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Cited by 553

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

Passive skin penetration enhancement and its quantification in vitro

Open access
Moser, K·2001·European Journal of Pharmaceutics and Biopharmaceutics
DOI 10.1016/s0939-6411(01)00166-7
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Abstract

The poor penetration of drugs into the skin (and, partially, the permeation across the stratum corneum) often limits the efficacy of topical formulations. Basically, skin penetration can be enhanced by the following strategies: (i) increasing drug diffusivity in the skin; (ii) increasing drug solubility in the skin, and/or (iii) increasing the degree of saturation of the drug in the formulation. In this article, we review the literature with respect to: (i) chemical penetration enhancers, which have been shown to influence the diffusivity and/or solubility of the drug in the skin and (ii) supersaturated formulations, in which the degree of saturation of the drug is increased compared to conventional formulations. In addition, three different in vitro methods, specifically, classic diffusion cell studies, attenuated total-reflectance-Fourier transform infrared spectroscopy, and tape stripping in conjunction with an appropriate analytical technique, are considered, emphasizing their application to obtain quantitative values for skin transport parameters and to separate the kinetic or thermodynamic effects of an enhancement strategy.

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Metadata

Authors
Moser, K.
Venue
European Journal of Pharmaceutics and Biopharmaceutics
Publisher
Elsevier BV
Published
2001-09
Volume
52
Issue
2
Pages
103-112
ISSN
0939-6411 (ISSN-L)
DOI
10.1016/s0939-6411(01)00166-7
OpenAlex
W2045456307
Cited by
553
References
43
FWCI
7.32
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Passive skin penetration enhancement and its quantification in vitro. https://app.cochat.ai/papers/10.1016/s0939-6411(01)00166-7
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Moser, K. (2001). Passive skin penetration enhancement and its quantification in vitro. European Journal of Pharmaceutics and Biopharmaceutics. https://doi.org/10.1016/s0939-6411(01)00166-7

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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