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Cited by 136Schizophrenia research and treatmentMental Health and PsychiatryBipolar Disorder and Treatment

Depressive symptoms in stable chronic schizophrenia: prevalence and relationship to psychopathology and treatment

Baynes, D., Mulholland, C., Cooper, S.J., Montgomery, R.C., MacFlynn, G., Lynch, G., Kelly, C., King, D.J.·2000·Schizophrenia Research
DOI 10.1016/s0920-9964(99)00205-4
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Abstract

The prevalence and correlates of the depressive syndrome were explored in a population of 120 patients with stable, chronic schizophrenia living in the community. The presence of clinically significant depressive symptoms was defined by a score of 17 or greater on the Beck Depression Inventory. Patients were examined to assess severity of schizophrenic symptoms and medication side-effects. Sixteen of the 120 patients (13.3%) had significant depressive symptoms. Depressive symptoms were significantly correlated with the hostility/suspiciousness (P<0.0001), the positive symptom (P=0.0009) factor of the BPRS and with scores on the Significant Others Scale, a measure of patients' perceived lack of social support (P=0.0004). The association between depression and akathisia approached significance (P=0.007). There was no correlation with demographic variables, alcohol intake, antipsychotic dosage or anticholinergic dosage. Using a scale that rates the subjective aspects of the depressive syndrome, we found no evidence of a relationship between depression and negative symptoms in this population. These results indicate that persistent depressive symptoms in stable patients in the community are related to the degree of persistent positive psychotic symptoms, patient perceptions of social support and, weakly, to the degree of akathisia but not other aspects of antipsychotic treatment.

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  • Depression and anxiety are strongly associated with positive symptoms, negative symptoms, psychotic relapses and impaired social function, and are among the best symptom predictors of quality of life outcomes in people with SSDs.

    “Depression and anxiety are strongly associated with positive symptoms,2,3,5–7,9 negative symptoms,2,8 psychotic relapses3,9 and impaired social function,3,5,9 and are among the best symptom predictors of quality of life outcomes in people with SSDs.2–9”

    From Dispositional Mindfulness and Psychotic Symptoms in Schizophrenia Spectrum Disorders: The Mediating Roles of Rumination and Negative Emotion (2022) · cites this paper as [5]

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Authors
Baynes, D., Mulholland, C., Cooper, S. J., Montgomery, R. C., MacFlynn, G., Lynch, G., Kelly, C., & King, D. J.
Affiliations
  • Northern Health and Social Care Trust (GB)
  • Queen's University Belfast (GB)
Corresponding author
Cooper, S.J.
ORCID
Venue
Schizophrenia Research
Publisher
Elsevier BV
Published
2000-09
Volume
45
Issue
1-2
Pages
47-56
ISSN
0920-9964 (ISSN-L)
DOI
10.1016/s0920-9964(99)00205-4
OpenAlex
W2120118985
Cited by
136
References
61
Citations by year
2026: 2 · 2024: 4 · 2023: 4 · 2022: 8 · 2021: 8 · 2020: 5 · 2019: 3 · 2018: 7 · 2017: 10 · 2016: 10 · 2015: 9 · 2014: 3 · 2013: 4 · 2012: 5
FWCI
1.86
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Schizophrenia Research (publishedVersion)
  • PubMed (publishedVersion)
  • Research Portal (Queen's University Belfast) (submittedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Keywords
depressive symptoms, chronic schizophrenia
MeSH terms
Adolescent, Adult, Aged, Chronic Disease, Depression, Female, Hostility, Humans, Male, Middle Aged, Brief Psychiatric Rating Scale, Psychomotor Agitation, Psychotic Disorders, Schizophrenia, Schizophrenic Psychology, Severity of Illness Index, Prevalence

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