JAK-STAT in Lipid Metabolism of Adipocytes

Xu, Dong; Yin, Chunyan; Wang, Sisi; Xiao, Yanfeng

doi:10.4161/jkst.27203

Cited by 69Cytokine Signaling Pathways and InteractionsAdipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

JAK-STAT in Lipid Metabolism of Adipocytes

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Xu, Dong, Yin, Chunyan, Wang, Sisi, Xiao, Yanfeng·2013·JAK-STAT

DOI 10.4161/jkst.27203PMC PMC3906428

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Abstract

JAK-STAT signaling pathway plays an important role in the cells' development and homeostasis. Over the past decades, the studies have identified the role of the JAK-STAT pathway in cell proliferation and apoptosis. Here, we want to discuss that whether and how the JAK-STAT pathway affects the lipid metabolism of adipose tissue. A host of cytokines and hormones can regulate lipid metabolism through activating the JAK-STAT signaling pathway. Activated STATs can regulate lipid metabolism directly by influencing the expression of enzymes. We have summarized the relevant research and articles of JAK-STAT during the recent years. Within this review, we will introduce you the recent research and highlight the unresolved problems in understanding how JAK-STAT signaling pathway contribute to the lipid metabolism in mature adipocytes and preadipocytes. Dysregulation of the JAK-STAT pathway would lead to a multiple metabolism disorders and medicines for this signaling pathway maybe become a new idea for diseases such as metabolic syndrome, especially in children.

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Activation of mbIL-6R leads to phosphorylation of JAK, the first step in JAK-STAT signaling, particularly STAT3, which promotes lipolysis and inhibits lipogenesis.
“The activation of mbIL-6R leads to the phosphorylation of Janus kinase (JAK), which represents the first step in the JAK–signal transducer and activator of transcription (STAT) signaling pathway, particularly STAT3, which promotes lipolysis and inhibits lipogenesis [39].”
From Exercise-Induced Muscle–Fat Crosstalk: Molecular Mediators and Their Pharmacological Modulation for the Maintenance of Metabolic Flexibility in Aging (2025) · cites this paper as [39]

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Authors: Xu, D., Yin, C., Wang, S., & Xiao, Y.
Affiliations: Second Affiliated Hospital of Xi'an Jiaotong University (CN)
Corresponding author: Xiao, Yanfeng
ORCID: Yin, Chunyan
Wang, Sisi
Xiao, Yanfeng
Venue: JAK-STAT
Publisher: Informa UK Limited
Published: 2013-10-16
Volume: 2
Issue: 4
Pages: e27203
ISSN: 2162-3988 (ISSN-L)
2162-3996
DOI: 10.4161/jkst.27203
PMC: PMC3906428
OpenAlex: W2147179990
Cited by: 69
References: 72
Citations by year: 2026: 3 · 2025: 4 · 2024: 10 · 2023: 4 · 2022: 8 · 2021: 6 · 2020: 8 · 2019: 9 · 2018: 4 · 2017: 6 · 2016: 2 · 2015: 4 · 2014: 1
FWCI: 0.25
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: JAK-STAT (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords: JAK/STAT signaling, adipocyte lipid metabolism, adipose tissue, preadipocytes, cytokines, hormones, STAT transcription factors, metabolic syndrome, children, lipid metabolism disorders

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JAK-STAT in Lipid Metabolism of Adipocytes

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