., Diehl, C., Cho, Y., Srihari, V. H., MORGAN, P. T., Krystal, J. H., Wang, X., et al. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.10.011 · Cited by 65 · see citing works
Brain morphological and functional features in cognitive subgroups of schizophrenia
Yasuda, Y., Okada, N., Nemoto, K., Fukunaga, M., Yamamori, H., Ohi, K., Koshiyama, D., Kudo, N., Shiino, T., Morita, S., et al. (2019) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12963 · Cited by 69 · see citing works
Rao, N., Northoff, G., Tagore, A., Rusjan, P., Kenk, M., Wilson, A., Houle, S., Strafella, A., Remington, G., & Mizrahi, R. (2019) · Schizophrenia Bulletin · doi:10.1093/schbul/sby076 · Cited by 67 · see citing works
Gilbert, E., Mérette, C., Jomphe, V., Émond, C., Rouleau, N., Bouchard, R.-H., Roy, M., Paccalet, T., & Maziade, M. (2013) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-013-0463-7 · Cited by 66 · see citing works
Potential and Challenges for the Clinical Use of d-Serine As a Cognitive Enhancer
Guercio, G. D., & Panizzutti, R. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00014 · Cited by 66 · see citing works
Inflammation and cognition in severe mental illness: patterns of covariation and subgroups
Sæther, L. S., Ueland, T., Haatveit, B. C., Maglanoc, L. A., Szabó, A., Djurovic, S., Aukrust, P., Roelfs, D., Mohn, C., Ormerod, M. B. E. G., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01924-w · Cited by 60 · see citing works
Identification and treatment of individuals with childhood-onset and early-onset schizophrenia
Correll, C. U., Arango, C., Fagerlund, B., Galderisi, S., Kas, M. J., & Leucht, S. (2024) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2024.02.005 · Cited by 63 · see citing works
Ayesa‐Arriola, R., Rodríguez-Sánchez, J. M., Pérez‐Iglesias, R., González‐Blanch, C., Pardo‐García, G., Tabarés‐Seisdedos, R., Vázquez‐Barquero, J. L., & Crespo‐Facorro, B. (2013) · Psychiatry Research · doi:10.1016/j.psychres.2013.01.024 · Cited by 59 · see citing works
Fu, S., Czajkowski, N. O., Rund, B. R., & Torgalsbøen, A. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.03.002 · Cited by 59 · see citing works
Allott, K., Cotton, S., Chinnery, G. L., Baksheev, G., Massey, J., Sun, P., Collins, Z., Barlow, E., Broussard, C., Wahid, T., et al. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.07.047 · Cited by 57 · see citing works
Impaired Midline Theta Power and Connectivity During Proactive Cognitive Control in Schizophrenia
Ryman, S. G., Cavanagh, J. F., Wertz, C. J., Shaff, N. A., Dodd, A. B., Stevens, B., Ling, J. M., Yeo, R. A., Hanlon, F. M., Bustillo, J., et al. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.04.021 · Cited by 57 · see citing works
Course and outcome of schizophrenia
THARA, R., & Mohan, G. (2012) · International Review of Psychiatry · doi:10.3109/09540261.2012.707973 · Cited by 55 · see citing works
Neurobiology of Cognitive Remediation Therapy for Schizophrenia: A Systematic Review
Thorsen, A. L., Johansson, K., & Løberg, E. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00103 · Cited by 55 · see citing works
mHealth for schizophrenia spectrum disorders management: A systematic review
Chivilgina, O., Wangmo, T., Elger, B. S., Heinrich, T. W., & Jotterand, F. (2020) · International Journal of Social Psychiatry · doi:10.1177/0020764020933287 · Cited by 55 · see citing works
Neurocognitive predictors of social cognition in remitted schizophrenia
Mehta, U. M., Bhagyavathi, H. D., Thirthalli, J., Kumar, K. J., & Gangadhar, B. N. (2014) · Psychiatry Research · doi:10.1016/j.psychres.2014.05.055 · Cited by 53 · see citing works
Improvement of cognitive function in schizophrenia withN-acetylcysteine: A theoretical review
Yolland, C. O. B., Phillipou, A., Castle, D. J., Neill, E., Hughes, M. E., Galletly, C. A., Smith, Z. M., Francis, P. S., Dean, O. M., Sarris, J. J., et al. (2018) · Nutritional Neuroscience · doi:10.1080/1028415x.2018.1478766 · Cited by 52 · see citing works
Neural correlates of global and specific cognitive deficits in schizophrenia
Jirsaraie, R. J., Sheffield, J. M., & Barch, D. M. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2018.06.017 · Cited by 53 · see citing works
Nuechterlein, K. H., Ventura, J., Subotnik, K. L., Hayata, J. N., Medalia, A. A., & Bell, M. D. (2014) · American Journal of Psychiatric Rehabilitation · doi:10.1080/15487768.2014.935674 · Cited by 53 · see citing works
Trends in big data analyses by multicenter collaborative translational research in psychiatry
Onitsuka, T., Hirano, Y., Nemoto, K., Hashimoto, N., Kushima, I., Koshiyama, D., Koeda, M., Takahashi, T., Noda, Y., Matsumoto, J., et al. (2021) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.13311 · Cited by 49 · see citing works
Social cognition of patients with schizophrenia across the phases of illness - A longitudinal study
Valaparla, V. L., Nehra, R., Mehta, U. M., Thirthalli, J., & Grover, S. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.03.008 · Cited by 48 · see citing works
Preliminary investigation of the effects of γ-tACS on working memory in schizophrenia
Hoy, K. E., Whitty, D., Bailey, N. W., & Fitzgerald, P. B. (2016) · Journal of Neural Transmission · doi:10.1007/s00702-016-1554-1 · Cited by 48 · see citing works
Predictors of employment in schizophrenia: The importance of intrinsic and extrinsic motivation
Reddy, L. F., Llerena, K., & Kern, R. S. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.08.006 · Cited by 46 · see citing works
Yang, Z., Lee, S. H., Rashid, N. A. A., See, Y. M., Dauwels, J., Tan, B., & Lee, J. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.639536 · Cited by 45 · see citing works
Neurocognitive performance in family-based and case-control studies of schizophrenia
Gur, R. C., BRAFF, D. L., Calkins, M. E., Dobie, D. J., Freedman, R., Greenwood, T. A., Greenwood, T. A., Lazzeroni, L. C., Light, G. A., Nuechterlein, K. H., et al. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.10.049 · Cited by 44 · see citing works
Llerena, K., Reddy, L. F., & Kern, R. S. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.06.001 · Cited by 44 · see citing works
Allott, K., Fraguas, D., Bartholomeusz, C. F., Díaz‐Caneja, C. M., Wannan, C., Parrish, E. M., Amminger, G. P., Pantelis, C., Arango, C., McGorry, P. D., et al. (2017) · Psychological Medicine · doi:10.1017/s0033291717003002 · Cited by 44 · see citing works
Course of cognitive deficits in first episode of non-affective psychosis: A 3-year follow-up study
Rodríguez-Sánchez, J. M., Ayesa‐Arriola, R., Pérez‐Iglesias, R., Periañez, J. A., Martínez‐García, O., Gómez-Ruíz, E., Tabarés‐Seisdedos, R., & Crespo‐Facorro, B. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.06.042 · Cited by 43 · see citing works
Trapp, W., Landgrebe, M., Hösl, K. M., Lautenbacher, S., Gallhofer, B., Günther, W., & Hajak, G. (2013) · BMC Psychiatry · doi:10.1186/1471-244x-13-184 · Cited by 43 · see citing works
The puzzle of schizophrenia: Tracking the core role of cognitive deficits
Nuechterlein, K. H., Subotnik, K. L., Ventura, J., Green, M. F., Gretchen‐Doorly, D., & Asarnow, R. F. (2012) · Development and Psychopathology · doi:10.1017/s0954579412000132 · Cited by 43 · see citing works
Sawada, K., Kanehara, A., Sakakibara, E., Eguchi, S., Tada, M., Satomura, Y., Suga, M., Koike, S., & Kasai, K. (2017) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12522 · Cited by 43 · see citing works
Affective systems induce formal thought disorder in early-stage psychosis.
Minor, K. S., Marggraf, M. P., Davis, B. J., Mehdiyoun, N. F., & Breier, A. F. (2016) · Journal of Abnormal Psychology · doi:10.1037/abn0000156 · Cited by 42 · see citing works
Stouten, L. H., Veling, W., Laan, W., van der Helm, M., & van der Gaag, M. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.06.023 · Cited by 41 · see citing works
A meta-analysis on the impact of psychiatric disorders and maltreatment on cognition.
Masson, M., East‐Richard, C., & Cellard, C. (2015) · Neuropsychology · doi:10.1037/neu0000228 · Cited by 39 · see citing works
Measuring psychosocial outcome is good
Lin, A. P., Wood, S. J., & Yung, A. R. (2013) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e32835d82aa · Cited by 39 · see citing works
Predicting employment status and subjective quality of life in patients with schizophrenia
Fujino, H., Sumiyoshi, C., Sumiyoshi, T., Yasuda, Y., Yamamori, H., Ohi, K., Fujimoto, M., Hashimoto, R., Takeda, M., & Imura, O. (2015) · Schizophrenia Research Cognition · doi:10.1016/j.scog.2015.10.005 · Cited by 39 · see citing works
Neuroscience‐informed computer‐assisted cognitive training in schizophrenia
Fisher, M., Herman, A. B., Stephens, D. B., & Vinogradov, S. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13042 · Cited by 40 · see citing works
Silva, A., Limongi, R., Mackinley, M., & Palaniyappan, L. K. (2021) · Schizophrenia Bulletin Open · doi:10.1093/schizbullopen/sgab010 · Cited by 41 · see citing works
Rowe, A. R., Mercer, L., Casetti, V., Sendt, K.-V., Giaroli, G., Shergill, S. S., & Tracy, D. K. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881114564096 · Cited by 38 · see citing works
Fraguas, D., Merchán‐Naranjo, J., Rey, A., Castro‐Fornieles, J., González-Pinto, A. M., Rapado‐Castro, M., Pina‐Camacho, L., Díaz‐Caneja, C. M., Graell, M., Otero, S., et al. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.06.038 · Cited by 38 · see citing works
Decision processes and the slowing of simple choices in schizophrenia.
Heathcote, A., Suraev, A., Curley, S., Gong, Q., Love, J., & Michie, P. T. (2015) · Journal of Abnormal Psychology · doi:10.1037/abn0000117 · Cited by 38 · see citing works
The RAISE Connection Program for Early Psychosis
Marino, L. A., Nossel, I. R., Choi, J. C., Nuechterlein, K. H., Wang, Y., Essock, S. M., Bennett, M. E., McNamara, K., Mendon, S. J., & Dixon, L. B. (2015) · The Journal of Nervous and Mental Disease · doi:10.1097/nmd.0000000000000293 · Cited by 37 · see citing works
A review of autobiographical memory studies on patients with schizophrenia spectrum disorders
Zhang, Y., Kuhn, S. K., Jobson, L., & Haque, S. (2019) · BMC Psychiatry · doi:10.1186/s12888-019-2346-6 · Cited by 35 · see citing works
Lystad, J. U., Falkum, E., Haaland, V. Ø., Bull, H. C., Evensen, S., McGurk, S. R., & Ueland, T. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.12.020 · Cited by 36 · see citing works
Liao, J., Yan, H., Liu, Q., Yan, J., Zhang, L., Jiang, S., Zhang, X., Dong, Z., Yang, W., Cai, L., et al. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.04.008 · Cited by 36 · see citing works
Loewy, R. L., Fisher, M., Ma, S., Carter, C., Ragland, J. D., Niendam, T. A., Stuart, B. K., Schlosser, D. A., Amirfathi, F., Yohannes, S., et al. (2021) · Schizophrenia Bulletin · doi:10.1093/schbul/sbab102 · Cited by 35 · see citing works
Computational approaches to schizophrenia: A perspective on negative symptoms
Deserno, L., Heinz, A., & Schlagenhauf, F. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2016.10.004 · Cited by 31 · see citing works
Sato, S., Iwata, K., Furukawa, S., Matsuda, Y., Hatsuse, N., & Ikebuchi, E. (2014) · Clinical Practice and Epidemiology in Mental Health · doi:10.2174/1745017901410010018 · Cited by 34 · see citing works
Virtual shopping: A viable alternative to direct assessment of real life function?
Greenwood, K., Morris, R. G., Smith, V. M., Bibby-Jones, A.-M., Pearman, D., & Wykes, T. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.02.029 · Cited by 34 · see citing works
Tishler, T. A., Bartzokis, G., Lu, P. H., Raven, E. P., Khanoyan, M., Kirkpatrick, C. J., Pyle, M., Villablanca, J. P., Altshuler, L. L., Mintz, J., et al. (2017) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2017.03.007 · Cited by 34 · see citing works
Campos, C., Rocha, N., Lattari, E., Nardi, A. E., & Machado, S. E. D. C. (2017) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527315666161223142918 · Cited by 33 · see citing works
Cortical thinning and flattening in schizophrenia and their unaffected parents
Yan, J., Cui, Y. J., Li, Q., Tian, L., Liu, B., Jiang, T., Zhang, D., & Yan, H. (2019) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s195134 · Cited by 32 · see citing works
Wang, Z., Zhang, Y., Zhang, H., & Li, Y. (2014) · Current Pharmaceutical Design · doi:10.2174/1381612820666140826115559 · Cited by 33 · see citing works
Jones, K. M., Mcdonald, I. M., Bourin, C., Olson, R., Bristow, L., & Easton, A. (2014) · Psychopharmacology · doi:10.1007/s00213-013-3275-6 · Cited by 33 · see citing works
Premorbid adjustment predictors of cognitive dysfunction in schizophrenia
Stefanatou, P., Karatosidi, C.-S., Tsompanaki, E. I., Κάττουλας, Ε. Ν., Stefanis, N. C., & Smyrnis, N. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.06.029 · Cited by 33 · see citing works
Simons, C. J. P., Bartels‐Velthuis, A. A., Pijnenborg, G. H. M., & Genetic Risk and Outcome of Psychosis (GROUP) Investigators (2016) · PLoS ONE · doi:10.1371/journal.pone.0151299 · Cited by 32 · see citing works
Moritz, S., Silverstein, S. M., Beblo, T., Özaslan, Z., Zink, M., & Gallinat, J. (2021) · Schizophrenia Bulletin Open · doi:10.1093/schizbullopen/sgaa034 · Cited by 30 · see citing works
Olivier, M. R., Killian, S., Chiliza, B., Asmal, L., Schoeman, R., Oosthuizen, P., Kidd, M., & Emsley, R. A. (2015) · Psychological Medicine · doi:10.1017/s0033291715000860 · Cited by 31 · see citing works
Ceaser, A. E., & Barch, D. M. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2015.00687 · Cited by 30 · see citing works
Ventura, J., Welikson, T., Ered, A., Subotnik, K. L., Keefe, R. S. E., Hellemann, G., & Nuechterlein, K. H. (2019) · Early Intervention in Psychiatry · doi:10.1111/eip.12831 · Cited by 30 · see citing works
Berry, C., & Greenwood, K. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.07.032 · Cited by 30 · see citing works
Bowie, C. R., McLaughlin, D., Carrión, R. E., Auther, A. M., & Cornblatt, B. A. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.02.008 · Cited by 30 · see citing works
Lahera, G., Ruiz, Á. Y., Brañas, A., Vicens, M., & Orozco, A. (2017) · Revista de Psiquiatría y Salud Mental · doi:10.1016/j.rpsm.2017.04.001 · Cited by 29 · see citing works
Practical Guidance on the Use of Lurasidone for the Treatment of Adults with Schizophrenia
Javed, A., Arthur, H., Curtis, L., Hansen, L. K., & Pappa, S. (2019) · Neurology and Therapy · doi:10.1007/s40120-019-0138-z · Cited by 29 · see citing works
Chang, W. C., Tang, J. Y. ‐., Hui, C. L. M., Chan, S. K. W., Lee, E. H. M., & Chen, E. Y. H. (2014) · Psychiatry Research · doi:10.1016/j.psychres.2014.09.012 · Cited by 30 · see citing works
An update on supported employment for people with severe mental illness
Marino, L. A., & Dixon, L. B. (2014) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000058 · Cited by 29 · see citing works
Neurocognition and Social Cognition Predicting 1-Year Outcomes in First-Episode Psychosis
Lindgren, M., Torniainen‐Holm, M., Kieseppä, T., & Suvisaari, J. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.603933 · Cited by 28 · see citing works
- Authors
- Nuechterlein, K. H., Subotnik, K. L., Green, M. F., Ventura, J., Asarnow, R. F., Gitlin, M. J., Yee, C. M., Gretchen-Doorly, D., & Mintz, J.
- Affiliations
- University of California, Los Angeles (US)
- The University of Texas at San Antonio Health Science Center (US)
- Corresponding author
- Nuechterlein, K. H.
- Venue
- Schizophrenia Bulletin
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-08-22
- Volume
- 37
- Issue
- suppl 2
- Pages
- S33-S40
- ISSN
- 0586-7614 (ISSN-L)
- 1745-1701
- PMC
- PMC3160123
- OpenAlex
- W2102694811
- Cited by
- 297
- References
- 47
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 19 · 2023: 5 · 2022: 19 · 2021: 19 · 2020: 23 · 2019: 24 · 2018: 28 · 2017: 22 · 2016: 29 · 2015: 30 · 2014: 29 · 2013: 24 · 2012: 9
- FWCI
- 14.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Schizophrenia Bulletin (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bristol-Myers Squibb
- Janssen Scientific Affairs
- National Institute of Mental Health (MH037705, MH-066286, MH030911, R01MH037705, P50MH066286)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Social Sciences › Safety Research › Disability Education and Employment
- Keywords
- recent-onset schizophrenia, first-episode psychosis
- MeSH terms
- Adolescent, Adult, Cognition, Female, Follow-Up Studies, Humans, Male, Neuropsychological Tests, Regression Analysis, Schizophrenia, Schizophrenic Psychology, Social Adjustment, Time Factors, Work, Outcome Assessment, Health Care, Young Adult
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