Regulation and function of the p53 tumor suppressor protein
Abstract
Loss of the p53 tumor suppressor pathway contributes to the development of most human cancers. p53 is a nuclear protein that functions as a regulator of transcription. Significant advances have been made recently in our understanding of how p53 function is regulated and the mechanisms by which p53 mediates its effects.
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Arsenic results in cytotoxicity by affecting the status of tumor-suppressor protein 53.
“Arsenic results in cytotoxicity by affecting the status of tumor-suppressor protein 53 [92, 93].”
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In pancreatic cancer, frequent mutations occur in driver genes KRAS (88%), TP53 (77%), SMAD4 (29%), CDKN2A (18%) and TGFBR2 (7%).
“In pancreatic cancer, frequent mutations occur in driver genes such as KRAS (88%), TP53 (77%), SMAD4 (29%), CDKN2A (18%) and TGFBR2 (7%) [7,8].”
From Significance of TP53, CDKN2A, SMAD4 and KRAS in Pancreatic Cancer (2024) · cites this paper as [7]
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- Authors
- Ryan, K. M., Phillips, A. C., & Vousden, K. H.
- Affiliations
- Frederick National Laboratory for Cancer Research (US)
- Corresponding author
- Vousden, Karen H
- Venue
- Current Opinion in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2001-06
- Volume
- 13
- Issue
- 3
- Pages
- 332-337
- ISSN
- 0955-0674 (ISSN-L)
- OpenAlex
- W2104398672
- Cited by
- 721
- References
- 9
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 14 · 2023: 26 · 2022: 18 · 2021: 28 · 2020: 20 · 2019: 13 · 2018: 22 · 2017: 12 · 2016: 21 · 2015: 34 · 2014: 41 · 2013: 32 · 2012: 24
- FWCI
- 6.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Keywords
- p53, tumor suppressor proteins, transcriptional regulation, p53 regulation, p53 function, carcinogenesis, transcriptional activation
- MeSH terms
- Animals, Cell Compartmentation, Cell Cycle, Cell Division, Humans, Mutation, Neoplasms, Transcription Factors, Transcription, Genetic, Gene Expression Regulation, Neoplastic, Tumor Suppressor Protein p53, Apoptosis, Active Transport, Cell Nucleus
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